IRGQ (immunity related GTPase Q) - Rat Genome Database

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Gene: IRGQ (immunity related GTPase Q) Canis lupus familiaris
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Symbol: IRGQ
Name: immunity related GTPase Q
RGD ID: 12258425
Description: ENCODES a protein that exhibits GTP binding (ortholog); GTPase activity (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN positive regulation of autophagy (ortholog); protein quality control for misfolded or incompletely synthesized proteins (ortholog); substrate localization to autophagosome (ortholog); ASSOCIATED WITH ethylmalonic encephalopathy (ortholog); prostate cancer (ortholog); schizophrenia (ortholog); FOUND IN autophagosome (ortholog); lysosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: immunity-related GTPase family Q protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,532,975 - 111,540,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,532,317 - 111,537,042 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,012,412 - 111,020,311 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,142,811 - 112,150,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,143,862 - 112,149,648 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,730,931 - 111,738,826 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,364,761 - 111,372,662 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,249,011 - 112,256,913 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
autophagosome  (ISO)
lysosome  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
IRGQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,532,975 - 111,540,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,532,317 - 111,537,042 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,012,412 - 111,020,311 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,142,811 - 112,150,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,143,862 - 112,149,648 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,730,931 - 111,738,826 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,364,761 - 111,372,662 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,249,011 - 112,256,913 (+)NCBIUU_Cfam_GSD_1.0
IRGQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381943,584,367 - 43,596,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1943,584,367 - 43,596,134 (-)EnsemblGRCh38hg38GRCh38
GRCh371944,088,519 - 44,100,286 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,787,866 - 48,791,516 (-)NCBINCBI36Build 36hg18NCBI36
Celera1940,890,998 - 40,902,768 (-)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1940,519,278 - 40,531,046 (-)NCBIHuRef
CHM1_11944,090,267 - 44,102,035 (-)NCBICHM1_1
T2T-CHM13v2.01946,406,008 - 46,417,777 (-)NCBIT2T-CHM13v2.0
Irgq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,230,073 - 24,238,025 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,230,114 - 24,238,025 (+)EnsemblGRCm39 Ensembl
GRCm38724,530,648 - 24,538,600 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,530,689 - 24,538,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,315,667 - 25,323,619 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,239,449 - 24,247,360 (+)NCBIMGSCv36mm8
Celera719,144,746 - 19,152,698 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map711.32NCBI
Irgq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,251,846 - 89,259,799 (+)NCBIGRCr8
mRatBN7.2180,123,925 - 80,131,881 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,123,925 - 80,131,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,517,541 - 85,525,491 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,067,378 - 94,075,331 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,273,366 - 87,281,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,395,922 - 81,403,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,395,841 - 81,399,672 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0182,656,242 - 82,664,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,816,826 - 79,824,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,893,608 - 79,902,886 (+)NCBI
Celera174,576,973 - 74,584,923 (+)NCBICelera
Cytogenetic Map1q21NCBI
Irgq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,329,812 - 1,334,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,328,187 - 1,335,018 (-)NCBIChiLan1.0ChiLan1.0
IRGQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22049,744,895 - 49,755,300 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11951,613,857 - 51,624,292 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01940,533,711 - 40,538,157 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11949,141,775 - 49,146,061 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1949,141,775 - 49,146,061 (-)Ensemblpanpan1.1panPan2
Irgq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,443,535 - 16,451,766 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706790,963 - 798,969 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706790,878 - 799,100 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRGQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl650,433,862 - 50,445,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,433,858 - 50,442,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,188,729 - 46,206,689 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRGQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1637,111,782 - 37,116,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl637,112,015 - 37,115,322 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607316,654,203 - 16,658,672 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irgq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,125,465 - 1,129,088 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,121,208 - 1,129,714 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IRGQ
70 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000048661   ⟹   ENSCAFP00000040197
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1111,532,317 - 111,537,042 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000083047   ⟹   ENSCAFP00000061936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1111,532,317 - 111,537,042 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845000168   ⟹   ENSCAFP00845000130
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1112,143,862 - 112,149,648 (+)Ensembl
RefSeq Acc Id: XM_005616493   ⟹   XP_005616550
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11111,533,274 - 111,540,585 (+)NCBI
Dog10K_Boxer_Tasha1111,013,006 - 111,020,311 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038467961   ⟹   XP_038323889
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11111,730,931 - 111,738,826 (+)NCBI
RefSeq Acc Id: XM_038467962   ⟹   XP_038323890
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11111,731,525 - 111,738,826 (+)NCBI
RefSeq Acc Id: XM_038528690   ⟹   XP_038384618
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01112,249,011 - 112,256,913 (+)NCBI
RefSeq Acc Id: XM_038528692   ⟹   XP_038384620
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01112,249,608 - 112,256,913 (+)NCBI
RefSeq Acc Id: XM_038592970   ⟹   XP_038448898
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01111,364,761 - 111,372,662 (+)NCBI
RefSeq Acc Id: XM_038592971   ⟹   XP_038448899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01111,365,355 - 111,372,662 (+)NCBI
RefSeq Acc Id: XM_038656778   ⟹   XP_038512706
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01112,142,811 - 112,150,712 (+)NCBI
RefSeq Acc Id: XM_038656779   ⟹   XP_038512707
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01112,143,405 - 112,150,712 (+)NCBI
RefSeq Acc Id: XM_850144   ⟹   XP_855237
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11111,532,975 - 111,540,585 (+)NCBI
Dog10K_Boxer_Tasha1111,012,412 - 111,020,311 (+)NCBI
Sequence:
RefSeq Acc Id: XP_855237   ⟸   XM_850144
- UniProtKB: A0A8C0SIP4 (UniProtKB/TrEMBL),   A0A8I3M9Y7 (UniProtKB/TrEMBL),   A0A8C0SIR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005616550   ⟸   XM_005616493
- UniProtKB: A0A8C0SIP4 (UniProtKB/TrEMBL),   A0A8I3M9Y7 (UniProtKB/TrEMBL),   A0A8C0SIR3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000061936   ⟸   ENSCAFT00000083047
Ensembl Acc Id: ENSCAFP00000040197   ⟸   ENSCAFT00000048661
RefSeq Acc Id: XP_038323889   ⟸   XM_038467961
RefSeq Acc Id: XP_038323890   ⟸   XM_038467962
RefSeq Acc Id: XP_038448898   ⟸   XM_038592970
RefSeq Acc Id: XP_038448899   ⟸   XM_038592971
RefSeq Acc Id: XP_038512706   ⟸   XM_038656778
- UniProtKB: A0A8C0SIP4 (UniProtKB/TrEMBL),   A0A8I3M9Y7 (UniProtKB/TrEMBL),   A0A8C0SIR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038512707   ⟸   XM_038656779
- UniProtKB: A0A8C0SIP4 (UniProtKB/TrEMBL),   A0A8I3M9Y7 (UniProtKB/TrEMBL),   A0A8C0SIR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384618   ⟸   XM_038528690
- UniProtKB: A0A8C0SIP4 (UniProtKB/TrEMBL),   A0A8C0SIR3 (UniProtKB/TrEMBL),   A0A8I3M9Y7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384620   ⟸   XM_038528692
- UniProtKB: A0A8C0SIP4 (UniProtKB/TrEMBL),   A0A8C0SIR3 (UniProtKB/TrEMBL),   A0A8I3M9Y7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845000130   ⟸   ENSCAFT00845000168
Protein Domains
IRG-type G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031996 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040013859 UniProtKB/TrEMBL
  ENSCAFG00845000097 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000048661.3 UniProtKB/TrEMBL
  ENSCAFT00040025554.1 UniProtKB/TrEMBL
  ENSCAFT00040025566.1 UniProtKB/TrEMBL
  ENSCAFT00845000168 ENTREZGENE
  ENSCAFT00845000168.1 UniProtKB/TrEMBL
InterPro G_IRG_dom UniProtKB/TrEMBL
  IRGQ UniProtKB/TrEMBL
KEGG Report cfa:612411 UniProtKB/TrEMBL
NCBI Gene IRGQ ENTREZGENE
PANTHER IMMUNITY-RELATED GTPASE FAMILY Q PROTEIN UniProtKB/TrEMBL
  PTHR19364 UniProtKB/TrEMBL
PROSITE G_IRG UniProtKB/TrEMBL
UniProt A0A8C0SIP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SIR3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3M9Y7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42098 ENTREZGENE