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Gene: ETS2 (ETS proto-oncogene 2, transcription factor) Canis lupus familiaris

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Symbol:

ETS2

Name:

ETS proto-oncogene 2, transcription factor

RGD ID:

12381990

Description:

ENCODES a protein that exhibits DNA binding (ortholog); nuclear glucocorticoid receptor binding (ortholog); INVOLVED IN ectodermal cell fate commitment (ortholog); mesoderm development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Breast Neoplasms (ortholog); Craniofacial Abnormalities (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protein C-ets-2; v-ets erythroblastosis virus E26 oncogene homolog 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	33,846,821 - 33,861,394 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	33,839,010 - 33,860,330 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	32,915,273 - 32,934,593 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	33,153,632 - 33,172,908 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	33,158,349 - 33,172,904 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	33,027,715 - 33,046,975 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	33,032,006 - 33,051,276 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	33,521,018 - 33,540,235 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

Breast Neoplasms (ISO)

Craniofacial Abnormalities (ISO)

Nerve Degeneration (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA)

ectodermal cell fate commitment (IEA,ISO)

mesoderm development (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

primitive streak formation (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA,IEA)

Cellular Component

cytosol (IEA)

nucleoplasm (IEA)

nucleus (IBA,IEA)

plasma membrane (IEA)

Molecular Function

DNA binding (IEA,ISO)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

nuclear glucocorticoid receptor binding (ISO)

protein binding (ISO)

protein domain specific binding (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ETS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	33,846,821 - 33,861,394 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	33,839,010 - 33,860,330 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	32,915,273 - 32,934,593 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	33,153,632 - 33,172,908 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	33,158,349 - 33,172,904 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	33,027,715 - 33,046,975 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	33,032,006 - 33,051,276 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	33,521,018 - 33,540,235 (+)	NCBI		UU_Cfam_GSD_1.0

ETS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	38,805,183 - 38,824,955 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	38,805,183 - 38,824,955 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	40,177,107 - 40,196,879 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	39,099,719 - 39,118,749 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	39,099,718 - 39,118,749	NCBI
Celera	21	25,375,600 - 25,394,615 (+)	NCBI		Celera
Cytogenetic Map	21	q22.2	ENTREZGENE
HuRef	21	25,647,131 - 25,666,960 (+)	NCBI		HuRef
CHM1_1	21	39,737,886 - 39,757,463 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	37,188,973 - 37,208,712 (+)	NCBI		T2T-CHM13v2.0

Ets2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	95,503,274 - 95,522,093 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	95,502,942 - 95,522,095 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	95,702,407 - 95,721,049 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	95,702,075 - 95,721,051 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	95,924,014 - 95,942,656 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	95,811,284 - 95,829,847 (+)	NCBI		MGSCv36	mm8
Celera	16	96,781,092 - 96,799,213 (+)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	56.64	NCBI

Ets2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	48,491,057 - 48,507,843 (+)	NCBI		GRCr8
mRatBN7.2	11	35,021,536 - 35,038,322 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	35,021,596 - 35,038,319 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	43,678,909 - 43,695,695 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	36,350,288 - 36,367,074 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	35,495,961 - 35,512,747 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	36,075,709 - 36,092,495 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	36,075,709 - 36,092,495 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	39,606,999 - 39,623,785 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	36,014,047 - 36,030,833 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	11	33,421,839 - 33,438,625 (-)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

Ets2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	37,747,000 - 37,765,237 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	37,747,152 - 37,764,170 (+)	NCBI	ChiLan1.0	ChiLan1.0

ETS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	34,907,852 - 34,929,140 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	29,766,719 - 29,786,817 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	25,158,457 - 25,178,035 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	38,505,685 - 38,527,651 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	38,512,835 - 38,527,651 (+)	Ensembl	panpan1.1		panPan2

Ets2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	33,210,523 - 33,223,117 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	4,244,604 - 4,257,265 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	4,244,706 - 4,257,223 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ETS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	202,468,405 - 202,484,608 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	202,464,341 - 202,483,534 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ETS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	82,751,196 - 82,770,051 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	82,757,930 - 82,770,165 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	10,604,412 - 10,623,391 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ets2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	25,096,337 - 25,110,123 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	25,096,587 - 25,113,953 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ETS2
204 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022413104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038443527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038461794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038517939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038581505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038645888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000015882 ⟹ ENSCAFP00000014692

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	31	33,839,010 - 33,860,330 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000072211 ⟹ ENSCAFP00000054495

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	31	33,846,283 - 33,860,330 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845051633 ⟹ ENSCAFP00845040512

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	31	33,158,349 - 33,172,904 (+)	Ensembl

RefSeq Acc Id:

XM_038443527 ⟹ XP_038299455

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	31	33,153,632 - 33,172,908 (+)	NCBI

RefSeq Acc Id:

XM_038461794 ⟹ XP_038317722

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	31	32,915,273 - 32,934,593 (+)	NCBI

RefSeq Acc Id:

XM_038517939 ⟹ XP_038373867

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	31	33,027,715 - 33,046,975 (+)	NCBI

RefSeq Acc Id:

XM_038581505 ⟹ XP_038437433

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	31	33,521,018 - 33,540,235 (+)	NCBI

RefSeq Acc Id:

XM_038645888 ⟹ XP_038501816

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	31	33,032,006 - 33,051,276 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038299455	(Get FASTA)	NCBI Sequence Viewer
	XP_038317722	(Get FASTA)	NCBI Sequence Viewer
	XP_038373867	(Get FASTA)	NCBI Sequence Viewer
	XP_038437433	(Get FASTA)	NCBI Sequence Viewer
	XP_038501816	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000014692.4
	ENSCAFP00030040848.1
	ENSCAFP00040035092.1
	ENSCAFP00845040512
	ENSCAFP00845040512.1

Ensembl Acc Id:

ENSCAFP00000014692 ⟸ ENSCAFT00000015882

Ensembl Acc Id:

ENSCAFP00000054495 ⟸ ENSCAFT00000072211

RefSeq Acc Id:

XP_038373867 ⟸ XM_038517939

RefSeq Acc Id:

XP_038501816 ⟸ XM_038645888

RefSeq Acc Id:	XP_038299455 ⟸ XM_038443527
- UniProtKB:	A0A8C0LNH9 (UniProtKB/TrEMBL), A0A8C0RTI9 (UniProtKB/TrEMBL), A0A8I3Q2W6 (UniProtKB/TrEMBL), A0A8C0TI50 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038317722 ⟸ XM_038461794
- UniProtKB:	A0A8C0LNH9 (UniProtKB/TrEMBL), A0A8C0RTI9 (UniProtKB/TrEMBL), A0A8I3Q2W6 (UniProtKB/TrEMBL), A0A8C0TI50 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038437433 ⟸ XM_038581505
- UniProtKB:	A0A8C0TI50 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845040512 ⟸ ENSCAFT00845051633

Protein Domains

ETS PNT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000009978	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030025296	UniProtKB/TrEMBL
	ENSCAFG00040021675	UniProtKB/TrEMBL
	ENSCAFG00845029168	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000015882.4	UniProtKB/TrEMBL
	ENSCAFT00030046728.1	UniProtKB/TrEMBL
	ENSCAFT00040040210.1	UniProtKB/TrEMBL
	ENSCAFT00845051633	ENTREZGENE
	ENSCAFT00845051633.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	1.10.150.50	UniProtKB/TrEMBL
InterPro	Ets1_N_flank	UniProtKB/TrEMBL
	Ets_dom	UniProtKB/TrEMBL
	ETS_fam	UniProtKB/TrEMBL
	Pointed_dom	UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/TrEMBL
	Transform_prot_C-ets	UniProtKB/TrEMBL
	Transform_prot_C-ets-2	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	ETS2	ENTREZGENE
PANTHER	PROTEIN C-ETS-2	UniProtKB/TrEMBL
	PTHR11849	UniProtKB/TrEMBL
Pfam	Ets	UniProtKB/TrEMBL
	Ets1_N_flank	UniProtKB/TrEMBL
	SAM_PNT	UniProtKB/TrEMBL
PIRSF	C-ets-2	UniProtKB/TrEMBL
	Transforming_factor_C-ets	UniProtKB/TrEMBL
PRINTS	ETSDOMAIN	UniProtKB/TrEMBL
PROSITE	ETS_DOMAIN_1	UniProtKB/TrEMBL
	ETS_DOMAIN_2	UniProtKB/TrEMBL
	ETS_DOMAIN_3	UniProtKB/TrEMBL
	PNT	UniProtKB/TrEMBL
SMART	ETS	UniProtKB/TrEMBL
	SAM_PNT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
	SSF47769	UniProtKB/TrEMBL
UniProt	A0A8C0LNH9	ENTREZGENE
	A0A8C0RTI9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0TI50	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3Q2W6	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:40495	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD