Cnr2 (cannabinoid receptor 2) - Rat Genome Database

Name: Cnr2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Cnr2 (cannabinoid receptor 2) Ictidomys tridecemlineatus

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Symbol:

Cnr2

Name:

cannabinoid receptor 2

RGD ID:

12707394

Description:

ENCODES a protein that exhibits cannabinoid receptor activity (ortholog); G protein-coupled receptor activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); leukocyte chemotaxis (ortholog); negative regulation of action potential (ortholog); ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); acute myeloid leukemia (ortholog); Animal Disease Models (ortholog); FOUND IN dendrite (ortholog); endoplasmic reticulum (ortholog); extrinsic component of cytoplasmic side of plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CNR2 (cannabinoid receptor 2)	NCBI	Ortholog
Mus musculus (house mouse):	Cnr2 (cannabinoid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cnr2 (cannabinoid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cnr2 (cannabinoid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CNR2 (cannabinoid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CNR2 (cannabinoid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CNR2 (cannabinoid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CNR2 (cannabinoid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cnr2 (cannabinoid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	43,193,178 - 43,215,797 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	9,019,067 - 9,020,110 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	9,019,044 - 9,020,110 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ISO)

acute myeloid leukemia (ISO)

Animal Disease Models (ISO)

Anterior Cruciate Ligament Injuries (ISO)

arthritis (ISO)

atherosclerosis (ISO)

Breast Neoplasms (ISO)

Catalepsy (ISO)

cholestasis (ISO)

depressive disorder (ISO)

Diamond-Blackfan anemia (ISO)

diarrhea (ISO)

Endometrial Neoplasms (ISO)

Huntington's disease (ISO)

Hyperalgesia (ISO)

Hyperemia (ISO)

hyperglycemia (ISO)

immune system disease (ISO)

inflammatory bowel disease (ISO)

liver cirrhosis (ISO)

Myocardial Reperfusion Injury (ISO)

Pain (ISO)

pancreatic cancer (ISO)

pancreatitis (ISO)

post-traumatic stress disorder (ISO)

sciatic neuropathy (ISO)

secondary Parkinson disease (ISO)

Spinal Cord Injuries (ISO)

systemic scleroderma (ISO)

Weight Loss (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cannabinoid signaling pathway (IEA)

cell communication (IEA)

G protein-coupled receptor signaling pathway (IEA,ISO)

leukocyte chemotaxis (IEA,ISO)

negative regulation of action potential (ISO)

negative regulation of mast cell activation (ISO)

negative regulation of nitric-oxide synthase activity (ISO)

negative regulation of synaptic transmission, GABAergic (ISO)

response to amphetamine (ISO)

response to lipopolysaccharide (ISO)

signaling (IEA)

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission (IEA)

Cellular Component

cell projection (IEA)

dendrite (ISO)

endoplasmic reticulum (IEA,ISO)

extrinsic component of cytoplasmic side of plasma membrane (ISO)

membrane (IEA)

neuron projection (IEA)

neuronal cell body (ISO)

plasma membrane (IEA)

postsynaptic membrane (ISO)

synapse (IEA)

Molecular Function

cannabinoid receptor activity (IEA,ISO)

G protein-coupled receptor activity (IEA,ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cnr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	43,193,178 - 43,215,797 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	9,019,067 - 9,020,110 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	9,019,044 - 9,020,110 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CNR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	23,870,515 - 23,913,362 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	23,870,515 - 23,913,362 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	24,197,005 - 24,239,852 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	24,073,047 - 24,112,404 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	23,945,765 - 23,985,123	NCBI
Celera	1	22,529,091 - 22,570,596 (-)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	22,452,107 - 22,493,123 (-)	NCBI		HuRef
CHM1_1	1	24,313,205 - 24,352,708 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	23,705,612 - 23,750,778 (-)	NCBI		T2T-CHM13v2.0

Cnr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	135,622,500 - 135,647,530 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	135,622,705 - 135,647,518 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	135,895,189 - 135,920,219 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	135,895,394 - 135,920,207 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	135,451,319 - 135,476,130 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	135,167,559 - 135,192,283 (+)	NCBI		MGSCv36	mm8
Celera	4	134,096,250 - 134,121,016 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	68.01	NCBI

Cnr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	153,408,968 - 153,435,092 (+)	NCBI		GRCr8
mRatBN7.2	5	148,125,222 - 148,151,548 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	148,125,604 - 148,151,548 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	150,824,702 - 150,850,276 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	152,598,978 - 152,624,546 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	152,580,980 - 152,606,559 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	154,242,010 - 154,268,126 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	154,260,062 - 154,268,126 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	158,006,539 - 158,032,977 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	154,674,754 - 154,702,552 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	154,709,561 - 154,712,096 (+)	NCBI
Celera	5	146,533,227 - 146,558,688 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Cnr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	3,763,742 - 3,795,069 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	3,763,742 - 3,795,069 (-)	NCBI	ChiLan1.0	ChiLan1.0

CNR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	203,024,666 - 203,070,013 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	202,127,725 - 202,173,040 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	23,066,153 - 23,108,065 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	24,046,009 - 24,135,236 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	24,050,008 - 24,051,090 (-)	Ensembl	panpan1.1		panPan2

CNR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	75,640,636 - 75,662,000 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	75,658,999 - 75,660,126 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	72,229,153 - 72,230,280 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	76,199,651 - 76,221,314 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	76,213,197 - 76,221,306 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	73,040,679 - 73,041,806 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	74,047,309 - 74,048,436 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	75,053,153 - 75,054,280 (+)	NCBI		UU_Cfam_GSD_1.0

CNR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	81,659,169 - 81,692,550 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	81,659,162 - 81,692,550 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	75,363,944 - 75,366,948 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CNR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	108,777,793 - 108,815,738 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	108,813,579 - 108,814,661 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	7,526,675 - 7,569,788 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cnr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	8,389,444 - 8,390,538 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	8,388,375 - 8,422,961 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005343004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000011943 ⟹ ENSSTOP00000010713

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936474	9,019,067 - 9,020,110 (-)	Ensembl

RefSeq Acc Id:

XM_005343004 ⟹ XP_005343061

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	43,193,178 - 43,215,797 (-)	NCBI
SpeTri2.0	NW_004936474	9,019,044 - 9,020,110 (-)	NCBI

Sequence:

show sequence

ATGGAGTTCTGCCTGGACACGGAGGCAGTCAATGGCTCAAAGAATGACTTGAATTTCAACCCCA
TGAAGGATTACATGGTCCTCAGCCGTCCTCAGCAGGTGGCGATTGCCGTGCTGTGCACCCTGCT
GAGCCTGCTAAGTGCCCTGGAGAACCTGACCGTGCTTTACCTGATTCTGTCCTCCCGCCGACTC
CGCAGGAAGCCCTCATACCTGTTCATTGGCAGCTTGGCTATAGCTGACTTCCTGGCCAGTGTGA
TCTTCGCCAGCAACTTTATCAATTTCCACGTCTTCCACAGCGTGGATTCCAAGGCCGTCTTCCT
GCTGAAGATCGGTAGTGTGACCCTGACCTTCACCGCCTCAGTGGGCAGCCTGCTGCTGACCGCC
ATTGACCGCTACCTCTGTCTGCGCTACCCACCTGCATACAAAACTCTACTCACCCATGGGAGGG
CCCTGGCAACCCTGGGCATCATGTGGGTCTTGTCAGCTTTGGTCTCCTACCTGCCTCTCATGGG
GTGGACCTGCTGTCCCAGTCCCTGCTCTCAGCTTATCCCGTTGGTCCCCGACAACTATATCCTG
GGCTGGCTCCTGCTGGTTGCCATTCTCTTCTCCGGCATTATCTACACCTACGGGCACGTCCTCT
GGAAGGCCTATCAGCATGCAGTCAACTTGGCCGAGCACCAGGACAGACAGCTGCCAGGGATGAT
CCGTATGAGGCTGGATGTGAGGTTGGCCAAGACCCTGGGGCTGCTGCTGGCTGTGTTGGTCCTA
TGCTGGTTCCCGGTACTGGCCCTCCTAGCCCACAGCCTGGTGGCCCCGCTGAGTGACCAGGTCA
AGAAGGTCTTTGCCTTCTGCTCCTTGCTGTGCCTCGTCAACGCCATGGTCGACCCTGTCATCTA
CGCCCTGCGGAGTCGGGAGATCCGCTCTTCTGCCCACCATAGCCTGGCCCGCTGGAAGGGCTAC
CTGAGAGGCCGTGGTCCTGAAGGAAAGGAAGAAGCCCCCAAGTCCTCCGTCACCGAGACAGAGG
CTGACATGAAAATCACCTAAGGACCCCAGGTCAGAGGTCCATT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005343061	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000010713.2
GenBank Protein	KAG3282406	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005343061 ⟸ XM_005343004

- UniProtKB:

I3MI94 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEFCLDTEAVNGSKNDLNFNPMKDYMVLSRPQQVAIAVLCTLLSLLSALENLTVLYLILSSRRL
RRKPSYLFIGSLAIADFLASVIFASNFINFHVFHSVDSKAVFLLKIGSVTLTFTASVGSLLLTA
IDRYLCLRYPPAYKTLLTHGRALATLGIMWVLSALVSYLPLMGWTCCPSPCSQLIPLVPDNYIL
GWLLLVAILFSGIIYTYGHVLWKAYQHAVNLAEHQDRQLPGMIRMRLDVRLAKTLGLLLAVLVL
CWFPVLALLAHSLVAPLSDQVKKVFAFCSLLCLVNAMVDPVIYALRSREIRSSAHHSLARWKGY
LRGRGPEGKEEAPKSSVTETEADMKIT

hide sequence

Ensembl Acc Id:

ENSSTOP00000010713 ⟸ ENSSTOT00000011943

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000011946	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000011943.2	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Canbinoid_rcpt_2	UniProtKB/TrEMBL
	Cnbnoid_rcpt	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	Cnr2	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	PTHR22750:SF10	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	CANABINOID2R	UniProtKB/TrEMBL
	CANNABINOIDR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
SMART	7TM_GPCR_Srsx	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	I3MI94	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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