MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like) - Rat Genome Database

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Gene: MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like) Canis lupus familiaris
Analyze
Symbol: MTHFD2L
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
RGD ID: 12336584
Description: ENCODES a protein that exhibits methenyltetrahydrofolate cyclohydrolase activity (ortholog); methylenetetrahydrofolate dehydrogenase (NAD+) activity (ortholog); methylenetetrahydrofolate dehydrogenase (NADP+) activity (ortholog); INVOLVED IN 10-formyltetrahydrofolate metabolic process (ortholog); tetrahydrofolate interconversion (ortholog); PARTICIPATES IN folate cycle metabolic pathway; FOUND IN mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,670,543 - 62,803,270 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,670,462 - 62,803,519 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,354,053 - 62,490,793 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,497,174 - 63,632,656 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,496,510 - 63,626,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11363,110,477 - 63,247,437 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,593,854 - 62,729,238 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,734,925 - 63,872,301 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MTHFD2L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,670,543 - 62,803,270 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,670,462 - 62,803,519 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,354,053 - 62,490,793 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,497,174 - 63,632,656 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,496,510 - 63,626,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11363,110,477 - 63,247,437 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,593,854 - 62,729,238 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,734,925 - 63,872,301 (+)NCBIUU_Cfam_GSD_1.0
MTHFD2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,114,560 - 74,303,099 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,114,174 - 74,303,099 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,988,990 - 75,168,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,207,855 - 75,387,680 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,430,545 - 75,533,847NCBI
Celera472,383,935 - 72,529,069 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,834,750 - 70,979,763 (+)NCBIHuRef
CHM1_1475,059,669 - 75,204,651 (+)NCBICHM1_1
T2T-CHM13v2.0477,457,787 - 77,646,724 (+)NCBIT2T-CHM13v2.0
Mthfd2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,078,704 - 91,169,227 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,078,976 - 91,169,227 (+)EnsemblGRCm39 Ensembl
GRCm38590,930,873 - 91,021,368 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,931,117 - 91,021,368 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,360,222 - 91,450,394 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,006,454 - 92,096,568 (+)NCBIMGSCv36mm8
Celera589,066,224 - 89,157,002 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Mthfd2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,374,139 - 17,455,508 (-)NCBIGRCr8
mRatBN7.21417,089,947 - 17,170,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,089,952 - 17,170,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,090,791 - 17,171,009 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,409,714 - 18,489,945 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,101,828 - 17,182,065 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,640,274 - 18,721,298 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,640,277 - 18,720,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,548,222 - 18,629,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,585,147 - 18,665,534 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,585,141 - 18,665,478 (-)NCBI
Celera1416,467,710 - 16,547,256 (-)NCBICelera
Cytogenetic Map14p22NCBI
Mthfd2l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474450,680 - 558,716 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474450,676 - 558,659 (+)NCBIChiLan1.0ChiLan1.0
MTHFD2L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,757,607 - 55,903,608 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1455,946,632 - 56,091,887 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0449,889,607 - 50,034,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,722,237 - 55,901,553 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,722,237 - 55,867,117 (-)Ensemblpanpan1.1panPan2
Mthfd2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528512,944,176 - 13,062,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,401,402 - 1,514,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,401,392 - 1,514,314 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD2L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,179,658 - 70,290,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,179,701 - 70,288,356 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,332,406 - 74,457,356 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD2L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,696,362 - 22,838,955 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,696,309 - 22,838,967 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037977,622 - 1,128,997 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mthfd2l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247301,416,186 - 1,520,509 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247301,416,239 - 1,520,087 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MTHFD2L
2078 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022427095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002632717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005300235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005335306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005335307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005369093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005369094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005403391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005403392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005436821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005436822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000043564   ⟹   ENSCAFP00000037367
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1362,671,605 - 62,797,190 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000076319   ⟹   ENSCAFP00000059857
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1362,670,462 - 62,797,190 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000091151   ⟹   ENSCAFP00000061384
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1362,670,462 - 62,803,519 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845011411   ⟹   ENSCAFP00845008913
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1363,496,510 - 63,626,257 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845011428   ⟹   ENSCAFP00845008926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1363,496,510 - 63,626,257 (+)Ensembl
RefSeq Acc Id: XM_022427095   ⟹   XP_022282803
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,671,620 - 62,803,270 (+)NCBI
Dog10K_Boxer_Tasha1362,355,149 - 62,490,543 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427096   ⟹   XP_022282804
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,671,619 - 62,730,847 (+)NCBI
Dog10K_Boxer_Tasha1362,355,149 - 62,414,422 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427099   ⟹   XP_022282807
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,671,327 - 62,798,369 (+)NCBI
Dog10K_Boxer_Tasha1362,354,856 - 62,485,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427100   ⟹   XP_022282808
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,670,910 - 62,798,369 (+)NCBI
Dog10K_Boxer_Tasha1362,354,427 - 62,485,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427101   ⟹   XP_022282809
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,670,543 - 62,798,369 (+)NCBI
Dog10K_Boxer_Tasha1362,354,053 - 62,485,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427103   ⟹   XP_022282811
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,671,608 - 62,798,369 (+)NCBI
Dog10K_Boxer_Tasha1362,355,134 - 62,485,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427104   ⟹   XP_022282812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,670,586 - 62,798,369 (+)NCBI
Dog10K_Boxer_Tasha1362,354,078 - 62,485,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038432581   ⟹   XP_038288509
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1362,355,149 - 62,485,638 (+)NCBI
RefSeq Acc Id: XM_038432582   ⟹   XP_038288510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1362,355,149 - 62,490,535 (+)NCBI
RefSeq Acc Id: XM_038494028   ⟹   XP_038349956
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,111,537 - 63,242,286 (+)NCBI
RefSeq Acc Id: XM_038494029   ⟹   XP_038349957
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,110,477 - 63,242,286 (+)NCBI
RefSeq Acc Id: XM_038494030   ⟹   XP_038349958
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,125,662 - 63,247,187 (+)NCBI
RefSeq Acc Id: XM_038494032   ⟹   XP_038349960
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,125,662 - 63,170,938 (+)NCBI
RefSeq Acc Id: XM_038494033   ⟹   XP_038349961
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,125,662 - 63,197,084 (+)NCBI
RefSeq Acc Id: XM_038494034   ⟹   XP_038349962
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,125,662 - 63,242,286 (+)NCBI
RefSeq Acc Id: XM_038494035   ⟹   XP_038349963
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,125,662 - 63,247,179 (+)NCBI
RefSeq Acc Id: XM_038556319   ⟹   XP_038412247
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,735,983 - 63,867,142 (+)NCBI
RefSeq Acc Id: XM_038556320   ⟹   XP_038412248
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,734,925 - 63,867,142 (+)NCBI
RefSeq Acc Id: XM_038556321   ⟹   XP_038412249
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,750,107 - 63,872,051 (+)NCBI
RefSeq Acc Id: XM_038556322   ⟹   XP_038412250
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,750,107 - 63,795,745 (+)NCBI
RefSeq Acc Id: XM_038556323   ⟹   XP_038412251
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,750,107 - 63,821,915 (+)NCBI
RefSeq Acc Id: XM_038556324   ⟹   XP_038412252
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,750,107 - 63,867,142 (+)NCBI
RefSeq Acc Id: XM_038556325   ⟹   XP_038412253
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,750,107 - 63,872,043 (+)NCBI
RefSeq Acc Id: XM_038620259   ⟹   XP_038476187
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,594,484 - 62,724,086 (+)NCBI
RefSeq Acc Id: XM_038620260   ⟹   XP_038476188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,594,484 - 62,728,988 (+)NCBI
RefSeq Acc Id: XM_038620261   ⟹   XP_038476189
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,593,854 - 62,654,030 (+)NCBI
RefSeq Acc Id: XM_038620262   ⟹   XP_038476190
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,593,854 - 62,678,664 (+)NCBI
RefSeq Acc Id: XM_038620263   ⟹   XP_038476191
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,594,484 - 62,724,086 (+)NCBI
RefSeq Acc Id: XM_038620264   ⟹   XP_038476192
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,594,484 - 62,728,980 (+)NCBI
RefSeq Acc Id: XM_038685886   ⟹   XP_038541814
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,497,808 - 63,627,484 (+)NCBI
RefSeq Acc Id: XM_038685887   ⟹   XP_038541815
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,497,808 - 63,632,406 (+)NCBI
RefSeq Acc Id: XM_038685888   ⟹   XP_038541816
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,497,174 - 63,557,403 (+)NCBI
RefSeq Acc Id: XM_038685889   ⟹   XP_038541817
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,497,174 - 63,582,231 (+)NCBI
RefSeq Acc Id: XM_038685890   ⟹   XP_038541818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,497,808 - 63,627,484 (+)NCBI
RefSeq Acc Id: XM_038685891   ⟹   XP_038541819
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,497,808 - 63,632,398 (+)NCBI
RefSeq Acc Id: XR_002632717
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11362,671,620 - 62,797,164 (+)NCBI
Dog10K_Boxer_Tasha1362,355,149 - 62,484,433 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005300235
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1362,355,149 - 62,490,793 (+)NCBI
RefSeq Acc Id: XR_005335306
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,125,662 - 63,247,437 (+)NCBI
RefSeq Acc Id: XR_005335307
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11363,125,662 - 63,241,081 (+)NCBI
RefSeq Acc Id: XR_005369093
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,750,107 - 63,872,301 (+)NCBI
RefSeq Acc Id: XR_005369094
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01363,750,107 - 63,865,937 (+)NCBI
RefSeq Acc Id: XR_005403391
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,594,484 - 62,729,238 (+)NCBI
RefSeq Acc Id: XR_005403392
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01362,594,484 - 62,722,880 (+)NCBI
RefSeq Acc Id: XR_005436821
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,497,808 - 63,632,656 (+)NCBI
RefSeq Acc Id: XR_005436822
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01363,497,808 - 63,626,279 (+)NCBI
Protein Sequences
Protein RefSeqs XP_022282803 (Get FASTA)   NCBI Sequence Viewer  
  XP_022282804 (Get FASTA)   NCBI Sequence Viewer  
  XP_022282807 (Get FASTA)   NCBI Sequence Viewer  
  XP_022282808 (Get FASTA)   NCBI Sequence Viewer  
  XP_022282809 (Get FASTA)   NCBI Sequence Viewer  
  XP_022282811 (Get FASTA)   NCBI Sequence Viewer  
  XP_022282812 (Get FASTA)   NCBI Sequence Viewer  
  XP_038288509 (Get FASTA)   NCBI Sequence Viewer  
  XP_038288510 (Get FASTA)   NCBI Sequence Viewer  
  XP_038349956 (Get FASTA)   NCBI Sequence Viewer  
  XP_038349957 (Get FASTA)   NCBI Sequence Viewer  
  XP_038349958 (Get FASTA)   NCBI Sequence Viewer  
  XP_038349960 (Get FASTA)   NCBI Sequence Viewer  
  XP_038349961 (Get FASTA)   NCBI Sequence Viewer  
  XP_038349962 (Get FASTA)   NCBI Sequence Viewer  
  XP_038349963 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412247 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412248 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412249 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412250 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412251 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412252 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412253 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476187 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476188 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476189 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476190 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476191 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476192 (Get FASTA)   NCBI Sequence Viewer  
  XP_038541814 (Get FASTA)   NCBI Sequence Viewer  
  XP_038541815 (Get FASTA)   NCBI Sequence Viewer  
  XP_038541816 (Get FASTA)   NCBI Sequence Viewer  
  XP_038541817 (Get FASTA)   NCBI Sequence Viewer  
  XP_038541818 (Get FASTA)   NCBI Sequence Viewer  
  XP_038541819 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000037367.1
  ENSCAFP00000059857.2
  ENSCAFP00030033414.1
  ENSCAFP00030033461.1
  ENSCAFP00030033530.1
  ENSCAFP00030033582.1
  ENSCAFP00030033624.1
  ENSCAFP00030033664.1
  ENSCAFP00040012801.1
  ENSCAFP00040012877.1
  ENSCAFP00845008913
  ENSCAFP00845008913.1
  ENSCAFP00845008926.1
RefSeq Acc Id: XP_022282809   ⟸   XM_022427101
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P430 (UniProtKB/TrEMBL),   A0A8I3MUW9 (UniProtKB/TrEMBL),   A0A8P0P8W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022282812   ⟸   XM_022427104
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P430 (UniProtKB/TrEMBL),   A0A8I3MUW9 (UniProtKB/TrEMBL),   A0A8P0P8W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022282808   ⟸   XM_022427100
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P430 (UniProtKB/TrEMBL),   A0A8I3MUW9 (UniProtKB/TrEMBL),   A0A8P0P8W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022282807   ⟸   XM_022427099
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P430 (UniProtKB/TrEMBL),   A0A8I3MUW9 (UniProtKB/TrEMBL),   A0A8P0P8W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022282811   ⟸   XM_022427103
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P430 (UniProtKB/TrEMBL),   A0A8I3MUW9 (UniProtKB/TrEMBL),   A0A8P0P8W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022282804   ⟸   XM_022427096
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022282803   ⟸   XM_022427095
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCAFP00000037367   ⟸   ENSCAFT00000043564
Ensembl Acc Id: ENSCAFP00000059857   ⟸   ENSCAFT00000076319
Ensembl Acc Id: ENSCAFP00000061384   ⟸   ENSCAFT00000091151
RefSeq Acc Id: XP_038349957   ⟸   XM_038494029
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038349956   ⟸   XM_038494028
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038349958   ⟸   XM_038494030
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038349963   ⟸   XM_038494035
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038349962   ⟸   XM_038494034
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038349961   ⟸   XM_038494033
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038349960   ⟸   XM_038494032
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038476190   ⟸   XM_038620262
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038476189   ⟸   XM_038620261
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038476188   ⟸   XM_038620260
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038476192   ⟸   XM_038620264
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038476187   ⟸   XM_038620259
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038476191   ⟸   XM_038620263
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038541817   ⟸   XM_038685889
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038541816   ⟸   XM_038685888
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038541815   ⟸   XM_038685887
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038541819   ⟸   XM_038685891
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038541814   ⟸   XM_038685886
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P430 (UniProtKB/TrEMBL),   A0A8I3MUW9 (UniProtKB/TrEMBL),   A0A8P0P8W9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038541818   ⟸   XM_038685890
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038288510   ⟸   XM_038432582
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038288509   ⟸   XM_038432581
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038412248   ⟸   XM_038556320
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P430 (UniProtKB/TrEMBL),   A0A8I3MUW9 (UniProtKB/TrEMBL),   A0A8P0P8W9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412247   ⟸   XM_038556319
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P430 (UniProtKB/TrEMBL),   A0A8I3MUW9 (UniProtKB/TrEMBL),   A0A8P0P8W9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412249   ⟸   XM_038556321
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038412253   ⟸   XM_038556325
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038412252   ⟸   XM_038556324
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038412251   ⟸   XM_038556323
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038412250   ⟸   XM_038556322
- Peptide Label: isoform X3
Ensembl Acc Id: ENSCAFP00845008926   ⟸   ENSCAFT00845011428
Ensembl Acc Id: ENSCAFP00845008913   ⟸   ENSCAFT00845011411
Protein Domains
Tetrahydrofolate dehydrogenase/cyclohydrolase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000028758 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030020866 UniProtKB/TrEMBL
  ENSCAFG00040007934 UniProtKB/TrEMBL
  ENSCAFG00845006423 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000043564.3 UniProtKB/TrEMBL
  ENSCAFT00000076319.2 UniProtKB/TrEMBL
  ENSCAFT00030038307.1 UniProtKB/TrEMBL
  ENSCAFT00030038359.1 UniProtKB/TrEMBL
  ENSCAFT00030038433.1 UniProtKB/TrEMBL
  ENSCAFT00030038491.1 UniProtKB/TrEMBL
  ENSCAFT00030038541.1 UniProtKB/TrEMBL
  ENSCAFT00030038586.1 UniProtKB/TrEMBL
  ENSCAFT00040014797.1 UniProtKB/TrEMBL
  ENSCAFT00040014876.1 UniProtKB/TrEMBL
  ENSCAFT00845011411 ENTREZGENE
  ENSCAFT00845011411.1 UniProtKB/TrEMBL
  ENSCAFT00845011428.1 UniProtKB/TrEMBL
Gene3D-CATH Leucine Dehydrogenase, chain A, domain 1 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  THF_DH/CycHdrlase UniProtKB/TrEMBL
  THF_DH/CycHdrlase_cat_dom UniProtKB/TrEMBL
  THF_DH/CycHdrlase_CS UniProtKB/TrEMBL
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/TrEMBL
NCBI Gene MTHFD2L ENTREZGENE
PANTHER BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE 2-RELATED UniProtKB/TrEMBL
  C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED UniProtKB/TrEMBL
Pfam THF_DHG_CYH UniProtKB/TrEMBL
  THF_DHG_CYH_C UniProtKB/TrEMBL
PRINTS THFDHDRGNASE UniProtKB/TrEMBL
PROSITE THF_DHG_CYH_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF53223 UniProtKB/TrEMBL
UniProt A0A8C0NX65_CANLF UniProtKB/TrEMBL
  A0A8C0P3I4_CANLF UniProtKB/TrEMBL
  A0A8C0P3S3_CANLF UniProtKB/TrEMBL
  A0A8C0P430 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QGK3_CANLF UniProtKB/TrEMBL
  A0A8C0RQ17_CANLF UniProtKB/TrEMBL
  A0A8I3MUW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MUX1_CANLF UniProtKB/TrEMBL
  A0A8P0P8W9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:51777 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 MTHFD2L  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like  Symbol and/or name change 5135510 APPROVED