RAB5B (RAB5B, member RAS oncogene family) - Rat Genome Database

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Gene: RAB5B (RAB5B, member RAS oncogene family) Canis lupus familiaris
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Symbol: RAB5B
Name: RAB5B, member RAS oncogene family
RGD ID: 12314467
Description: ENCODES a protein that exhibits GDP binding (inferred); GTP binding (inferred); GTP-dependent protein binding (inferred); INVOLVED IN endosome organization (ortholog); regulation of endocytosis (ortholog); ASSOCIATED WITH Pulmonary Surfactant Metabolism Dysfunction 1 (ortholog); FOUND IN synaptic vesicle membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ras-related protein Rab-5B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110307,693 - 325,766 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10320,366 - 323,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10369,626 - 387,933 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010314,513 - 332,609 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10314,547 - 332,362 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110292,317 - 310,622 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010535,089 - 553,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010659,367 - 677,675 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
RAB5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110307,693 - 325,766 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10320,366 - 323,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10369,626 - 387,933 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010314,513 - 332,609 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10314,547 - 332,362 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110292,317 - 310,622 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010535,089 - 553,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010659,367 - 677,675 (+)NCBIUU_Cfam_GSD_1.0
RAB5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,973,949 - 55,996,683 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,973,913 - 55,996,683 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,367,733 - 56,390,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,654,129 - 54,674,757 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,654,128 - 54,674,753NCBI
Celera1256,020,546 - 56,041,174 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,406,584 - 53,429,353 (+)NCBIHuRef
CHM1_11256,334,808 - 56,357,578 (+)NCBICHM1_1
T2T-CHM13v2.01255,941,012 - 55,963,746 (+)NCBIT2T-CHM13v2.0
Rab5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,511,980 - 128,532,160 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,513,044 - 128,532,133 (-)EnsemblGRCm39 Ensembl
GRCm3810128,677,170 - 128,696,284 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,677,175 - 128,696,264 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,114,235 - 128,133,324 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,080,826 - 128,099,213 (-)NCBIMGSCv36mm8
Celera10131,069,284 - 131,088,400 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.13NCBI
Rab5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,693,971 - 1,712,936 (-)NCBIGRCr8
mRatBN7.271,109,449 - 1,128,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,109,454 - 1,128,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,872,624 - 3,891,374 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,748,296 - 5,767,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,045,368 - 6,063,861 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,104,530 - 3,123,384 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,104,551 - 3,123,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,077,228 - 3,096,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,979,776 - 1,998,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,980,577 - 1,998,878 (-)NCBI
Celera7979,663 - 998,427 (-)NCBICelera
Cytogenetic Map7q11NCBI
Rab5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,576,247 - 3,580,192 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,563,363 - 3,582,620 (+)NCBIChiLan1.0ChiLan1.0
RAB5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,334,994 - 38,355,711 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,329,770 - 38,352,483 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,916,314 - 32,939,047 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,168,248 - 33,188,865 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,168,254 - 33,188,676 (-)Ensemblpanpan1.1panPan2
Rab5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,461,972 - 58,483,266 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646386,833 - 410,192 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646386,958 - 408,265 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,387,250 - 21,389,745 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,373,333 - 21,392,729 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAB5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,912,417 - 51,933,862 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1151,926,016 - 51,931,356 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037194,051,372 - 194,074,986 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480212,059,503 - 12,066,296 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480212,058,916 - 12,065,177 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RAB5B
142 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000000142   ⟹   ENSCAFP00000000123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10320,366 - 323,538 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000087717   ⟹   ENSCAFP00000065532
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10320,366 - 323,844 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845010569   ⟹   ENSCAFP00845008229
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10314,547 - 332,362 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845010583   ⟹   ENSCAFP00845008241
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10314,575 - 332,361 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845010588   ⟹   ENSCAFP00845008246
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10314,575 - 332,361 (+)Ensembl
RefSeq Acc Id: XM_038487731   ⟹   XP_038343659
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110292,317 - 310,622 (+)NCBI
RefSeq Acc Id: XM_038549619   ⟹   XP_038405547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010659,367 - 677,675 (+)NCBI
RefSeq Acc Id: XM_038613590   ⟹   XP_038469518
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010535,089 - 553,175 (+)NCBI
RefSeq Acc Id: XM_038678954   ⟹   XP_038534882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010314,513 - 332,609 (+)NCBI
RefSeq Acc Id: XM_531627   ⟹   XP_531627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110307,693 - 325,766 (+)NCBI
Dog10K_Boxer_Tasha10369,626 - 387,933 (+)NCBI
Sequence:
RefSeq Acc Id: XP_531627   ⟸   XM_531627
- UniProtKB: A0A8C0LQ91 (UniProtKB/TrEMBL),   A0A8C0Q6S0 (UniProtKB/TrEMBL),   A0A8I3RUF7 (UniProtKB/TrEMBL),   A0A8I3RUF5 (UniProtKB/TrEMBL),   A0A8P0PHU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000065532   ⟸   ENSCAFT00000087717
Ensembl Acc Id: ENSCAFP00000000123   ⟸   ENSCAFT00000000142
RefSeq Acc Id: XP_038343659   ⟸   XM_038487731
RefSeq Acc Id: XP_038469518   ⟸   XM_038613590
RefSeq Acc Id: XP_038534882   ⟸   XM_038678954
- UniProtKB: A0A8C0LQ91 (UniProtKB/TrEMBL),   A0A8C0Q6S0 (UniProtKB/TrEMBL),   A0A8I3RUF7 (UniProtKB/TrEMBL),   A0A8I3RUF5 (UniProtKB/TrEMBL),   A0A8P0PHU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405547   ⟸   XM_038549619
- UniProtKB: A0A8C0LQ91 (UniProtKB/TrEMBL),   A0A8C0Q6S0 (UniProtKB/TrEMBL),   A0A8I3RUF5 (UniProtKB/TrEMBL),   A0A8I3RUF7 (UniProtKB/TrEMBL),   A0A8P0PHU0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845008229   ⟸   ENSCAFT00845010569
Ensembl Acc Id: ENSCAFP00845008241   ⟸   ENSCAFT00845010583
Ensembl Acc Id: ENSCAFP00845008246   ⟸   ENSCAFT00845010588

Promoters
RGD ID:13684864
Promoter ID:EPDNEW_C2931
Type:multiple initiation site
Name:RAB5B_1
Description:RAB5B, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110320,330 - 320,390EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000087 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015996 UniProtKB/TrEMBL
  ENSCAFG00040003968 UniProtKB/TrEMBL
  ENSCAFG00845005969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000142.5 UniProtKB/TrEMBL
  ENSCAFT00000087717.2 UniProtKB/TrEMBL
  ENSCAFT00000095257.1 UniProtKB/TrEMBL
  ENSCAFT00030029502.1 UniProtKB/TrEMBL
  ENSCAFT00030029540.1 UniProtKB/TrEMBL
  ENSCAFT00040007572.1 UniProtKB/TrEMBL
  ENSCAFT00040007582.1 UniProtKB/TrEMBL
  ENSCAFT00845010569.1 UniProtKB/TrEMBL
  ENSCAFT00845010583 ENTREZGENE
  ENSCAFT00845010583.1 UniProtKB/TrEMBL
  ENSCAFT00845010588.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report cfa:474394 UniProtKB/TrEMBL
NCBI Gene RAB5B ENTREZGENE
PANTHER PTHR47978 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0LQ91 ENTREZGENE
  A0A8C0Q6S0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QC84_CANLF UniProtKB/TrEMBL
  A0A8I3MVT3_CANLF UniProtKB/TrEMBL
  A0A8I3RUF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RUF7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PHU0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45292 ENTREZGENE