Alx3 (ALX homeobox 3) - Rat Genome Database

Name: Alx3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Alx3 (ALX homeobox 3) Ictidomys tridecemlineatus

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Symbol:

Alx3

Name:

ALX homeobox 3

RGD ID:

12720415

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN embryonic forelimb morphogenesis (ortholog); embryonic hindlimb morphogenesis (ortholog); embryonic skeletal system morphogenesis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); developmental and epileptic encephalopathy 32 (ortholog); frontonasal dysplasia (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homeobox protein aristaless-like 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ALX3 (ALX homeobox 3)	NCBI	Ortholog
Mus musculus (house mouse):	Alx3 (aristaless-like homeobox 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Alx3 (ALX homeobox 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Alx3 (ALX homeobox 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ALX3 (ALX homeobox 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ALX3 (ALX homeobox 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ALX3 (ALX homeobox 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ALX3 (ALX homeobox 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Alx3 (ALX homeobox 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	18,583,676 - 18,594,240 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936704	1,520,639 - 1,530,470 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936704	1,519,932 - 1,530,470 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

developmental and epileptic encephalopathy 32 (ISO)

frontonasal dysplasia (ISO)

frontonasal dysplasia 1 (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 63 (ISO)

neural tube defect (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

embryonic forelimb morphogenesis (IEA,ISO)

embryonic hindlimb morphogenesis (IEA,ISO)

embryonic skeletal system morphogenesis (IEA,ISO)

pattern specification process (IEA,ISO)

regulation of apoptotic process (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Alx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	18,583,676 - 18,594,240 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936704	1,520,639 - 1,530,470 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936704	1,519,932 - 1,530,470 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALX3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	110,059,870 - 110,070,672 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	110,059,870 - 110,070,672 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	110,602,492 - 110,613,294 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	110,404,520 - 110,414,845 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	110,314,657 - 110,325,276	NCBI
Celera	1	108,849,991 - 108,860,317 (-)	NCBI		Celera
Cytogenetic Map	1	p13.3	NCBI
HuRef	1	108,472,464 - 108,482,722 (-)	NCBI		HuRef
CHM1_1	1	110,717,826 - 110,728,192 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	110,069,997 - 110,080,800 (-)	NCBI		T2T-CHM13v2.0

Alx3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	107,502,347 - 107,513,191 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	107,502,347 - 107,513,092 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	107,595,031 - 107,605,875 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	107,595,031 - 107,605,776 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	107,397,949 - 107,408,687 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	107,723,087 - 107,733,825 (+)	NCBI		MGSCv36	mm8
Celera	3	109,927,775 - 109,938,110 (+)	NCBI		Celera
Cytogenetic Map	3	F2.3	NCBI
cM Map	3	46.83	NCBI

Alx3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	197,919,381 - 197,929,795 (+)	NCBI		GRCr8
mRatBN7.2	2	195,231,197 - 195,241,609 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	195,231,197 - 195,241,609 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	202,872,313 - 202,882,773 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	200,754,503 - 200,764,930 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	195,571,442 - 195,581,869 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	210,376,510 - 210,386,928 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	210,381,829 - 210,386,928 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	229,848,442 - 229,853,533 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	203,156,009 - 203,157,503 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	203,118,763 - 203,120,257 (+)	NCBI
Celera	2	187,880,150 - 187,890,555 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Alx3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	13,583,611 - 13,594,316 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	13,584,129 - 13,594,316 (-)	NCBI	ChiLan1.0	ChiLan1.0

ALX3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	116,971,829 - 116,988,237 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	116,119,978 - 116,136,356 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	112,706,782 - 112,717,635 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	127,624,197 - 127,640,181 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	127,624,197 - 127,634,004 (+)	Ensembl	panpan1.1		panPan2

ALX3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	41,899,288 - 41,907,832 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	41,903,474 - 41,906,963 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	44,675,283 - 44,684,410 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	42,230,252 - 42,239,390 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	42,189,746 - 42,238,523 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	41,963,188 - 41,972,320 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	41,921,357 - 41,930,486 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	42,356,448 - 42,365,589 (+)	NCBI		UU_Cfam_GSD_1.0

ALX3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	110,047,116 - 110,057,872 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	110,047,254 - 110,058,205 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	120,519,402 - 120,527,514 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALX3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	23,471,651 - 23,482,317 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	23,471,736 - 23,481,543 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	34,976,812 - 34,987,885 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Alx3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	5,826,600 - 5,836,853 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	5,826,823 - 5,836,853 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005338113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000009595 ⟹ ENSSTOP00000008608

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936704	1,520,639 - 1,530,470 (-)	Ensembl

RefSeq Acc Id:

XM_005338113 ⟹ XP_005338170

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	18,583,676 - 18,594,240 (+)	NCBI
SpeTri2.0	NW_004936704	1,519,932 - 1,530,470 (-)	NCBI

Sequence:

show sequence

CCCTCCCCCTTGGCGGGAGCTCACAGGCCGCGCGGGTAGCGCGAGCCCCGGCGGCCTGTGAGCC
CCGAACCGGCATGGACCCTGAGCGCTGCACGCCTTTCGGCGTGGGGCCCGCACCCGGCCCCTAC
GGGACCGCAGGGGACGATTCTCCAGGTCCCCAGGGGACTCCAGCCGTGGCGCCTCACCTGCAGC
CCGCGCCGCCCTGCGGCCCGCGGCTGACCCGCTTTCCGGCCTGCGGGCCCCTGGAGCCCTACCT
CCCAGAGCCAGCCAAGCCGCCCGCCAAGTACCTGCAGGACCTCGGGCCCGGCCCGGCGCCCAAC
GGCGGCCACTTCTACGAGGGCCCAGCGGAAGCTGAGGAGACAGCTTCCAAAGCCGCCAGCTTCC
CCCAGCTGCCCTTGGACTGCCAAGGGGGCCCCAGAGACGGGCCCGCTAACTTGCAAGGCTCCCC
AGGCCCCTGCCTGGCCAGTCTTCGTGTCCCTCTTTCCCCGGGACTCCCTGACTCCATGGAGTTA
GCCAAGAACAAGAGCAAGAAGCGCCGTAACCGCACAACCTTCAGCACATTCCAGCTGGAGGAGT
TGGAGAAGGTCTTCCAGAAAACCCACTACCCTGATGTGTACGCCCGGGAGCAGCTGGCTCTGCG
CACAGACCTGACCGAGGCTCGGGTTCAGGTCTGGTTCCAGAATCGCAGAGCCAAGTGGCGGAAG
CGCGAGCGTTATGGGAAGATGCAGGAGGGGCGGAACCCCTTCACAGCTGCCTATGACATCTCTG
TGCTGCCCCGAACTGACAGTCACCCCCAGCTGCAGAGCTCCCTGTGGCCCAGTCCAGGGCCCGG
GAGCCCAGGAGGCCCTTGCCTCGTCTCTCCGGAGGGCATTCCCTCCCCATGCATGTCCCCATAC
TCCCACTCCCATGGGAATGTGGCTGGCTTCATGGGGATGCCAGCCTCCCCTGCAGCCCACCCTG
GCATCTACTCCATCCACAGCTTTCCACCTGCCCTGGGGGGCCACAGCTTTGAGCCCTCTCCGGA
TGGCGACTACAAGTCTCCAAGTCTCGTCTCACTCAGGGTGAAGCCCAAGGAGCCGCCCAGCCTG
CTGAACTGGACCACGTGATGGGTGGCATTGACATGTAACTGAGCTGCCCACCCCCATTTATGTT
CTGAGCTGCTCTGGGCCCACCCTGCCTGGACACCAGAGAGCACACACGTCTGCCTCCAGGGGCC
TCGGAGAGGGACCCTCAGCCCTGGCAGGAAACATGCAATAGGGTCTTTCCTTTAGGACTGTTTA
GGAGAAAGGGGTTTCTAAGCAGACAGGATCCTTCCTGTTACAAAAGTCCTTTCATTCAAACTGG
ACTGGAGGGAGAGACATTGCCCTACCTACTCCAGACTGCCCAAGTCCAGCTGTTGCCTTTCCAG
CTAAAAAGGCCCAACTCTTCATTCAGGGAGCCCAGGAAAAGGGGAGAAGACAAATTGAACTGGG
AGGAACTCTTTGTTACACAGGGGAAACCAAAGAGTTTGGTTTATGACAAAGGGGAAACCAGAGT
TGAGGGTTGGCCTCACTTTTCCCACCACCGAGGAGCATGCACCCAGTGTCTGGCTTGGAGGACA
ACATGAATGGTGTGGTCTCCTCTGCTCCAGCCATCCCTTACTCCTGCCCTGTGCCCGATCTCCC
AACATGCTATGCAGTCATCTCCTCCAAAGGACAGAAATTCCTCCAGAAACCACCAAATATTTGG
ATTCACTTCCATGGGACCAGACCAGGCTAGGCCACGGAAGCTGTGTTAGATGTAGATCAGATTC
AAACATTTCTATAGTCTCGGAGCCCCTGGGATTCTAACCCCCATTTTTGTAAAGATACTTTTGT
AAACAAAACAAGTGTTGCCCGGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005338170	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008608.2
GenBank Protein	KAG3281304	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005338170 ⟸ XM_005338113

- UniProtKB:

I3MDU7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDPERCTPFGVGPAPGPYGTAGDDSPGPQGTPAVAPHLQPAPPCGPRLTRFPACGPLEPYLPEP
AKPPAKYLQDLGPGPAPNGGHFYEGPAEAEETASKAASFPQLPLDCQGGPRDGPANLQGSPGPC
LASLRVPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDL
TEARVQVWFQNRRAKWRKRERYGKMQEGRNPFTAAYDISVLPRTDSHPQLQSSLWPSPGPGSPG
GPCLVSPEGIPSPCMSPYSHSHGNVAGFMGMPASPAAHPGIYSIHSFPPALGGHSFEPSPDGDY
KSPSLVSLRVKPKEPPSLLNWTT

hide sequence

Ensembl Acc Id:

ENSSTOP00000008608 ⟸ ENSSTOT00000009595

Protein Domains

Homeobox

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009606	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009595.3	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Paired_Homeobox_TFs	UniProtKB/TrEMBL
NCBI Gene	Alx3	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN ARISTALESS	UniProtKB/TrEMBL
	HOMEOBOX PROTEIN ARISTALESS-LIKE 3	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	I3MDU7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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