Gpr108 (G protein-coupled receptor 108)

Gene: Gpr108 (G protein-coupled receptor 108) Ictidomys tridecemlineatus

Analyze

Symbol:

Gpr108

Name:

G protein-coupled receptor 108

RGD ID:

12443822

Description:

INVOLVED IN negative regulation of toll-like receptor signaling pathway (inferred); regulation of immune response (inferred); ASSOCIATED WITH genetic disease (ortholog); mucolipidosis type IV (ortholog); FOUND IN cis-Golgi network membrane (inferred); Golgi apparatus (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	213,800,582 - 213,807,713 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	4,027,392 - 4,034,162 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	4,027,068 - 4,034,188 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

mucolipidosis type IV (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of toll-like receptor signaling pathway (IEA)

regulation of immune response (IEA)

Cellular Component

cis-Golgi network membrane (IEA)

Golgi apparatus (IEA)

membrane (IEA)

trans-Golgi network (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gpr108
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	213,800,582 - 213,807,713 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	4,027,392 - 4,034,162 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	4,027,068 - 4,034,188 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR108
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	6,729,914 - 6,737,580 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	6,729,914 - 6,737,580 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	6,729,925 - 6,737,591 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	6,680,925 - 6,688,633 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	6,672,183 - 6,679,888 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	6,492,417 - 6,500,113 (-)	NCBI		HuRef
CHM1_1	19	6,729,775 - 6,737,483 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	6,719,314 - 6,726,971 (-)	NCBI		T2T-CHM13v2.0

Gpr108
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	57,541,914 - 57,555,743 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	57,541,635 - 57,555,446 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	57,234,914 - 57,248,743 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	57,234,635 - 57,248,446 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	57,374,337 - 57,387,064 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	56,920,249 - 56,932,976 (-)	NCBI		MGSCv36	mm8
Celera	17	61,582,912 - 61,595,639 (-)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.74	NCBI

Gpr108
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	2,207,716 - 2,218,738 (-)	NCBI		GRCr8
mRatBN7.2	9	2,120,740 - 2,131,771 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	2,120,744 - 2,132,572 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	2,548,682 - 2,559,221 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,898,057 - 7,908,596 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,853,914 - 6,864,453 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	9,704,300 - 9,714,767 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,704,346 - 9,714,755 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	8,711,637 - 8,722,117 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	6,389,776 - 6,400,755 (+)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

Gpr108
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	2,782,606 - 2,789,815 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	2,782,549 - 2,789,470 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR108
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	11,143,245 - 11,151,087 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	10,369,357 - 10,377,051 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	5,762,576 - 5,770,169 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	6,684,024 - 6,691,620 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	6,684,024 - 6,691,620 (-)	Ensembl	panpan1.1		panPan2

GPR108
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	53,554,574 - 53,560,845 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	53,554,445 - 53,565,239 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	53,303,031 - 53,309,226 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	54,209,031 - 54,215,223 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	54,208,903 - 54,216,335 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	53,276,386 - 53,282,573 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	53,724,378 - 53,730,570 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	53,953,848 - 53,960,021 (+)	NCBI		UU_Cfam_GSD_1.0

GPR108
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	72,418,261 - 72,427,988 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	72,418,219 - 72,427,624 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	72,750,411 - 72,755,262 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR108
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	6,299,294 - 6,306,957 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	6,299,548 - 6,306,564 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	1,688,442 - 1,695,938 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr108
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	3,805,366 - 3,812,055 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	3,805,151 - 3,812,113 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040290565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000023721 ⟹ ENSSTOP00000017201

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936588	4,027,392 - 4,034,162 (-)	Ensembl

RefSeq Acc Id:

XM_005332095 ⟹ XP_005332152

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	213,800,582 - 213,807,713 (+)	NCBI
SpeTri2.0	NW_004936588	4,027,068 - 4,034,188 (-)	NCBI

Sequence:

show sequence

TGTCAAGGGAGGCGGCAGCTCCAGAGATGGCAGTGAGCGAGAGGAGGGGGCTCGGCCGCTGGAG
CCCCGCAGAGTCGGGGCAGCGGCTCCTTCTGCTGTTGCTGTTGGGCGGCTGCTCCGGGCGTATC
CACCGGCTGGTGCTGACGGGGGAGAAGCGAGCAGATATCCAGCTCAACAGCTTTGGGTTCTACG
CCAATGGCTCCCTGGAAGTGGATTTGAGGCTCCTACGGCTGGACCTCCAAGAGACAGACGAGAA
GGCCCCCTTGGTGGGGTTCAGCCTGAGCCGGGTTCGATCTGGTGGCATTCGCTCCTACTCAACC
CGGGATTACCATGACTGTCCTCTACAAAGAAACAGTAGCAGCTTCCTGGTCCTGTTCCTCATCG
ACACCAAGGGTCTGCAGGTCCAGGTACGAAAATATGGGGAGCAGAAGAAATTGTTCATCTCTCC
TGGGCTTCTCCCCGAAGAGACTTCCAAACCAGCGCTTCCGAAGCCAGAGCCCACAGTCACCCCC
AAAGCAGACAGTGGAACCTCCACAGTCAACAAAGCCAAGGCAAAACTCGCAGTGTCTCAGGACC
CCAATGGGAAGGACAAGGAGCTGGTGTTGGGCCTGAGCCACCTCAACAACTCCTACAACTTCAG
CTTCCACGTGGTGATCGGCTCCAGGGCAGAGGAAGGCCAGTACAACCTCAATTTCCACAACTGC
TACAACTCCATGCCCGGCCGGGAGCGTCCATTTGACATCACTGTGATGATCCGGGAGAAGAACC
CCGACGGCTTCCTGTCTGCTGCTGAAATTCCCCTCTTCAAGCTGTACCTGATCATGTCTGCCTG
CTTCCTGGCGGCTGGCGTCTTCTGGGTGTCCGTGCTCTGCAGGAACACGTACAATGTCTTCAAG
ATCCACTGGCTCATGGCGGCCTTGGCGTTCACCAAGAGCATCTCCCTCCTCTTCCACAGTATCA
ACTACTACTTCATCAACAGCCAGGGCCACCCCATCGAAGGCCTCGCTGTCGTGCACTACATCAC
ACACCTGCTGAAGGGAGCGCTCCTGTTCATCACCATCGCCCTGATCGGCTCGGGCTGGGCCTTC
ATCAAGTACATCCTGTCTGACAAGGAGAAGAAGGTGTTTGGGGTGGTGATCCCCCTGCAGGTCC
TGGCCAACGTGGCGTACATTGTCATCGAGTCCCGCGAGGAGGGCGCCAGCGACTACGGGCTCTG
GAAGGAGATCCTGTTTCTAGTGGACCTCATCTGCTGTGGCGCCATCCTCTTCCCAGTTGTCTGG
TCCATCCGGCATCTCCAGGACGCGTCTGACACCGACGGGAAGGTGGCAGTGAACCTGGCCAAGC
TGAAGCTGTTCCGACATTACTATGTCATGGTCATCTGTTATGTCTACTTCACTCGCATCATTGC
CATTCTCCTGCGGGTGGCAGTGCCCTTCCAGTGGCAGTGGCTGTACCAGCTCTTGGTGGAGGGC
TCCACCCTTGCCTTCTTCGTGCTCACCGGCTACAAATTCCAGCCAGCTGGGGACAACCCGTACC
TGCAGCTGCCCCAGGAGGATGAGGAAGATGTTCAGATGGAGCAAGTAATGACGGATTCTGGGTT
CCGGGAAGGCCTGTCCAAAGTCAGCAAAACAGCCAGCAGGCGGGAGTTCTTGTGAAGTCTCTGC
ACCCTGAGCCAGCGGCCTCCTCTCGCCCGCTTCTCAGCCTGACACTCCAAAGCCTGTGGGAGCT
GGGGGACCTGCTCTCGGGCTACTGTCCCCAGAGGAGCCCATCTACAAGTTGGACTGCCCCTTCC
TCCCGGCAACTGGTGGGCAGCCCTGTCCTCACCAGGGGACCACCACCCACTTCCAGGTGTACAA
TAAGGACCACTCCGTTTCTGCTACCCTGATTTCTTGCCTTTCTGGGGGTTGAGGTCTCGGTGGA
AGTTGTGTTTACAACCTGTATTTGCTTTACACGGTCAATAAATATTAATTGAGCAACTA

hide sequence

RefSeq Acc Id:

XM_040290565 ⟹ XP_040146499

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	213,800,933 - 213,807,713 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005332152	(Get FASTA)	NCBI Sequence Viewer
	XP_040146499	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000017201.2
GenBank Protein	KAG3280580	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005332152 ⟸ XM_005332095
- Peptide Label:	isoform X2
- UniProtKB:	I3MYK5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVSERRGLGRWSPAESGQRLLLLLLLGGCSGRIHRLVLTGEKRADIQLNSFGFYANGSLEVDL RLLRLDLQETDEKAPLVGFSLSRVRSGGIRSYSTRDYHDCPLQRNSSSFLVLFLIDTKGLQVQV RKYGEQKKLFISPGLLPEETSKPALPKPEPTVTPKADSGTSTVNKAKAKLAVSQDPNGKDKELV LGLSHLNNSYNFSFHVVIGSRAEEGQYNLNFHNCYNSMPGRERPFDITVMIREKNPDGFLSAAE IPLFKLYLIMSACFLAAGVFWVSVLCRNTYNVFKIHWLMAALAFTKSISLLFHSINYYFINSQG HPIEGLAVVHYITHLLKGALLFITIALIGSGWAFIKYILSDKEKKVFGVVIPLQVLANVAYIVI ESREEGASDYGLWKEILFLVDLICCGAILFPVVWSIRHLQDASDTDGKVAVNLAKLKLFRHYYV MVICYVYFTRIIAILLRVAVPFQWQWLYQLLVEGSTLAFFVLTGYKFQPAGDNPYLQLPQEDEE DVQMEQVMTDSGFREGLSKVSKTASRREFL hide sequence

RefSeq Acc Id:	XP_040146499 ⟸ XM_040290565
- Peptide Label:	isoform X1
- UniProtKB:	I3MYK5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000017201 ⟸ ENSSTOT00000023721

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000028930	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000023721.2	UniProtKB/TrEMBL
InterPro	GPR107/GPR108-like	UniProtKB/TrEMBL
NCBI Gene	Gpr108	ENTREZGENE
PANTHER	PROTEIN GPR108	UniProtKB/TrEMBL
	PTHR21229	UniProtKB/TrEMBL
Pfam	Lung_7-TM_R	UniProtKB/TrEMBL
UniProt	I3MYK5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar