ELAC1 (elaC ribonuclease Z 1) - Rat Genome Database

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Gene: ELAC1 (elaC ribonuclease Z 1) Homo sapiens
Analyze
Symbol: ELAC1
Name: elaC ribonuclease Z 1
RGD ID: 1312386
HGNC Page HGNC:14197
Description: Enables tRNA-specific ribonuclease activity. Involved in rescue of stalled ribosome and tRNA 3'-end processing. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D29; deleted in Ma29; elaC homolog 1; elaC homolog protein 1; FLJ59261; ribonuclease Z 1; RNase Z 1; RNaseZ(S); tRNA 3 endonuclease 1; tRNA 3' processing endoribonuclease; tRNA Z (short form); tRNase Z 1; tRNase ZS; zinc phosphodiesterase ELAC protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381850,968,040 - 50,988,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1850,967,991 - 50,988,121 (+)EnsemblGRCh38hg38GRCh38
GRCh371848,494,410 - 48,514,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,748,385 - 46,768,488 (+)NCBINCBI36Build 36hg18NCBI36
Build 341846,748,384 - 46,768,488NCBI
Celera1845,351,172 - 45,371,275 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1845,349,736 - 45,369,837 (+)NCBIHuRef
CHM1_11848,489,814 - 48,509,914 (+)NCBICHM1_1
T2T-CHM13v2.01851,169,751 - 51,189,833 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ELAC1Humanintellectual disability  IAGPRGD:1512326818554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

1 to 20 of 51 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ELAC1Human(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ELAC1 mRNACTDPMID:22079256
ELAC1Human1,2-dimethylhydrazine increases expressionISORGD:162215264804641,2-Dimethylhydrazine results in increased expression of ELAC1 mRNACTDPMID:22206623
ELAC1Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:16221526480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ELAC1 promoter]CTDPMID:19654925
ELAC1Human3,4-methylenedioxymethamphetamine decreases expressionISORGD:16221526480464N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ELAC1 mRNACTDPMID:26251327
ELAC1Human3-isobutyl-1-methyl-7H-xanthine multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...CTDPMID:28628672
ELAC1Human4-hydroxyphenyl retinamide decreases expressionISORGD:16221526480464Fenretinide results in decreased expression of ELAC1 mRNACTDPMID:28973697
ELAC1Human6-propyl-2-thiouracil increases expressionISORGD:13047576480464Propylthiouracil results in increased expression of ELAC1 mRNACTDPMID:25825206
ELAC1Humanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of ELAC1 geneCTDPMID:27153756
ELAC1Humanarsane affects methylationEXP 6480464Arsenic affects the methylation of ELAC1 geneCTDPMID:25304211
ELAC1Humanarsenic atom affects methylationEXP 6480464Arsenic affects the methylation of ELAC1 geneCTDPMID:25304211
ELAC1Humanbenzo[a]pyrene increases methylationEXP 6480464Benzo(a)pyrene results in increased methylation of ELAC1 3' UTRCTDPMID:27901495
ELAC1Humanbisphenol A affects expressionISORGD:13047576480464bisphenol A affects the expression of ELAC1 mRNACTDPMID:25181051
ELAC1Humanbisphenol A decreases expressionISORGD:16221526480464bisphenol A results in decreased expression of ELAC1 mRNACTDPMID:33221593
ELAC1Humanbisphenol A increases methylationISORGD:13047576480464bisphenol A results in increased methylation of ELAC1 geneCTDPMID:28505145
ELAC1Humanbisphenol A multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...CTDPMID:28628672
ELAC1Humanbisphenol F multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...CTDPMID:28628672
ELAC1Humancarbamazepine affects expressionEXP 6480464Carbamazepine affects the expression of ELAC1 mRNACTDPMID:25979313
ELAC1Humancarbon nanotube decreases expressionISORGD:16221526480464Nanotubes, Carbon analog results in decreased expression of ELAC1 mRNA; Nanotubes, Carbon results in decreased more ...CTDPMID:25554681
ELAC1Humancisplatin multiple interactionsEXP 6480464[Cisplatin co-treated with jinfukang] results in increased expression of ELAC1 mRNACTDPMID:27392435
ELAC1Humancisplatin increases expressionEXP 6480464Cisplatin results in increased expression of ELAC1 mRNACTDPMID:27392435

1 to 20 of 51 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ELAC1Humanrescue of stalled ribosome involved_inIDA 150520179 PMID:32075755UniProtPMID:32075755
ELAC1HumantRNA 3'-end processing involved_inIDA 150520179 PMID:32075755UniProtPMID:32075755
ELAC1HumantRNA processing involved_inIEAUniProtKB-KW:KW-0819150520179 UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ELAC1Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
ELAC1Humancytosol located_inIEAUniProtKB-SubCell:SL-0091150520179 UniProtGO_REF:0000044
ELAC1Humancytosol located_inIDA 150520179 PMID:21593607UniProtGO_REF:0000052|PMID:21593607
ELAC1Humannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
ELAC1Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
ELAC1Humannucleus is_active_inIBAPANTHER:PTN000285036|UniProtKB:Q9H777150520179 GO_CentralGO_REF:0000033
ELAC1Humannucleus located_inIDA 150520179 PMID:21593607UniProtPMID:21593607
ELAC1Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ELAC1Human3'-tRNA processing endoribonuclease activity enablesIEAEC:3.1.26.11150520179 UniProtGO_REF:0000003
ELAC1Human3'-tRNA processing endoribonuclease activity enablesIBAPANTHER:PTN000284960|UniProtKB:P0A8V0150520179 GO_CentralGO_REF:0000033
ELAC1Humanendonuclease activity enablesIEAUniProtKB-KW:KW-0255150520179 UniProtGO_REF:0000043
ELAC1Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
ELAC1Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
ELAC1Humannuclease activity enablesIEAUniProtKB-KW:KW-0540150520179 UniProtGO_REF:0000043
ELAC1HumanRNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism enablesIEAInterPro:IPR013471150520179 InterProGO_REF:0000002
ELAC1HumantRNA-specific ribonuclease activity enablesIDA 150520179 PMID:32075755UniProtPMID:32075755

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ELAC1HumantRNA maturation pathway  TAS 9685334 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ELAC1HumanIntellectual disability  IAGPRGD:1512326818554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. 3' processing of eukaryotic precursor tRNAs. Maraia RJ and Lamichhane TN, Wiley Interdiscip Rev RNA. 2011 May-Jun;2(3):362-75. doi: 10.1002/wrna.64.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8125298   PMID:11175785   PMID:11401430   PMID:12477932   PMID:12711671   PMID:14702039   PMID:15489334   PMID:18573253   PMID:21461837   PMID:21559454   PMID:21593607   PMID:21873635  
PMID:22610502   PMID:28431233   PMID:32075755   PMID:34808499   PMID:34864548   PMID:36724073   PMID:37071682  



ELAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381850,968,040 - 50,988,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1850,967,991 - 50,988,121 (+)EnsemblGRCh38hg38GRCh38
GRCh371848,494,410 - 48,514,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,748,385 - 46,768,488 (+)NCBINCBI36Build 36hg18NCBI36
Build 341846,748,384 - 46,768,488NCBI
Celera1845,351,172 - 45,371,275 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1845,349,736 - 45,369,837 (+)NCBIHuRef
CHM1_11848,489,814 - 48,509,914 (+)NCBICHM1_1
T2T-CHM13v2.01851,169,751 - 51,189,833 (+)NCBIT2T-CHM13v2.0
Elac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391873,868,109 - 73,887,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1873,868,109 - 73,887,550 (-)EnsemblGRCm39 Ensembl
GRCm381873,735,038 - 73,754,519 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,735,038 - 73,754,479 (-)EnsemblGRCm38mm10GRCm38
MGSCv371873,894,692 - 73,914,133 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361873,851,527 - 73,879,818 (-)NCBIMGSCv36mm8
Celera1874,971,996 - 74,991,451 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.83NCBI
Elac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81869,596,475 - 69,617,206 (-)NCBIGRCr8
mRatBN7.21867,321,231 - 67,341,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,323,583 - 67,340,936 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,431,671 - 69,449,018 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,106,253 - 70,123,599 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01867,971,620 - 67,988,967 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01869,706,522 - 69,723,869 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,706,522 - 69,723,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01868,848,766 - 68,868,465 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,512,719 - 70,530,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11870,587,581 - 70,603,285 (-)NCBI
Celera1865,324,281 - 65,341,610 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
Elac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,904,553 - 35,918,111 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,904,552 - 35,918,120 (+)NCBIChiLan1.0ChiLan1.0
ELAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21768,486,790 - 68,508,057 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11854,179,382 - 54,200,662 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01844,339,868 - 44,359,150 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11847,692,305 - 47,706,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,692,305 - 47,706,019 (+)Ensemblpanpan1.1panPan2
ELAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,931,360 - 23,971,516 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,960,723 - 23,969,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,944,290 - 24,956,679 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,848,106 - 23,861,309 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,846,515 - 23,862,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,909,322 - 23,921,706 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,795,517 - 23,807,905 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,042,523 - 24,082,686 (-)NCBIUU_Cfam_GSD_1.0
Elac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,081,836 - 37,100,062 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,326,679 - 12,339,167 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649712,323,699 - 12,338,991 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1100,514,760 - 100,535,993 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11100,514,662 - 100,536,579 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21110,449,860 - 110,467,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ELAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11829,988,218 - 30,008,164 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660504,115,032 - 4,135,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477814,517,716 - 14,530,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477814,517,934 - 14,536,509 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in ELAC1
29 total Variants

1 to 10 of 78 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 18q21.1-23(chr18:50068129-80252149)x3 copy number gain See cases [RCV000050989] Chr18:50068129..80252149 [GRCh38]
Chr18:47594499..78010032 [GRCh37]
Chr18:45848497..76111023 [NCBI36]
Chr18:18q21.1-23
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80252149)x3 copy number gain See cases [RCV000051048] Chr18:148963..80252149 [GRCh38]
Chr18:148963..78010032 [GRCh37]
Chr18:138963..76111023 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18q11.1-23(chr18:20960320-80234429)x3 copy number gain See cases [RCV000052543] Chr18:20960320..80234429 [GRCh38]
Chr18:18540281..77992312 [GRCh37]
Chr18:16794279..76093303 [NCBI36]
Chr18:18q11.1-23
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:53345-80209986)x3 copy number gain See cases [RCV000052501] Chr18:53345..80209986 [GRCh38]
Chr18:53345..77967869 [GRCh37]
Chr18:43345..76068860 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18q11.1-23(chr18:20989762-80209986)x3 copy number gain See cases [RCV000052549] Chr18:20989762..80209986 [GRCh38]
Chr18:18569723..77967869 [GRCh37]
Chr18:16823721..76068860 [NCBI36]
Chr18:18q11.1-23
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148763-80252290)x3 copy number gain See cases [RCV000052507] Chr18:148763..80252290 [GRCh38]
Chr18:148763..78010173 [GRCh37]
Chr18:138763..76111164 [NCBI36]
Chr18:18p11.32-q23
pathogenic
GRCh38/hg38 18q12.1-22.1(chr18:29249202-65448117)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052563]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052563]|See cases [RCV000052563] Chr18:29249202..65448117 [GRCh38]
Chr18:26829167..63115353 [GRCh37]
Chr18:25083165..61266333 [NCBI36]
Chr18:18q12.1-22.1
pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80244381)x3 copy number gain See cases [RCV000052514] Chr18:148963..80244381 [GRCh38]
Chr18:148963..78002264 [GRCh37]
Chr18:138963..76103255 [NCBI36]
Chr18:18p11.32-q23
pathogenic
NM_018696.2(ELAC1):c.157+2783C>T single nucleotide variant Lung cancer [RCV000100860] Chr18:50977344 [GRCh38]
Chr18:48503714 [GRCh37]
Chr18:18q21.2
uncertain significance
GRCh38/hg38 18p11.32-q23(chr18:149089-80234391)x3 copy number gain See cases [RCV000134110] Chr18:149089..80234391 [GRCh38]
Chr18:149089..77992274 [GRCh37]
Chr18:139089..76093265 [NCBI36]
Chr18:18p11.32-q23
pathogenic
1 to 10 of 78 rows

Predicted Target Of
Summary Value
Count of predictions:817
Count of miRNA genes:628
Interacting mature miRNAs:707
Transcripts:ENST00000269466, ENST00000586966, ENST00000588577, ENST00000591429
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
407339348GWAS988324_Heosinophil count QTL GWAS988324 (human)6e-10eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)185098802550988026Human
597285424GWAS1381498_Hinflammatory bowel disease QTL GWAS1381498 (human)2e-08inflammatory bowel disease185097753750977538Human
597287573GWAS1383647_Hulcerative colitis QTL GWAS1383647 (human)0.000003ulcerative colitis185097753750977538Human
596979594GWAS1099113_Hulcerative colitis QTL GWAS1099113 (human)0.000003ulcerative colitis185097753750977538Human

RH45926  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371848,513,463 - 48,513,603UniSTSGRCh37
Build 361846,767,461 - 46,767,601RGDNCBI36
Celera1845,370,248 - 45,370,388RGD
Cytogenetic Map18q21UniSTS
HuRef1845,368,810 - 45,368,950UniSTS
D18S897E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371848,513,496 - 48,513,596UniSTSGRCh37
Build 361846,767,494 - 46,767,594RGDNCBI36
Celera1845,370,281 - 45,370,381RGD
Cytogenetic Map18q21UniSTS
HuRef1845,368,843 - 45,368,943UniSTS
ELAC1__7576  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371848,513,032 - 48,513,732UniSTSGRCh37
Build 361846,767,030 - 46,767,730RGDNCBI36
Celera1845,369,817 - 45,370,517RGD
HuRef1845,368,379 - 45,369,079UniSTS
SGC38219  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371848,513,112 - 48,513,362UniSTSGRCh37
Build 361846,767,110 - 46,767,360RGDNCBI36
Celera1845,369,897 - 45,370,147RGD
Cytogenetic Map18q21UniSTS
HuRef1845,368,459 - 45,368,709UniSTS
GeneMap99-GB4 RH Map18358.19UniSTS
Whitehead-RH Map18374.1UniSTS
NCBI RH Map18605.9UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4973 1726 2349 6 624 1950 465 2269 7305 6471 53 3734 1 852 1743 1614 174 1



Ensembl Acc Id: ENST00000269466   ⟹   ENSP00000269466
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1850,968,040 - 50,988,121 (+)Ensembl
Ensembl Acc Id: ENST00000586966
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1850,968,045 - 50,969,866 (+)Ensembl
Ensembl Acc Id: ENST00000588577   ⟹   ENSP00000467389
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1850,967,991 - 50,986,946 (+)Ensembl
Ensembl Acc Id: ENST00000591429   ⟹   ENSP00000464770
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1850,968,048 - 50,984,838 (+)Ensembl
RefSeq Acc Id: NM_018696   ⟹   NP_061166
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381850,968,040 - 50,988,121 (+)NCBI
GRCh371848,494,387 - 48,514,491 (+)NCBI
Build 361846,748,385 - 46,768,488 (+)NCBI Archive
Celera1845,351,172 - 45,371,275 (+)RGD
HuRef1845,349,736 - 45,369,837 (+)RGD
CHM1_11848,489,814 - 48,509,914 (+)NCBI
T2T-CHM13v2.01851,169,751 - 51,189,833 (+)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_061166 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG24917 (Get FASTA)   NCBI Sequence Viewer  
  AAH14624 (Get FASTA)   NCBI Sequence Viewer  
  BAA96799 (Get FASTA)   NCBI Sequence Viewer  
  BAB15021 (Get FASTA)   NCBI Sequence Viewer  
  BAD97227 (Get FASTA)   NCBI Sequence Viewer  
  EAW62983 (Get FASTA)   NCBI Sequence Viewer  
  EAW62984 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000269466
  ENSP00000269466.3
GenBank Protein Q9H777 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_061166   ⟸   NM_018696
- UniProtKB: Q9NS99 (UniProtKB/Swiss-Prot),   Q9H777 (UniProtKB/Swiss-Prot),   Q53EY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000269466   ⟸   ENST00000269466
Ensembl Acc Id: ENSP00000467389   ⟸   ENST00000588577
Ensembl Acc Id: ENSP00000464770   ⟸   ENST00000591429
Metallo-beta-lactamase

Name Modeler Protein Id AA Range Protein Structure
AF-Q9H777-F1-model_v2 AlphaFold Q9H777 1-363 view protein structure

RGD ID:6794817
Promoter ID:HG_KWN:28028
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000255992,   UC010DPE.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361846,748,151 - 46,748,651 (+)MPROMDB
RGD ID:7237349
Promoter ID:EPDNEW_H24420
Type:initiation region
Name:ELAC1_1
Description:elaC ribonuclease Z 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381850,968,040 - 50,968,100EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
COSMIC ELAC1 COSMIC
Ensembl Genes ENSG00000141642 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000269466 ENTREZGENE
  ENST00000269466.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.15.10 UniProtKB/Swiss-Prot
GTEx ENSG00000141642 GTEx
HGNC ID HGNC:14197 ENTREZGENE
Human Proteome Map ELAC1 Human Proteome Map
InterPro Metallo-B-lactamas UniProtKB/Swiss-Prot
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot
  RNase_Z/BN UniProtKB/Swiss-Prot
  Zinc_phosphodiesterase_ELAC UniProtKB/Swiss-Prot
KEGG Report hsa:55520 UniProtKB/Swiss-Prot
NCBI Gene 55520 ENTREZGENE
OMIM 608079 OMIM
PANTHER ZINC PHOSPHODIESTERASE ELAC PROTEIN 1 UniProtKB/Swiss-Prot
  ZINC PHOSPHODIESTERASE ELAC PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Lactamase_B UniProtKB/Swiss-Prot
PharmGKB PA27738 PharmGKB
Superfamily-SCOP SSF56281 UniProtKB/Swiss-Prot
UniProt K7EIJ1_HUMAN UniProtKB/TrEMBL
  K7EPH7_HUMAN UniProtKB/TrEMBL
  Q53EY2 ENTREZGENE, UniProtKB/TrEMBL
  Q9H777 ENTREZGENE
  Q9NS99 ENTREZGENE
  RNZ1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q9NS99 UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-04 ELAC1  elaC ribonuclease Z 1    elaC homolog 1 (E. coli)  Symbol and/or name change 5135510 APPROVED