Steap4 (STEAP4 metalloreductase) - Rat Genome Database

Name: Steap4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Steap4 (STEAP4 metalloreductase) Ictidomys tridecemlineatus

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Symbol:

Steap4

Name:

STEAP4 metalloreductase

RGD ID:

12674559

Description:

ENCODES a protein that exhibits cupric reductase (NADH) activity (inferred); electron transfer activity (inferred); FAD binding (inferred); INVOLVED IN copper ion import (ortholog); iron import into cell (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); pleomorphic xanthoastrocytoma (ortholog); Prostatic Neoplasms (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

metalloreductase STEAP4; STEAP4 metalloreductase, transcript variant X1; STEAP4 metalloreductase, transcript variant X2; STEAP4 metalloreductase, transcript variant X3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	27,329,679 - 27,355,494 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936763	645,858 - 670,863 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936763	645,910 - 671,674 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

pleomorphic xanthoastrocytoma (ISO)

Prostatic Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

copper ion import (IEA,ISO)

fat cell differentiation (IEA)

iron import into cell (IEA,ISO)

iron ion transport (IEA)

protein homotrimerization (IEA)

Cellular Component

endosome (IEA)

endosome membrane (IEA)

membrane (IEA)

nucleoplasm (IEA)

plasma membrane (IEA)

Molecular Function

cupric reductase (NADH) activity (IEA)

electron transfer activity (IEA)

FAD binding (IEA)

ferric-chelate reductase (NADPH) activity (IEA)

heme binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Steap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	27,329,679 - 27,355,494 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936763	645,858 - 670,863 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936763	645,910 - 671,674 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STEAP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	88,270,892 - 88,306,894 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	88,270,892 - 88,306,894 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	87,900,207 - 87,936,209 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	87,743,680 - 87,774,145 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	87,552,405 - 87,580,857	NCBI
Celera	7	82,610,349 - 82,640,811 (-)	NCBI		Celera
Cytogenetic Map	7	q21.12	NCBI
HuRef	7	82,516,141 - 82,546,083 (-)	NCBI		HuRef
CHM1_1	7	87,836,261 - 87,866,753 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	89,521,348 - 89,557,349 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	87,237,102 - 87,267,587 (-)	NCBI

Steap4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	8,010,472 - 8,032,213 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	8,010,457 - 8,032,213 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	7,960,472 - 7,982,213 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	7,960,457 - 7,982,213 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	7,960,472 - 7,982,213 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	7,966,478 - 7,988,219 (+)	NCBI		MGSCv36	mm8
Celera	5	7,894,149 - 7,915,890 (+)	NCBI		Celera
Cytogenetic Map	5	A1	NCBI
cM Map	5	3.37	NCBI

Steap4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	27,032,096 - 27,054,769 (-)	NCBI		GRCr8
mRatBN7.2	4	26,077,182 - 26,099,859 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	26,054,671 - 26,099,859 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	31,062,973 - 31,085,424 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	26,989,171 - 27,011,628 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	25,366,207 - 25,388,643 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	23,112,682 - 23,135,354 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	23,090,029 - 23,135,354 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	23,040,108 - 23,062,780 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	22,688,597 - 22,711,432 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	21,558,227 - 21,580,908 (-)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI

Steap4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	5,618,086 - 5,641,565 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	5,618,086 - 5,641,372 (-)	NCBI	ChiLan1.0	ChiLan1.0

STEAP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	106,147,728 - 106,186,805 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	154,412,366 - 154,451,373 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	80,263,528 - 80,299,470 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	93,918,320 - 93,948,754 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	93,918,327 - 93,948,754 (-)	Ensembl	panpan1.1		panPan2

STEAP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	14,319,895 - 14,345,719 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	14,321,757 - 14,327,720 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	13,892,008 - 13,917,634 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	14,131,025 - 14,155,283 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	14,129,628 - 14,155,148 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl	14	14,085,062 - 14,111,604 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	14,295,085 - 14,320,670 (-)	NCBI		UMICH_Zoey_3.1

STEAP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	68,546,465 - 68,570,424 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	68,549,142 - 68,570,350 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	74,984,352 - 75,005,812 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STEAP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	60,653,504 - 60,680,414 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	60,653,454 - 60,680,323 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	43,423,109 - 43,451,475 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Steap4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624809	5,084,814 - 5,103,980 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624809	5,084,992 - 5,103,765 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005340005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013365049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021719940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000009807 ⟹ ENSSTOP00000008794

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936763	645,858 - 670,863 (+)	Ensembl

RefSeq Acc Id:

XM_005340005 ⟹ XP_005340062

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	27,329,679 - 27,355,494 (-)	NCBI
SpeTri2.0	NW_004936763	645,910 - 671,674 (+)	NCBI

Sequence:

show sequence

CGCGGAGAGCAGCGAGCTGCAGGAGTGAGCTGGAGGGGACTTCCCGCAAAGCTTCTCTCTCCGG
GCCAGACCCGTGGCGCGCACGCTGCAGCTCCGCTGGACCCCAGCACCGGGAGGCGCTCATCCCG
CAGTAATGGAGAAAACTTGTACAGTTATGCTTCCTCTTACAATGAATTCTTCAGAAAAGCCACA
GACTGTCTGCATTTTTGGAACAGGAGATTTTGGAAGATCACTTGGATTTAAAATGTTCCAGTGT
GGTTATTCTGTTATATTTGGAAGTCGAAACTCCAGGATGTCCAGCCTGCTGCACAGTGGTGCCG
AGGTCTTCAGCTATTCAGAAGCTGCCCAGAAGTCTGACATCATATTTATTGCAATCCACAGAGA
GCATTATGAATTTCTCAGAGAACTAACTGAGGATCTCAACGGGAAAATATTGGTAGATGTCAGC
AACAACCCCAAAATTAATCAGTATCCAGAATCTAATGCAGAATACCTTGCTCAGTTGGTGCAGG
GAGCTTATGTGGTAAAAGCATTTAACACCATTTCAGCCTGGGCTCTCCAGTCAGGAGCACTGGA
TGCAAGTCGGCAGGTGTTTGTCTGTGGAAATGACAGCAAAGCCAAACAAAGAGTGATGGACATT
GTTTGTGCTCTTGGACTTACCCCGTTGGATCGAGGATCTCTCAAGGCAGCCACCGAAATTGAAA
ACTACCCCCTGCAACTATTTCCCATGTGGAGGTTCCCCTTCTATTTGTCTGCTGCACTCTGTCT
CTTCTTCTTTATCTACTGTGTTGTAAGAGACATAATCTACCCCTATGTGATTGAGAACAAAGAC
AGCACATTTCGCTTGGCTGTATCCATTCCGAATCGTGTCTTCCCTATAACAGCACTTACCCTGC
TTGCCTTGGTTTACCTTCCTGGCGTCATTGCCGCCATCCTGCAGCTGTACCAAGGTACCAAATA
CCGACGATTCCCAGACTGGCTCGACCACTGGATGCTTTGCAGAAAGCAGCTTGGCTTGGTGGCT
CTGGGGTTCGCCTTCCTTCACGCCATCTACACGCTTGTGATTCCTATTCGTTATTATGTACGAT
GGAGGATGAGAAACACAACCCTTACTAAGGTGATCACCAAGGAAGATGATCCATTTTTTACCTC
TACAGCCTGGCATAGTGATTCATATTTGTCTGTGGGAATCCTTGGATTTTTTCTGTTTGTGCTC
TTGGGAATCACTTCCTTGCCATCAGTTAGCAACATGATGAACTGGAGAGAGTTCCGGTTTATCC
AGTCCAAACTGGGTTATTTGACCCTGATCTTATGCACAGCCCACGCCCTACTCTATGGCGGGAA
GAGGTTCCTCAGCCCTTCAATTCTAAGATGGTACCTTCCTTCAGCCTATGTTTTAGCACTTATC
ATTCCCTGCACAGTGCTGGTGATCAAGTTTATCCTCATCATGCCGTGCATCAACAATCCCCTTA
AGCGGATCCGCCGGGGCTGGGAAAGGGATTCAAAATCCTCAGAATCAGCACTGAATGGAAAATC
AGATATTTAAAGGAAAGTTGAATTTACCTGGACTTTTGAAGCATAGTATTGAATGTTTAGAGAA
GAATAATGGATACAGAAATGGGTAAGACAGCTCTTTTTCTCTCACCATGGCCTGAAGTTTATCA
ACACGGACAGAAACTTTGCTAACTAATAAAATGACAGATTGGAAGAGAACACCATTCTTTCTCA
AGTTAGTGATGGGATCAGAGCAGGTCCCCCCCTCCTCCTCCTCCGAGGCCATGGGGCTGCCAAC
AGAATAGTTTTGTGGTTTCACATTAAGAAGTTTCTTTGCTGTAGGCAACATTCATGATCTTATC
TTGCAAAATCCAGAAAAGTACATACAACTTCCTCCTTACATTCAAGCACTGAGTTACATGAAAG
AGAAAGTAGCACCACAGTGGCCACAGATAAAGGCTTTGCACAATATGTCTGAAGAATAGGCTCA
AATGGAGTAAAAAGAATGAAATTTTTTGTTTCCTTTTTGGAAGTAAAATGGTGACCATAAATAT
GCCATAGTGTATTTTGGTTTTGTTGTTTTGTTTTACAATGCTATGGCCAATCCAGCACCTTGAA
CATGTTAGGCAAGCACCGTACCACTGAGCTACACCTCCAACCCTGTCACAGTGAAATCCATGTT
TAAGTGTATCCCTTTATTTTGTTTTTAACAGTACATATATCTACCATGGAAAACTATTTTGGAA
CGCAACAAAAGTATTGCATTTGATTGGAAGTAACCATGCCTTGGATATATACAAATCTATATAA
TTATTTTAGTCAGGGTTATTTTTTTTTTTTTTGCCTCTGTGTCCAAAAGACCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005340062	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008794.2
GenBank Protein	KAG3277539	(Get FASTA)	NCBI Sequence Viewer
	KAG3277540	(Get FASTA)	NCBI Sequence Viewer
	KAG3277541	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005340062 ⟸ XM_005340005

- UniProtKB:

I3ME92 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEKTCTVMLPLTMNSSEKPQTVCIFGTGDFGRSLGFKMFQCGYSVIFGSRNSRMSSLLHSGAEV
FSYSEAAQKSDIIFIAIHREHYEFLRELTEDLNGKILVDVSNNPKINQYPESNAEYLAQLVQGA
YVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVCALGLTPLDRGSLKAATEIENY
PLQLFPMWRFPFYLSAALCLFFFIYCVVRDIIYPYVIENKDSTFRLAVSIPNRVFPITALTLLA
LVYLPGVIAAILQLYQGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHAIYTLVIPIRYYVRWR
MRNTTLTKVITKEDDPFFTSTAWHSDSYLSVGILGFFLFVLLGITSLPSVSNMMNWREFRFIQS
KLGYLTLILCTAHALLYGGKRFLSPSILRWYLPSAYVLALIIPCTVLVIKFILIMPCINNPLKR
IRRGWERDSKSSESALNGKSDI

hide sequence

Ensembl Acc Id:

ENSSTOP00000008794 ⟸ ENSSTOT00000009807

Protein Domains

Ferric oxidoreductase Pyrroline-5-carboxylate reductase catalytic N-

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009812	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009807.3	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	Fe3_Rdtase_TM_dom	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	P5C_Rdtase_cat_N	UniProtKB/TrEMBL
	STEAP_metalloreductase	UniProtKB/TrEMBL
NCBI Gene	Steap4	ENTREZGENE
PANTHER	DUDULIN-RELATED	UniProtKB/TrEMBL
	METALLOREDUCTASE STEAP4	UniProtKB/TrEMBL
Pfam	F420_oxidored	UniProtKB/TrEMBL
	Ferric_reduct	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	I3ME92	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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