Smc3 (structural maintenance of chromosomes 3) - Rat Genome Database

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Gene: Smc3 (structural maintenance of chromosomes 3) Ictidomys tridecemlineatus
Analyze
Symbol: Smc3
Name: structural maintenance of chromosomes 3
RGD ID: 12595408
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN meiotic cell cycle (ortholog); stem cell population maintenance (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Cornelia de Lange syndrome (ortholog); Cornelia de Lange syndrome 1 (ortholog); FOUND IN basement membrane (ortholog); synaptonemal complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: structural maintenance of chromosomes protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721324,122,824 - 24,157,519 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,408,045 - 1,435,875 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,409,757 - 1,436,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Smc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721324,122,824 - 24,157,519 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,408,045 - 1,435,875 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,409,757 - 1,436,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810110,567,695 - 110,606,048 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10110,567,684 - 110,606,048 (+)EnsemblGRCh38hg38GRCh38
GRCh3710112,327,453 - 112,365,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,317,439 - 112,354,382 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410112,317,473 - 112,354,380NCBI
Celera10106,059,046 - 106,095,991 (+)NCBICelera
Cytogenetic Map10q25.2NCBI
HuRef10105,957,043 - 105,993,961 (+)NCBIHuRef
CHM1_110112,609,271 - 112,646,175 (+)NCBICHM1_1
T2T-CHM13v2.010111,451,468 - 111,489,803 (+)NCBIT2T-CHM13v2.0
Smc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391953,588,827 - 53,634,262 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1953,588,829 - 53,634,264 (+)EnsemblGRCm39 Ensembl
GRCm381953,600,396 - 53,645,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,600,398 - 53,645,833 (+)EnsemblGRCm38mm10GRCm38
MGSCv371953,674,886 - 53,720,321 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361953,653,759 - 53,698,460 (+)NCBIMGSCv36mm8
Celera1955,793,196 - 55,838,677 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1948.13NCBI
Smc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,606,731 - 262,649,832 (+)NCBIGRCr8
mRatBN7.21252,601,422 - 252,644,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,601,753 - 252,644,522 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1260,791,015 - 260,833,731 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,497,086 - 267,539,800 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,152,142 - 260,195,192 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,310,120 - 274,352,856 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,309,758 - 274,352,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01281,719,796 - 281,762,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41259,822,480 - 259,865,602 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11260,033,557 - 260,076,645 (+)NCBI
Celera1248,320,880 - 248,363,620 (+)NCBICelera
Cytogenetic Map1q55NCBI
Smc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955485815,281 - 848,561 (-)NCBIChiLan1.0ChiLan1.0
SMC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28122,450,881 - 122,488,731 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110122,456,339 - 122,494,067 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010107,164,086 - 107,201,220 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110110,613,824 - 110,650,923 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10110,613,824 - 110,653,075 (+)Ensemblpanpan1.1panPan2
SMC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12821,889,690 - 21,928,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2821,889,662 - 21,928,034 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,041,009 - 22,080,134 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,416,380 - 22,455,786 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,416,380 - 22,455,779 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12821,973,911 - 22,012,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02821,979,557 - 22,018,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,114,201 - 22,153,585 (+)NCBIUU_Cfam_GSD_1.0
SMC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14120,969,631 - 121,021,497 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114120,969,629 - 121,008,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214131,854,806 - 131,894,120 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19103,506,779 - 103,543,836 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9103,506,689 - 103,545,523 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604864,709,561 - 64,746,712 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473735,694,566 - 35,730,829 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473735,698,722 - 35,730,854 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000041634   ⟹   ENSSTOP00000032666
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364861,408,045 - 1,435,875 (+)Ensembl
RefSeq Acc Id: XM_040272528   ⟹   XP_040128462
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721324,122,824 - 24,157,519 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040128462 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000032666.1
RefSeq Acc Id: XP_040128462   ⟸   XM_040272528
- UniProtKB: A0A287DGG8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000032666   ⟸   ENSSTOT00000041634
Protein Domains
RecF/RecN/SMC N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000030449 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000041634.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1060.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  RecF/RecN/SMC_N UniProtKB/TrEMBL
  SMC3_ABC_euk UniProtKB/TrEMBL
  SMC_hinge_sf UniProtKB/TrEMBL
NCBI Gene Smc3 ENTREZGENE
PANTHER STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 UniProtKB/TrEMBL
  STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 UniProtKB/TrEMBL
Pfam SMC_N UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF75553 UniProtKB/TrEMBL
UniProt A0A287DGG8 ENTREZGENE, UniProtKB/TrEMBL