PLPP2 (phospholipid phosphatase 2) - Rat Genome Database

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Gene: PLPP2 (phospholipid phosphatase 2) Canis lupus familiaris
Analyze
Symbol: PLPP2
Name: phospholipid phosphatase 2
RGD ID: 12364932
Description: ENCODES a protein that exhibits ceramide-1-phosphate phosphatase activity (ortholog); phosphatidate phosphatase activity (ortholog); sphingosine-1-phosphate phosphatase activity (ortholog); INVOLVED IN ceramide metabolic process (ortholog); phospholipid dephosphorylation (ortholog); regulation of cell cycle G1/S phase transition (ortholog); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN caveola (ortholog); early endosome (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lipid phosphate phosphohydrolase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12058,083,902 - 58,095,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2058,087,289 - 58,095,421 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,887,253 - 57,898,727 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,827,680 - 58,839,197 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12057,881,535 - 57,893,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,361,438 - 58,372,906 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,564,919 - 58,576,416 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PLPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12058,083,902 - 58,095,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2058,087,289 - 58,095,421 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,887,253 - 57,898,727 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,827,680 - 58,839,197 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12057,881,535 - 57,893,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,361,438 - 58,372,906 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,564,919 - 58,576,416 (+)NCBIUU_Cfam_GSD_1.0
PLPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819281,043 - 291,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19281,040 - 291,403 (-)EnsemblGRCh38hg38GRCh38
GRCh3719281,043 - 291,403 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619232,043 - 242,435 (-)NCBINCBI36Build 36hg18NCBI36
Build 3419232,045 - 242,169NCBI
Celera19520,837 - 531,227 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef1951,652 - 61,794 (-)NCBIHuRef
CHM1_119281,584 - 291,992 (-)NCBICHM1_1
T2T-CHM13v2.019232,088 - 242,448 (-)NCBIT2T-CHM13v2.0
Plpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,362,258 - 79,369,621 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,362,264 - 79,369,630 (-)EnsemblGRCm39 Ensembl
GRCm381079,526,424 - 79,533,787 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,526,430 - 79,533,796 (-)EnsemblGRCm38mm10GRCm38
MGSCv371078,989,174 - 78,996,532 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361078,930,455 - 78,936,897 (-)NCBIMGSCv36mm8
Celera1080,539,736 - 80,547,094 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Plpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,826,534 - 10,834,628 (+)NCBIGRCr8
mRatBN7.2710,175,918 - 10,184,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,175,948 - 10,184,071 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,048,437 - 13,056,468 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,926,524 - 14,934,552 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,788,432 - 12,796,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,062,168 - 13,070,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,062,196 - 13,070,280 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,225,606 - 13,233,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,694,272 - 11,702,348 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,694,271 - 11,702,348 (+)NCBI
Celera78,341,562 - 8,349,386 (+)NCBICelera
Cytogenetic Map7q11NCBI
Plpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,307,079 - 7,310,955 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,307,079 - 7,310,898 (+)NCBIChiLan1.0ChiLan1.0
PLPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,579,604 - 4,590,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,823,191 - 3,833,873 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl19238,770 - 246,004 (-)Ensemblpanpan1.1panPan2
Plpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,814,296 - 217,820,361 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493658814,399 - 20,514 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493658814,422 - 20,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,945,841 - 77,957,313 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,945,760 - 77,957,318 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,284,680 - 79,296,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,326 - 26,759 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl614,945 - 26,703 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660819,082,318 - 9,093,896 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248288,058,329 - 8,062,677 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248288,058,688 - 8,062,679 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLPP2
227 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000031378   ⟹   ENSCAFP00000029206
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2058,087,289 - 58,095,421 (+)Ensembl
RefSeq Acc Id: XM_003639749   ⟹   XP_003639797
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12058,088,226 - 58,095,621 (+)NCBI
Dog10K_Boxer_Tasha2057,891,360 - 57,898,727 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022407336   ⟹   XP_022263044
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12058,083,902 - 58,095,621 (+)NCBI
Dog10K_Boxer_Tasha2057,887,253 - 57,898,727 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038429408   ⟹   XP_038285336
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02058,831,820 - 58,839,197 (+)NCBI
RefSeq Acc Id: XM_038429409   ⟹   XP_038285337
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02058,827,680 - 58,839,197 (+)NCBI
RefSeq Acc Id: XM_038504936   ⟹   XP_038360864
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12057,885,651 - 57,893,021 (+)NCBI
RefSeq Acc Id: XM_038504937   ⟹   XP_038360865
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12057,881,535 - 57,893,021 (+)NCBI
RefSeq Acc Id: XM_038568095   ⟹   XP_038424023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02058,569,041 - 58,576,416 (+)NCBI
RefSeq Acc Id: XM_038568096   ⟹   XP_038424024
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02058,564,919 - 58,576,416 (+)NCBI
RefSeq Acc Id: XM_038632195   ⟹   XP_038488123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02058,365,549 - 58,372,906 (+)NCBI
RefSeq Acc Id: XM_038632196   ⟹   XP_038488124
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02058,361,438 - 58,372,906 (+)NCBI
RefSeq Acc Id: XP_003639797   ⟸   XM_003639749
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KU33 (UniProtKB/TrEMBL),   A0A8P0NKX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022263044   ⟸   XM_022407336
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCAFP00000029206   ⟸   ENSCAFT00000031378
RefSeq Acc Id: XP_038360865   ⟸   XM_038504937
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038360864   ⟸   XM_038504936
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038488124   ⟸   XM_038632196
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038488123   ⟸   XM_038632195
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038285337   ⟸   XM_038429409
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038285336   ⟸   XM_038429408
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KU33 (UniProtKB/TrEMBL),   A0A8P0NKX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038424024   ⟸   XM_038568096
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038424023   ⟸   XM_038568095
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KU33 (UniProtKB/TrEMBL),   A0A8P0NKX2 (UniProtKB/TrEMBL)
Protein Domains
Phosphatidic acid phosphatase type 2/haloperoxidase

Promoters
RGD ID:13687145
Promoter ID:EPDNEW_C5214
Type:initiation region
Name:PLPP2_1
Description:phospholipid phosphatase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12058,088,218 - 58,088,278EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019734 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845015663 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031378.5 UniProtKB/TrEMBL
  ENSCAFT00000095080.1 UniProtKB/TrEMBL
  ENSCAFT00845027928.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/TrEMBL
InterPro P_Acid_Pase_2/haloperoxi_sf UniProtKB/TrEMBL
  P_Acid_Pase_2/haloperoxidase UniProtKB/TrEMBL
  PA_PP_rel UniProtKB/TrEMBL
NCBI Gene PLPP2 ENTREZGENE
PANTHER PTHR10165 UniProtKB/TrEMBL
  PTHR10165:SF25 UniProtKB/TrEMBL
Pfam PAP2 UniProtKB/TrEMBL
SMART acidPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF48317 UniProtKB/TrEMBL
UniProt A0A8C0KU33 ENTREZGENE
  A0A8I3NUP1_CANLF UniProtKB/TrEMBL
  A0A8P0NKX2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PKM4_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44706 ENTREZGENE