Letmd1 (LETM1 domain containing 1) - Rat Genome Database

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Gene: Letmd1 (LETM1 domain containing 1) Ictidomys tridecemlineatus
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Symbol: Letmd1
Name: LETM1 domain containing 1
RGD ID: 12493401
Description: ENCODES a protein that exhibits molecular adaptor activity (inferred); ribosome binding (inferred); INVOLVED IN intracellular monoatomic cation homeostasis (inferred); mitochondrion organization (inferred); positive regulation of cold-induced thermogenesis (inferred); ASSOCIATED WITH breast cancer (ortholog); ovarian carcinoma (ortholog); renal carcinoma (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LETM1 domain containing 1, transcript variant X1; LETM1 domain containing 1, transcript variant X2; LETM1 domain containing 1, transcript variant X3; LETM1 domain containing 1, transcript variant X4; LETM1 domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,468,798 - 64,480,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,684,587 - 8,694,074 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365128,684,597 - 8,694,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Letmd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,468,798 - 64,480,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,684,587 - 8,694,074 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365128,684,597 - 8,694,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LETMD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,048,220 - 51,068,958 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,047,962 - 51,060,424 (+)EnsemblGRCh38hg38GRCh38
GRCh371251,442,003 - 51,462,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361249,728,351 - 49,740,474 (+)NCBINCBI36Build 36hg18NCBI36
Build 341249,728,398 - 49,740,468NCBI
Celera1250,244,071 - 50,256,194 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1248,474,666 - 48,486,493 (+)NCBIHuRef
CHM1_11251,408,361 - 51,420,485 (+)NCBICHM1_1
T2T-CHM13v2.01251,011,103 - 51,031,877 (+)NCBIT2T-CHM13v2.0
Letmd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,360,302 - 100,377,133 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,366,904 - 100,377,045 (+)EnsemblGRCm39 Ensembl
GRCm3815100,462,421 - 100,479,252 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,469,023 - 100,479,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715100,299,465 - 100,309,683 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,297,128 - 100,307,198 (+)NCBIMGSCv36mm8
Celera15102,621,292 - 102,631,510 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.31NCBI
Letmd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,461,920 - 133,476,592 (+)NCBIGRCr8
mRatBN7.27131,584,241 - 131,597,797 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,584,259 - 131,597,796 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,386,530 - 133,396,013 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,612,107 - 135,621,590 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,525,758 - 135,535,244 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,106,364 - 142,119,900 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,106,465 - 142,119,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,913,885 - 139,927,371 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,172,373 - 139,181,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7128,061,659 - 128,071,143 (+)NCBICelera
Cytogenetic Map7q36NCBI
Letmd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555471,574,265 - 1,582,786 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555471,574,210 - 1,586,432 (+)NCBIChiLan1.0ChiLan1.0
LETMD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21043,125,558 - 43,138,023 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11243,122,320 - 43,134,785 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,685,741 - 37,705,104 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,587,366 - 38,609,810 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,597,728 - 38,609,810 (-)Ensemblpanpan1.1panPan2
LETMD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,761,880 - 3,770,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,761,203 - 3,770,103 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,486,087 - 42,494,364 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,809,305 - 3,817,581 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,809,309 - 3,817,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,776,041 - 3,784,312 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,763,396 - 3,771,684 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02742,882,837 - 42,891,111 (+)NCBIUU_Cfam_GSD_1.0
LETMD1
(Sus scrofa - pig)
No map positions available.
LETMD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,258,097 - 47,270,474 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,258,084 - 47,270,756 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037198,830,226 - 198,842,605 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Letmd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248161,158,662 - 1,170,988 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248161,148,634 - 1,170,981 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000009101   ⟹   ENSSTOP00000008160
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365128,684,587 - 8,694,074 (+)Ensembl
RefSeq Acc Id: XM_021726160   ⟹   XP_021581835
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494564,470,742 - 64,480,237 (-)NCBI
SpeTri2.0NW_0049365128,684,903 - 8,694,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021726162   ⟹   XP_021581837
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494564,470,742 - 64,480,237 (-)NCBI
SpeTri2.0NW_0049365128,684,598 - 8,694,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021726164   ⟹   XP_021581839
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494564,470,742 - 64,480,237 (-)NCBI
SpeTri2.0NW_0049365128,684,901 - 8,694,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040280634   ⟹   XP_040136568
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494564,470,742 - 64,480,237 (-)NCBI
RefSeq Acc Id: XR_005731826
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494564,468,798 - 64,480,237 (-)NCBI
RefSeq Acc Id: XP_021581837   ⟸   XM_021726162
- Peptide Label: isoform X1
- UniProtKB: I3MCX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581839   ⟸   XM_021726164
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021581835   ⟸   XM_021726160
- Peptide Label: isoform X1
- UniProtKB: I3MCX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040136568   ⟸   XM_040280634
- Peptide Label: isoform X2
- UniProtKB: I3MCX9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000008160   ⟸   ENSSTOT00000009101
Protein Domains
Letm1 RBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009107 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009101.3 UniProtKB/TrEMBL
InterPro LETM1/MDM38-like UniProtKB/TrEMBL
  LETM1_RBD UniProtKB/TrEMBL
NCBI Gene Letmd1 ENTREZGENE
PANTHER LETM1 DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PTHR14009 UniProtKB/TrEMBL
Pfam LETM1 UniProtKB/TrEMBL
PROSITE LETM1_RBD UniProtKB/TrEMBL
UniProt I3MCX9 ENTREZGENE, UniProtKB/TrEMBL