PTP4A2 (protein tyrosine phosphatase 4A2) - Rat Genome Database

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Gene: PTP4A2 (protein tyrosine phosphatase 4A2) Canis lupus familiaris
Analyze
Symbol: PTP4A2
Name: protein tyrosine phosphatase 4A2
RGD ID: 12254307
Description: ENCODES a protein that exhibits enzyme inhibitor activity (inferred); protein tyrosine phosphatase activity (inferred); ASSOCIATED WITH diastolic heart failure (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,222,525 - 69,238,436 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,223,615 - 69,236,292 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,786,916 - 65,818,451 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,773,180 - 69,804,682 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,773,164 - 69,802,941 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,609,300 - 66,640,704 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,605,378 - 67,636,786 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,604,839 - 68,636,499 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
nucleus  (IBA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTP4A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,222,525 - 69,238,436 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,223,615 - 69,236,292 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,786,916 - 65,818,451 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,773,180 - 69,804,682 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,773,164 - 69,802,941 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,609,300 - 66,640,704 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,605,378 - 67,636,786 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,604,839 - 68,636,499 (+)NCBIUU_Cfam_GSD_1.0
PTP4A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38131,906,421 - 31,938,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl131,906,421 - 31,944,856 (-)EnsemblGRCh38hg38GRCh38
GRCh37132,372,022 - 32,403,969 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,146,380 - 32,176,575 (-)NCBINCBI36Build 36hg18NCBI36
Build 34132,043,161 - 32,073,048NCBI
Celera130,642,021 - 30,673,892 (-)NCBICelera
Cytogenetic Map1p35.2NCBI
HuRef130,488,649 - 30,520,870 (-)NCBIHuRef
CHM1_1132,487,686 - 32,519,598 (-)NCBICHM1_1
T2T-CHM13v2.0131,764,401 - 31,796,321 (-)NCBIT2T-CHM13v2.0
Ptp4a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,704,982 - 129,743,800 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,705,012 - 129,743,796 (+)EnsemblGRCm39 Ensembl
GRCm384129,811,165 - 129,850,003 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,811,219 - 129,850,003 (+)EnsemblGRCm38mm10GRCm38
MGSCv374129,497,723 - 129,527,247 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364129,341,777 - 129,352,279 (+)NCBIMGSCv36mm8
Celera4128,154,497 - 128,184,314 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.38NCBI
Ptp4a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85147,449,733 - 147,476,739 (+)NCBIGRCr8
mRatBN7.25142,165,405 - 142,192,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5142,165,700 - 142,191,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,882,870 - 144,891,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,652,691 - 146,661,751 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,649,509 - 146,658,574 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05148,035,501 - 148,060,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5148,051,126 - 148,060,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,758,017 - 151,784,448 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5140,653,929 - 140,663,126 (+)NCBICelera
Cytogenetic Map5q36NCBI
Ptp4a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545210,293,958 - 10,331,868 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545210,293,958 - 10,331,868 (-)NCBIChiLan1.0ChiLan1.0
PTP4A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21194,909,399 - 194,922,012 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11194,030,919 - 194,042,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,193,735 - 31,222,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1132,209,863 - 32,238,489 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl132,209,863 - 32,231,847 (-)Ensemblpanpan1.1panPan2
Ptp4a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,168,958 - 49,198,951 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647414,993,399 - 15,005,219 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647414,993,741 - 15,005,219 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTP4A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl688,419,453 - 88,447,832 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1688,419,444 - 88,452,757 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,337,830 - 82,348,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTP4A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,936,786 - 100,965,496 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20100,952,722 - 100,963,323 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603315,726,009 - 15,755,081 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptp4a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,130,044 - 15,165,048 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,131,457 - 15,165,331 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTP4A2
156 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038461922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038461923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_846983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000017195   ⟹   ENSCAFP00000015910
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl269,223,615 - 69,235,947 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000074689   ⟹   ENSCAFP00000063090
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl269,223,615 - 69,234,864 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000075103   ⟹   ENSCAFP00000064657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl269,223,690 - 69,236,292 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000082766   ⟹   ENSCAFP00000057120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl269,223,615 - 69,235,865 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009133   ⟹   ENSCAFP00845007197
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl269,773,164 - 69,802,161 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009135   ⟹   ENSCAFP00845007199
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl269,773,167 - 69,802,941 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009140   ⟹   ENSCAFP00845007201
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl269,782,736 - 69,793,691 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845009144   ⟹   ENSCAFP00845007204
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl269,790,002 - 69,802,941 (+)Ensembl
RefSeq Acc Id: XM_038461922   ⟹   XP_038317850
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha265,786,916 - 65,818,451 (+)NCBI
RefSeq Acc Id: XM_038461923   ⟹   XP_038317851
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha265,786,916 - 65,818,451 (+)NCBI
RefSeq Acc Id: XM_038470424   ⟹   XP_038326352
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1266,609,300 - 66,640,704 (+)NCBI
RefSeq Acc Id: XM_038470425   ⟹   XP_038326353
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1266,609,300 - 66,640,704 (+)NCBI
RefSeq Acc Id: XM_038531265   ⟹   XP_038387193
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0268,604,839 - 68,636,499 (+)NCBI
RefSeq Acc Id: XM_038531267   ⟹   XP_038387195
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0268,604,839 - 68,636,499 (+)NCBI
RefSeq Acc Id: XM_038595487   ⟹   XP_038451415
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0267,605,378 - 67,636,786 (+)NCBI
RefSeq Acc Id: XM_038595488   ⟹   XP_038451416
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0267,605,378 - 67,636,786 (+)NCBI
RefSeq Acc Id: XM_038659572   ⟹   XP_038515500
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,773,180 - 69,804,682 (+)NCBI
RefSeq Acc Id: XM_038659573   ⟹   XP_038515501
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,773,399 - 69,804,682 (+)NCBI
Ensembl Acc Id: ENSCAFP00000063090   ⟸   ENSCAFT00000074689
Ensembl Acc Id: ENSCAFP00000057120   ⟸   ENSCAFT00000082766
Ensembl Acc Id: ENSCAFP00000064657   ⟸   ENSCAFT00000075103
Ensembl Acc Id: ENSCAFP00000015910   ⟸   ENSCAFT00000017195
RefSeq Acc Id: XP_038326353   ⟸   XM_038470425
RefSeq Acc Id: XP_038326352   ⟸   XM_038470424
RefSeq Acc Id: XP_038451416   ⟸   XM_038595488
RefSeq Acc Id: XP_038451415   ⟸   XM_038595487
RefSeq Acc Id: XP_038515500   ⟸   XM_038659572
- UniProtKB: A0A8C0NS34 (UniProtKB/TrEMBL),   A0A8C0LKH2 (UniProtKB/TrEMBL),   A0A8I3MUD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515501   ⟸   XM_038659573
- UniProtKB: A0A8C0NS34 (UniProtKB/TrEMBL),   A0A8C0LKH2 (UniProtKB/TrEMBL),   A0A8I3MUD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317851   ⟸   XM_038461923
- UniProtKB: A0A8C0NS34 (UniProtKB/TrEMBL),   A0A8C0LKH2 (UniProtKB/TrEMBL),   A0A8I3MUD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317850   ⟸   XM_038461922
- UniProtKB: A0A8C0NS34 (UniProtKB/TrEMBL),   A0A8C0LKH2 (UniProtKB/TrEMBL),   A0A8I3MUD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387195   ⟸   XM_038531267
- UniProtKB: A0A8C0LKH2 (UniProtKB/TrEMBL),   A0A8C0NS34 (UniProtKB/TrEMBL),   A0A8I3MUD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387193   ⟸   XM_038531265
- UniProtKB: A0A8C0LKH2 (UniProtKB/TrEMBL),   A0A8C0NS34 (UniProtKB/TrEMBL),   A0A8I3MUD7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845007199   ⟸   ENSCAFT00845009135
Ensembl Acc Id: ENSCAFP00845007201   ⟸   ENSCAFT00845009140
Ensembl Acc Id: ENSCAFP00845007204   ⟸   ENSCAFT00845009144
Ensembl Acc Id: ENSCAFP00845007197   ⟸   ENSCAFT00845009133
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Promoters
RGD ID:13682554
Promoter ID:EPDNEW_C622
Type:single initiation site
Name:PTP4A2_1
Description:protein tyrosine phosphatase type IVA, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1269,223,283 - 69,223,343EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010816 Ensembl
  ENSCAFG00000051663 UniProtKB/TrEMBL
  ENSCAFG00030017790 UniProtKB/TrEMBL
  ENSCAFG00040021824 UniProtKB/TrEMBL
  ENSCAFG00845005093 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000082766.2 UniProtKB/TrEMBL
  ENSCAFT00000101239.1 UniProtKB/TrEMBL
  ENSCAFT00000108392.1 UniProtKB/TrEMBL
  ENSCAFT00030032868.1 UniProtKB/TrEMBL
  ENSCAFT00030032918.1 UniProtKB/TrEMBL
  ENSCAFT00030032955.1 UniProtKB/TrEMBL
  ENSCAFT00030033021.1 UniProtKB/TrEMBL
  ENSCAFT00040040573.1 UniProtKB/TrEMBL
  ENSCAFT00040040611.1 UniProtKB/TrEMBL
  ENSCAFT00040040636.1 UniProtKB/TrEMBL
  ENSCAFT00040040669.1 UniProtKB/TrEMBL
  ENSCAFT00845009133.1 UniProtKB/TrEMBL
  ENSCAFT00845009135 ENTREZGENE
  ENSCAFT00845009135.1 UniProtKB/TrEMBL
  ENSCAFT00845009140.1 UniProtKB/TrEMBL
  ENSCAFT00845009144.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
NCBI Gene PTP4A2 ENTREZGENE
PANTHER TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/TrEMBL
Pfam Tc-R-P UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
SMART PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A8C0LKH2 ENTREZGENE
  A0A8C0NQU2_CANLF UniProtKB/TrEMBL
  A0A8C0NRS7_CANLF UniProtKB/TrEMBL
  A0A8C0NS09_CANLF UniProtKB/TrEMBL
  A0A8C0NS34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQ39_CANLF UniProtKB/TrEMBL
  A0A8I3MUD7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MW97_CANLF UniProtKB/TrEMBL
  A0A8I3MYP4_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0PIB1 UniProtKB/TrEMBL
VGNC ID VGNC:45162 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 PTP4A2  protein tyrosine phosphatase 4A2    protein tyrosine phosphatase type IVA, member 2  Symbol and/or name change 5135510 APPROVED