Cfap298 (cilia and flagella associate protien 298) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cfap298 (cilia and flagella associate protien 298) Mus musculus
Analyze
Symbol: Cfap298
Name: cilia and flagella associate protien 298
RGD ID: 1315862
MGI Page MGI
Description: Predicted to be involved in cilium assembly and regulation of cilium movement. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 26. Orthologous to human CFAP298 (cilia and flagella associated protein 298).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110004E09Rik; cilia- and flagella-associated protein 298; hypothetical protein LOC68001; RIKEN cDNA 1110004E09 gene; uncharacterized protein LOC68001; UPF0769 protein C21orf59 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,721,178 - 90,731,737 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1690,722,697 - 90,732,002 (-)EnsemblGRCm39 Ensembl
GRCm381690,925,811 - 90,934,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,925,809 - 90,935,114 (-)EnsemblGRCm38mm10GRCm38
MGSCv371690,926,056 - 90,935,094 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361690,814,692 - 90,823,672 (-)NCBIMGSCv36mm8
Celera1692,007,683 - 92,016,703 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1652.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (IEA)
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12466854   PMID:12466855   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18799693  
PMID:21267068   PMID:21677750   PMID:32325033  


Genomics

Comparative Map Data
Cfap298
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,721,178 - 90,731,737 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1690,722,697 - 90,732,002 (-)EnsemblGRCm39 Ensembl
GRCm381690,925,811 - 90,934,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,925,809 - 90,935,114 (-)EnsemblGRCm38mm10GRCm38
MGSCv371690,926,056 - 90,935,094 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361690,814,692 - 90,823,672 (-)NCBIMGSCv36mm8
Celera1692,007,683 - 92,016,703 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1652.17NCBI
CFAP298
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382132,599,354 - 32,612,377 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2132,592,079 - 32,612,603 (-)EnsemblGRCh38hg38GRCh38
GRCh372133,971,664 - 33,984,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362132,895,966 - 32,906,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 342132,895,979 - 32,906,537NCBI
Celera2119,157,614 - 19,168,548 (-)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2119,383,353 - 19,394,289 (-)NCBIHuRef
CHM1_12133,535,638 - 33,546,572 (-)NCBICHM1_1
T2T-CHM13v2.02130,965,355 - 30,978,378 (-)NCBIT2T-CHM13v2.0
Cfap298
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,667,996 - 43,678,049 (-)NCBIGRCr8
mRatBN7.21130,181,916 - 30,191,302 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,181,905 - 30,191,346 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,868,697 - 38,878,058 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,540,122 - 31,549,483 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,714,602 - 30,723,965 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,094,103 - 31,103,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,094,084 - 31,103,520 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01134,705,577 - 34,714,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,910,153 - 30,919,537 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,910,063 - 30,919,444 (-)NCBI
Celera1129,849,218 - 29,858,582 (-)NCBICelera
Cytogenetic Map11q11NCBI
Cfap298
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540732,076,507 - 32,089,307 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540732,076,670 - 32,089,307 (-)NCBIChiLan1.0ChiLan1.0
CFAP298
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22228,694,642 - 28,732,677 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12123,554,599 - 23,592,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02118,944,205 - 18,982,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12132,347,675 - 32,360,658 (-)NCBIpanpan1.1PanPan1.1panPan2
CFAP298
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13127,296,841 - 27,305,941 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3127,286,376 - 27,305,608 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3127,289,820 - 27,298,627 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03127,416,658 - 27,425,567 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3127,416,665 - 27,425,843 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13127,361,664 - 27,370,488 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03127,373,445 - 27,382,254 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03127,880,768 - 27,889,603 (-)NCBIUU_Cfam_GSD_1.0
Cfap298
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497127,879,715 - 27,889,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365009,578,162 - 9,588,289 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365009,578,354 - 9,588,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFAP298
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13196,210,011 - 196,224,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113196,210,006 - 196,225,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213206,220,246 - 206,235,893 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CFAP298
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,529,058 - 59,542,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl259,528,538 - 59,543,974 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660712,069,003 - 2,082,415 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfap298
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474520,862,538 - 20,876,646 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474520,862,313 - 20,877,188 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfap298
394 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:891
Count of miRNA genes:473
Interacting mature miRNAs:539
Transcripts:ENSMUST00000023694, ENSMUST00000125519, ENSMUST00000129345, ENSMUST00000131583, ENSMUST00000142340, ENSMUST00000149833
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302194Pgia10_mproteoglycan induced arthritis 10 (mouse)Not determined166860072298008968Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1558740Bpq9_mblood pressure QTL 9 (mouse)Not determined166332733697327472Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141113Tgq28_mtriglyceride QTL 28 (mouse)Not determined6298664696986646Mouse
4142262Lmr18_mleishmaniasis resistance 18 (mouse)Not determined166912761198008968Mouse
1301598Renf2_mrenal failure 2 (mouse)Not determined167038025298008968Mouse
11049573Lmr18b_mleishmaniasis resistance 18b (mouse)166912761198008968Mouse
11522753Cocia19_mcocaine-induced activity, QTL 19 (mouse)166925448298008968Mouse
11049574Lmr18a_mleishmaniasis resistance 18a (mouse)166912761198008968Mouse
1300928Etia_methanol induced activation (mouse)Not determined166331390797314016Mouse
1301125Sluc27_msusceptibility to lung cancer 27 (mouse)Not determined166160864495608764Mouse
1301032Tauph_mtau phosphorylation (mouse)Not determined166907613298008968Mouse

Markers in Region
AV040741  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381690,935,279 - 90,935,391UniSTSGRCm38
MGSCv371690,935,524 - 90,935,636UniSTSGRCm37
Celera1692,017,133 - 92,017,245UniSTS
Cytogenetic Map16C3.3UniSTS
Whitehead/MRC_RH16976.58UniSTS
1110004E09Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371690,926,172 - 90,927,469UniSTSGRCm37
Celera1692,007,799 - 92,009,096UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic MapXA7.3UniSTS
cM Map16 UniSTS
1110004E09Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381690,925,927 - 90,927,224UniSTSGRCm38
MGSCv371690,926,172 - 90,927,469UniSTSGRCm37
Celera1692,007,799 - 92,009,096UniSTS
Cytogenetic Map16C3.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000023694   ⟹   ENSMUSP00000023694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1690,722,697 - 90,732,002 (-)Ensembl
GRCm38.p6 Ensembl1690,925,809 - 90,935,114 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125519   ⟹   ENSMUSP00000117691
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1690,722,858 - 90,731,815 (-)Ensembl
GRCm38.p6 Ensembl1690,925,970 - 90,934,927 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129345   ⟹   ENSMUSP00000122163
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1690,722,841 - 90,726,871 (-)Ensembl
GRCm38.p6 Ensembl1690,925,953 - 90,929,983 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131583
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1690,724,268 - 90,731,714 (-)Ensembl
GRCm38.p6 Ensembl1690,927,380 - 90,934,826 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142340   ⟹   ENSMUSP00000120107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1690,724,070 - 90,731,394 (-)Ensembl
GRCm38.p6 Ensembl1690,927,182 - 90,934,506 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149833   ⟹   ENSMUSP00000123417
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1690,724,007 - 90,731,611 (-)Ensembl
GRCm38.p6 Ensembl1690,927,119 - 90,934,723 (-)Ensembl
Ensembl Acc Id: ENSMUST00000231711
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1690,723,191 - 90,724,393 (-)Ensembl
GRCm38.p6 Ensembl1690,926,303 - 90,927,505 (-)Ensembl
RefSeq Acc Id: NM_026502   ⟹   NP_080778
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391690,722,699 - 90,731,737 (-)NCBI
GRCm381690,925,811 - 90,934,849 (-)ENTREZGENE
MGSCv371690,926,056 - 90,935,094 (-)RGD
Celera1692,007,683 - 92,016,703 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036160103   ⟹   XP_036015996
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391690,721,178 - 90,731,415 (-)NCBI
Sequence:
RefSeq Acc Id: NP_080778   ⟸   NM_026502
- UniProtKB: Q8VCL7 (UniProtKB/Swiss-Prot),   Q8BL95 (UniProtKB/Swiss-Prot),   Q9CU27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000117691   ⟸   ENSMUST00000125519
Ensembl Acc Id: ENSMUSP00000123417   ⟸   ENSMUST00000149833
Ensembl Acc Id: ENSMUSP00000122163   ⟸   ENSMUST00000129345
Ensembl Acc Id: ENSMUSP00000120107   ⟸   ENSMUST00000142340
Ensembl Acc Id: ENSMUSP00000023694   ⟸   ENSMUST00000023694
RefSeq Acc Id: XP_036015996   ⟸   XM_036160103
- Peptide Label: isoform X1
- UniProtKB: Q9CU27 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BL95-F1-model_v2 AlphaFold Q8BL95 1-290 view protein structure

Promoters
RGD ID:6826682
Promoter ID:MM_KWN:21666
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:AK019718_4930534H18RIK,   OTTMUST00000047484,   OTTMUST00000047485,   OTTMUST00000047486,   OTTMUST00000084745,   OTTMUST00000084746,   UC007ZWU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361690,934,461 - 90,935,917 (+)MPROMDB
RGD ID:13674414
Promoter ID:EPDNEW_M21356
Type:initiation region
Name:1110004E09Rik_1
Description:Mus musculus RIKEN cDNA 1110004E09 gene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381690,934,826 - 90,934,886EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915251 AgrOrtholog
Ensembl Genes ENSMUSG00000022972 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023694 ENTREZGENE
  ENSMUST00000023694.11 UniProtKB/Swiss-Prot
  ENSMUST00000125519.8 UniProtKB/TrEMBL
  ENSMUST00000129345.8 UniProtKB/TrEMBL
  ENSMUST00000142340.2 UniProtKB/TrEMBL
  ENSMUST00000149833.8 UniProtKB/TrEMBL
InterPro CFAP298 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68001 UniProtKB/Swiss-Prot
MGD MGI:1915251 ENTREZGENE
NCBI Gene 68001 ENTREZGENE
PANTHER CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 298 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13238 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF2870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cfap298 PhenoGen
UniProt CF298_MOUSE UniProtKB/Swiss-Prot
  D3YUI6_MOUSE UniProtKB/TrEMBL
  D3YZC4_MOUSE UniProtKB/TrEMBL
  D6REH7_MOUSE UniProtKB/TrEMBL
  F7C0A6_MOUSE UniProtKB/TrEMBL
  Q8BL95 ENTREZGENE
  Q8VCL7 ENTREZGENE
  Q9CU27 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8VCL7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-05 Cfap298  cilia and flagella associate protien 298  1110004E09Rik  RIKEN cDNA 1110004E09 gene  Symbol and/or name change 5135510 APPROVED