Rxfp4 (relaxin family peptide/INSL5 receptor 4)

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Gene: Rxfp4 (relaxin family peptide/INSL5 receptor 4) Ictidomys tridecemlineatus

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Symbol:

Rxfp4

Name:

relaxin family peptide/INSL5 receptor 4

RGD ID:

12453297

Description:

ENCODES a protein that exhibits C-C chemokine binding (inferred); C-C chemokine receptor activity (inferred); G protein-coupled receptor activity (inferred); INVOLVED IN positive regulation of feeding behavior (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); gastrointestinal stromal tumor (ortholog); immunodeficiency 42 (ortholog); FOUND IN external side of plasma membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

relaxin-3 receptor 2; relaxin/insulin like family peptide receptor 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	26,176,806 - 26,181,612 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	5,208,222 - 5,209,346 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	5,208,001 - 5,209,711 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

gastrointestinal stromal tumor (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

Noonan syndrome 8 (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IEA)

cell chemotaxis (IEA)

chemokine-mediated signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA)

immune response (IEA)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of feeding behavior (IEA,ISO)

Cellular Component

external side of plasma membrane (IEA)

membrane (IEA)

Molecular Function

C-C chemokine binding (IEA)

C-C chemokine receptor activity (IEA)

G protein-coupled receptor activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Rxfp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	26,176,806 - 26,181,612 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	5,208,222 - 5,209,346 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	5,208,001 - 5,209,711 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RXFP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	155,941,638 - 155,943,087 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	155,941,638 - 155,943,087 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	155,911,429 - 155,912,878 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	154,178,104 - 154,179,249 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	152,724,573 - 152,725,698	NCBI
Celera	1	128,984,365 - 128,985,510 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI
HuRef	1	127,272,361 - 127,273,506 (+)	NCBI		HuRef
CHM1_1	1	157,307,273 - 157,308,418 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	155,079,771 - 155,081,220 (+)	NCBI		T2T-CHM13v2.0

Rxfp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	88,559,081 - 88,560,489 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	88,559,205 - 88,560,449 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	88,651,898 - 88,653,142 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	88,651,898 - 88,653,142 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	88,455,820 - 88,457,064 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	88,737,825 - 88,739,069 (-)	NCBI		MGSCv36	mm8
Celera	3	88,692,014 - 88,693,258 (-)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	38.92	NCBI

Rxfp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	176,421,332 - 176,422,486 (-)	NCBI		GRCr8
mRatBN7.2	2	174,123,510 - 174,124,664 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_WKY_Bbb_1.0	2	173,892,170 - 173,893,324 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	188,026,531 - 188,027,685 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	207,428,265 - 207,431,695 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	180,780,814 - 180,781,968 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	168,067,829 - 168,068,983 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Rxfp4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955545	2,143,832 - 2,145,939 (+)	NCBI	ChiLan1.0	ChiLan1.0

RXFP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	93,909,021 - 93,920,143 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	93,640,167 - 93,651,884 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	131,275,631 - 131,279,593 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	135,106,869 - 135,108,093 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	135,106,884 - 135,108,008 (+)	Ensembl	panpan1.1		panPan2

RXFP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	94,082,826 - 94,088,224 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	94,083,974 - 94,085,095 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	102,826,985 - 102,828,106 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RXFP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	7,930,719 - 7,933,422 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	7,232,682 - 7,234,402 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rxfp4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624885	1,309,418 - 1,312,004 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005331368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000000613 ⟹ ENSSTOP00000000558

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936580	5,208,222 - 5,209,346 (+)	Ensembl

RefSeq Acc Id:

XM_005331368 ⟹ XP_005331425

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	26,176,806 - 26,181,612 (+)	NCBI
SpeTri2.0	NW_004936580	5,208,001 - 5,209,711 (+)	NCBI

Sequence:

show sequence

ATCTTGGTATGCCCCACCCACCACTGGTCTGGCCCAACAGGGAGCAGGCAGCTGTCCTCACACC
CCTCCCTCTGAGGTGTGGGTGTGGGCTGCGGCTCCTGGCTGGCGGCAGAGAAGCACTCACACCC
TGAGCCTCCTGCTGAGCGCCTCAGTGGCCCCTGCCAGCCTGGCAGGCACTTGCTGGCTCTTTAT
TCAGCACCACCAACCTCCGATGTCCTGCGATGCCCACACCCAACACTTCCTCCCCTCTACCCAC
GTTCTTCTGGGTCAATGCCTCTGGAGGCAGCGCGCTGAGTGCCGACGATGCTGGGATGCCCGTG
CAGTTCCTCGCCCTCAGGGTCACGGTTGCTTTGGCCTACGGGATGGTAGGGGCCATCGGCTTGC
TGGGCAATTCGGCTGTGCTGTGGGTGCCGGGCAGCTGCGCGAGGAGAGTCCCTGGCCCACCTTC
CGACACTTTTGTCTTCAACCTGGCTCTGGCGGACTTGGGGCTGGCCCTCACTCTCCCCTTCTGG
GCAGCAGAGTCAGCACTGGACTTCCACTGGCCCTTTGGAAGTGCCCTTTGCAAAGTGGTCCTGA
CGGCCACTGTCCTCAACATCTATGCCAGCATCTTCCTCATCACAGCACTGAGTGTCGCCCGATA
CTGGGTGGTGGCCATGGCTGTGGGGCCAAGCACCCACCTCTCACTCTTCTGGGCCCGTGCGGCC
ACCCTGGGAGTGTGGCTGGCGGCGGCTCTGGTGACGGTGCCCACGGCCATCTTTGGGTCTGAGG
GCGAGGTGTGGGGTGTGCGCCTCTGCCTTCTGCGCTTCCCCAGCAGGTACTGGCTGGGGGCCTA
CCAGCTGCAGAGGGTGGTCCTGGCTTTCGTGGTGCCCTTGGGCGTCATCACCACCAGCTACCTG
CTGCTGCTGGCCTTCCTGCGGCGGCGGCAGAGGCGGCGGCAGGACAGCAGAGTTGTGGCCCGCT
CTGTCCGTATCCTGGTGGCCTCCTTCTTCCTCTGCTGGTTCCCCAACCATGTGGTCACTCTCTG
GGGTGTCCTGGTGAAGTTTGACCTGGCGCCCTGGAACAGCACTTTCTACACCATCCACACCTAC
GTCTTCCCCGTCACCACGTGCCTGGCACACAGCAACAGCTGCCTCAACCCCGTGCTCTACTGTC
TCCTGCGCAGGGAGCCTCGGCAGGCCCTGGCAGACACCTTCAGGGACTTGCGCTCAAGGCTGTG
GCCCCAGGGCCCGAGCTGGAAGGAACATGTGGCCCTAAAGGAGGTAGGCAGGCAGTGGGCAGCC
AGTACGCCCCAGGAGAGCGGTCCTTCTGCCATGCTCATGAGCGGAGACAGAGGGACACCTGGGT
GAAGGGTACAGCAGGTGCAGGATCCACACATTCTAAGCTGCCCTGGGCCAGGCTCAGTGTCCTC
TGGGAAAGTCTGACCTTTGATCACCAACTCTGGGTGTGGTGGAATGGGGGAGGCCAGGGCCTGG
GGCCAGGGGATAAGGGCTGGGGCAACAGCTCACAGAGGTGGGAAAGAGGAGGAACCCAGAATAA
ACCTCTGTCACCTACAGGTGTCTTGACCCTTCATCCTTGTTCTGCCTCCAGGACAGTGCAAGAA
TTCTCAGGACATTTTCCCCATAGGGGTCTAGGCTCATGGATCAAAGGTCAGTGCCCATCTCCCT
CTGCCCATCCTCCCCACTCTCACCTCTAAACAGACTATTTCTTCTTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005331425	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000000558.2
GenBank Protein	KAG3281768	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005331425 ⟸ XM_005331368

- UniProtKB:

I3LX15 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPTPNTSSPLPTFFWVNASGGSALSADDAGMPVQFLALRVTVALAYGMVGAIGLLGNSAVLWVP
GSCARRVPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGSALCKVVLTATVLNIYAS
IFLITALSVARYWVVAMAVGPSTHLSLFWARAATLGVWLAAALVTVPTAIFGSEGEVWGVRLCL
LRFPSRYWLGAYQLQRVVLAFVVPLGVITTSYLLLLAFLRRRQRRRQDSRVVARSVRILVASFF
LCWFPNHVVTLWGVLVKFDLAPWNSTFYTIHTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQAL
ADTFRDLRSRLWPQGPSWKEHVALKEVGRQWAASTPQESGPSAMLMSGDRGTPG

hide sequence

Ensembl Acc Id:

ENSSTOP00000000558 ⟸ ENSSTOT00000000613

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000000616	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000000613.2	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	ATII_rcpt	UniProtKB/TrEMBL
	GPCR1	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	Rxfp4	ENTREZGENE
PANTHER	CELL ADHESION MOLECULE	UniProtKB/TrEMBL
	RELAXIN FAMILY PEPTIDE RECEPTOR 3.3A1-RELATED	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	ANGIOTENSINR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	I3LX15	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-02-27	Rxfp4	relaxin family peptide/INSL5 receptor 4		relaxin/insulin like family peptide receptor 4	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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