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Gene: Nt5c1a (5'-nucleotidase, cytosolic IA) Ictidomys tridecemlineatus

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Symbol:

Nt5c1a

Name:

5'-nucleotidase, cytosolic IA

RGD ID:

12638168

Description:

ENCODES a protein that exhibits 5'-nucleotidase activity (ortholog); INVOLVED IN adenosine metabolic process (ortholog); purine nucleoside monophosphate catabolic process (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytosolic 5'-nucleotidase 1A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	55,703,426 - 55,717,483 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	21,535,467 - 21,542,588 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	21,535,197 - 21,542,417 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenosine metabolic process (IEA,ISO)

allantoin metabolic process (IEA)

AMP catabolic process (IEA)

dAMP catabolic process (IEA)

dGMP catabolic process (IEA)

IMP catabolic process (IEA)

nucleotide metabolic process (IEA)

purine nucleoside monophosphate catabolic process (IEA,ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

Molecular Function

5'-nucleotidase activity (IEA,ISO)

IMP 5'-nucleotidase activity (IEA)

magnesium ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Nt5c1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	55,703,426 - 55,717,483 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	21,535,467 - 21,542,588 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	21,535,197 - 21,542,417 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NT5C1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	39,651,229 - 39,672,107 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	39,651,229 - 39,672,107 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	40,116,901 - 40,137,779 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	39,897,380 - 39,910,297 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	39,793,885 - 39,806,803	NCBI
Celera	1	38,406,541 - 38,419,451 (-)	NCBI		Celera
Cytogenetic Map	1	p34.2	NCBI
HuRef	1	38,243,165 - 38,256,339 (-)	NCBI		HuRef
CHM1_1	1	40,240,158 - 40,253,074 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	39,519,647 - 39,541,479 (-)	NCBI		T2T-CHM13v2.0

Nt5c1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	123,095,026 - 123,119,128 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	123,095,297 - 123,110,068 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	123,201,230 - 123,225,339 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	123,201,504 - 123,216,275 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	122,878,796 - 122,893,450 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	122,703,861 - 122,718,510 (+)	NCBI		MGSCv36	mm8
Celera	4	121,533,931 - 121,548,583 (+)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	57.4	NCBI

Nt5c1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	140,758,219 - 140,782,706 (+)	NCBI		GRCr8
mRatBN7.2	5	135,473,107 - 135,494,400 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	135,473,231 - 135,499,338 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	138,179,527 - 138,194,604 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	139,949,490 - 139,964,567 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	139,956,631 - 139,971,708 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	140,888,862 - 140,909,322 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	140,888,973 - 140,904,207 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	144,678,889 - 144,697,399 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	142,509,257 - 142,524,280 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	142,514,549 - 142,529,506 (+)	NCBI
Celera	5	134,012,146 - 134,027,198 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Nt5c1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	17,172,217 - 17,188,756 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	17,172,217 - 17,188,597 (-)	NCBI	ChiLan1.0	ChiLan1.0

NT5C1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	187,143,395 - 187,170,949 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	186,281,086 - 186,308,577 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	38,943,479 - 38,962,804 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	40,268,821 - 40,289,221 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	40,275,870 - 40,289,221 (-)	Ensembl	panpan1.1		panPan2

NT5C1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	3,209,771 - 3,230,104 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	3,209,869 - 3,222,983 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	3,468,550 - 3,488,826 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	3,329,926 - 3,350,213 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	3,329,942 - 3,350,172 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	3,206,121 - 3,226,364 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	3,267,136 - 3,287,417 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	3,282,706 - 3,302,991 (+)	NCBI		UU_Cfam_GSD_1.0

NT5C1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	95,473,266 - 95,497,000 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	95,473,259 - 95,497,645 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	88,561,471 - 88,585,252 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NT5C1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	93,261,913 - 93,278,063 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	93,264,543 - 93,277,688 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	23,598,905 - 23,620,239 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nt5c1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	22,151,246 - 22,168,322 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	22,147,077 - 22,168,337 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013364919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040288434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005735131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000010430 ⟹ ENSSTOP00000009361

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936474	21,535,467 - 21,542,588 (-)	Ensembl

RefSeq Acc Id:

XM_013364919 ⟹ XP_013220373

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	55,703,426 - 55,717,480 (-)	NCBI
SpeTri2.0	NW_004936474	21,535,197 - 21,542,417 (-)	NCBI

Sequence:

show sequence

CAGTTTACCTGGAGTGATCCCTGAGCCATTTAGTTGCTAAAATGGAAACCTGGCAGCAGTGCTG
TGTACCCTTCTGATGGAGTTCTGGAGTGGATGGTGGTGCTGAGCCCGGAGGTGAGGGAAAAGGG
GAGGGATAAAGTTGGGGGTGGAGGAAGTGGTGGCAATTCAGCCTCAGGCATGATGAGTTGAAGC
TGGGGCAGTTGGATATTTGAATCTGGAGCTCAGGAGACAGATCTGGGCTGGAGATAAATTTTCT
TATGTAACTGCTATGTTCCTGGCCATCAATTTCTTCCTTAGGGTATGTAGCTCTCATTTCCTAA
TGGAAACCACCTGGATCTCAAGCATCAGTCATACTTGGGCCACATACATCATATTCATTTTTCT
ATTGTATTCAGATGTCCCAACCAGATTGCGAACTCCTTGAGGGCATGTCCCTCCTTCAGATTGC
ACTCTAGGTGGCAAACCACCCTCTGCCTCTGGGTTCTCTGTAAACAGGGTCCTAACCTGTCTTC
CTCTTCCCAGACTGAGTCTCTTTAGGGAAAAGCCTGGGCCTGGGTCTTTTCCACGTCTTCAGTA
GCTGAGGGGCTTGCATAGGAACACCTGCCCCGGAGCAAGACTGAGTGACAGCCCTTACTCCTGC
ACCTCTACAGCCCAGGCCTCAGAATGCTGTCACCATTGCTGTGTCCTCCCGAGCCTTGTTCCGC
ATGGACGAGGAGCAGCGGATCTACACGGAGCAGGGCGTGGAGGAGTACGTGCGCTACCAGCTGG
AGCACGAGAATGAGCCCTTCAGTCCCGGGCCAGCCTTCCCCTTCGTGAAGGCTCTGGAGGCTGT
GAATAAGCGGCTTCGGGAGCTGTACCCCGACAGTGAGGATGTCTTTGACATCGTGCTCATGACC
AACAACCACGCTCAAGTGGGAGTCCGCCTCATCAACAGTATCAACCACTACGATCTGTTCATCG
AGAGGTTCTGCATGACAGGAGGGAACAGCCCCATCTGCTACCTCAAGGCCTATCACACCAACCT
CTACTTGTCAGCTGATGCAGAAAAAGTGCGAGAAGCCATTGATGAGGGGATTGCAGCTGCCACC
ATCTTCAGTCCCAGCAGGGATGTCGTTGTGTCTCAGAGTCAACTGCGCGTGGCTTTCGATGGGG
ATGCTGTGCTCTTCTCAGACGAGTCAGAGCGCATTGTCAAGGCGCACGGGCTGGACAGATTCTT
CGAGCATGAGAAGGCCCATGAGAACAAACCTTTGGCCCAGGGCCCCTTAAAGGGCTTCCTGGAG
GCACTTGGTAGGCTACAGAAGAAGTTCTACTCCAAGGGCCTGCGGCTAGAATGCCCAATTCGCA
CCTACTTGGTGACAGCACGCAGCGCAGCCAGTTCTGGGGCCCGAGCTCTCAAGACCCTGCGCAG
CTGGGGCCTGGAGACGGATGAGGCCTTGTTCCTAGCTGGAGCACCCAAAGGCCCCCTCCTGGAG
AAGATTCGCCCACATATCTTCTTTGATGATCAGATGTTCCACGTGGCTGGGGCTCAGGAGATGG
GCACCGTGGCTGCCCATGTGCCTTACGGTGTGGCACAGACACCCCGGCGGGCTGCACCTGCAAA
GCAGGCCCCATCTGCACAGTAGCTGAGCCACTTCCCTTCAGGCTTCCTGTCTTAGTTCCACACC
TTGTCTGGTGGCCCCTTCTGGTTCCTCGCCATTCTGTCCTTCCGCACGTCTGCCCTCATCCCTT
TGGGTGAGATACTTGTAGGAAATCACACAGACTGGGTCAACGAACTGACTGACCATGCCCCCTT
TTGGGCAAACACTGTGCCATGATCCTAGCTAGGACAGTCGGATCATGCAGAGTAGCTCGGTTTC
AGGGAGAAGTTGATGGGACTGAGCAGGGGAGGGTCA

hide sequence

RefSeq Acc Id:

XM_040288434 ⟹ XP_040144368

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	55,710,907 - 55,717,483 (-)	NCBI

RefSeq Acc Id:

XR_005735131

Type:

NON-CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	55,703,426 - 55,717,480 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_013220373	(Get FASTA)	NCBI Sequence Viewer
	XP_040144368	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000009361.3
GenBank Protein	KAG3282842	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_013220373 ⟸ XM_013364919
- Peptide Label:	isoform X1
- UniProtKB:	I3MFG9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDVFDIVLMT NNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAAT IFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLE ALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLE KIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRAAPAKQAPSAQ hide sequence

RefSeq Acc Id:	XP_040144368 ⟸ XM_040288434
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000009361 ⟸ ENSSTOT00000010430

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000010430	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000010430.3	UniProtKB/TrEMBL
InterPro	5-nucleotidase	UniProtKB/TrEMBL
NCBI Gene	Nt5c1a	ENTREZGENE
PANTHER	CYTOSOLIC 5'-NUCLEOTIDASE 1A	UniProtKB/TrEMBL
	PTHR31367	UniProtKB/TrEMBL
Pfam	5-nucleotidase	UniProtKB/TrEMBL
UniProt	I3MFG9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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