Cpxm1 (carboxypeptidase X, M14 family member 1)

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Gene: Cpxm1 (carboxypeptidase X, M14 family member 1) Ictidomys tridecemlineatus

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Symbol:

Cpxm1

Name:

carboxypeptidase X, M14 family member 1

RGD ID:

12484181

Description:

ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN proteolysis (ortholog); ASSOCIATED WITH Huntington's disease-like 1 (ortholog); pantothenate kinase-associated neurodegeneration (ortholog); FOUND IN extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

probable carboxypeptidase X1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	167,498,509 - 167,505,280 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,929,799 - 15,936,648 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	15,929,888 - 15,936,647 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Huntington's disease-like 1 (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA,ISO)

Cellular Component

extracellular space (IEA)

Molecular Function

carboxypeptidase activity (ISO)

metallocarboxypeptidase activity (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Cpxm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	167,498,509 - 167,505,280 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,929,799 - 15,936,648 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	15,929,888 - 15,936,647 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CPXM1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	2,794,074 - 2,800,627 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	2,794,074 - 2,800,627 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	2,774,720 - 2,781,273 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	2,722,715 - 2,729,282 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	2,722,714 - 2,729,266	NCBI
Celera	20	2,839,233 - 2,845,810 (-)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	2,724,251 - 2,730,828 (-)	NCBI		HuRef
CHM1_1	20	2,774,764 - 2,781,341 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	2,824,548 - 2,831,102 (-)	NCBI		T2T-CHM13v2.0

Cpxm1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	130,232,695 - 130,239,549 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	130,232,695 - 130,239,494 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	130,390,775 - 130,397,629 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	130,390,775 - 130,397,574 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	130,216,511 - 130,223,365 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	130,082,216 - 130,089,015 (-)	NCBI		MGSCv36	mm8
Celera	2	131,615,457 - 131,622,311 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.22	NCBI

Cpxm1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	138,041,645 - 138,048,443 (-)	NCBI		GRCr8
mRatBN7.2	3	117,588,532 - 117,595,330 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,588,532 - 117,595,330 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	121,486,474 - 121,493,272 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,081,972 - 130,088,770 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	127,742,598 - 127,749,396 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	122,913,886 - 122,920,684 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	122,913,886 - 122,920,684 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	129,414,247 - 129,421,045 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,000,980 - 118,007,777 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	117,906,682 - 117,913,606 (-)	NCBI
Celera	3	116,402,737 - 116,409,535 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Cpxm1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	13,756,889 - 13,763,120 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	13,756,752 - 13,763,764 (-)	NCBI	ChiLan1.0	ChiLan1.0

CPXM1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	3,768,999 - 3,775,576 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	3,765,824 - 3,772,378 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	2,888,062 - 2,894,614 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	2,651,390 - 2,657,821 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	2,651,390 - 2,661,001 (-)	Ensembl	panpan1.1		panPan2

CPXM1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	18,453,874 - 18,460,350 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	18,453,712 - 18,461,738 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	18,275,230 - 18,289,912 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	18,866,383 - 18,881,069 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	18,874,609 - 18,881,077 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	18,459,571 - 18,474,246 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	18,570,347 - 18,585,030 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	18,899,134 - 18,913,816 (+)	NCBI		UU_Cfam_GSD_1.0

CPXM1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	32,845,232 - 32,852,062 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	32,845,154 - 32,852,065 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	37,216,074 - 37,222,963 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CPXM1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	53,747,355 - 53,753,899 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	53,747,441 - 53,754,750 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666087	162,104 - 169,145 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cpxm1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	3,930,547 - 3,936,572 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	3,930,417 - 3,936,649 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005320543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000016356 ⟹ ENSSTOP00000014645

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936485	15,929,799 - 15,936,648 (+)	Ensembl

RefSeq Acc Id:

XM_005320543 ⟹ XP_005320600

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	167,498,509 - 167,505,280 (+)	NCBI
SpeTri2.0	NW_004936485	15,929,888 - 15,936,647 (+)	NCBI

Sequence:

show sequence

CCACCGACCGCTCGCAGTCCGGAGCACCAGAGTTCTGCGCCCGACATGTGGGGTCTCTTGCTGG
CCTTGGCGGCCTTAGCGCCTTCTGTCGGCCTGGGTCTGGGGGCGCCCAGCGCCTCCGTGCTGGG
CCTAATACCGTCGGCGACCACCGAGGCCACCGGCTCGACCCCGGCTCCGCGTAGCGGTCCTGCA
CAGCCGTCCGGGAAGGCTAATGCGACTTCAGAACAACAGATTCGGATTCGAGTCATCAAAAAGA
AAAAGGTCATTGTGAAGAAGCGAAAGAAATTAATTCGCCCCAGTCCTCCAGTGACTGCCAAGCC
CATGGTGACCACCAGCCCAACAAGGTCTCCTAATCGCCCTGAGAAACAAGAACCAGGCTGTCCC
CCTTTGGGCCTGGAGTCCCTGCGAGTTTCAGATAGCCAGTTTGAGGCATCCAGCAGCCAGTCCT
TTGGTCTTGGACCACATCGAGGTCGGCTCAACATCCAGTCAGGCCTGGAGGATGGCGATCTATA
CGATGGGGCCTGGTGTGCTGAGCAGCAGGACACTGAGCCGTGGTTTCAAGTGGATGCTAGGAAC
CCCATCCGCTTCTCAGGCATTGTCACACAGGGCAGGAACTCTATCTGGAGGTATGACTGGGTTA
CATCATACAAGGTCCAGTTCAGCAATGACAGTCGGACCTGGTGGACAAGTCGGAATCACAGCAG
TGGGATGGATGCGGTATTTCCTGCCAATTCGGACCCAGAAACCCCAGTGCTGAACCTCCTGCCA
GAGCCTCAGGTGGCCCGTTTCATTCGTCTGCTGCCCCAGACCTGGTTCCAGGAAGGTGCACCTT
GTCTCCGGGCAGAGATCCTGGCCTGCCCTGTCTCAGATCCTAATGACCTACCCCCAGAGGCCCA
TTCACTGGGATCTTCTGACCCTCTGGACTTTCGGCATCACAATTATAAGGCCATGAGGAAGCTG
ATGAAGGAGGTGAATGAGCAATGCCCCAACATCACCCGCATCTACAGCATTGGGAAGAGCTACC
AGGGCCTGAAGCTATATGTGATGGAAATGTCAGACAAGCCTGGGGAGCATGAGCTGGGAGAGCC
TGAGGTACGCTATGTGGCTGGCATGCATGGGAATGAGGCCCTGGGGCGGGAGCTGCTTCTGCTG
CTGATGCAGTTCTTGTGCCATGAGTTCCTGCGTGGGAACCCACGAGTGACCCGGCTGCTCACTG
AGATGCGCATTCACCTGTTGCCCTCCATGAACCCTGATGGCTATGAGACCGCCTACCGCCGGGG
CTCAGAGCTTGTGGGCTGGGCAGAAGGTCGCTGGAACCACCAGGGCATTGACCTTAACCACAAT
TTTGCTGACCTCAACACACCATTGTGGGATGCTGAGGATGATGGGCTGGTGCCCCACATTTTCC
CCAACCATCATGTGCCACTGCCTACTTATTACACTCTGCCCAATGCCACTGTGGCCCCTGAAAC
ACGGGCAGTGATCGAGTGGATGAAGCGGATCCCCTTTGTGCTGAGTGCCAATCTCCATGGGGGT
GAGCTGGTGGTGTCTTACCCATTCGACATGACTCGGACCCCGTGGGCTGCACGTGAACTCACCC
CGACGCCGGATGACGCCGTCTTTCGCTGGCTCAGCACTGTCTATGCTGGCACTAATCGGGTCAT
GCAGGACACAGATCGCCGACCCTGCCACAACCAGGACTTCTCTTTGCATGGCAACATCATCAAC
GGGGCTGACTGGCACACAGTCCCCGGGAGCATGAATGACTTCAGCTACCTACATACCAACTGCT
TTGAGGTCACTGTGGAGCTGTCCTGTGACAAGTTCCCTCATGAGAATGAGCTTCCCCAAGAATG
GGAGAACAACAAAGAAGCCCTCCTCACCTACCTGGAGCAGGTGCGCATGGGCATTACAGGAGTT
GTGCGGGACAAGGACACACAGCTTGGGATTGCTGATGCTGTCATTGCCGTGGAGGGGATTAACC
ATGACGTTACAACGGCTTGGGGCGGGGATTACTGGCGGCTGCTGACCCCAGGGGACTATACGGT
GACTGCCAGTGCTGAGGGCTACCATTCAGTGACACAGACCTGCCGGGTCCCCTTTGAAGAGGGC
CCTGTCCCCTGCAATTTCATGCTCACCAAGACTCCCAAACAAAGACTGAGAGAGCTGCTGGCAG
CAGGGGTCAAGGTGCCCCCGGACCTTCGAAGGCGACTGGAGCGATTGAGGGGACAGAAGGATTA
AGCGGAAGAGAGCCAATGTCTCGGGCAGGCTGGACCTGTCCAGAACTGAAGGGGAAGAGTGGGG
AGGGAGGGACAAAGTGGGGGTAGAGGTGCTTCAGCTCATTAAAGCTACCTGGTACCTTAGCT

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Protein Sequences


Protein RefSeqs	XP_005320600	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014645.3
GenBank Protein	KAG3262950	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005320600 ⟸ XM_005320543

- UniProtKB:

I3MRE3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWGLLLALAALAPSVGLGLGAPSASVLGLIPSATTEATGSTPAPRSGPAQPSGKANATSEQQIR
IRVIKKKKVIVKKRKKLIRPSPPVTAKPMVTTSPTRSPNRPEKQEPGCPPLGLESLRVSDSQFE
ASSSQSFGLGPHRGRLNIQSGLEDGDLYDGAWCAEQQDTEPWFQVDARNPIRFSGIVTQGRNSI
WRYDWVTSYKVQFSNDSRTWWTSRNHSSGMDAVFPANSDPETPVLNLLPEPQVARFIRLLPQTW
FQEGAPCLRAEILACPVSDPNDLPPEAHSLGSSDPLDFRHHNYKAMRKLMKEVNEQCPNITRIY
SIGKSYQGLKLYVMEMSDKPGEHELGEPEVRYVAGMHGNEALGRELLLLLMQFLCHEFLRGNPR
VTRLLTEMRIHLLPSMNPDGYETAYRRGSELVGWAEGRWNHQGIDLNHNFADLNTPLWDAEDDG
LVPHIFPNHHVPLPTYYTLPNATVAPETRAVIEWMKRIPFVLSANLHGGELVVSYPFDMTRTPW
AARELTPTPDDAVFRWLSTVYAGTNRVMQDTDRRPCHNQDFSLHGNIINGADWHTVPGSMNDFS
YLHTNCFEVTVELSCDKFPHENELPQEWENNKEALLTYLEQVRMGITGVVRDKDTQLGIADAVI
AVEGINHDVTTAWGGDYWRLLTPGDYTVTASAEGYHSVTQTCRVPFEEGPVPCNFMLTKTPKQR
LRELLAAGVKVPPDLRRRLERLRGQKD

hide sequence

Ensembl Acc Id:

ENSSTOP00000014645 ⟸ ENSSTOT00000016356

Protein Domains

F5/8 type C

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016354	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016356.3	UniProtKB/TrEMBL
Gene3D-CATH	Carboxypeptidase-like, regulatory domain	UniProtKB/TrEMBL
	Galactose-binding domain-like	UniProtKB/TrEMBL
	Zn peptidases	UniProtKB/TrEMBL
InterPro	CarboxyPept-like_regulatory	UniProtKB/TrEMBL
	FA58C	UniProtKB/TrEMBL
	Galactose-bd-like_sf	UniProtKB/TrEMBL
	Peptidase_M14	UniProtKB/TrEMBL
	Peptidase_M14_domain	UniProtKB/TrEMBL
NCBI Gene	Cpxm1	ENTREZGENE
PANTHER	CARBOXYPEPTIDASE X1-RELATED	UniProtKB/TrEMBL
	PROTEASE M14 CARBOXYPEPTIDASE	UniProtKB/TrEMBL
Pfam	CarboxypepD_reg	UniProtKB/TrEMBL
	F5_F8_type_C	UniProtKB/TrEMBL
	Peptidase_M14	UniProtKB/TrEMBL
PRINTS	CRBOXYPTASEA	UniProtKB/TrEMBL
PROSITE	CARBOXYPEPT_ZN_1	UniProtKB/TrEMBL
	CARBOXYPEPT_ZN_2	UniProtKB/TrEMBL
	FA58C_3	UniProtKB/TrEMBL
SMART	FA58C	UniProtKB/TrEMBL
	Zn_pept	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49464	UniProtKB/TrEMBL
	SSF49785	UniProtKB/TrEMBL
	Zn-dependent exopeptidases	UniProtKB/TrEMBL
UniProt	I3MRE3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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