NTMT2 (N-terminal Xaa-Pro-Lys N-methyltransferase 2) - Rat Genome Database

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Gene: NTMT2 (N-terminal Xaa-Pro-Lys N-methyltransferase 2) Canis lupus familiaris
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Symbol: NTMT2
Name: N-terminal Xaa-Pro-Lys N-methyltransferase 2
RGD ID: 12156096
Description: ENCODES a protein that exhibits methyltransferase activity (inferred); N-terminal protein N-methyltransferase activity (inferred); protein methyltransferase activity (inferred); INVOLVED IN N-terminal protein amino acid methylation (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); gastrointestinal stromal tumor (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha N-terminal protein methyltransferase 1B; methyltransferase like 11B; METTL11B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,520,322 - 28,543,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,524,761 - 28,544,379 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,050,008 - 28,075,309 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0728,319,994 - 28,345,331 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,326,278 - 28,345,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,168,977 - 28,194,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,204,127 - 28,229,336 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,440,703 - 28,466,048 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NTMT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,520,322 - 28,543,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,524,761 - 28,544,379 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,050,008 - 28,075,309 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0728,319,994 - 28,345,331 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,326,278 - 28,345,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,168,977 - 28,194,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,204,127 - 28,229,336 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,440,703 - 28,466,048 (-)NCBIUU_Cfam_GSD_1.0
NTMT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,145,959 - 170,168,866 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1170,145,959 - 170,168,866 (+)EnsemblGRCh38hg38GRCh38
GRCh371170,115,100 - 170,138,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361168,381,873 - 168,403,522 (+)NCBINCBI36Build 36hg18NCBI36
Celera1143,225,003 - 143,246,729 (+)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1141,338,644 - 141,360,374 (+)NCBIHuRef
CHM1_11171,537,509 - 171,559,238 (+)NCBICHM1_1
T2T-CHM13v2.01169,501,867 - 169,524,770 (+)NCBIT2T-CHM13v2.0
Ntmt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,529,415 - 163,552,801 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,529,825 - 163,552,801 (-)EnsemblGRCm39 Ensembl
GRCm381163,702,993 - 163,725,232 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1163,702,256 - 163,725,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv371165,633,124 - 165,655,363 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,539,692 - 165,561,837 (-)NCBIMGSCv36mm8
Celera1166,151,346 - 166,171,120 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map171.0NCBI
Ntmt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81378,585,663 - 78,627,144 (-)NCBIGRCr8
mRatBN7.21376,050,683 - 76,093,972 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,053,127 - 76,093,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1378,671,188 - 78,712,033 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,973,844 - 80,014,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,228,406 - 77,269,323 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01381,987,877 - 82,027,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1381,988,926 - 82,006,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01386,868,523 - 86,886,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,460,482 - 79,475,999 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1375,787,990 - 75,828,691 (-)NCBICelera
Cytogenetic Map13q22NCBI
Ntmt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554626,450,063 - 6,473,919 (+)NCBIChiLan1.0ChiLan1.0
NTMT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2179,592,643 - 79,616,241 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1179,266,074 - 79,289,687 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,635,789 - 145,658,564 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11149,352,738 - 149,374,488 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1149,352,738 - 149,374,488 (+)Ensemblpanpan1.1panPan2
Ntmt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934498,710,607 - 98,752,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648116,582,901 - 16,598,504 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648116,582,352 - 16,598,385 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTMT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl480,857,344 - 80,877,566 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1480,854,850 - 80,932,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2488,437,293 - 88,460,702 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NTMT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12558,898,029 - 58,919,835 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2558,898,262 - 58,919,292 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605560,552,178 - 60,574,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntmt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248267,938,688 - 7,948,369 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NTMT2
237 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 1 3 16 8 5 1 4 11 10 11 13 5

Sequence


Ensembl Acc Id: ENSCAFT00000023844   ⟹   ENSCAFP00000022134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl728,524,761 - 28,544,379 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845003009   ⟹   ENSCAFP00845002400
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl728,326,278 - 28,345,227 (-)Ensembl
RefSeq Acc Id: XM_038481221   ⟹   XP_038337149
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1728,168,977 - 28,194,281 (-)NCBI
RefSeq Acc Id: XM_038542573   ⟹   XP_038398501
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0728,440,703 - 28,466,048 (-)NCBI
RefSeq Acc Id: XM_038606727   ⟹   XP_038462655
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0728,204,127 - 28,229,336 (-)NCBI
RefSeq Acc Id: XM_038671404   ⟹   XP_038527332
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0728,319,994 - 28,345,331 (-)NCBI
RefSeq Acc Id: XM_547472   ⟹   XP_547472
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1728,520,323 - 28,543,846 (-)NCBI
Dog10K_Boxer_Tasha728,050,008 - 28,075,309 (-)NCBI
Sequence:
RefSeq Acc Id: XP_547472   ⟸   XM_547472
- UniProtKB: A0A8C0PPR0 (UniProtKB/TrEMBL),   A0A8C0L7J4 (UniProtKB/TrEMBL),   A0A8I3RRP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000022134   ⟸   ENSCAFT00000023844
RefSeq Acc Id: XP_038337149   ⟸   XM_038481221
RefSeq Acc Id: XP_038462655   ⟸   XM_038606727
RefSeq Acc Id: XP_038527332   ⟸   XM_038671404
- UniProtKB: A0A8C0PPR0 (UniProtKB/TrEMBL),   A0A8C0L7J4 (UniProtKB/TrEMBL),   A0A8I3RRP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038398501   ⟸   XM_038542573
- UniProtKB: A0A8C0L7J4 (UniProtKB/TrEMBL),   A0A8C0PPR0 (UniProtKB/TrEMBL),   A0A8I3RRP4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845002400   ⟸   ENSCAFT00845003009


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015027 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030025101 UniProtKB/TrEMBL
  ENSCAFG00040000293 UniProtKB/TrEMBL
  ENSCAFG00845001718 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023844.5 UniProtKB/TrEMBL
  ENSCAFT00030046319.1 UniProtKB/TrEMBL
  ENSCAFT00040000487.1 UniProtKB/TrEMBL
  ENSCAFT00845003009 ENTREZGENE
  ENSCAFT00845003009.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro MeTrfase_NTM1 UniProtKB/TrEMBL
  SAM-dependent_MTases_sf UniProtKB/TrEMBL
KEGG Report cfa:490351 UniProtKB/TrEMBL
NCBI Gene METTL11B ENTREZGENE
PANTHER ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1B UniProtKB/TrEMBL
  PTHR12753 UniProtKB/TrEMBL
Pfam Methyltransf_PK UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8C0L7J4 ENTREZGENE
  A0A8C0PPR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RRP4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43170 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-24 NTMT2  N-terminal Xaa-Pro-Lys N-methyltransferase 2  METTL11B  methyltransferase like 11B  Symbol and/or name change 19259463 PROVISIONAL