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Gene: Fbxo27 (F-box protein 27) Ictidomys tridecemlineatus

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Symbol:

Fbxo27

Name:

F-box protein 27

RGD ID:

12522922

Description:

ENCODES a protein that exhibits ubiquitin protein ligase activity (inferred); INVOLVED IN ERAD pathway (inferred); glycoprotein catabolic process (inferred); SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH maturity-onset diabetes of the young type 1 (ortholog); type 2 diabetes mellitus (ortholog); FOUND IN cytoplasm (inferred); SCF ubiquitin ligase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

F-box only protein 27

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FBXO27 (F-box protein 27)	NCBI	Ortholog
Mus musculus (house mouse):	Fbxo27 (F-box protein 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Fbxo27 (F-box protein 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fbxo27 (F-box protein 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FBXO27 (F-box protein 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FBXO27 (F-box protein 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FBXO27 (F-box protein 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fbxo27 (F-box protein 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	13,502,958 - 13,508,785 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	1,931,025 - 1,936,526 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	1,931,036 - 1,936,548 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

maturity-onset diabetes of the young type 1 (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ERAD pathway (IEA)

glycoprotein catabolic process (IEA)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

cytoplasm (IEA)

SCF ubiquitin ligase complex (IEA)

Molecular Function

protein binding (ISO)

ubiquitin protein ligase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Fbxo27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	13,502,958 - 13,508,785 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	1,931,025 - 1,936,526 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	1,931,036 - 1,936,548 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXO27
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	39,005,842 - 39,032,549 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	38,990,714 - 39,032,785 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	39,514,661 - 39,523,189 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	44,206,501 - 44,215,038 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	44,206,503 - 44,215,038	NCBI
Celera	19	36,317,092 - 36,325,633 (-)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	35,961,841 - 35,970,384 (-)	NCBI		HuRef
CHM1_1	19	39,515,013 - 39,523,556 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	41,809,624 - 41,837,135 (-)	NCBI		T2T-CHM13v2.0

Fbxo27
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	28,392,205 - 28,398,763 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	28,392,274 - 28,398,763 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	28,692,780 - 28,699,338 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	28,692,849 - 28,699,338 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	29,477,868 - 29,484,357 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	28,401,609 - 28,408,094 (+)	NCBI		MGSCv36	mm8
Celera	7	23,258,883 - 23,265,372 (+)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	16.89	NCBI

Fbxo27
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	93,092,900 - 93,115,312 (+)	NCBI		GRCr8
mRatBN7.2	1	83,965,426 - 83,987,781 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	83,965,986 - 83,987,778 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	89,390,766 - 89,397,653 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	97,849,822 - 97,856,709 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	91,146,629 - 91,153,516 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	86,872,808 - 86,878,709 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	88,054,843 - 88,060,744 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	83,800,440 - 83,806,448 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	78,373,424 - 78,380,351 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Fbxo27
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	518,769 - 525,051 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	520,321 - 525,051 (+)	NCBI	ChiLan1.0	ChiLan1.0

FBXO27
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	45,302,951 - 45,330,192 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	47,173,467 - 47,200,577 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	36,113,773 - 36,133,009 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	44,674,775 - 44,681,873 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	44,675,354 - 44,681,541 (-)	Ensembl	panpan1.1		panPan2

FBXO27
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	114,120,617 - 114,145,295 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	114,120,638 - 114,127,100 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	113,522,347 - 113,546,953 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	114,720,423 - 114,745,019 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	114,720,378 - 114,726,839 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	114,278,360 - 114,285,254 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	113,911,520 - 113,936,119 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	114,906,958 - 114,931,588 (+)	NCBI		UU_Cfam_GSD_1.0

FBXO27
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	33,611,205 - 33,630,008 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	33,621,386 - 33,629,223 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	11,625,890 - 11,653,587 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbxo27
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624794	12,370,117 - 12,375,180 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005336404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040279543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000021997 ⟹ ENSSTOP00000019400

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936661	1,931,025 - 1,936,526 (-)	Ensembl

RefSeq Acc Id:

XM_005336404 ⟹ XP_005336461

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,502,958 - 13,508,785 (-)	NCBI
SpeTri2.0	NW_004936661	1,931,036 - 1,936,548 (-)	NCBI

Sequence:

show sequence

CCTGACCCTTTCTCGCCCGCAGCCGCCGCTGGCTCCGGCCGGGGGACCATGGGCGCCTCCGCCT
CCAGGGGCCAGGCCACCCGGGTCCCCGAGCCGAAGCTGGACCCGGAGGAGGCGCTGGACCTGAG
CCAACTGCCACCCGAGCTGCTCCTGGTGGTGCTGAGCCACGTGCCCCCACGCACGCTCCTCACC
CGCTGCCGCCGGGTGTGCCGCGAGTGGCGCGCCCTGGTGGACGGCCAGGCCCTGTGGCTCCTGA
TCCTGGCCCGGGACCATGGCGCCGCTGGCCGCGCCCTGATGTCGTTCGTCCGCAACTGCCTGCC
CCCCGCTTGCGACGCCAGGCCTTGTCCTCTGGGCCGCTTCTGCGTGCGCAGACCGTTGGGACGC
AACCTCATCTGCAACCCCTGCGGCCAGGAAGGCCTCCGGAAATGGATGGTGCAGCACGGTGGAG
ATGGCTGGGTGGTGGAAGAAAACAGGAGAACTGTGCCGGGGGCCCCTTCACAAACCTGTTTCGT
AACTTCCTTCCGTTGGTGCCGCAAGAAGCAGGTCTTGGACCTGGAGGAGGAGGGTCTGTGGCCA
GAACTGCTGGACAGTGGCAGGATTGAGATCTGTGTCTCTGACTGGTGGGGAGCCAGACACGACT
GTGGCTGTAAGTATCGACTCCTTGTCCAACTTCTAGACGCTGACCAGACCATTCTAGATACCTT
CTCTGCTGTGCCTGACCCCATCGAGCAGTGGAACAACAATATCTGTTTTCAGGTCACCCATGTG
TTCTCCAACATCAAGACAGGCGTCCGTTTCGTGTCTTTTGAACACTGGGGGCAGGACACGCAGT
TCTGGGCTGGCCACTATGGAGCCCGTGTGACCAACTCCAGCGTGATCCTACGAGTCTCTCAGTC
CTAGACCAGGGACGCCTTTCTTGTGAGAGAGCCTGACCATGCCGTCTAGGCGCCGGGACGTTTG
GCTGGGACCCCTCGTTAACCAAGTGCTTCTACCTCCCCGGCACTCCGAGAACTTCAGGGTGCAG
CCAGGGTCCTTCTGGGCCCTGCATTCAGGTTCTGGAAACCACTGGAAGCCTGGTCTTCCATCAG
GTCTGCCTACGGCTGCTGCTTTGGGTGGACACAGCACTGCGCAATGGAGACCCACAGGCGGCAC
CTGAGGAGGCCTGCTCACCCCTCTTCCCCCCACCAGCAGTTCAGCACAGCCCCCTCTGCCCTGT
CCCCTCTCCTTTCTGCTTCAGGGACTTAGCTGTCCTTTCAGGGAAGCCCTGCACTGGACTCTGA
ACGCTTTCTAGCCAGATTGCAGCCGCCTTGGGTGGTGACCTTGACCTTCGGGGCCTTCTGAGCT
GCAGGGCTGGACCCAGGCCTTGAAGCTAAAGGTCACCTTGGTTCAGACAGGATTTGGAGATAGA
TCTGCCCACACGGGCTTCCCTGGGAAATGAGGAGGTACCTCAAGCCCAGCCCTGATCCTCAAGG
ACCTCTGTAATTGTGTGATATTTAAAATGATTTTATTTTTCATTTTGACATTTTGTTTTCCGAA
CAGCAAGAGAGTAATCTGTCAGCTATGATATATAATGTATCTAGAATGCATCTGGTGATCATAT
ATAATAAATTTATTATTTTG

hide sequence

RefSeq Acc Id:

XM_040279543 ⟹ XP_040135477

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,502,958 - 13,508,500 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005336461	(Get FASTA)	NCBI Sequence Viewer
	XP_040135477	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019400.1
GenBank Protein	KAG3256006	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005336461 ⟸ XM_005336404
- Peptide Label:	isoform X2
- UniProtKB:	I3N4V4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGASASRGQATRVPEPKLDPEEALDLSQLPPELLLVVLSHVPPRTLLTRCRRVCREWRALVDGQ ALWLLILARDHGAAGRALMSFVRNCLPPACDARPCPLGRFCVRRPLGRNLICNPCGQEGLRKWM VQHGGDGWVVEENRRTVPGAPSQTCFVTSFRWCRKKQVLDLEEEGLWPELLDSGRIEICVSDWW GARHDCGCKYRLLVQLLDADQTILDTFSAVPDPIEQWNNNICFQVTHVFSNIKTGVRFVSFEHW GQDTQFWAGHYGARVTNSSVILRVSQS hide sequence

RefSeq Acc Id:	XP_040135477 ⟸ XM_040279543
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSSTOP00000019400 ⟸ ENSSTOT00000021997

Protein Domains

F-box FBA

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027765	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000021997.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1280.50	UniProtKB/TrEMBL
	Galactose-binding domain-like	UniProtKB/TrEMBL
InterPro	F-box-assoc_dom	UniProtKB/TrEMBL
	F-box-like_dom_sf	UniProtKB/TrEMBL
	F-box_dom	UniProtKB/TrEMBL
	F-box_only	UniProtKB/TrEMBL
	Galactose-bd-like_sf	UniProtKB/TrEMBL
NCBI Gene	Fbxo27	ENTREZGENE
PANTHER	F-BOX ONLY PROTEIN 27	UniProtKB/TrEMBL
	PTHR12125	UniProtKB/TrEMBL
Pfam	F-box	UniProtKB/TrEMBL
	FBA	UniProtKB/TrEMBL
PROSITE	FBA	UniProtKB/TrEMBL
	FBOX	UniProtKB/TrEMBL
SMART	FBA	UniProtKB/TrEMBL
	FBOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49785	UniProtKB/TrEMBL
	SSF81383	UniProtKB/TrEMBL
UniProt	I3N4V4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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