Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Smyd4 | Mouse | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMYD4 mRNA | CTD | PMID:36331819 | Smyd4 | Mouse | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SMYD4 mRNA | CTD | PMID:22206623 | Smyd4 | Mouse | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMYD4 mRNA | CTD | PMID:17942748 | Smyd4 | Mouse | 17beta-estradiol | increases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SMYD4 mRNA | CTD | PMID:32030086 | Smyd4 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMYD4 mRNA | CTD | PMID:17942748 | Smyd4 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMYD4 mRNA | CTD | PMID:33387578 | Smyd4 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SMYD4 mRNA | CTD | PMID:21570461 | Smyd4 | Mouse | 2,4-dinitrotoluene | affects expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of SMYD4 mRNA | CTD | PMID:21346803 | Smyd4 | Mouse | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMYD4 mRNA | CTD | PMID:28628672 | Smyd4 | Mouse | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of SMYD4 mRNA | CTD | PMID:18648102 | Smyd4 | Mouse | acrolein | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of SMYD4 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Smyd4 | Mouse | acrylamide | increases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | Acrylamide results in increased expression of SMYD4 mRNA | CTD | PMID:28959563 | Smyd4 | Mouse | all-trans-retinoic acid | decreases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SMYD4 mRNA | CTD | PMID:33167477 | Smyd4 | Mouse | alpha-pinene | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of SMYD4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of SMYD4 mRNA | CTD | PMID:32699268 | Smyd4 | Mouse | amphetamine | decreases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of SMYD4 mRNA | CTD | PMID:30779732 | Smyd4 | Mouse | benzo[a]pyrene | increases mutagenesis | ISO | SMYD4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of SMYD4 gene | CTD | PMID:25435355 | Smyd4 | Mouse | benzo[a]pyrene | decreases methylation | ISO | SMYD4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SMYD4 3' UTR | CTD | PMID:27901495 | Smyd4 | Mouse | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SMYD4 mRNA | CTD | PMID:22228805 | Smyd4 | Mouse | bisphenol A | affects expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of SMYD4 mRNA | CTD | PMID:25181051 | Smyd4 | Mouse | bisphenol A | affects methylation | ISO | SMYD4 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of SMYD4 gene | CTD | PMID:31601247 | Smyd4 | Mouse | bisphenol A | decreases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SMYD4 mRNA | CTD | PMID:30816183 more ... | Smyd4 | Mouse | bisphenol A | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SMYD4 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMYD4 mRNA | CTD | PMID:28628672 and PMID:31601247 | Smyd4 | Mouse | cadmium dichloride | decreases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SMYD4 mRNA | CTD | PMID:38568856 | Smyd4 | Mouse | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon results in increased expression of SMYD4 mRNA | CTD | PMID:25620056 | Smyd4 | Mouse | CGP 52608 | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SMYD4 gene] | CTD | PMID:28238834 | Smyd4 | Mouse | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of SMYD4 mRNA | CTD | PMID:23811191 | Smyd4 | Mouse | cyclosporin A | decreases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SMYD4 mRNA | CTD | PMID:25562108 | Smyd4 | Mouse | dexamethasone | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMYD4 mRNA | CTD | PMID:28628672 | Smyd4 | Mouse | Dibutyl phosphate | affects expression | ISO | SMYD4 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SMYD4 mRNA | CTD | PMID:37042841 | Smyd4 | Mouse | doxorubicin | decreases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SMYD4 mRNA | CTD | PMID:29803840 | Smyd4 | Mouse | endosulfan | increases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of SMYD4 mRNA | CTD | PMID:29391264 | Smyd4 | Mouse | ethyl methanesulfonate | increases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of SMYD4 mRNA | CTD | PMID:23649840 | Smyd4 | Mouse | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of SMYD4 mRNA | CTD | PMID:25629700 | Smyd4 | Mouse | fulvestrant | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SMYD4 gene | CTD | PMID:31601247 | Smyd4 | Mouse | gentamycin | increases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of SMYD4 mRNA | CTD | PMID:33387578 | Smyd4 | Mouse | hypochlorous acid | increases expression | EXP | | 6480464 | Hypochlorous Acid results in increased expression of SMYD4 mRNA | CTD | PMID:19376150 | Smyd4 | Mouse | indometacin | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMYD4 mRNA | CTD | PMID:28628672 | Smyd4 | Mouse | leflunomide | decreases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of SMYD4 mRNA | CTD | PMID:28988120 | Smyd4 | Mouse | methyl methanesulfonate | increases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SMYD4 mRNA | CTD | PMID:23649840 | Smyd4 | Mouse | ozone | multiple interactions | ISO | SMYD4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of SMYD4 mRNA more ... | CTD | PMID:32699268 more ... | Smyd4 | Mouse | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of SMYD4 mRNA | CTD | PMID:34911549 | Smyd4 | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of SMYD4 mRNA | CTD | PMID:17562736 | Smyd4 | Mouse | paracetamol | increases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of SMYD4 mRNA | CTD | PMID:33387578 | Smyd4 | Mouse | paracetamol | increases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SMYD4 mRNA | CTD | PMID:22230336 | Smyd4 | Mouse | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMYD4 mRNA | CTD | PMID:36331819 | Smyd4 | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of SMYD4 mRNA | CTD | PMID:18301758 and PMID:23811191 | Smyd4 | Mouse | silver atom | increases expression | EXP | | 6480464 | Silver results in increased expression of SMYD4 mRNA | CTD | PMID:27131904 | Smyd4 | Mouse | silver(0) | increases expression | EXP | | 6480464 | Silver results in increased expression of SMYD4 mRNA | CTD | PMID:27131904 | Smyd4 | Mouse | sodium arsenite | decreases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SMYD4 mRNA | CTD | PMID:38568856 | Smyd4 | Mouse | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of SMYD4 mRNA and [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SMYD4 mRNA | CTD | PMID:21641980 and PMID:26378955 | Smyd4 | Mouse | sunitinib | increases expression | ISO | SMYD4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SMYD4 mRNA | CTD | PMID:31533062 | Smyd4 | Mouse | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of SMYD4 mRNA | CTD | PMID:17484886 | Smyd4 | Mouse | thioacetamide | decreases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of SMYD4 mRNA | CTD | PMID:34492290 | Smyd4 | Mouse | titanium dioxide | increases methylation | EXP | | 6480464 | titanium dioxide results in increased methylation of SMYD4 gene | CTD | PMID:35295148 | Smyd4 | Mouse | trichloroethene | increases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of SMYD4 mRNA | CTD | PMID:33387578 | Smyd4 | Mouse | triphenyl phosphate | affects expression | ISO | SMYD4 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SMYD4 mRNA | CTD | PMID:37042841 | Smyd4 | Mouse | valdecoxib | decreases expression | ISO | Smyd4 (Rattus norvegicus) | 6480464 | valdecoxib results in decreased expression of SMYD4 mRNA | CTD | PMID:24136188 | Smyd4 | Mouse | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of SMYD4 mRNA | CTD | PMID:17292431 | |