ARMC12 (armadillo repeat containing 12) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: ARMC12 (armadillo repeat containing 12) Homo sapiens
Analyze
Symbol: ARMC12
Name: armadillo repeat containing 12
RGD ID: 1314376
HGNC Page HGNC:21099
Description: Involved in positive regulation of cell growth and sperm mitochondrial sheath assembly. Located in nucleoplasm and plasma membrane. Implicated in spermatogenic failure 90.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: armadillo repeat-containing protein 12; C6orf81; FLJ25390; hypothetical protein LOC221481; SPGF90; uncharacterized protein C6orf81
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38635,731,524 - 35,749,079 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl635,737,032 - 35,749,079 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,704,809 - 35,716,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36635,812,837 - 35,824,663 (+)NCBINCBI36Build 36hg18NCBI36
Build 34635,812,836 - 35,824,663NCBI
Celera637,259,440 - 37,271,267 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,422,647 - 35,434,414 (+)NCBIHuRef
CHM1_1635,703,507 - 35,715,333 (+)NCBICHM1_1
T2T-CHM13v2.0635,551,853 - 35,569,445 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial outer membrane  (IEA,ISS)
mitochondrion  (IEA)
nucleoplasm  (IDA)
nucleus  (HDA,IBA,IDA,IEA)
plasma membrane  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15489334   PMID:16344560   PMID:17081983   PMID:21630459   PMID:21873635   PMID:30026490   PMID:32296183   PMID:33536340   PMID:33961781   PMID:35534203  
PMID:36949045  


Genomics

Comparative Map Data
ARMC12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38635,731,524 - 35,749,079 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl635,737,032 - 35,749,079 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,704,809 - 35,716,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36635,812,837 - 35,824,663 (+)NCBINCBI36Build 36hg18NCBI36
Build 34635,812,836 - 35,824,663NCBI
Celera637,259,440 - 37,271,267 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,422,647 - 35,434,414 (+)NCBIHuRef
CHM1_1635,703,507 - 35,715,333 (+)NCBICHM1_1
T2T-CHM13v2.0635,551,853 - 35,569,445 (+)NCBIT2T-CHM13v2.0
Armc12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,749,835 - 28,757,949 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,749,780 - 28,758,084 (+)EnsemblGRCm39 Ensembl
GRCm381728,530,861 - 28,538,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,530,806 - 28,539,110 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,667,806 - 28,675,920 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,258,450 - 28,266,696 (+)NCBIMGSCv36mm8
Celera1729,084,741 - 29,092,791 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.74NCBI
Armc12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,589,573 - 6,600,059 (+)NCBIGRCr8
mRatBN7.2206,587,859 - 6,598,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,587,859 - 6,598,352 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,301,048 - 7,311,664 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,662,882 - 6,673,499 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,142,006 - 7,152,439 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0208,109,691 - 8,120,183 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl208,109,635 - 8,120,180 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,308,966 - 10,319,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,769,884 - 6,780,377 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,770,117 - 6,780,418 (+)NCBI
Celera208,144,369 - 8,154,820 (+)NCBICelera
Cytogenetic Map20p12NCBI
Armc12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,592,085 - 3,600,959 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,591,343 - 3,599,887 (+)NCBIChiLan1.0ChiLan1.0
ARMC12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2550,205,668 - 50,218,753 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1646,072,652 - 46,085,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,299,170 - 35,311,231 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,500,828 - 36,512,824 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,500,828 - 36,512,824 (+)Ensemblpanpan1.1panPan2
ARMC12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,868,831 - 4,879,801 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,869,774 - 4,879,793 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,884,085 - 4,895,222 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,210,677 - 5,221,818 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,211,677 - 5,221,807 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,866,533 - 4,877,668 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,945,650 - 4,956,778 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,046,021 - 5,057,189 (+)NCBIUU_Cfam_GSD_1.0
Armc12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,398,547 - 40,422,216 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,537,987 - 23,555,667 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,538,020 - 23,562,126 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARMC12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,586,797 - 31,603,600 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,583,544 - 31,601,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,508,170 - 36,529,669 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARMC12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,368,789 - 36,392,119 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,368,832 - 36,388,749 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604435,655,193 - 35,668,194 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Armc12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,788,031 - 21,795,807 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,787,998 - 21,795,825 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARMC12
26 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001286574.2(ARMC12):c.163+28C>T single nucleotide variant not provided [RCV000122585] Chr6:35737299 [GRCh38]
Chr6:35705076 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.601G>T (p.Asp201Tyr) single nucleotide variant Malignant tumor of prostate [RCV000149344] Chr6:35747417 [GRCh38]
Chr6:35715194 [GRCh37]
Chr6:6p21.31		 uncertain significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_001286574.2(ARMC12):c.784C>T (p.Arg262Trp) single nucleotide variant not specified [RCV004285803] Chr6:35748631 [GRCh38]
Chr6:35716408 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.542A>G (p.Asp181Gly) single nucleotide variant not specified [RCV004305194] Chr6:35747358 [GRCh38]
Chr6:35715135 [GRCh37]
Chr6:6p21.31		 uncertain significance
GRCh37/hg19 6p21.31-21.2(chr6:34683518-36905281)x3 copy number gain not provided [RCV000682660] Chr6:34683518..36905281 [GRCh37]
Chr6:6p21.31-21.2		 likely pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
NM_001286574.2(ARMC12):c.194G>A (p.Arg65Gln) single nucleotide variant not specified [RCV004284451] Chr6:35738057 [GRCh38]
Chr6:35705834 [GRCh37]
Chr6:6p21.31		 uncertain significance
GRCh37/hg19 6p21.31-21.2(chr6:34401304-38435497) copy number loss Severe intrauterine growth retardation [RCV001291973] Chr6:34401304..38435497 [GRCh37]
Chr6:6p21.31-21.2		 pathogenic
NC_000006.11:g.(?_30695893)_(36953949_?)dup duplication Proteasome-associated autoinflammatory syndrome 1 [RCV003113679] Chr6:30695893..36953949 [GRCh37]
Chr6:6p21.33-21.2		 uncertain significance
NM_001286574.2(ARMC12):c.994A>G (p.Ser332Gly) single nucleotide variant not specified [RCV004142138] Chr6:35748841 [GRCh38]
Chr6:35716618 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.346G>A (p.Gly116Ser) single nucleotide variant not specified [RCV004104365] Chr6:35738420 [GRCh38]
Chr6:35706197 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.466G>A (p.Glu156Lys) single nucleotide variant not specified [RCV004198031] Chr6:35747282 [GRCh38]
Chr6:35715059 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.938T>C (p.Ile313Thr) single nucleotide variant not specified [RCV004228782] Chr6:35748785 [GRCh38]
Chr6:35716562 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.43C>T (p.Arg15Cys) single nucleotide variant not specified [RCV004172416] Chr6:35737151 [GRCh38]
Chr6:35704928 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.1016C>T (p.Thr339Met) single nucleotide variant not specified [RCV004229488] Chr6:35748863 [GRCh38]
Chr6:35716640 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.163+38G>C single nucleotide variant not specified [RCV004167243] Chr6:35737309 [GRCh38]
Chr6:35705086 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.863C>T (p.Ser288Phe) single nucleotide variant not specified [RCV004120678] Chr6:35748710 [GRCh38]
Chr6:35716487 [GRCh37]
Chr6:6p21.31		 uncertain significance
NC_000006.11:g.(?_32148920)_(36953949_?)dup duplication not provided [RCV003154914] Chr6:32148920..36953949 [GRCh37]
Chr6:6p21.32-21.2		 uncertain significance
NM_001286574.2(ARMC12):c.311C>T (p.Ala104Val) single nucleotide variant not specified [RCV004252204] Chr6:35738385 [GRCh38]
Chr6:35706162 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.163+19G>C single nucleotide variant not specified [RCV004354368] Chr6:35737290 [GRCh38]
Chr6:35705067 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.185G>A (p.Arg62Gln) single nucleotide variant not specified [RCV004354824] Chr6:35738048 [GRCh38]
Chr6:35705825 [GRCh37]
Chr6:6p21.31		 uncertain significance
GRCh37/hg19 6p21.31-21.1(chr6:35562152-42003452)x1 copy number loss not provided [RCV003485510] Chr6:35562152..42003452 [GRCh37]
Chr6:6p21.31-21.1		 pathogenic
NM_001286574.2(ARMC12):c.213G>A (p.Arg71=) single nucleotide variant not provided [RCV003428839] Chr6:35738076 [GRCh38]
Chr6:35705853 [GRCh37]
Chr6:6p21.31		 likely benign
NM_001286574.2(ARMC12):c.52G>A (p.Val18Ile) single nucleotide variant not specified [RCV004417952] Chr6:35737160 [GRCh38]
Chr6:35704937 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.326C>T (p.Thr109Met) single nucleotide variant not specified [RCV004417951] Chr6:35738400 [GRCh38]
Chr6:35706177 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.686G>A (p.Cys229Tyr) single nucleotide variant Spermatogenic failure 90 [RCV003883481] Chr6:35747643 [GRCh38]
Chr6:35715420 [GRCh37]
Chr6:6p21.31		 pathogenic
NM_001286574.2(ARMC12):c.635T>C (p.Leu212Pro) single nucleotide variant Spermatogenic failure 90 [RCV003883479] Chr6:35747592 [GRCh38]
Chr6:35715369 [GRCh37]
Chr6:6p21.31		 pathogenic
NM_001286574.2(ARMC12):c.632G>A (p.Arg211Gln) single nucleotide variant Spermatogenic failure 90 [RCV003883480] Chr6:35747589 [GRCh38]
Chr6:35715366 [GRCh37]
Chr6:6p21.31		 pathogenic
NM_001286574.2(ARMC12):c.458A>T (p.Lys153Ile) single nucleotide variant not specified [RCV004417953] Chr6:35747274 [GRCh38]
Chr6:35715051 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.460G>C (p.Val154Leu) single nucleotide variant not specified [RCV004665864] Chr6:35747276 [GRCh38]
Chr6:35715053 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.322A>G (p.Thr108Ala) single nucleotide variant not specified [RCV004665868] Chr6:35738396 [GRCh38]
Chr6:35706173 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.541G>A (p.Asp181Asn) single nucleotide variant not specified [RCV004665841] Chr6:35747357 [GRCh38]
Chr6:35715134 [GRCh37]
Chr6:6p21.31		 uncertain significance
NM_001286574.2(ARMC12):c.980C>A (p.Ser327Tyr) single nucleotide variant not specified [RCV004674269] Chr6:35748827 [GRCh38]
Chr6:35716604 [GRCh37]
Chr6:6p21.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:749
Count of miRNA genes:364
Interacting mature miRNAs:395
Transcripts:ENST00000288065, ENST00000373866, ENST00000373869, ENST00000471400
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
406971458GWAS620434_Hbone mineral content measurement QTL GWAS620434 (human)0.000001bone mineral content measurement63574305535743056Human
407340036GWAS989012_HBMI-adjusted waist-hip ratio QTL GWAS989012 (human)1e-09BMI-adjusted waist-hip ratio63574605835746059Human
406971748GWAS620724_Hfemoral neck bone mineral density QTL GWAS620724 (human)0.000006femoral neck bone mineral densitybone mineral density (CMO:0001226)63574305535743056Human
407350530GWAS999506_HBMI-adjusted waist-hip ratio QTL GWAS999506 (human)8e-11BMI-adjusted waist-hip ratio63574605835746059Human
406971832GWAS620808_Hbone mineral content measurement QTL GWAS620808 (human)0.000002bone mineral content measurement63574531335745314Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human

Markers in Region
RH102021  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37635,715,130 - 35,715,395UniSTSGRCh37
Build 36635,823,108 - 35,823,373RGDNCBI36
Celera637,269,712 - 37,269,977RGD
Cytogenetic Map6p21.31UniSTS
HuRef635,432,859 - 35,433,124UniSTS
GeneMap99-GB4 RH Map6128.91UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2391 2784 2240 4925 1719 2325 2 618 1934 461 2253 7191 6420 52 3706 816 1703 1594 168

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_052798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054354594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA625684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK058119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL157823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR735810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB070109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000288065   ⟹   ENSP00000288065
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl635,737,082 - 35,748,908 (+)Ensembl
Ensembl Acc Id: ENST00000373866   ⟹   ENSP00000362973
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl635,737,032 - 35,749,079 (+)Ensembl
Ensembl Acc Id: ENST00000373869   ⟹   ENSP00000362976
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl635,737,032 - 35,748,911 (+)Ensembl
Ensembl Acc Id: ENST00000471400   ⟹   ENSP00000418825
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl635,737,092 - 35,738,509 (+)Ensembl
RefSeq Acc Id: NM_001286574   ⟹   NP_001273503
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,737,032 - 35,749,079 (+)NCBI
HuRef635,422,597 - 35,434,419 (+)NCBI
CHM1_1635,703,457 - 35,715,338 (+)NCBI
T2T-CHM13v2.0635,557,396 - 35,569,445 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001286576   ⟹   NP_001273505
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,737,032 - 35,748,913 (+)NCBI
HuRef635,422,597 - 35,434,419 (+)NCBI
CHM1_1635,703,457 - 35,715,338 (+)NCBI
T2T-CHM13v2.0635,557,396 - 35,569,279 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145028   ⟹   NP_659465
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,737,032 - 35,749,079 (+)NCBI
GRCh37635,701,567 - 35,716,690 (+)NCBI
Build 36635,812,837 - 35,824,663 (+)NCBI Archive
Celera637,259,440 - 37,271,267 (+)RGD
HuRef635,422,597 - 35,434,419 (+)NCBI
CHM1_1635,703,457 - 35,715,338 (+)NCBI
T2T-CHM13v2.0635,557,396 - 35,569,445 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011514381   ⟹   XP_011512683
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,524 - 35,749,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011514382   ⟹   XP_011512684
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,737,032 - 35,749,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017010435   ⟹   XP_016865924
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,524 - 35,749,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047418343   ⟹   XP_047274299
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,524 - 35,749,079 (+)NCBI
RefSeq Acc Id: XM_047418344   ⟹   XP_047274300
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,524 - 35,749,079 (+)NCBI
RefSeq Acc Id: XM_047418345   ⟹   XP_047274301
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,524 - 35,749,079 (+)NCBI
RefSeq Acc Id: XM_047418346   ⟹   XP_047274302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,524 - 35,749,079 (+)NCBI
RefSeq Acc Id: XM_047418347   ⟹   XP_047274303
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,524 - 35,749,079 (+)NCBI
RefSeq Acc Id: XM_047418348   ⟹   XP_047274304
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,524 - 35,749,079 (+)NCBI
RefSeq Acc Id: XM_054354591   ⟹   XP_054210566
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0635,555,342 - 35,569,445 (+)NCBI
RefSeq Acc Id: XM_054354592   ⟹   XP_054210567
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0635,551,861 - 35,569,445 (+)NCBI
RefSeq Acc Id: XM_054354593   ⟹   XP_054210568
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0635,551,853 - 35,569,445 (+)NCBI
RefSeq Acc Id: XM_054354594   ⟹   XP_054210569
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0635,557,396 - 35,569,445 (+)NCBI
RefSeq Acc Id: NP_659465   ⟸   NM_145028
- Peptide Label: isoform a
- UniProtKB: Q5T9G4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273503   ⟸   NM_001286574
- Peptide Label: isoform b
- UniProtKB: Q8NEB2 (UniProtKB/Swiss-Prot),   Q96LL8 (UniProtKB/Swiss-Prot),   Q5T9G4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273505   ⟸   NM_001286576
- Peptide Label: isoform c
- UniProtKB: Q5T9G4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011512683   ⟸   XM_011514381
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011512684   ⟸   XM_011514382
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016865924   ⟸   XM_017010435
- Peptide Label: isoform X1
- UniProtKB: Q5T9G4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000362973   ⟸   ENST00000373866
Ensembl Acc Id: ENSP00000362976   ⟸   ENST00000373869
Ensembl Acc Id: ENSP00000288065   ⟸   ENST00000288065
Ensembl Acc Id: ENSP00000418825   ⟸   ENST00000471400
RefSeq Acc Id: XP_047274303   ⟸   XM_047418347
- Peptide Label: isoform X2
- UniProtKB: Q8NEB2 (UniProtKB/Swiss-Prot),   Q5T9G4 (UniProtKB/Swiss-Prot),   Q96LL8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047274299   ⟸   XM_047418343
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047274300   ⟸   XM_047418344
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047274301   ⟸   XM_047418345
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047274304   ⟸   XM_047418348
- Peptide Label: isoform X2
- UniProtKB: Q8NEB2 (UniProtKB/Swiss-Prot),   Q5T9G4 (UniProtKB/Swiss-Prot),   Q96LL8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047274302   ⟸   XM_047418346
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054210568   ⟸   XM_054354593
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054210567   ⟸   XM_054354592
- Peptide Label: isoform X2
- UniProtKB: Q8NEB2 (UniProtKB/Swiss-Prot),   Q5T9G4 (UniProtKB/Swiss-Prot),   Q96LL8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054210566   ⟸   XM_054354591
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054210569   ⟸   XM_054354594
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5T9G4-F1-model_v2 AlphaFold Q5T9G4 1-340 view protein structure

Promoters
RGD ID:6872988
Promoter ID:EPDNEW_H9653
Type:initiation region
Name:ARMC12_1
Description:armadillo repeat containing 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9654  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,731,562 - 35,731,622EPDNEW
RGD ID:6872978
Promoter ID:EPDNEW_H9654
Type:initiation region
Name:ARMC12_2
Description:armadillo repeat containing 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9653  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,737,064 - 35,737,124EPDNEW
RGD ID:6804770
Promoter ID:HG_KWN:53335
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour
Transcripts:ENST00000373866,   ENST00000373869,   NM_145028,   NR_027117,   OTTHUMT00000040314
Position:
Human AssemblyChrPosition (strand)Source
Build 36635,812,111 - 35,813,412 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21099 AgrOrtholog
COSMIC ARMC12 COSMIC
Ensembl Genes ENSG00000157343 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000288065 ENTREZGENE
  ENST00000288065.6 UniProtKB/Swiss-Prot
  ENST00000373866 ENTREZGENE
  ENST00000373866.4 UniProtKB/Swiss-Prot
  ENST00000373869 ENTREZGENE
  ENST00000373869.7 UniProtKB/Swiss-Prot
  ENST00000471400.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
GTEx ENSG00000157343 GTEx
HGNC ID HGNC:21099 ENTREZGENE
Human Proteome Map ARMC12 Human Proteome Map
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-rpt_dom UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Armc12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:221481 UniProtKB/Swiss-Prot
NCBI Gene 221481 ENTREZGENE
OMIM 620377 OMIM
PANTHER ARMADILLO REPEAT-CONTAINING PROTEIN 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47144 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arm_2 UniProtKB/Swiss-Prot
PharmGKB PA134885894 PharmGKB
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt ARM12_HUMAN UniProtKB/Swiss-Prot
  F8WC51_HUMAN UniProtKB/TrEMBL
  Q5T9G4 ENTREZGENE
  Q8NEB2 ENTREZGENE
  Q96LL8 ENTREZGENE
UniProt Secondary Q8NEB2 UniProtKB/Swiss-Prot
  Q96LL8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-12-20 ARMC12  armadillo repeat containing 12  C6orf81  chromosome 6 open reading frame 81  Symbol and/or name change 5135510 APPROVED