Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin) - Rat Genome Database

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Gene: Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin) Ictidomys tridecemlineatus
Analyze
Symbol: Spg7
Name: SPG7 matrix AAA peptidase subunit, paraplegin
RGD ID: 12720027
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); ATP-dependent peptidase activity (inferred); INVOLVED IN anterograde axonal transport (ortholog); mitochondrion organization (ortholog); ASSOCIATED WITH hereditary spastic paraplegia 7 (ortholog); FOUND IN axon cytoplasm (inferred); m-AAA complex (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: paraplegin; SPG7, paraplegin matrix AAA peptidase subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,698,215 - 24,730,707 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641452,475 - 484,220 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936641451,762 - 484,229 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Spg7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,698,215 - 24,730,707 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641452,475 - 484,220 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936641451,762 - 484,229 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPG7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381689,490,970 - 89,499,282 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1689,490,719 - 89,557,766 (+)EnsemblGRCh38hg38GRCh38
GRCh371689,574,802 - 89,624,174 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,102,306 - 88,151,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 341688,102,305 - 88,151,674NCBI
Celera1674,638,312 - 74,687,680 (+)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,270,019 - 75,319,275 (+)NCBIHuRef
CHM1_11690,968,590 - 90,976,192 (+)NCBICHM1_1
T2T-CHM13v2.01695,571,346 - 95,579,922 (+)NCBIT2T-CHM13v2.0
Spg7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,792,247 - 123,824,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,789,681 - 123,824,499 (+)EnsemblGRCm39 Ensembl
GRCm388123,065,508 - 123,097,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,062,942 - 123,097,760 (+)EnsemblGRCm38mm10GRCm38
MGSCv378125,589,408 - 125,621,651 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368125,951,269 - 125,983,845 (+)NCBIMGSCv36mm8
Celera8127,301,723 - 127,334,887 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.04NCBI
Spg7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,025,619 - 68,059,754 (+)NCBIGRCr8
mRatBN7.21951,117,088 - 51,151,228 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,117,057 - 51,150,484 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,911,092 - 57,945,311 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,592,011 - 58,626,149 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,809,698 - 60,843,918 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,880,549 - 55,914,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,880,561 - 55,915,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,586,319 - 66,618,933 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,400,904 - 53,433,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11953,405,784 - 53,438,623 (+)NCBI
Celera1950,353,488 - 50,385,526 (+)NCBICelera
Cytogenetic Map19q12NCBI
Spg7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555413,109,892 - 3,140,958 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555413,092,968 - 3,141,157 (+)NCBIChiLan1.0ChiLan1.0
SPG7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21899,290,474 - 99,341,056 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116105,207,771 - 105,258,390 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01670,258,902 - 70,309,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,866,884 - 89,917,867 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,866,884 - 89,917,867 (+)Ensemblpanpan1.1panPan2
SPG7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,984,716 - 64,023,271 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,985,658 - 64,023,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha563,996,864 - 64,035,406 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,212,077 - 64,250,632 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,210,575 - 64,256,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,231,998 - 64,270,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,069,471 - 64,108,027 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,476,292 - 64,514,838 (-)NCBIUU_Cfam_GSD_1.0
SPG7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,862,524 - 74,916,214 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,862,551 - 74,916,033 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666047592,653 - 647,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spg7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746346,492 - 377,882 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746344,754 - 377,939 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000014686   ⟹   ENSSTOP00000013155
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936641452,475 - 484,220 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000033289   ⟹   ENSSTOP00000026384
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936641452,601 - 457,958 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000034494   ⟹   ENSSTOP00000026208
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936641452,475 - 484,220 (-)Ensembl
RefSeq Acc Id: XM_005335417   ⟹   XP_005335474
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934924,698,444 - 24,730,673 (-)NCBI
SpeTri2.0NW_004936641451,762 - 484,229 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040279876   ⟹   XP_040135810
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934924,698,215 - 24,730,707 (-)NCBI
RefSeq Acc Id: XM_040279877   ⟹   XP_040135811
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934924,698,915 - 24,730,707 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005335474 (Get FASTA)   NCBI Sequence Viewer  
  XP_040135810 (Get FASTA)   NCBI Sequence Viewer  
  XP_040135811 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000013155.3
  ENSSTOP00000026208.1
  ENSSTOP00000026384.1
GenBank Protein KAG3256679 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005335474   ⟸   XM_005335417
- Peptide Label: isoform X2
- UniProtKB: I3MND6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040135810   ⟸   XM_040279876
- Peptide Label: isoform X1
- UniProtKB: I3MND6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040135811   ⟸   XM_040279877
- Peptide Label: isoform X3
- UniProtKB: I3MND6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000026208   ⟸   ENSSTOT00000034494
Ensembl Acc Id: ENSSTOP00000026384   ⟸   ENSSTOT00000033289
Ensembl Acc Id: ENSSTOP00000013155   ⟸   ENSSTOT00000014686
Protein Domains
AAA+ ATPase   Peptidase M41


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000014682 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000014686.3 UniProtKB/TrEMBL
  ENSSTOT00000033289.1 UniProtKB/TrEMBL
  ENSSTOT00000034494.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  1.20.58.760 UniProtKB/TrEMBL
  3.40.1690.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  ATP-dep_Zn_Metalloprotease UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  FtsH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Pept_M41_FtsH_extracell UniProtKB/TrEMBL
  Peptidase_M41 UniProtKB/TrEMBL
  Peptidase_M41-like UniProtKB/TrEMBL
NCBI Gene Spg7 ENTREZGENE
PANTHER ATP-DEPENDENT PROTEASE UniProtKB/TrEMBL
  PARAPLEGIN UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  FtsH_ext UniProtKB/TrEMBL
  Peptidase_M41 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF140990 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A287CY55_ICTTR UniProtKB/TrEMBL
  A0A287CYQ2_ICTTR UniProtKB/TrEMBL
  I3MND6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-05 Spg7  SPG7 matrix AAA peptidase subunit, paraplegin    SPG7, paraplegin matrix AAA peptidase subunit  Symbol and/or name change 5135510 APPROVED