LPAR6 (lysophosphatidic acid receptor 6)

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Gene: LPAR6 (lysophosphatidic acid receptor 6) Canis lupus familiaris

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Symbol:

LPAR6

Name:

lysophosphatidic acid receptor 6

RGD ID:

12412242

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN blastocyst hatching (ortholog); ASSOCIATED WITH Autosomal Recessive Woolly Hair (ortholog); chromosome 13q14 deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	3,110,797 - 3,112,973 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	3,111,462 - 3,112,499 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	3,139,671 - 3,141,658 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	3,175,184 - 3,176,372 (+)	NCBI		ROS_Cfam_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Autosomal Recessive Woolly Hair (ISO)

chromosome 13q14 deletion syndrome (ISO)

genetic disease (ISO)

hypotrichosis (ISO)

hypotrichosis 1 (ISO)

hypotrichosis 8 (ISO)

intellectual disability (ISO)

mitochondrial DNA depletion syndrome 5 (ISO)

retinoblastoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst hatching (ISO)

G protein-coupled receptor signaling pathway (IEA)

Cellular Component

membrane (IEA)

plasma membrane (ISO)

Molecular Function

G protein-coupled receptor activity (IEA)

protein binding (ISO)

References

Genomics

Comparative Map Data

LPAR6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	3,110,797 - 3,112,973 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	3,111,462 - 3,112,499 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	3,139,671 - 3,141,658 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	3,175,184 - 3,176,372 (+)	NCBI		ROS_Cfam_1.0

LPAR6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	48,389,571 - 48,444,669 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	48,389,567 - 48,444,704 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	48,985,274 - 49,018,805 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	47,883,182 - 47,887,947 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	47,883,275 - 47,887,947	NCBI
Celera	13	30,039,912 - 30,073,567 (-)	NCBI		Celera
Cytogenetic Map	13	q14.2	NCBI
HuRef	13	29,777,751 - 29,810,928 (-)	NCBI		HuRef
CHM1_1	13	48,952,866 - 48,985,831 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	47,609,888 - 47,664,937 (-)	NCBI		T2T-CHM13v2.0

Lpar6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	73,475,331 - 73,477,798 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	73,475,335 - 73,480,734 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	73,237,891 - 73,240,358 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	73,237,895 - 73,243,294 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	73,637,698 - 73,640,165 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	71,972,050 - 71,974,497 (+)	NCBI		MGSCv36	mm8
Celera	14	70,758,227 - 70,760,692 (+)	NCBI		Celera
Cytogenetic Map	14	D3	NCBI
cM Map	14	38.75	NCBI

Lpar6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	54,826,110 - 54,827,919 (+)	NCBI		GRCr8
mRatBN7.2	15	48,416,548 - 48,418,357 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	48,416,544 - 48,422,331 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	52,557,397 - 52,559,217 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	53,668,972 - 53,670,792 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	50,514,212 - 50,516,021 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	55,126,953 - 55,128,762 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	55,126,953 - 55,128,761 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	58,850,070 - 58,851,879 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	53,875,463 - 53,877,272 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	48,066,078 - 48,067,887 (+)	NCBI		Celera
Cytogenetic Map	15	q11	NCBI

Lpar6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	2,077,269 - 2,078,300 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955431	2,077,093 - 2,079,000 (-)	NCBI	ChiLan1.0	ChiLan1.0

LPAR6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	49,860,878 - 49,893,160 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	48,511,768 - 48,544,291 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	29,561,219 - 29,567,414 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	48,262,910 - 48,295,264 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	48,263,254 - 48,264,291 (-)	Ensembl	panpan1.1		panPan2

Lpar6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	158,204,006 - 158,205,826 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936565	1,688,314 - 1,689,348 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936565	1,688,218 - 1,689,876 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LPAR6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	19,219,077 - 19,220,347 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	19,216,305 - 19,220,913 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	19,680,377 - 19,682,665 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LPAR6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	26,332,770 - 26,335,289 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	26,333,023 - 26,334,054 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666057	17,570,804 - 17,573,633 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lpar6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624748	6,423,861 - 6,424,892 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624748	6,423,170 - 6,425,149 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in LPAR6
9 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022408289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038430815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000044900 ⟹ ENSCAFP00000037189

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	22	3,111,462 - 3,112,499 (+)	Ensembl

RefSeq Acc Id:

XM_022408289 ⟹ XP_022263997

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	22	3,110,797 - 3,112,973 (+)	NCBI
Dog10K_Boxer_Tasha	22	3,139,671 - 3,141,658 (+)	NCBI

Sequence:

show sequence

TGATGTCATACTACAAATCTAGCAAGCCTTTCTTTTCTACTTCAGAGAAAGCCCATCTCACAAT
ACATCTGGCAACGGAGGAAAAGGCTTCAAGCCAGCAAGAGCTAACACGCCTAGGAATTTATTTC
AGAAACTTTGAAAGACTCTTCTGCTTACCACCATCTGGAATCCACTGCTGGAATATCAAAAAGA
AAAACTTCATTTAAAAGAAGAAGTTGGCTTCACGGACTATATTTTTCAAAAGTTGTTCGTCGGT
TACCTAGACCCTGGATTCACGGATATTCTGGAGATTAGAAGAAAGGATTTGCCTGTTGAAGGGC
CAAGTGGAAACTCTGTGACAACGAATTTCATGTTTCTTACCAAGATTTCAAAGAAAAAGGAAGT
ATTTCTAAAACCACCCAAAGATACAAAGAATCTGCAAATACTCTGGAGGTTATAAAGCCGGCAC
AATCGGAATACCAAAGGCTGCAGTGACCAAAGGACTTCCATACAGTAGAGCGGCCGTGCCTTTA
TGATGGTAAGCAGTAACAGCTCCAGCTGCTCCTATGACGACTCCTTTAAGTACACTTTGTATGG
GTGCATGTTTAGTATGGTGTTTGTGCTTGGGTTAATATCCAACTGTGTTGCCATATACATTTTC
ATCTGCACCCTCAAAGTGCGAAACGAAACCACAACGTACATGATTAACTTGGCAATGTCAGACT
TGCTTTTTGTTTTTACTTTACCCTTCAGGATTTTTTACTTTGCAACACAGAATTGGCCATTCGG
AGATCCACTTTGTAAAATCTCAGTGATGCTCTTTTATACCAACATGTACGGAAGCATTCTGTTC
TTAACCTGTATAAGTGTGGATAGGTTTCTGGCAATTGTCCACCCGTTTAAGTCAAAGACTCTGA
GAACCAAACGAAATGCAAAACTCGTATGCATTGCTGTGTGGCTAACTGTGATAGGAGGAAGTGC
GCCCGCAGTTTTTTTTCAGTCCACCCACATTCAGGAGAACAATTCCACAGCAGCCTGCTTTGAA
AAATTTCCAGAAGCCACATGGAAAACATATCTCTCAAGGATTGTAATTTTCATTGAAATAGTGG
GATTTTTTATTCCTCTAATTTTAAACGTAACTTGTTCTAGTATGGTGCTAAGAACTTTAAATAA
ACCTGTTACATTAAGTAGAAGCAAAATAAATAAAACTAAAGTTTTAAAAATGATTTTTGTACAT
TTGGCCATATTCTGCTTCTGTTTTGTGCCTTACAATATCAATCTTATTTTATATTCTCTAATGA
GAACACAAACATTTGTTAATTGCTCAGCAGTGGCAGCAGTAAGGACAATGTACCCAATCACTCT
TTGCATTGCTGTTTCAAACTGTTGCTTTGACCCTATAATTTACTACTTCACGTCGGACACAATT
CAGAATTCAATAAAAATGAAAAACTGGTCTGCTAAAAGAAGTGACTTCAGATTCTCTGAAGTTC
AGAGTACAGAGAACTTCATTCAACATAGTCTGCAGACCTTAAAATGTAAGATATCTGACAATGA
ATCTACAATATAAGCTGCCTGAAATAAAACCACTGGGACTTCACTGGGAACCTCTAAGTTCCTT
CAACTGTGAACAGTTTTTTCTTGGACAACTATTTCTCCACCTCTGAAAGAAACACGTGGACATT
TTAAAGTTATAGTATAAAAAATTGTATTTGATGTGTTAAGCATTAAAATGTCTTCTATTCTTGT
ATACATACCATTTTATTTTTCTGAGCCATTTGGACTTGTACCTTCCTCTTCATTAAAAAACCCC
TAAAAGACTTGTTCAAAGCTTTAAACTGACTATGATTTAAATCATGTTGCAACCATGTGTACTG
TTTTTTAATTTCTTAGCAATTTTAAACTAAATGATTTATAACACTTTAAGTATTTAATATTTTT
ATTCAACATATATCTAATTTCTATTTCAACCTGAATTGAAACTAGTAATCACGTTTCTTGAGCT
ATAATGTAAATGAGGAAGGAGAATAACTTTAAATAACAA

hide sequence

RefSeq Acc Id:

XM_038430815 ⟹ XP_038286743

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	22	3,175,184 - 3,176,372 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_022263997	(Get FASTA)	NCBI Sequence Viewer
	XP_038286743	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000037189.1
	ENSCAFP00040019745.1
	ENSCAFP00845036938
	ENSCAFP00845036938.1

RefSeq Acc Id:	XP_022263997 ⟸ XM_022408289
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0SES5 (UniProtKB/TrEMBL), A0A8P0NPH2 (UniProtKB/TrEMBL), A0A8I3QBR1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMVSSNSSSCSYDDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICTLKVRNETTTYMINLAMSD LLFVFTLPFRIFYFATQNWPFGDPLCKISVMLFYTNMYGSILFLTCISVDRFLAIVHPFKSKTL RTKRNAKLVCIAVWLTVIGGSAPAVFFQSTHIQENNSTAACFEKFPEATWKTYLSRIVIFIEIV GFFIPLILNVTCSSMVLRTLNKPVTLSRSKINKTKVLKMIFVHLAIFCFCFVPYNINLILYSLM RTQTFVNCSAVAAVRTMYPITLCIAVSNCCFDPIIYYFTSDTIQNSIKMKNWSAKRSDFRFSEV QSTENFIQHSLQTLKCKISDNESTI hide sequence

Ensembl Acc Id:

ENSCAFP00000037189 ⟸ ENSCAFT00000044900

RefSeq Acc Id:	XP_038286743 ⟸ XM_038430815
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3QBR1 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000029700	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00040012372	UniProtKB/TrEMBL
	ENSCAFG00845026714	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000044900.2	UniProtKB/TrEMBL
	ENSCAFT00040022792.1	UniProtKB/TrEMBL
	ENSCAFT00845047067	ENTREZGENE
	ENSCAFT00845047067.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	LPAR6	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	LYSOPHOSPHATIDIC ACID RECEPTOR 6	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	P2Y5ORPHANR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A8C0SES5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3QBR1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NPH2	ENTREZGENE
UniProt Secondary	A0A8P0NPH2	UniProtKB/TrEMBL
VGNC ID	VGNC:42747	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - OMIM