GBX2 (gastrulation brain homeobox 2) - Rat Genome Database

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Gene: GBX2 (gastrulation brain homeobox 2) Canis lupus familiaris
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Symbol: GBX2
Name: gastrulation brain homeobox 2
RGD ID: 12432916
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN autonomic nervous system development (ortholog); axon guidance (ortholog); branching involved in blood vessel morphogenesis (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Bethlem Myopathy 1A (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein GBX-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12547,005,509 - 47,008,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2547,005,504 - 47,008,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2547,508,245 - 47,511,037 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02547,359,565 - 47,362,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2547,359,543 - 47,362,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12547,267,592 - 47,270,382 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02547,061,156 - 47,063,938 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02547,291,077 - 47,293,871 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GBX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12547,005,509 - 47,008,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2547,005,504 - 47,008,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2547,508,245 - 47,511,037 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02547,359,565 - 47,362,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2547,359,543 - 47,362,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12547,267,592 - 47,270,382 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02547,061,156 - 47,063,938 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02547,291,077 - 47,293,871 (-)NCBIUU_Cfam_GSD_1.0
GBX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,161,340 - 236,168,386 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,165,236 - 236,168,386 (-)EnsemblGRCh38hg38GRCh38
GRCh372237,073,879 - 237,077,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,739,046 - 236,741,391 (-)NCBINCBI36Build 36hg18NCBI36
Build 342236,856,306 - 236,858,652NCBI
Celera2230,787,441 - 230,789,786 (-)NCBICelera
Cytogenetic Map2q37.2NCBI
HuRef2228,868,880 - 228,871,225 (-)NCBIHuRef
CHM1_12237,080,112 - 237,082,457 (-)NCBICHM1_1
T2T-CHM13v2.02236,651,067 - 236,658,113 (-)NCBIT2T-CHM13v2.0
Gbx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39189,855,684 - 89,858,898 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl189,855,678 - 89,858,901 (-)EnsemblGRCm39 Ensembl
GRCm38189,927,962 - 89,931,176 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl189,927,956 - 89,931,179 (-)EnsemblGRCm38mm10GRCm38
MGSCv37191,824,537 - 91,827,751 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36191,759,133 - 91,762,347 (-)NCBIMGSCv36mm8
Celera192,869,152 - 92,872,368 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map145.06NCBI
Gbx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8997,957,304 - 97,959,883 (-)NCBIGRCr8
mRatBN7.2990,509,633 - 90,512,212 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl990,509,633 - 90,512,212 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx998,936,286 - 98,938,865 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09104,072,186 - 104,074,765 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09102,437,722 - 102,440,301 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0997,063,265 - 97,065,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,063,728 - 97,065,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0996,754,122 - 96,756,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4989,034,340 - 89,037,102 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1989,239,950 - 89,240,065 (-)NCBI
Celera988,058,118 - 88,060,697 (-)NCBICelera
Cytogenetic Map9q36NCBI
Gbx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955453538,280 - 540,306 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955453538,066 - 541,415 (+)NCBIChiLan1.0ChiLan1.0
GBX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213138,794,032 - 138,798,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B138,808,996 - 138,813,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B123,392,499 - 123,399,549 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Gbx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303189,066,154 - 189,069,657 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365251,870,195 - 1,873,539 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365251,870,211 - 1,873,536 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GBX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15136,029,070 - 136,032,316 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115136,029,393 - 136,032,568 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215150,464,293 - 150,466,933 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GBX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110122,177,725 - 122,184,448 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10122,182,301 - 122,184,446 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604077,219,450 - 77,225,155 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gbx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248471,879,007 - 1,881,669 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248471,878,946 - 1,881,794 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GBX2
47 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 4 5 23 18 10 2 4 2 6 24 18 12 14 8

Sequence


Ensembl Acc Id: ENSCAFT00000019301   ⟹   ENSCAFP00000017900
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2547,005,504 - 47,008,512 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845048285   ⟹   ENSCAFP00845037874
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2547,359,543 - 47,362,930 (-)Ensembl
RefSeq Acc Id: XM_038434646   ⟹   XP_038290574
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02547,359,565 - 47,362,361 (-)NCBI
RefSeq Acc Id: XM_038511059   ⟹   XP_038366987
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12547,267,592 - 47,270,382 (-)NCBI
RefSeq Acc Id: XM_038573094   ⟹   XP_038429022
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02547,291,077 - 47,293,871 (-)NCBI
RefSeq Acc Id: XM_038637331   ⟹   XP_038493259
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02547,061,156 - 47,063,938 (-)NCBI
RefSeq Acc Id: XM_543300   ⟹   XP_543300
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12547,005,509 - 47,008,366 (-)NCBI
Dog10K_Boxer_Tasha2547,508,245 - 47,511,037 (-)NCBI
Sequence:
RefSeq Acc Id: XP_543300   ⟸   XM_543300
- UniProtKB: A0A8C0T2B4 (UniProtKB/TrEMBL),   A0A8C0LKJ5 (UniProtKB/TrEMBL),   A0A8I3Q2E7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000017900   ⟸   ENSCAFT00000019301
RefSeq Acc Id: XP_038366987   ⟸   XM_038511059
RefSeq Acc Id: XP_038493259   ⟸   XM_038637331
RefSeq Acc Id: XP_038290574   ⟸   XM_038434646
- UniProtKB: A0A8C0T2B4 (UniProtKB/TrEMBL),   A0A8C0LKJ5 (UniProtKB/TrEMBL),   A0A8I3Q2E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038429022   ⟸   XM_038573094
- UniProtKB: A0A8C0LKJ5 (UniProtKB/TrEMBL),   A0A8C0T2B4 (UniProtKB/TrEMBL),   A0A8I3Q2E7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845037874   ⟸   ENSCAFT00845048285
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012148 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019748 UniProtKB/TrEMBL
  ENSCAFG00040017687 UniProtKB/TrEMBL
  ENSCAFG00845027418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019301.6 UniProtKB/TrEMBL
  ENSCAFT00030036278.1 UniProtKB/TrEMBL
  ENSCAFT00040032698.1 UniProtKB/TrEMBL
  ENSCAFT00845048285 ENTREZGENE
  ENSCAFT00845048285.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro GBX-1/2 UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
KEGG Report cfa:486174 UniProtKB/TrEMBL
NCBI Gene GBX2 ENTREZGENE
PANTHER PTHR24334 UniProtKB/TrEMBL
  PTHR24334:SF3 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C0LKJ5 ENTREZGENE
  A0A8C0T2B4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q2E7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41135 ENTREZGENE