RGD Reference Report - Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status.

General

Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status.
Authors:	Ha, SA Lee, YS Shin, SM Kim, HK Kim, S Namkoong, H Kim, HJ Jung, SM
Citation:	Ha SA, etal., BMC Cancer. 2009 Feb 11;9:51.
RGD ID:	2314917
Pubmed:	PMID:19208263 (View Abstract at PubMed)
PMCID:	PMC2672955 (View Article at PubMed Central)
BACKGROUND: Oncoprotein HCCR-1 functions as a negative regulator of the p53 and contributes breast tumorigenesis. The serum HCCR-1 assay is useful in diagnosing breast cancer and mice transgenic for HCCR developed breast cancers. But it is unknown how HCCR-1 contributes to human breast tumorigenesis. METHODS: Oncogene HCCR-1 expression levels were determined in normal breast tissues, breast cancer tissues and cancer cell lines. We examined whether HCCR-1 protein expression in breast cancer is related to different biological characteristics, including ER, PR, p53 genotype, and HER2 status in 104 primary breast cancer tissues using immunohistochemical analyses. RESULTS: HCCR-1 was upregulated in breast cancer cells and tissues compared with normal breast tissues. In this study, overexpression of HCCR-1 was well correlated with known breast cancer prognostic markers including the presence of steroid receptors (ER and PR), p53 mutation and high HER2 overexpression. HCCR-1 was not detected in the ER-negative, PR-negative, p53 negative and low HER2 breast cancer tissues. These data indicate that the level of HCCR-1 in breast cancer tissues is relatively well correlated with known breast cancer factors, including the HER2 overexpression, p53 mutation, and ER/PR status. CONCLUSION: Determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
breast cancer		IEP		2314917	protein:increased expression:breast	RGD
breast cancer		ISO	LETMD1 (Homo sapiens)	2314917; 2314917	protein:increased expression:breast	RGD

Objects Annotated

Genes (Rattus norvegicus)

Letmd1 (LETM1 domain containing 1)

Genes (Mus musculus)

Letmd1 (LETM1 domain containing 1)

Genes (Homo sapiens)

LETMD1 (LETM1 domain containing 1)

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Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status.