QPRT (quinolinate phosphoribosyltransferase) - Rat Genome Database

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Gene: QPRT (quinolinate phosphoribosyltransferase) Canis lupus familiaris
Analyze
Symbol: QPRT
Name: quinolinate phosphoribosyltransferase
RGD ID: 12226480
Description: ENCODES a protein that exhibits identical protein binding (ortholog); nicotinate-nucleotide diphosphorylase (carboxylating) activity (ortholog); INVOLVED IN NAD biosynthetic process (ortholog); quinolinate catabolic process (ortholog); quinolinate metabolic process (ortholog); PARTICIPATES IN de novo nicotinamide adenine dinucleotide biosynthetic pathway; niacin metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); chromosome 16p11.2 deletion syndrome, 593-kb (ortholog); FOUND IN catalytic complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nicotinate-nucleotide pyrophosphorylase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,778,664 - 17,794,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,779,439 - 17,794,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,355,777 - 19,371,193 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,913,305 - 17,928,517 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1617,712,824 - 17,728,246 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,628,300 - 17,643,725 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,944,000 - 17,959,189 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
QPRT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,778,664 - 17,794,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,779,439 - 17,794,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,355,777 - 19,371,193 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,913,305 - 17,928,517 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1617,712,824 - 17,728,246 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,628,300 - 17,643,725 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,944,000 - 17,959,189 (+)NCBIUU_Cfam_GSD_1.0
QPRT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381629,679,008 - 29,698,699 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1629,663,279 - 29,698,699 (+)EnsemblGRCh38hg38GRCh38
GRCh371629,690,329 - 29,710,020 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,597,942 - 29,616,816 (+)NCBINCBI36Build 36hg18NCBI36
Build 341629,597,941 - 29,616,813NCBI
Celera1673,086,675 - 73,105,568 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,351,724 - 27,370,618 (+)NCBIHuRef
CHM1_11630,702,266 - 30,721,120 (+)NCBICHM1_1
T2T-CHM13v2.01629,947,774 - 29,980,720 (+)NCBIT2T-CHM13v2.0
Qprt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,706,942 - 126,721,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,706,286 - 126,721,398 (-)EnsemblGRCm39 Ensembl
GRCm387127,107,770 - 127,122,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,107,114 - 127,122,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,251,284 - 134,265,543 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,898,918 - 126,913,177 (-)NCBIMGSCv36mm8
Celera7126,956,210 - 126,970,579 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.33NCBI
Qprt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,148,715 - 191,164,006 (-)NCBIGRCr8
mRatBN7.21181,718,189 - 181,733,486 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,718,190 - 181,733,486 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,069,579 - 190,084,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,255,666 - 197,270,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,924,049 - 189,939,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,544,262 - 198,559,556 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,544,262 - 198,559,568 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,534,747 - 205,550,129 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,358,523 - 186,374,681 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,508,404 - 186,524,562 (-)NCBI
Celera1179,371,205 - 179,386,496 (-)NCBICelera
Cytogenetic Map1q37NCBI
Qprt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,224,983 - 7,242,852 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,225,472 - 7,243,078 (-)NCBIChiLan1.0ChiLan1.0
QPRT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,429,278 - 30,448,926 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,778,256 - 35,796,841 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1630,049,806 - 30,070,469 (+)Ensemblpanpan1.1panPan2
Qprt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,647,145 - 124,665,262 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,742,157 - 12,763,187 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,743,634 - 12,763,068 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QPRT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,987,242 - 18,001,711 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,987,223 - 18,001,712 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,588,984 - 18,603,469 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QPRT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,953,980 - 26,970,120 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,950,391 - 26,970,079 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,548,157 - 2,573,292 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in QPRT
193 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6 8
Low 5 2 5
Below cutoff 5 5 11 6 6 6 10 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000044421   ⟹   ENSCAFP00000038575
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl617,779,439 - 17,794,035 (+)Ensembl
RefSeq Acc Id: XM_038478584   ⟹   XP_038334512
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1617,712,824 - 17,728,246 (+)NCBI
RefSeq Acc Id: XM_038539832   ⟹   XP_038395760
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0617,944,000 - 17,959,189 (+)NCBI
RefSeq Acc Id: XM_038603910   ⟹   XP_038459838
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0617,628,300 - 17,643,725 (+)NCBI
RefSeq Acc Id: XM_038668637   ⟹   XP_038524565
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0617,913,305 - 17,928,517 (+)NCBI
RefSeq Acc Id: XM_844422   ⟹   XP_849515
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1617,778,664 - 17,794,110 (+)NCBI
Dog10K_Boxer_Tasha619,355,777 - 19,371,193 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_849515   ⟸   XM_844422
- UniProtKB: A0A8C0SLU0 (UniProtKB/TrEMBL),   A0A8C0R2Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000038575   ⟸   ENSCAFT00000044421
RefSeq Acc Id: XP_038334512   ⟸   XM_038478584
RefSeq Acc Id: XP_038459838   ⟸   XM_038603910
RefSeq Acc Id: XP_038524565   ⟸   XM_038668637
- UniProtKB: A0A8C0RAR5 (UniProtKB/TrEMBL),   A0A8I3NJF4 (UniProtKB/TrEMBL),   A0A8C0R2Y6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395760   ⟸   XM_038539832
- UniProtKB: A0A8C0R2Y6 (UniProtKB/TrEMBL),   A0A8C0SLU0 (UniProtKB/TrEMBL)
Protein Domains
Quinolinate phosphoribosyl transferase C-terminal   Quinolinate phosphoribosyl transferase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030720 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002056 UniProtKB/TrEMBL
  ENSCAFG00040014705 UniProtKB/TrEMBL
  ENSCAFG00845014366 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000044421.3 UniProtKB/TrEMBL
  ENSCAFT00030003756.1 UniProtKB/TrEMBL
  ENSCAFT00040027176.1 UniProtKB/TrEMBL
  ENSCAFT00845025711 ENTREZGENE
  ENSCAFT00845025711.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
  3.90.1170.20 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  NadC UniProtKB/TrEMBL
  NadC/ModD UniProtKB/TrEMBL
  Nicotinate_pribotase-like_C UniProtKB/TrEMBL
  Quinolinate_PRibosylTase_N_sf UniProtKB/TrEMBL
  Quinolinate_PRibosylTrfase_C UniProtKB/TrEMBL
  Quinolinate_PRibosylTrfase_N UniProtKB/TrEMBL
KEGG Report cfa:607664 UniProtKB/TrEMBL
NCBI Gene QPRT ENTREZGENE
PANTHER NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] UniProtKB/TrEMBL
  PTHR32179 UniProtKB/TrEMBL
Pfam QRPTase_C UniProtKB/TrEMBL
  QRPTase_N UniProtKB/TrEMBL
PIRSF NadC_ModD UniProtKB/TrEMBL
Superfamily-SCOP Nicotinate/Quinolinate PRTase N-terminal domain-like UniProtKB/TrEMBL
  SSF51690 UniProtKB/TrEMBL
UniProt A0A8C0R2Y6 ENTREZGENE
  A0A8C0RAR5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SLU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NJF4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NQ98_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:103699 ENTREZGENE