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Gene: Crebl2 (cAMP responsive element binding protein like 2) Ictidomys tridecemlineatus

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Symbol:

Crebl2

Name:

cAMP responsive element binding protein like 2

RGD ID:

12516150

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of D-glucose import (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulation of fat cell differentiation (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 6 (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cAMP-responsive element-binding protein-like 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	94,915,874 - 94,936,293 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936587	4,643,123 - 4,663,964 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936587	4,645,507 - 4,663,920 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Crebl2	Squirrel	autosomal dominant intellectual developmental disorder 6		ISO	CREBL2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability and autosomal dominant 6	ClinVar	PMID:28492532

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Crebl2	Squirrel	positive regulation of D-glucose import	involved_in	ISO	Crebl2 (Mus musculus)	9068941	PMID:21728997	UniProt	PMID:21728997
Crebl2	Squirrel	positive regulation of DNA-templated transcription	involved_in	ISO	Crebl2 (Mus musculus)	9068941	PMID:21728997	UniProt	PMID:21728997
Crebl2	Squirrel	positive regulation of fat cell differentiation	involved_in	ISO	Crebl2 (Mus musculus)	9068941	PMID:21728997	UniProt	PMID:21728997
Crebl2	Squirrel	positive regulation of lipid biosynthetic process	involved_in	ISO	Crebl2 (Mus musculus)	9068941	PMID:21728997	UniProt	PMID:21728997
Crebl2	Squirrel	positive regulation of peptidyl-serine phosphorylation	involved_in	ISO	Crebl2 (Mus musculus)	9068941	PMID:21728997	UniProt	PMID:21728997
Crebl2	Squirrel	protein stabilization	involved_in	ISO	Crebl2 (Mus musculus)	9068941	PMID:21728997	UniProt	PMID:21728997
Crebl2	Squirrel	regulation of DNA-templated transcription	involved_in	IEA	PANTHER:PTN000471698	150520179		TreeGrafter	GO_REF:0000118
Crebl2	Squirrel	regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR004827 and InterPro:IPR046347	150520179		InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Crebl2	Squirrel	nucleus	located_in	IEA	PANTHER:PTN000471698	150520179		TreeGrafter	GO_REF:0000118
Crebl2	Squirrel	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044
Crebl2	Squirrel	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	150520179		UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Crebl2	Squirrel	DNA binding	enables	IEA	UniProtKB-KW:KW-0238	150520179		UniProt	GO_REF:0000043
Crebl2	Squirrel	DNA-binding transcription factor activity	enables	IEA	InterPro:IPR004827 and InterPro:IPR046347	150520179		InterPro	GO_REF:0000002
Crebl2	Squirrel	protein binding	enables	ISO	UniProtKB:Q01147	9068941	PMID:21728997	IntAct	PMID:21728997
Crebl2	Squirrel	protein binding	enables	ISO	UniProtKB:P35638 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
Crebl2	Squirrel	protein binding	enables	ISO	UniProtKB:Q16236	9068941	PMID:32911434	IntAct	PMID:32911434

PMID:22301074	PMID:30032202

Crebl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	94,915,874 - 94,936,293 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936587	4,643,123 - 4,663,964 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936587	4,645,507 - 4,663,920 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CREBL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	12,611,876 - 12,645,108 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	12,611,827 - 12,645,108 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	12,764,810 - 12,798,042 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	12,656,098 - 12,689,308 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	12,656,097 - 12,689,308	NCBI
Celera	12	17,908,970 - 17,942,189 (+)	NCBI		Celera
Cytogenetic Map	12	p13.1	NCBI
HuRef	12	12,529,511 - 12,563,345 (+)	NCBI		HuRef
CHM1_1	12	12,729,857 - 12,763,067 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	12,481,031 - 12,514,259 (+)	NCBI		T2T-CHM13v2.0

Crebl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	134,807,090 - 134,835,894 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	134,807,117 - 134,835,894 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	134,830,127 - 134,880,580 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	134,830,154 - 134,858,931 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	134,780,217 - 134,807,901 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	134,795,892 - 134,823,576 (+)	NCBI		MGSCv36	mm8
Celera	6	137,786,985 - 137,814,582 (+)	NCBI		Celera
Cytogenetic Map	6	G1	NCBI
cM Map	6	65.77	NCBI

Crebl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	169,404,630 - 169,430,618 (+)	NCBI		GRCr8
mRatBN7.2	4	167,673,359 - 167,699,299 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	167,673,315 - 167,699,292 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	173,966,821 - 173,992,692 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	169,749,912 - 169,775,777 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	168,373,843 - 168,399,670 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	168,599,387 - 168,625,239 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	168,599,331 - 168,619,764 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	232,874,601 - 232,900,502 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	171,744,836 - 171,771,198 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	171,989,771 - 172,016,132 (+)	NCBI
Celera	4	156,270,048 - 156,295,864 (+)	NCBI		Celera
Cytogenetic Map	4	q43	NCBI

Crebl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	9,513,625 - 9,535,817 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	9,513,625 - 9,535,817 (+)	NCBI	ChiLan1.0	ChiLan1.0

CREBL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	18,076,295 - 18,109,159 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	18,073,054 - 18,105,918 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	12,632,763 - 12,665,646 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	13,010,802 - 13,043,708 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

CREBL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	33,684,376 - 33,711,625 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	33,687,491 - 33,711,512 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	12,733,992 - 12,761,343 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	33,991,666 - 34,018,945 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	33,991,679 - 34,018,669 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	33,884,586 - 33,911,795 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	33,833,953 - 33,861,265 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	12,468,125 - 12,495,502 (+)	NCBI		UU_Cfam_GSD_1.0

CREBL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	59,805,600 - 59,831,183 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	59,804,348 - 59,831,197 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CREBL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	12,510,529 - 12,541,026 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	12,510,540 - 12,537,901 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	22,778,192 - 22,808,330 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crebl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624752	25,280,957 - 25,301,562 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005331908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000032520 ⟹ ENSSTOP00000027536

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936587	4,643,123 - 4,663,964 (-)	Ensembl

RefSeq Acc Id:

XM_005331908 ⟹ XP_005331965

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	94,915,874 - 94,936,293 (-)	NCBI
SpeTri2.0	NW_004936587	4,645,507 - 4,663,920 (-)	NCBI

Sequence:

show sequence

GCCCACTTTCAGGACTCGGCGGCTCTCCAGGGCCTCTGTAAACACACTCAGAGACTGTCATGGAGGGGGAGGAGGAGGCGGCGGCAGTGAAAGGAGGCGTTTTGGGCCGCCTCCAAGGTCCGCTCTGC
CATTCCTGAACTAGTCCCTGGTCCCCGTGACTGGCATCAGGGAAGTGAACTGTTAGGCGAGAGAAGGAGACAGTCAGAACCATATCTCCTTCTTCCCCGGGGCGGGGGCCGGGCCGGGCCGGGCCGGC
TGAGCCAGGGGAGGGCCGGGGGAGGGAGTGCCTGGCCGGGCCGGCCTGTCTGCCGAAATGGATGACAGTAAGGTGGTTGGAGGCAAAGTAAAGAAGCCTGGTAAACGTGGCCGGAAGCCAGCCAAAAT
TGACTTGAAGGCAAAACTTGAGAGGAGCCGGCAGAGTGCAAGAGAATGCCGGGCCAGAAAAAAGCTGAGATACCAGTATTTGGAAGAGTTAGTATCCAGTCGAGAAAGAGCTATATGTGCCCTCCGAG
AGGAACTGGAAATGTACAAGCAGTGGTGCATGGCAATGGACCAAGGAAAAATCCCTTCTGAAATAAAGGCCCTACTCACTGGAGAAGAGCAGAACAAATCTCAGCAGAATTCAAGCAGACACACCAAA
GCTGGGAAGACAGATGCTAATAGCAATTCCTGGTGAAGATGATATAAAATGATGAATCAGTGATTGAAGCCAATATTCTAATTTCCATGGAGGAAGAATAGGCAAGATTTTGCTTCTTGGCTCCACTT
ACTACCTACTGCTCAGTAGTCATCTCTGTAAATCTGCAGTTTCTACCAAAATGTGGGATTACAGATCTCAGATGATCTTGCTTTAACTTTTAATACTTAGAAATTTTTCAAACATTCAGATCTGTTCT
GTACTACTACCCATGACATTTAACATGTTAGGATGCTTGAAAACACAAGAGTAGAGAAAAGTGGTTGAAGATTGTATTTTTGCACCTTAACTCCACATTGCTTTATTGGTTAATTTATATTCATGTAA
TTCACATAATTGTATGTGTATGTGTGTTTAGGTGTCACCTCCTTTCATGTTTCTGATTGCCCTTCAAAGAGAAACCAAATGGGCTGATTGCTAACTGTAAGTTCTCAGCCTTTATGGACCTAATATTA
TTTCTTTTTATTTACTTGAGTAATGTTTATTTTCTGCATGAACCATGATTTCTCCTGTGAGCCATTCCAGCATAAGCTGTGAATATGTATTAACAAATATATACATTTCTATTTTTATAATCCATAGA
TATGCCTGTTTTAAATAATGTATATGTTTAAAAAATACATCAAGAAAAGCCTTAAGACAGCCTCTATTTAAAACTTTTGTTGCTGTCTTATCCAAATGTATTTATAAAAGTTTGGTAGGTCCACACTT
TGATAATAGTCAAATTTTACTTTTAAGCAGAAGTAACCTTTTAGGCATTTCAGCAGCATACATTATCTTGACAACCTAGAGTATGTATGTATATGTATATGTTTCTATTTTATGTTTATATATGTATG
TGGGGAGGACAGGAGTGAATGTTCACACATTTTCTTGTGTACTCAACTAAATCAGAGAATTTTTCTGGAGAAAATAGGATGAGGGCTGGGATGTAGCTCAGTGGTAGAATGCTTGTCTTAGCATGCAT
GAGGCCCTGGGTTCAGTCCCCAGCACTGGAAAAAAAAAAAAAAAAAAGATGAAGAAATTAGCTGCTGAGATTGAGTTTCTGCCTTGAGATCTGGAAAAAAA

hide sequence


Protein RefSeqs	XP_005331965	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000027536.1
GenBank Protein	KAG3292370	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005331965 ⟸ XM_005331908
- UniProtKB:	A0A287D1S2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW hide sequence

Ensembl Acc Id:

ENSSTOP00000027536 ⟸ ENSSTOT00000032520

Protein Domains

bZIP

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000032150	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000032520.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
InterPro	bZIP	UniProtKB/TrEMBL
	bZIP_sf	UniProtKB/TrEMBL
	CREBL2/REPTOR-BP	UniProtKB/TrEMBL
NCBI Gene	Crebl2	ENTREZGENE
PANTHER	CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2	UniProtKB/TrEMBL
	PTHR21051	UniProtKB/TrEMBL
Pfam	bZIP_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57959	UniProtKB/TrEMBL
UniProt	A0A287D1S2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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