Ccr1l1 (chemokine (C-C motif) receptor 1-like 1) - Rat Genome Database

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Gene: Ccr1l1 (chemokine (C-C motif) receptor 1-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ccr1l1
Name: chemokine (C-C motif) receptor 1-like 1
RGD ID: 1308007
Description: Predicted to enable C-C chemokine receptor activity; chemokine (C-C motif) ligand 5 binding activity; and chemokine (C-C motif) ligand 7 binding activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be active in cytoplasm and external side of plasma membrane. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C chemokine receptor 1-like protein 1; LOC301088
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,467,425 - 132,478,489 (-)NCBIGRCr8
mRatBN7.28123,589,997 - 123,613,767 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,589,621 - 123,612,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,187,636 - 129,188,706 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,386,765 - 127,387,835 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,204,632 - 125,205,702 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,127,220 - 133,128,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,127,220 - 133,128,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,278,357 - 132,279,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,728,145 - 128,729,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,747,881 - 128,748,952 (-)NCBI
Celera8122,692,756 - 122,693,826 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccr1l1Ratcalcium-mediated signaling involved_inIBAPANTHER:PTN001628461 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratcell chemotaxis involved_inIBAMGI:103567 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratchemokine-mediated signaling pathway involved_inIEAGO:00164931600115GO_REF:0000108GOCGO_REF:0000108
Ccr1l1Ratchemokine-mediated signaling pathway involved_inIEAGO:00049501600115GO_REF:0000108GOCGO_REF:0000108
Ccr1l1Ratchemotaxis involved_inIEAInterPro:IPR0003551600115GO_REF:0000002InterProGO_REF:0000002
Ccr1l1RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Ccr1l1RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Ccr1l1Ratimmune response involved_inIBAMGI:103011 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratimmune response involved_inIEAInterPro:IPR0022361600115GO_REF:0000002InterProGO_REF:0000002
Ccr1l1Ratinflammatory response involved_inIBAMGI:104618 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratinflammatory response involved_inIEAInterPro:IPR0022361600115GO_REF:0000002InterProGO_REF:0000002
Ccr1l1Ratpositive regulation of cytosolic calcium ion concentration involved_inIBAMGI:1096320 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratpositive regulation of monocyte chemotaxis involved_inIEAInterPro:IPR0022361600115GO_REF:0000002InterProGO_REF:0000002
Ccr1l1Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccr1l1Ratcytoplasm is_active_inIBAPANTHER:PTN001628676 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratexternal side of plasma membrane is_active_inIBAMGI:103011 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Ccr1l1Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Ccr1l1Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Ccr1l1Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccr1l1RatC-C chemokine receptor activity enablesIBAMGI:103011 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1RatC-C chemokine receptor activity enablesIEAInterPro:IPR0022361600115GO_REF:0000002InterProGO_REF:0000002
Ccr1l1Ratchemokine (C-C motif) ligand 5 binding enablesIBAPANTHER:PTN001200786 and UniProtKB:P322461600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratchemokine (C-C motif) ligand 7 binding enablesIBAPANTHER:PTN001200786 and UniProtKB:P322461600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr1l1Ratchemokine receptor activity enablesIEAInterPro:IPR0003551600115GO_REF:0000002InterProGO_REF:0000002
Ccr1l1RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Ccr1l1RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccr1l1Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Ccr1l1Ratcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Ccr1l1
141 total Variants

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:79
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000008783
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat

UniSTS:496023  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,591,860 - 123,591,936 (+)MAPPERmRatBN7.2
Rnor_6.08133,128,054 - 133,128,129NCBIRnor6.0
Rnor_5.08132,279,191 - 132,279,266UniSTSRnor5.0
RGSC_v3.48128,728,979 - 128,729,054UniSTSRGSC3.4
Celera8122,693,590 - 122,693,665UniSTS
Cytogenetic Map8q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 7 19 63 60 64 36 25 36 2 117 54 52 12 41 28



Ensembl Acc Id: ENSRNOT00000008783   ⟹   ENSRNOP00000008783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,589,621 - 123,600,418 (-)Ensembl
Rnor_6.0 Ensembl8133,127,220 - 133,128,290 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114047   ⟹   ENSRNOP00000079629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,589,621 - 123,612,687 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117179   ⟹   ENSRNOP00000085920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,589,621 - 123,612,687 (-)Ensembl
RefSeq Acc Id: NM_001106872   ⟹   NP_001100342
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,468,452 - 132,469,522 (-)NCBI
mRatBN7.28123,591,027 - 123,592,097 (-)NCBI
Rnor_6.08133,127,220 - 133,128,290 (-)NCBI
Rnor_5.08132,278,357 - 132,279,427 (-)NCBI
RGSC_v3.48128,728,145 - 128,729,215 (-)RGD
Celera8122,692,756 - 122,693,826 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081322   ⟹   XP_038937250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,467,425 - 132,478,489 (-)NCBI
mRatBN7.28123,589,997 - 123,601,372 (-)NCBI
Protein RefSeqs NP_001100342 (Get FASTA)   NCBI Sequence Viewer  
  XP_038937250 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76747 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008783.1
  ENSRNOP00000079629.1
  ENSRNOP00000085920.1
  ENSRNOP00000108021
RefSeq Acc Id: NP_001100342   ⟸   NM_001106872
- UniProtKB: D3ZFW8 (UniProtKB/TrEMBL),   A6I4D0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008783   ⟸   ENSRNOT00000008783
RefSeq Acc Id: XP_038937250   ⟸   XM_039081322
- Peptide Label: isoform X1
- UniProtKB: D3ZFW8 (UniProtKB/TrEMBL),   A6I4D0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079629   ⟸   ENSRNOT00000114047
Ensembl Acc Id: ENSRNOP00000085920   ⟸   ENSRNOT00000117179
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFW8-F1-model_v2 AlphaFold D3ZFW8 1-356 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-28598 BioCyc
Ensembl Genes ENSRNOG00000006730 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000083822 ENTREZGENE
Ensembl Transcript ENSRNOT00000008783.3 UniProtKB/TrEMBL
  ENSRNOT00000114047.1 UniProtKB/TrEMBL
  ENSRNOT00000117179.1 UniProtKB/TrEMBL
  ENSRNOT00000161113 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  CC_1_rcpt UniProtKB/TrEMBL
  Chmkine_rcpt UniProtKB/TrEMBL
  GPCR1 UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:301088 UniProtKB/TrEMBL
NCBI Gene 301088 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR 1-LIKE PROTEIN 1 UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Ccr1l1 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  CHEMOKINER1 UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006730 RatGTEx
  ENSRNOG00000083822 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6I4D0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFW8 ENTREZGENE, UniProtKB/TrEMBL
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ccr1l1  chemokine (C-C motif) receptor 1-like 1   Ccr1l1_predicted  chemokine (C-C motif) receptor 1-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ccr1l1_predicted  chemokine (C-C motif) receptor 1-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED