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Gene: VPS4A (vacuolar protein sorting 4 homolog A) Canis lupus familiaris

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Symbol:

VPS4A

Name:

vacuolar protein sorting 4 homolog A

RGD ID:

12298834

Description:

ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN endosome organization (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); Chromosome 16q12 Duplication Syndrome (ortholog); CIMDAG SYNDROME (ortholog); FOUND IN early endosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC111096052; uncharacterized LOC111096052; vacuolar protein sorting-associated protein 4A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	80,327,059 - 80,340,380 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	80,311,739 - 80,330,670 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	80,755,360 - 80,774,301 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	80,759,718 - 80,774,322 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	80,582,504 - 80,601,442 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	80,265,344 - 80,284,280 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	80,904,921 - 80,923,853 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

Chromosome 16q12 Duplication Syndrome (ISO)

CIMDAG SYNDROME (ISO)

congenital dyserythropoietic anemia (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

endosomal transport (IBA,IEA)

endosomal vesicle fusion (IEA)

endosome organization (IEA,ISO)

intracellular cholesterol transport (IEA)

late endosomal microautophagy (IEA)

midbody abscission (IEA)

mitotic cytokinesis checkpoint signaling (IEA)

mitotic metaphase chromosome alignment (IEA)

multivesicular body assembly (IEA)

negative regulation of cytokinesis (IEA)

nucleus organization (IEA)

positive regulation of exosomal secretion (IEA)

positive regulation of viral budding via host ESCRT complex (IEA)

protein targeting to lysosome (IEA)

regulation of protein localization (IEA)

regulation of protein localization to plasma membrane (IEA)

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IEA)

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway (IEA)

vacuole organization (IBA)

vesicle budding from membrane (IEA)

vesicle uncoating (IEA)

vesicle-mediated transport (IEA)

viral budding from plasma membrane (IEA)

viral budding via host ESCRT complex (IEA)

viral release from host cell (IEA)

Cellular Component

centrosome (IEA)

cytoplasm (IEA)

cytosol (IEA)

early endosome (IEA,ISO)

endosome (IEA)

endosome membrane (IEA)

Flemming body (IEA)

late endosome (IEA)

late endosome membrane (IEA)

lysosome (IEA)

midbody (IEA)

nucleus (IEA)

perinuclear region of cytoplasm (IEA)

plasma membrane (IEA)

spindle pole (IEA)

vacuolar membrane (IEA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IBA,IEA)

protein binding (ISO)

protein-containing complex binding (IEA)

small GTPase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

VPS4A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	80,327,059 - 80,340,380 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	80,311,739 - 80,330,670 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	80,755,360 - 80,774,301 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	80,759,718 - 80,774,322 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	80,582,504 - 80,601,442 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	80,265,344 - 80,284,280 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	80,904,921 - 80,923,853 (-)	NCBI		UU_Cfam_GSD_1.0

VPS4A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	69,311,350 - 69,326,939 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	69,311,336 - 69,326,939 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	69,345,253 - 69,360,842 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	67,902,788 - 67,916,447 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	67,902,787 - 67,916,446	NCBI
Celera	16	53,859,828 - 53,873,486 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	55,223,517 - 55,237,174 (+)	NCBI		HuRef
CHM1_1	16	70,753,291 - 70,766,948 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	75,113,104 - 75,128,634 (+)	NCBI		T2T-CHM13v2.0

Vps4a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	107,757,901 - 107,772,392 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	107,757,854 - 107,772,387 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	107,031,269 - 107,045,760 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	107,031,222 - 107,045,755 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	109,555,226 - 109,569,656 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	109,920,455 - 109,934,885 (+)	NCBI		MGSCv36	mm8
Celera	8	111,257,885 - 111,272,306 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.53	NCBI

Vps4a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	51,838,411 - 51,858,639 (+)	NCBI		GRCr8
mRatBN7.2	19	34,934,999 - 34,948,888 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	34,934,961 - 34,948,887 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	41,750,699 - 41,763,746 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	42,404,046 - 42,417,093 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	44,703,279 - 44,716,379 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	39,230,050 - 39,243,298 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	39,229,754 - 39,243,496 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	50,093,663 - 50,106,670 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	36,887,345 - 36,900,864 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	36,892,225 - 36,905,745 (+)	NCBI
Celera	19	34,358,772 - 34,371,812 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Vps4a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	7,368,938 - 7,375,969 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	7,368,938 - 7,375,964 (-)	NCBI	ChiLan1.0	ChiLan1.0

VPS4A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	78,845,740 - 78,869,672 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	84,767,388 - 84,781,302 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	49,685,827 - 49,699,542 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	68,946,466 - 69,085,714 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	69,074,091 - 69,085,714 (+)	Ensembl	panpan1.1		panPan2

Vps4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	40,144,891 - 40,156,804 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	19,432,229 - 19,444,223 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	19,432,311 - 19,444,223 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VPS4A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	17,654,638 - 17,669,841 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	17,657,792 - 17,669,560 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	16,604,522 - 16,616,293 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VPS4A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	58,081,800 - 58,095,115 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	58,082,521 - 58,095,173 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	20,811,652 - 20,825,117 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vps4a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	17,047,519 - 17,054,738 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	17,044,173 - 17,059,295 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in VPS4A
117 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005620772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014114051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038477283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038477284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038538486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038538487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038602603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038602604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038667209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038667210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_536805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005326331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005354922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005360206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005394719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005427839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00845017269 ⟹ ENSCAFP00845013459

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	5	80,759,718 - 80,774,322 (-)	Ensembl

RefSeq Acc Id:

XM_005620772 ⟹ XP_005620829

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	80,328,532 - 80,340,380 (-)	NCBI
Dog10K_Boxer_Tasha	5	80,318,841 - 80,330,666 (-)	NCBI

Sequence:

show sequence

GCTCGCCCTGCGACTCGGCTCCGGCTGCGAGCGGACGCCCTGCCCGCGCCCAGCGCCCACCGCC
GGGCTCCGCGCCCCCGACCCAGCCGCTCGGCTCCCCGGGGCCGGACCGAGGCCGCAAGCAGCGC
CGCGGGGTGTGGGGCCGACCCAGGAGATGAAATGACAACGTCAACCCTCCAGAAAGCCATTGAT
CTGGTGACAAAAGCCACAGAAGAGGATAAAGCCAAGAATTACGAGGAGGCACTCCGGCTCTACC
AGCATGCCGTGGAGTATTTCCTACACGCTATCAAATATGAGGCACACAGCGACAAGGCCAAGGA
GAGCATTCGAGCCAAGTGCATGCAGTACCTAGATCGGGCCGAGAAGCTGAAGGATTATTTACGA
AACAAAGAGAAGCATGGCAAGAAGCCAGTGAAAGAAAATCAGAGTGAGAGCAAGGGTGATAGTG
ACAGTGAAGGGGACAACCCAGAGAAAAAGAAATTGCAAGAACAACTGATGGGTGCTGTTGTGAT
AGAGAAGCCCAACATTCGGTGGAATGATGTGGCTGGGCTGGAGGGGGCCAAGGAAGCCCTCAAA
GAAGCTGTCATTTTGCCAATTAAATTCCCACACTTGTTCACAGGCAAGCGTACGCCTTGGCGAG
GGATACTGCTCTTCGGACCCCCTGGCACAGGGAAATCCTACCTGGCCAAAGCAGTGGCCACGGA
GGCCAACAACTCCACCTTCTTCTCTGTGTCCTCCTCGGACCTGATGTCTAAGTGGTTGGGGGAG
AGTGAGAAGCTAGTCAAGAACCTGTTTGAGCTGGCCAGGCAGCACAAGCCCTCCATCATCTTCA
TCGATGAGGTGGATTCCCTCTGCGGGTCCCGCAATGAAAATGAGAGTGAGGCCGCCCGAAGGAT
CAAAACGGAGTTCTTGGTTCAGATGCAGGGGGTGGGGAATAACAACGATGGGACTCTGGTTCTT
GGTGCCACAAACATCCCATGGGTGTTGGATTCAGCCATTAGAAGGAGGTTTGAAAAGAGGATTT
ACATCCCACTGCCCGAGGAGGCTGCCCGTGCCCAGATGTTCCGGTTGCATCTGGGGAGCACTCC
CCACAATCTCACGGATGCCAACATCCATGAGCTGGCCCGGAAGACGGAAGGCTACTCAGGTGCC
GACATCAGCATCATTGTGCGGGACTCCCTCATGCAGCCTGTCAGAAAAGTTCAGTCAGCAACAC
ACTTCAAAAAGGTCTGTGGCCCTTCCCGCACCAACCCTAGCGTTATGATCGATGACCTCCTGAC
CCCATGCTCACCAGGGGACCCGGGGGCCATGGAGATGACTTGGATGGATGTCCCCGGTGACAAA
CTCCTAGAGCCTGTGGTTTGCATGTCGGACATGCTCCGGTCTCTGGCCACCACTCGGCCCACCG
TGAATGCAGATGACCTCTTGAAAGTGAAGAAATTCTCAGAGGACTTTGGACAGGAGAGTTAAAA
ATTTCTTCACTTGGTGATGGTGAAGGTGGGAGGTAGATTGGGGTAATAAATCCACGGCACTCCC
CAGGTCAGTGGCCAGACAGGGCACTGGGGCTCATCTTAACGTCACTACAGCGTCCCCTCTGCTG
TCTGGCCGCCAGCCGGGGAGCATAAAAGAAGGGCCTCCCTGGCCACAAAGACACAGAAGCACAT
TCGGCACTGGGTGGAATACTGGTTCTTCCTACTTCCTCCTCCTCCTCCTCCTCTTCTGGATGCT
CACCAACTCCTTGTCCTGCCCCTGTTTTTTGTTTTGTTTTTTAAACCTTTCTTTGTTCCCCTAA
ATTAATGCTGCTTGGATTTTTGTCTTGTTTATAAATAAAATTAAAATCTCCCAGAAGCATCAAG
GAGTAGGAGCAGCCCGCACTGTGGGGTTGTTGCCGACCTTCAGAACGGCTTGCCAGGCCCATCC
ACCTGTTCCTTCTAACCCGGGTTTTACTCTTTGTGAACACTATGACTGACGCCCTGGGTCGCCA
GCCCAAGCCCTGCCTGTAAAGGCCAAGAGTAAAACCAAGCTATTCCCAACCTCCCAGGTCAGCA
TCCTGGGCTCTGTGTCCTCCCTGCGAGAGGAAAGATGGGTTTTGTGAGCACAGAGCTGTGGAGA
TCAGAATGAGTGAAGGCAGTCAGGTGGGTTTCACTGCTGCCTTTTCTTCCCTCTGAATGTGAGA
ACACCGAACCCCGCCACTGCTCCTGGCTCTCTGCCCTGGAAATGGGCTAATAAATCCTTTTCCC
TCTTGA

hide sequence

RefSeq Acc Id:

XM_038477283 ⟹ XP_038333211

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	80,589,602 - 80,601,442 (-)	NCBI

RefSeq Acc Id:

XM_038477284 ⟹ XP_038333212

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	80,589,602 - 80,601,438 (-)	NCBI

RefSeq Acc Id:

XM_038538486 ⟹ XP_038394414

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	80,912,023 - 80,923,853 (-)	NCBI

RefSeq Acc Id:

XM_038538487 ⟹ XP_038394415

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	80,912,023 - 80,923,849 (-)	NCBI

RefSeq Acc Id:

XM_038602603 ⟹ XP_038458531

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	80,272,442 - 80,284,280 (-)	NCBI

RefSeq Acc Id:

XM_038602604 ⟹ XP_038458532

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	80,272,442 - 80,284,276 (-)	NCBI

RefSeq Acc Id:

XM_038667209 ⟹ XP_038523137

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	80,762,461 - 80,774,301 (-)	NCBI

RefSeq Acc Id:

XM_038667210 ⟹ XP_038523138

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	80,762,461 - 80,774,297 (-)	NCBI

RefSeq Acc Id:

XM_536805 ⟹ XP_536805

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	80,328,532 - 80,340,379 (-)	NCBI
Dog10K_Boxer_Tasha	5	80,318,841 - 80,330,670 (-)	NCBI

Sequence:

show sequence

CTCGCCCTGCGACTCGGCTCCGGCTGCGAGCGGACGCCCTGCCCGCGCCCAGCGCCCACCGCCG
GGCTCCGCGCCCCCGACCCAGCCGCTCGGCTCCCCGGGGCCGGACCGAGGCCGCAAGCAGCGCC
GCGGGGTGTGGGGCCGACCCAGGAGATGAAATGACAACGTCAACCCTCCAGAAAGCCATTGATC
TGGTGACAAAAGCCACAGAAGAGGATAAAGCCAAGAATTACGAGGAGGCACTCCGGCTCTACCA
GCATGCCGTGGAGTATTTCCTACACGCTATCAAATATGAGGCACACAGCGACAAGGCCAAGGAG
AGCATTCGAGCCAAGTGCATGCAGTACCTAGATCGGGCCGAGAAGCTGAAGGATTATTTACGAA
ACAAAGAGAAGCATGGCAAGAAGCCAGTGAAAGAAAATCAGAGTGAGAGCAAGGGCAGTGATAG
TGACAGTGAAGGGGACAACCCAGAGAAAAAGAAATTGCAAGAACAACTGATGGGTGCTGTTGTG
ATAGAGAAGCCCAACATTCGGTGGAATGATGTGGCTGGGCTGGAGGGGGCCAAGGAAGCCCTCA
AAGAAGCTGTCATTTTGCCAATTAAATTCCCACACTTGTTCACAGGCAAGCGTACGCCTTGGCG
AGGGATACTGCTCTTCGGACCCCCTGGCACAGGGAAATCCTACCTGGCCAAAGCAGTGGCCACG
GAGGCCAACAACTCCACCTTCTTCTCTGTGTCCTCCTCGGACCTGATGTCTAAGTGGTTGGGGG
AGAGTGAGAAGCTAGTCAAGAACCTGTTTGAGCTGGCCAGGCAGCACAAGCCCTCCATCATCTT
CATCGATGAGGTGGATTCCCTCTGCGGGTCCCGCAATGAAAATGAGAGTGAGGCCGCCCGAAGG
ATCAAAACGGAGTTCTTGGTTCAGATGCAGGGGGTGGGGAATAACAACGATGGGACTCTGGTTC
TTGGTGCCACAAACATCCCATGGGTGTTGGATTCAGCCATTAGAAGGAGGTTTGAAAAGAGGAT
TTACATCCCACTGCCCGAGGAGGCTGCCCGTGCCCAGATGTTCCGGTTGCATCTGGGGAGCACT
CCCCACAATCTCACGGATGCCAACATCCATGAGCTGGCCCGGAAGACGGAAGGCTACTCAGGTG
CCGACATCAGCATCATTGTGCGGGACTCCCTCATGCAGCCTGTCAGAAAAGTTCAGTCAGCAAC
ACACTTCAAAAAGGTCTGTGGCCCTTCCCGCACCAACCCTAGCGTTATGATCGATGACCTCCTG
ACCCCATGCTCACCAGGGGACCCGGGGGCCATGGAGATGACTTGGATGGATGTCCCCGGTGACA
AACTCCTAGAGCCTGTGGTTTGCATGTCGGACATGCTCCGGTCTCTGGCCACCACTCGGCCCAC
CGTGAATGCAGATGACCTCTTGAAAGTGAAGAAATTCTCAGAGGACTTTGGACAGGAGAGTTAA
AAATTTCTTCACTTGGTGATGGTGAAGGTGGGAGGTAGATTGGGGTAATAAATCCACGGCACTC
CCCAGGTCAGTGGCCAGACAGGGCACTGGGGCTCATCTTAACGTCACTACAGCGTCCCCTCTGC
TGTCTGGCCGCCAGCCGGGGAGCATAAAAGAAGGGCCTCCCTGGCCACAAAGACACAGAAGCAC
ATTCGGCACTGGGTGGAATACTGGTTCTTCCTACTTCCTCCTCCTCCTCCTCCTCTTCTGGATG
CTCACCAACTCCTTGTCCTGCCCCTGTTTTTTGTTTTGTTTTTTAAACCTTTCTTTGTTCCCCT
AAATTAATGCTGCTTGGATTTTTGTCTTGTTTATAAATAAAATTAAAATCTCCCAGAAGCATCA
AGGAGTAGGAGCAGCCCGCACTGTGGGGTTGTTGCCGACCTTCAGAACGGCTTGCCAGGCCCAT
CCACCTGTTCCTTCTAACCCGGGTTTTACTCTTTGTGAACACTATGACTGACGCCCTGGGTCGC
CAGCCCAAGCCCTGCCTGTAAAGGCCAAGAGTAAAACCAAGCTATTCCCAACCTCCCAGGTCAG
CATCCTGGGCTCTGTGTCCTCCCTGCGAGAGGAAAGATGGGTTTTGTGAGCACAGAGCTGTGGA
GATCAGAATGAGTGAAGGCAGTCAGGTGGGTTTCACTGCTGCCTTTTCTTCCCTCTGAATGTGA
GAACACCGAACCCCGCCACTGCTCCTGGCTCTCTGCCCTGGAAATGGGCTAATAAATCCTTTTC
CCTCTTGA

hide sequence

RefSeq Acc Id:

XR_005326331

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	80,582,504 - 80,601,442 (-)	NCBI

RefSeq Acc Id:

XR_005354922

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	5	80,311,739 - 80,330,670 (-)	NCBI

RefSeq Acc Id:

XR_005360206

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	80,904,921 - 80,923,853 (-)	NCBI

RefSeq Acc Id:

XR_005394719

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	80,265,344 - 80,284,280 (-)	NCBI

RefSeq Acc Id:

XR_005427839

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	80,755,360 - 80,774,301 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005620829	(Get FASTA)	NCBI Sequence Viewer
	XP_038333211	(Get FASTA)	NCBI Sequence Viewer
	XP_038333212	(Get FASTA)	NCBI Sequence Viewer
	XP_038394414	(Get FASTA)	NCBI Sequence Viewer
	XP_038394415	(Get FASTA)	NCBI Sequence Viewer
	XP_038458531	(Get FASTA)	NCBI Sequence Viewer
	XP_038458532	(Get FASTA)	NCBI Sequence Viewer
	XP_038523137	(Get FASTA)	NCBI Sequence Viewer
	XP_038523138	(Get FASTA)	NCBI Sequence Viewer
	XP_536805	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000063882.1
	ENSCAFP00030021250.1
	ENSCAFP00030021311.1
	ENSCAFP00040015281.1
	ENSCAFP00040015374.1
	ENSCAFP00845013459
	ENSCAFP00845013459.1

RefSeq Acc Id:	XP_005620829 ⟸ XM_005620772
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0N9D2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYL DRAEKLKDYLRNKEKHGKKPVKENQSESKGDSDSEGDNPEKKKLQEQLMGAVVIEKPNIRWNDV AGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVS SSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQG VGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHE LARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAM EMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES hide sequence

RefSeq Acc Id:	XP_536805 ⟸ XM_536805
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0S3G1 (UniProtKB/TrEMBL), A0A8I3N2G3 (UniProtKB/TrEMBL), A0A8C0N9D2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYL DRAEKLKDYLRNKEKHGKKPVKENQSESKGSDSDSEGDNPEKKKLQEQLMGAVVIEKPNIRWND VAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSV SSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQ GVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIH ELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGA MEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES hide sequence

RefSeq Acc Id:	XP_038333211 ⟸ XM_038477283
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038333212 ⟸ XM_038477284
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038458531 ⟸ XM_038602603
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038458532 ⟸ XM_038602604
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038523137 ⟸ XM_038667209
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0S3G1 (UniProtKB/TrEMBL), A0A8I3N2G3 (UniProtKB/TrEMBL), A0A8C0N9D2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038523138 ⟸ XM_038667210
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0N9D2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038394414 ⟸ XM_038538486
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0N9D2 (UniProtKB/TrEMBL), A0A8C0S3G1 (UniProtKB/TrEMBL), A0A8I3N2G3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038394415 ⟸ XM_038538487
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0N9D2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845013459 ⟸ ENSCAFT00845017269

Protein Domains

AAA+ ATPase MIT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000020283	UniProtKB/TrEMBL
	ENSCAFG00030013161	UniProtKB/TrEMBL
	ENSCAFG00040009480	UniProtKB/TrEMBL
	ENSCAFG00845009805	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000084337.2	UniProtKB/TrEMBL
	ENSCAFT00030024354.1	UniProtKB/TrEMBL
	ENSCAFT00030024420.1	UniProtKB/TrEMBL
	ENSCAFT00040017612.1	UniProtKB/TrEMBL
	ENSCAFT00040017713.1	UniProtKB/TrEMBL
	ENSCAFT00845017269	ENTREZGENE
	ENSCAFT00845017269.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	Phosphotransferase system, lactose/cellobiose-type IIA subunit	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/TrEMBL
	ATPase_AAA_CS	UniProtKB/TrEMBL
	MIT_dom	UniProtKB/TrEMBL
	MIT_dom_sf	UniProtKB/TrEMBL
	MT-severing_AAA_ATPase	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Vps4_C	UniProtKB/TrEMBL
	VPS4_MIT	UniProtKB/TrEMBL
NCBI Gene	VPS4A	ENTREZGENE
PANTHER	AAA DOMAIN-CONTAINING	UniProtKB/TrEMBL
	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A	UniProtKB/TrEMBL
Pfam	AAA	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
	MIT	UniProtKB/TrEMBL
	Vps4_C	UniProtKB/TrEMBL
PROSITE	AAA	UniProtKB/TrEMBL
SMART	AAA	UniProtKB/TrEMBL
	MIT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF116846	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8C0N9D2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0S3E9_CANLF	UniProtKB/TrEMBL
	A0A8C0S3G1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3N2G3	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:110108	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-01-14	VPS4A	vacuolar protein sorting 4 homolog A	LOC111096052	uncharacterized LOC111096052	Data merged from RGD:13222361	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations