Iws1 (interacts with SUPT6H, CTD assembly factor 1) - Rat Genome Database

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Gene: Iws1 (interacts with SUPT6H, CTD assembly factor 1) Ictidomys tridecemlineatus
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Symbol: Iws1
Name: interacts with SUPT6H, CTD assembly factor 1
RGD ID: 12734307
Description: INVOLVED IN chromatin remodeling (inferred); poly(A)+ mRNA export from nucleus (inferred); regulation of mRNA export from nucleus (inferred); ASSOCIATED WITH autosomal dominant thrombophilia due to protein C deficiency (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2W (ortholog); centronuclear myopathy 2 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: IWS1, SUPT6H interacting protein, transcript variant X1; IWS1, SUPT6H interacting protein, transcript variant X2; IWS1, SUPT6H interacting protein, transcript variant X3; protein IWS1 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,813,621 - 97,851,019 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,766,663 - 43,808,333 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,766,699 - 43,805,919 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Iws1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,813,621 - 97,851,019 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,766,663 - 43,808,333 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,766,699 - 43,805,919 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IWS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,480,812 - 127,527,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2127,436,207 - 127,526,886 (-)EnsemblGRCh38hg38GRCh38
GRCh372128,238,388 - 128,284,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,954,860 - 128,000,514 (-)NCBINCBI36Build 36hg18NCBI36
Celera2121,549,354 - 121,595,041 (-)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,545,348 - 120,591,062 (-)NCBIHuRef
CHM1_12128,242,935 - 128,288,602 (-)NCBICHM1_1
T2T-CHM13v2.02127,916,064 - 127,962,573 (-)NCBIT2T-CHM13v2.0
Iws1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,200,377 - 32,237,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,200,794 - 32,237,381 (+)EnsemblGRCm39 Ensembl
GRCm381832,067,326 - 32,104,331 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,067,741 - 32,104,328 (+)EnsemblGRCm38mm10GRCm38
MGSCv371832,227,388 - 32,263,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,210,774 - 32,240,318 (+)NCBIMGSCv36mm8
Celera1832,548,980 - 32,585,919 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.92NCBI
Iws1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81823,969,352 - 24,011,560 (+)NCBIGRCr8
mRatBN7.21823,695,496 - 23,737,363 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,695,425 - 23,736,172 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,823,597 - 23,861,406 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,579,583 - 24,617,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01823,918,579 - 23,956,389 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,849,508 - 24,891,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,849,545 - 24,880,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,564,090 - 24,606,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,489,571 - 24,524,125 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,494,575 - 24,550,538 (+)NCBI
Celera1823,448,049 - 23,478,821 (+)NCBICelera
Cytogenetic Map18p12NCBI
Iws1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,021,764 - 3,063,128 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,021,320 - 3,063,363 (+)NCBIChiLan1.0ChiLan1.0
IWS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21348,118,820 - 48,221,507 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B48,133,798 - 48,200,382 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B32,750,718 - 32,810,360 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B128,132,447 - 128,192,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B128,146,087 - 128,192,258 (-)Ensemblpanpan1.1panPan2
IWS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11923,081,625 - 23,122,618 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,082,096 - 23,122,618 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,329,380 - 23,370,167 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01924,408,165 - 24,448,927 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,408,412 - 24,448,918 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11923,112,151 - 23,152,919 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,306,466 - 23,347,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,438,452 - 24,479,477 (+)NCBIUU_Cfam_GSD_1.0
IWS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1559,822,822 - 59,879,422 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11559,822,789 - 59,875,867 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IWS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,688,690 - 2,747,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl102,689,031 - 2,734,828 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606120,024,617 - 20,070,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iws1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473213,966,393 - 14,001,713 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473213,961,929 - 14,002,003 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000022238   ⟹   ENSSTOP00000022329
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493646943,781,660 - 43,800,800 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000039277   ⟹   ENSSTOP00000026867
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493646943,766,663 - 43,808,333 (+)Ensembl
RefSeq Acc Id: XM_005315875   ⟹   XP_005315932
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530397,813,621 - 97,851,018 (-)NCBI
SpeTri2.0NW_00493646943,766,700 - 43,805,919 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013366558   ⟹   XP_013222012
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530397,813,852 - 97,851,018 (-)NCBI
SpeTri2.0NW_00493646943,766,700 - 43,804,098 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005737920
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530397,813,958 - 97,851,019 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005315932 (Get FASTA)   NCBI Sequence Viewer  
  XP_013222012 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000022329.2
  ENSSTOP00000026867.1
GenBank Protein KAG3274320 (Get FASTA)   NCBI Sequence Viewer  
  KAG3274321 (Get FASTA)   NCBI Sequence Viewer  
  KAG3274322 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_013222012   ⟸   XM_013366558
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005315932   ⟸   XM_005315875
- Peptide Label: isoform X1
- UniProtKB: A0A287CZX7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000022329   ⟸   ENSSTOT00000022238
Ensembl Acc Id: ENSSTOP00000026867   ⟸   ENSSTOT00000039277
Protein Domains
TFIIS N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028209 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022238.2 UniProtKB/TrEMBL
  ENSSTOT00000039277.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.930.10 UniProtKB/TrEMBL
InterPro RNAPII_TF_IWS1 UniProtKB/TrEMBL
  TFIIS/LEDGF_dom_sf UniProtKB/TrEMBL
  TFIIS_N UniProtKB/TrEMBL
NCBI Gene Iws1 ENTREZGENE
PANTHER PROTEIN IWS1 HOMOLOG UniProtKB/TrEMBL
  PROTEIN IWS1 HOMOLOG UniProtKB/TrEMBL
Pfam Med26 UniProtKB/TrEMBL
PROSITE TFIIS_N UniProtKB/TrEMBL
Superfamily-SCOP SSF47676 UniProtKB/TrEMBL
UniProt A0A287CZX7 ENTREZGENE, UniProtKB/TrEMBL
  I3ND82_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-27 Iws1  interacts with SUPT6H, CTD assembly factor 1  Iws1  IWS1, SUPT6H interacting protein  Symbol and/or name change 5135510 APPROVED