Gpaa1 (glycosylphosphatidylinositol anchor attachment 1)

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Gene: Gpaa1 (glycosylphosphatidylinositol anchor attachment 1) Ictidomys tridecemlineatus

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Symbol:

Gpaa1

Name:

glycosylphosphatidylinositol anchor attachment 1

RGD ID:

12584965

Description:

ENCODES a protein that exhibits GPI anchor binding (ortholog); INVOLVED IN attachment of GPI anchor to protein (inferred); ASSOCIATED WITH Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN centrosome (inferred); cytosol (inferred); endoplasmic reticulum (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	666,664 - 670,968 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	8,092,855 - 8,096,074 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	8,092,758 - 8,096,277 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brown-Vialetto-Van Laere syndrome 2 (ISO)

epidermolysis bullosa simplex with muscular dystrophy (ISO)

genetic disease (ISO)

Glycosylphosphatidylinositol Biosynthesis Defect 15 (ISO)

holoprosencephaly (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

attachment of GPI anchor to protein (IEA)

Cellular Component

centrosome (IEA)

cytosol (IEA)

endoplasmic reticulum (IEA)

GPI-anchor transamidase complex (IEA)

membrane (IEA)

mitochondrion (IEA)

Molecular Function

GPI anchor binding (IEA,ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gpaa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	666,664 - 670,968 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	8,092,855 - 8,096,074 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	8,092,758 - 8,096,277 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPAA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	144,082,634 - 144,086,216 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	144,082,337 - 144,093,149 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	145,137,537 - 145,141,119 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	145,209,512 - 145,213,107 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	145,209,526 - 145,213,102	NCBI
Celera	8	141,475,157 - 141,478,683 (+)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	140,413,426 - 140,417,021 (+)	NCBI		HuRef
CHM1_1	8	145,177,776 - 145,181,371 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	145,243,485 - 145,247,067 (+)	NCBI		T2T-CHM13v2.0

Gpaa1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	76,215,494 - 76,219,099 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	76,215,431 - 76,219,107 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	76,331,294 - 76,334,900 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	76,331,231 - 76,334,907 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	76,161,724 - 76,165,329 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	76,158,549 - 76,162,154 (+)	NCBI		MGSCv36	mm8
Celera	15	77,831,354 - 77,834,959 (+)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	35.72	NCBI

Gpaa1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	109,932,556 - 109,936,139 (+)	NCBI		GRCr8
mRatBN7.2	7	108,051,896 - 108,055,479 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	108,051,861 - 108,055,484 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	109,795,563 - 109,799,146 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	112,019,257 - 112,022,840 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	111,977,711 - 111,981,294 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	117,394,367 - 117,397,950 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	117,394,372 - 117,397,956 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	117,381,997 - 117,385,580 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	114,378,978 - 114,382,561 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	114,413,207 - 114,416,790 (+)	NCBI
Celera	7	104,404,246 - 104,407,829 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Gpaa1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	2,735,463 - 2,738,956 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	2,735,463 - 2,738,956 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC100979844
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	17,768,812 - 17,773,809 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	17,771,585 - 17,781,036 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	91,716,647 - 91,721,082 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	111,487,498 - 111,510,259 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	143,840,524 - 143,845,352 (+)	Ensembl	panpan1.1		panPan2

GPAA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	37,577,162 - 37,580,346 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	37,576,354 - 37,580,345 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	37,540,819 - 37,543,992 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	38,053,394 - 38,056,568 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	38,053,345 - 38,069,424 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	37,725,487 - 37,728,658 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	37,853,701 - 37,856,859 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	38,330,285 - 38,333,466 (+)	NCBI		UU_Cfam_GSD_1.0

GPAA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	614,601 - 618,241 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	614,596 - 618,274 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	767,760 - 771,431 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPAA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	138,295,851 - 138,299,461 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	138,296,002 - 138,299,370 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	1,573,518 - 1,577,182 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpaa1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	12,739,750 - 12,743,223 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	12,739,750 - 12,743,219 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013357439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000025632 ⟹ ENSSTOP00000015326

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936470	8,092,855 - 8,096,074 (-)	Ensembl

RefSeq Acc Id:

XM_013357439 ⟹ XP_013212893

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	666,664 - 670,968 (-)	NCBI
SpeTri2.0	NW_004936470	8,092,758 - 8,096,277 (-)	NCBI

Sequence:

show sequence

CGAGTCGCTCAGGTTCCGGCTCCCTGCAACCCTAGGGCCTCCAGCAGCCGAGCTGGAGAAAGGT
TCTTTGCGCACGCGCAGCGGCGCGAATTTCAGTGGGACCGGAAGTGCGGCTGGGTTTGGGTTCG
GGGTCTGACAGGAGCAACTCGCGCTCCGCGGCTGGAGCTGGCTGCGAGAGCAGGGTCCCGCGTC
GCCCTCCCGCCATGGGCCTCCTGTCGGACCCCGTGCGCCGGCGCGCGCTGGCCCGTCTCGTGCT
GCGCCTCAACGCGCCGCTCTGCGTGCTGAGCTACGTGGCGGGCATCGCCTGGTTCTTGGCTCTG
GCCTTCCCGCCGTTGACCCAGCGTACTTACATGTCGGAGAACGCCATGGGATCCACCATGGTGG
AGGAGCAGTTTGTGGGCGGAGACCGTGCCCGGGGCTTTGCCCGCGATTTCGCTGCCCACCGCAG
GAAGTCGGGGGCTCTGCCAGTGGCCTGGCTGCAGCGGACGATGCGTACAGTAGGGCTGGAGGTC
TACACGCAGAGTTTCTCTCGGAAACTGCCCTTCCCGGATGAGACCCACGAGCGCTATATGGTAT
CAGGCACCAACGTGTATGGCATCCTGCGGGCCCCACGTGCTGCCAGCACCGAGTCTCTGGTGCT
CACTGTACCCTGTAACTCTGACTCCACCAATAGCCAGGCTGTTGGACTGCTGCTAGCACTTGCT
GCCCATTTCCGAGGGCAGATTTACTGGGCCAAAGATATCATCTTTCTGGTGACAGAACATGATC
TTCTGGGCACTGAGGCTTGGCTTGAAGCCTACCACGACGTTAATATAACTGGCATGCAGTCATC
CCCGTTGCAGGGCCGGGCTGGAGCCATTCAGGCAGCTGTGGCCCTGGAGTTGAGCAGTGATGTG
GTTACCAGCCTTGATGTGACTGTGGAGGGTCTCAATGGACAGCTGCCCAACCTTGACCTGCTCA
ACCTTTTCCAGACCTTCTGCCAGAAAGGGGGGCTGCTATGCACACTTCAGGGCAAGCTTCAGCT
CCAGGATTGGACAACGCTGGATGGGCCATTGCAGGGCCTGCAGACACTGCTGCTGATGGTTCTG
CGGCAGGCCTCTGGCCGCCCCCATGGCCCTCATGGCCTCTTTCTGCGGTACCGGGTAGAGGCCC
TGACCCTTCGGGGCATCAATAGCTTCCGGCAGTACAAGTATGACTTGGTGGCTGTTGGCAAGGC
TCTGGAGGGCATGTTCCGAAAGCTCAACCACCTGTTGGAGCGCCTACACCAGTCATTCTTCTTC
TACCTGCTTCCTGCTCTATCTCGCTTTGTCTCCATTGGTCTCTACATGCCTGCTGCTGGCTTCT
TGCTCCTGGTCCTTGGTCTCAAGGCTCTGGAGCTGTGGATGCAGCTGCATGAAGCTGGAGTGGG
CTCTGAAGAGGCTGGAGGTGCTCCTGGACCAAGTACCCAATTTCCCCCAGCACAGGGTGTGGGG
CTGGCCTCGCTTGTAGCACCCCTGCTGATCTCTCAGGCCATGGGCCTGGCCCTCTACATCCTGC
CTGTGTTGGGTCAACATGTGGCCGCCCAACACTTCCCAGTGGCTGAGGCTGAGGCCGTGGTGCT
GACACTGCTGGCAATTTATGCAGCTGGCCTGGCTCTTCCTCACAACACCCACCGGGTAATGAGC
ACACAGGCCTCAGACAGGGGATGGATGGCACTGAAACTGGTGGCTCTGATCTACCTAGCACTAC
AGCTAGGTTGCATCACCCTCACCAACTTCTCCCTGGGTTTCCTGCTAGCTGCCACCATGGTACC
TGCTGCTGCACTTACCAGACCCTATGGGCCTCGGCCACTCTATGCTGCCCTACTGGTGCTGACA
AGCCCAGCAGCCATGCTCCTGGGCAGCCTGTTCCTGTGGCGGGAGCTACAGGAGGCACCGCTGT
CACTTGCTGAGGGGTGGCAGCTTTTCCTCGTGGCACTGGCCCAGGGCGTGCTGGAGCACCACAC
CTATGGTGCCTTGCTCTTCCCACTGCTCTCCTTGGGCCTGTACCCTTGTTGGCTGCTCTTCTGG
AATGTGCTCTTCTGGAAGTGAGGTCTGCTACCTGGGCACAAAGGCTGGGGCAGGGCTCTCCAAG
CCCTCACCATTTTTCCTCCTCCCTGGGAAATAAACAAGTGTCTGTTTCAGCTGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_013212893	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000015326.2

RefSeq Acc Id:

XP_013212893 ⟸ XM_013357439

- UniProtKB:

I3MT81 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGLLSDPVRRRALARLVLRLNAPLCVLSYVAGIAWFLALAFPPLTQRTYMSENAMGSTMVEEQF
VGGDRARGFARDFAAHRRKSGALPVAWLQRTMRTVGLEVYTQSFSRKLPFPDETHERYMVSGTN
VYGILRAPRAASTESLVLTVPCNSDSTNSQAVGLLLALAAHFRGQIYWAKDIIFLVTEHDLLGT
EAWLEAYHDVNITGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVTVEGLNGQLPNLDLLNLFQ
TFCQKGGLLCTLQGKLQLQDWTTLDGPLQGLQTLLLMVLRQASGRPHGPHGLFLRYRVEALTLR
GINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFFYLLPALSRFVSIGLYMPAAGFLLLV
LGLKALELWMQLHEAGVGSEEAGGAPGPSTQFPPAQGVGLASLVAPLLISQAMGLALYILPVLG
QHVAAQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVMSTQASDRGWMALKLVALIYLALQLGC
ITLTNFSLGFLLAATMVPAAALTRPYGPRPLYAALLVLTSPAAMLLGSLFLWRELQEAPLSLAE
GWQLFLVALAQGVLEHHTYGALLFPLLSLGLYPCWLLFWNVLFWK

hide sequence

Ensembl Acc Id:

ENSSTOP00000015326 ⟸ ENSSTOT00000025632

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000026163	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000025632.2	UniProtKB/TrEMBL
Gene3D-CATH	Zn peptidases	UniProtKB/TrEMBL
InterPro	Gaa1	UniProtKB/TrEMBL
NCBI Gene	Gpaa1	ENTREZGENE
PANTHER	GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN	UniProtKB/TrEMBL
	PTHR13304	UniProtKB/TrEMBL
Pfam	Gaa1	UniProtKB/TrEMBL
PIRSF	GAA1	UniProtKB/TrEMBL
UniProt	I3MT81	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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