Hecw2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2) - Rat Genome Database

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Gene: Hecw2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2) Ictidomys tridecemlineatus
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Symbol: Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
RGD ID: 12537491
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein ubiquitination (inferred); regulation of dendrite morphogenesis (inferred); regulation of mitotic metaphase/anaphase transition (inferred); ASSOCIATED WITH Developmental Disease (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred); mitotic spindle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase HECW2; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, transcript variant X1; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303153,928,957 - 154,281,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365062,558,249 - 2,909,110 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365062,704,885 - 2,913,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hecw2SquirrelDevelopmental Disease  ISOHECW2 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
Hecw2Squirrelgenetic disease  ISOHECW2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:23545411 more ...
Hecw2Squirrelintellectual disability  ISOHECW2 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868 and PMID:28492532
Hecw2SquirrelMoebius syndrome  ISOHECW2 (Homo sapiens)8554872ClinVar Annotator: match by term: Oromandibular-limb hypogenesis spectrumClinVar 
Hecw2SquirrelNervous System Malformations  ISOHECW2 (Homo sapiens)8554872ClinVar Annotator: match by term: Abnormality of the nervous systemClinVarPMID:25741868
Hecw2SquirrelNEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, SEIZURES, AND ABSENT LANGUAGE  ISOHECW2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23545411 more ...
Hecw2SquirrelNeurodevelopmental Disorder with Progressive Microcephaly, Spasticity, and Brain Anomalies  ISOHECW2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorder with progressive microcephaly more ...ClinVarPMID:23545411 more ...
Hecw2SquirrelNeurodevelopmental Disorders  ISOHECW2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868
Hecw2Squirrelschizophrenia  ISOHECW2 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hecw2SquirrelNEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, SEIZURES, AND ABSENT LANGUAGE  ISOHECW2 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hecw2Squirrelprotein ubiquitination involved_inIEAUniPathway:UPA00143150520179 UniProtGO_REF:0000041
Hecw2Squirrelprotein ubiquitination involved_inIEAPANTHER:PTN001679372150520179 TreeGrafterGO_REF:0000118
Hecw2Squirrelregulation of dendrite morphogenesis involved_inIEAPANTHER:PTN001679372150520179 TreeGrafterGO_REF:0000118
Hecw2Squirrelregulation of mitotic metaphase/anaphase transition involved_inIEAUniProtKB:Q9P2P5 and ensembl:ENSP00000495418150520179 EnsemblGO_REF:0000107
Hecw2Squirrelubiquitin-dependent protein catabolic process involved_inIEAPANTHER:PTN001679372150520179 TreeGrafterGO_REF:0000118

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hecw2Squirrelcytoplasm located_inIEAPANTHER:PTN001679372150520179 TreeGrafterGO_REF:0000118
Hecw2Squirrelmitotic spindle located_inIEAUniProtKB:Q9P2P5 and ensembl:ENSP00000495418150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hecw2Squirrelprotein binding enablesISOUniProtKB:Q158849068941 PMID:28514442 more ...IntActPMID:28514442 more ...
Hecw2Squirrelprotein binding enablesISOUniProtKB:Q9UM119068941 PMID:24163370UniProtPMID:24163370
Hecw2Squirrelubiquitin protein ligase activity enablesIEAPANTHER:PTN001679372150520179 TreeGrafterGO_REF:0000118
Hecw2Squirrelubiquitin-protein transferase activity enablesIEAInterPro:IPR000569 and InterPro:IPR035983150520179 InterProGO_REF:0000002

PMID:22301074   PMID:30032202  



Hecw2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303153,928,957 - 154,281,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365062,558,249 - 2,909,110 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365062,704,885 - 2,913,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HECW2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382196,194,072 - 196,593,554 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2196,189,099 - 196,593,684 (-)EnsemblGRCh38hg38GRCh38
GRCh372197,058,796 - 197,458,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362196,772,222 - 197,165,580 (-)NCBINCBI36Build 36hg18NCBI36
Build 342196,889,482 - 197,282,841NCBI
Celera2190,819,831 - 191,213,211 (-)NCBICelera
Cytogenetic Map2q32.3NCBI
HuRef2188,916,792 - 189,310,064 (-)NCBIHuRef
CHM1_12197,069,845 - 197,463,246 (-)NCBICHM1_1
T2T-CHM13v2.02196,678,133 - 197,077,648 (-)NCBIT2T-CHM13v2.0
Hecw2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,846,031 - 54,234,193 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,846,035 - 54,234,327 (-)EnsemblGRCm39 Ensembl
GRCm38153,806,872 - 54,195,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,806,876 - 54,195,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv37153,863,718 - 54,251,878 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36153,757,767 - 53,985,072 (-)NCBIMGSCv36mm8
Celera154,347,232 - 54,580,782 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Hecw2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8962,853,904 - 63,247,472 (-)NCBIGRCr8
mRatBN7.2955,359,462 - 55,753,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl955,365,203 - 55,580,327 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx963,873,173 - 64,095,115 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0968,988,953 - 69,210,905 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0967,284,797 - 67,500,140 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0960,451,476 - 60,843,160 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl960,457,215 - 60,672,246 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0960,137,069 - 60,526,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4952,623,951 - 52,839,918 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera952,860,020 - 53,074,467 (-)NCBICelera
Cytogenetic Map9q31NCBI
Hecw2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554033,752,461 - 4,090,041 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554033,902,881 - 4,096,189 (+)NCBIChiLan1.0ChiLan1.0
HECW2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21398,821,302 - 99,214,271 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B98,836,292 - 99,228,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B83,445,401 - 83,838,065 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B201,346,145 - 201,736,143 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B201,351,023 - 201,584,044 (-)Ensemblpanpan1.1panPan2
HECW2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1375,850,518 - 6,213,353 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl375,856,513 - 6,213,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha376,799,246 - 7,162,228 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0375,738,571 - 6,103,245 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl375,743,029 - 6,060,033 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1375,739,218 - 6,102,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0375,705,967 - 6,070,337 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0375,728,026 - 6,091,688 (-)NCBIUU_Cfam_GSD_1.0
HECW2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15100,092,882 - 100,498,157 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115100,086,724 - 100,499,566 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215111,160,775 - 111,337,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HECW2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11081,739,680 - 82,127,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1081,743,021 - 81,974,689 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040117,327,029 - 117,706,765 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hecw2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624854618,262 - 824,178 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624854475,098 - 831,202 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSSTOT00000015213   ⟹   ENSSTOP00000013632
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365062,558,249 - 2,907,061 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000035313   ⟹   ENSSTOP00000027228
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365062,704,995 - 2,909,110 (+)Ensembl
RefSeq Acc Id: XM_013358202   ⟹   XP_013213656
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303153,928,957 - 154,279,735 (-)NCBI
SpeTri2.0NW_0049365062,704,885 - 2,913,663 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725750   ⟹   XP_021581425
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303153,928,957 - 154,076,230 (-)NCBI
SpeTri2.0NW_0049365062,761,551 - 2,913,663 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040294631   ⟹   XP_040150565
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303153,928,957 - 154,281,017 (-)NCBI
RefSeq Acc Id: XM_040294632   ⟹   XP_040150566
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303153,928,957 - 154,281,017 (-)NCBI
Protein RefSeqs XP_013213656 (Get FASTA)   NCBI Sequence Viewer  
  XP_021581425 (Get FASTA)   NCBI Sequence Viewer  
  XP_040150565 (Get FASTA)   NCBI Sequence Viewer  
  XP_040150566 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000013632.3
  ENSSTOP00000027228.1
GenBank Protein KAG3274907 (Get FASTA)   NCBI Sequence Viewer  
  KAG3274908 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_013213656   ⟸   XM_013358202
- Peptide Label: isoform X1
- UniProtKB: I3MPD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581425   ⟸   XM_021725750
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040150566   ⟸   XM_040294632
- Peptide Label: isoform X1
- UniProtKB: I3MPD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040150565   ⟸   XM_040294631
- Peptide Label: isoform X1
- UniProtKB: I3MPD0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000013632   ⟸   ENSSTOT00000015213
C2   HECT   WW



1 to 38 of 38 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000015188 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000015213.3 UniProtKB/TrEMBL
  ENSSTOT00000035313.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  2.60.40.2840 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2_HECW UniProtKB/TrEMBL
  E3_ubiq-protein_ligase UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  HECW1_helix UniProtKB/TrEMBL
  HECW_N UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene Hecw2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HECW2 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  HECW1_helix UniProtKB/TrEMBL
  HECW_N UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt I3MPD0 ENTREZGENE, UniProtKB/TrEMBL
1 to 38 of 38 rows