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Gene: HGD (homogentisate 1,2-dioxygenase) Canis lupus familiaris

Analyze

Symbol:

HGD

Name:

homogentisate 1,2-dioxygenase

RGD ID:

12152193

Description:

ENCODES a protein that exhibits dioxygenase activity (inferred); GTP binding (inferred); homogentisate 1,2-dioxygenase activity (inferred); INVOLVED IN amino acid metabolic process (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH alkaptonuria (ortholog); Alkaptonuric Ochronosis (ortholog); genetic disease (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homogentisate 1,2-dioxygenase (homogentisate oxidase)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	24,066,099 - 24,107,827 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	24,066,306 - 24,151,354 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	24,095,501 - 24,137,233 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	24,305,826 - 24,347,869 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	24,306,037 - 24,391,382 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	24,106,833 - 24,148,576 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	24,146,893 - 24,188,831 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	24,711,359 - 24,753,085 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alkaptonuria (ISO)

Alkaptonuric Ochronosis (ISO)

genetic disease (ISO)

Hereditary Ochronosis (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid metabolic process (IEA,ISO)

L-phenylalanine catabolic process (IBA,IEA)

tyrosine metabolic process (IEA)

Molecular Function

dioxygenase activity (IEA)

GTP binding (IEA)

homogentisate 1,2-dioxygenase activity (IBA,IEA)

identical protein binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alkaptonuria pathway (ISO)

disulfiram pharmacodynamics pathway (ISO)

dopamine beta-hydroxylase deficiency pathway (ISO)

hawkinsinuria pathway (ISO)

phenylketonuria pathway (ISO)

tyrosine metabolic pathway (ISO)

tyrosinemia type I pathway (ISO)

tyrosinemia type II pathway (ISO)

tyrosinemia type III pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HGD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	24,066,099 - 24,107,827 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	24,066,306 - 24,151,354 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	24,095,501 - 24,137,233 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	24,305,826 - 24,347,869 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	24,306,037 - 24,391,382 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	24,106,833 - 24,148,576 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	24,146,893 - 24,188,831 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	24,711,359 - 24,753,085 (-)	NCBI		UU_Cfam_GSD_1.0

HGD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	120,628,172 - 120,682,239 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	120,628,172 - 120,682,269 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	120,347,019 - 120,401,086 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	121,829,705 - 121,884,018 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	118,756,410 - 118,810,810 (-)	NCBI		Celera
Cytogenetic Map	3	q13.33	NCBI
HuRef	3	117,720,226 - 117,775,229 (-)	NCBI		HuRef
CHM1_1	3	120,310,676 - 120,365,085 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	123,348,044 - 123,402,117 (-)	NCBI		T2T-CHM13v2.0

Hgd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	37,400,104 - 37,452,388 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	37,400,515 - 37,452,382 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	37,579,742 - 37,632,026 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	37,580,153 - 37,632,020 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	37,580,239 - 37,632,112 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	37,499,489 - 37,551,259 (+)	NCBI		MGSCv36	mm8
Celera	16	37,988,030 - 38,039,914 (+)	NCBI		Celera
Cytogenetic Map	16	B3	NCBI
cM Map	16	26.4	NCBI

Hgd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	76,592,202 - 76,643,776 (-)	NCBI		GRCr8
mRatBN7.2	11	63,086,750 - 63,138,325 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	63,086,752 - 63,138,323 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	71,899,210 - 71,950,766 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	64,561,435 - 64,613,001 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	63,611,104 - 63,662,387 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	65,983,221 - 66,034,555 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	65,983,221 - 66,034,573 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	69,075,116 - 69,126,725 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	64,876,269 - 64,928,243 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	64,933,859 - 64,985,832 (-)	NCBI
Celera	11	62,583,352 - 62,634,571 (-)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI

Hgd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955427	20,137,861 - 20,188,700 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955427	20,141,522 - 20,188,700 (-)	NCBI	ChiLan1.0	ChiLan1.0

HGD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	118,590,548 - 118,644,540 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	118,595,326 - 118,649,318 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	117,735,772 - 117,790,096 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	124,646,431 - 124,700,733 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	124,646,431 - 124,700,733 (-)	Ensembl	panpan1.1		panPan2

Hgd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	130,162,151 - 130,207,463 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936536	7,314,754 - 7,352,222 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936536	7,314,548 - 7,359,426 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HGD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	139,660,343 - 139,710,404 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	139,660,315 - 139,710,402 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

HGD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	60,136,293 - 60,192,275 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	60,137,532 - 60,192,430 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	106,112,902 - 106,170,562 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hgd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	27,548,922 - 27,604,131 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	27,549,245 - 27,604,142 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HGD
460 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022413913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038445078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038445079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038462486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038519339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038519340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038582961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038582962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038647357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_535754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000017915 ⟹ ENSCAFP00000016589

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	33	24,066,306 - 24,107,964 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000017947 ⟹ ENSCAFP00000016620

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	33	24,116,445 - 24,151,354 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000072647 ⟹ ENSCAFP00000049161

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	33	24,066,306 - 24,103,025 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000075383 ⟹ ENSCAFP00000058708

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	33	24,066,306 - 24,103,025 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000080556 ⟹ ENSCAFP00000059587

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	33	24,066,306 - 24,120,338 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000091345 ⟹ ENSCAFP00000064854

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	33	24,116,445 - 24,151,272 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845033440 ⟹ ENSCAFP00845026178

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	33	24,306,037 - 24,360,333 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845033595 ⟹ ENSCAFP00845026301

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	33	24,306,037 - 24,347,956 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845033745 ⟹ ENSCAFP00845026413

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	33	24,306,037 - 24,347,869 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845033875 ⟹ ENSCAFP00845026506

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	33	24,306,037 - 24,343,012 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845034010 ⟹ ENSCAFP00845026614

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	33	24,354,632 - 24,391,382 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845034086 ⟹ ENSCAFP00845026685

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	33	24,354,632 - 24,391,382 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845034162 ⟹ ENSCAFP00845026744

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	33	24,354,871 - 24,391,038 (-)	Ensembl

RefSeq Acc Id:

XM_038445078 ⟹ XP_038301006

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	33	24,305,826 - 24,343,014 (-)	NCBI

RefSeq Acc Id:

XM_038445079 ⟹ XP_038301007

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	33	24,305,826 - 24,347,869 (-)	NCBI

RefSeq Acc Id:

XM_038462486 ⟹ XP_038318414

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	33	24,095,501 - 24,132,375 (-)	NCBI

RefSeq Acc Id:

XM_038519339 ⟹ XP_038375267

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	33	24,106,833 - 24,143,718 (-)	NCBI

RefSeq Acc Id:

XM_038519340 ⟹ XP_038375268

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	33	24,106,833 - 24,148,576 (-)	NCBI

RefSeq Acc Id:

XM_038582961 ⟹ XP_038438889

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	33	24,711,359 - 24,748,227 (-)	NCBI

RefSeq Acc Id:

XM_038582962 ⟹ XP_038438890

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	33	24,711,359 - 24,753,085 (-)	NCBI

RefSeq Acc Id:

XM_038647357 ⟹ XP_038503285

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	33	24,146,893 - 24,188,831 (-)	NCBI

RefSeq Acc Id:

XM_535754 ⟹ XP_535754

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	33	24,066,099 - 24,107,821 (-)	NCBI
Dog10K_Boxer_Tasha	33	24,095,501 - 24,137,233 (-)	NCBI

Sequence:

show sequence

GGTGGGAATAACATCCAGAAAGTGGGTTGAAGGAGAAACCGAAGTATTTTGGCTCCATACCTTC
TCTGAGCCCACATTTCCTGAAGTCATCACGCCTGCAGCAGAGGGAAAATGGCCGAGTTAAAGTA
CATCCCCGGATTTGGGAATGAGTGTGCCTCAGAGGACCCTCGCTGCCCAGGTGCCCTGCCAGAA
GGACAGAACAATCCTCAAGTCTGCCCTTACAATCTGTATGCTGAACAGCTCTCAGGATCTGCTT
TCACTTGTCCACGGAGCACAAATAAGAGAAGTTGGCTGTATAGAATTCTACCTTCAGTTTGTCA
CAAGCCCTTTGAATCCATTGACCAAGGCCATGTCACTCACAACTGGGATGAAGTTGATCCTGAC
CCTAACCAGCTTCGATGGAAACCATTTGAAATTCCAAAAGCATCTCAGAAGAAAGTGGACTTTG
TGAGTGGCCTGCATACCTTGTGTGGAGCTGGAGACATAAGGTCTAACAATGGACTTGCCATCCA
TATTTTTCTCTGCAACACCTCCATGGGGAACAGATGCTTTTACAATTCAGATGGGGACTTCTTG
ATTGTTCCCCAGAAAGGAAAACTTCTCATTTACACTGAGTTTGGCAAGATGCTTGTGCAGCCCA
ACGAGATCTGCGTCATTCAGAGAGGAATGCGGTTCAGCATAGATGTCTTCGAGGAGACCAGGGG
CTATATCCTGGAGGTCTACGGTGTCCACTTTGAGTTGCCTGACCTGGGACCAATTGGAGCCAAT
GGCTTGGCCAATCCTCGTGATTTTTTGATACCCGTTGCCTGGTATGAAGATCGCCAAGTACCAG
GTGGCTACACTGTGATTAATAAATACCAGGGGAAGCTATTTGCTGCCAAACAGAATGTCTCCCC
ATTCAATGTCGTGGCGTGGCATGGGAACTACACCCCCTACAAGTACAACTTGGAGAACTTCATG
GTCATTAACTCGGTGGCCTTTGACCATGCAGACCCATCCATCTTCACAGTGTTGACCGCCAAAT
CTGTCCGTCCTGGAGTAGCTGTTGCTGATTTTGTCATCTTCCCGCCTCGATGGGGGGTTGCTGA
CAAGACTTTCAGGCCTCCTTATTACCACAGGAACTGCATGAGTGAATTCATGGGACTTATCAAA
GGTCATTATGAGGCAAAGCAGGGTGAGTTCCTGCCAGGAGGAGGCAGCCTGCACAGCTCAATGA
CCCCCCACGGGCCTGATGCTGACTGCTTTGAGAAGGCCAGCAAAGCCAAGTTGGCACCCGAGAG
GATTGCTGATGGCACCATGGCATTTATGTTTGAATCTTCTCTAAGTATGGCCGTCACCAAGTGG
GGGCTCAAGTCCTCTAGTTGTTTGGATGAGAACTACTATAAGTGCTGGGAACCTCTCAAGAGCC
ACTTCACCCCTGATTCCAGGAAACCAGCAGGACCTAACTGAGACTGGAGCATTTGCTGCCAAAA
TTGAAAATGGATCTGTGTGGTTTTGTTTAGAATTTCATGCCCTCTGGTAGTATGGGGTGGGGGG
GGGTGGTTAAAATGAGAACTCATTTTTTCACAGTCAAGTAATTCAGACATTTGTCGAAATGTAT
TTGGAAAGTTCTGTGTCAGCTTAATTACTCAATAAATACTTGGCTGATGCTCTGTGTAAGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038301006	(Get FASTA)	NCBI Sequence Viewer
	XP_038301007	(Get FASTA)	NCBI Sequence Viewer
	XP_038318414	(Get FASTA)	NCBI Sequence Viewer
	XP_038375267	(Get FASTA)	NCBI Sequence Viewer
	XP_038375268	(Get FASTA)	NCBI Sequence Viewer
	XP_038438889	(Get FASTA)	NCBI Sequence Viewer
	XP_038438890	(Get FASTA)	NCBI Sequence Viewer
	XP_038503285	(Get FASTA)	NCBI Sequence Viewer
	XP_535754	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000016589.3
	ENSCAFP00000058708.1
	ENSCAFP00000059587.1
	ENSCAFP00030016012.1
	ENSCAFP00030016081.1
	ENSCAFP00030016174.1
	ENSCAFP00040031726.1
	ENSCAFP00040031815.1
	ENSCAFP00040031928.1
	ENSCAFP00040031990.1
	ENSCAFP00845026178.1
	ENSCAFP00845026301
	ENSCAFP00845026301.1
	ENSCAFP00845026413
	ENSCAFP00845026413.1
	ENSCAFP00845026506.1
	ENSCAFP00845026744.1

RefSeq Acc Id:	XP_535754 ⟸ XM_535754
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0MZ30 (UniProtKB/TrEMBL), A0A8P0NDB6 (UniProtKB/TrEMBL), A0A8C0K0R5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAELKYIPGFGNECASEDPRCPGALPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLYRI LPSVCHKPFESIDQGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLCGAGDIRSN NGLAIHIFLCNTSMGNRCFYNSDGDFLIVPQKGKLLIYTEFGKMLVQPNEICVIQRGMRFSIDV FEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDRQVPGGYTVINKYQGKLFAA KQNVSPFNVVAWHGNYTPYKYNLENFMVINSVAFDHADPSIFTVLTAKSVRPGVAVADFVIFPP RWGVADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGEFLPGGGSLHSSMTPHGPDADCFEKASKA KLAPERIADGTMAFMFESSLSMAVTKWGLKSSSCLDENYYKCWEPLKSHFTPDSRKPAGPN hide sequence

Ensembl Acc Id:

ENSCAFP00000064854 ⟸ ENSCAFT00000091345

Ensembl Acc Id:

ENSCAFP00000016620 ⟸ ENSCAFT00000017947

Ensembl Acc Id:

ENSCAFP00000016589 ⟸ ENSCAFT00000017915

Ensembl Acc Id:

ENSCAFP00000049161 ⟸ ENSCAFT00000072647

Ensembl Acc Id:

ENSCAFP00000059587 ⟸ ENSCAFT00000080556

Ensembl Acc Id:

ENSCAFP00000058708 ⟸ ENSCAFT00000075383

RefSeq Acc Id:	XP_038375268 ⟸ XM_038519340
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038375267 ⟸ XM_038519339
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038503285 ⟸ XM_038647357
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038301007 ⟸ XM_038445079
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I3P921 (UniProtKB/TrEMBL), A0A8C0K0R5 (UniProtKB/TrEMBL), A0A8I3PDU0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038301006 ⟸ XM_038445078
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3P3K4 (UniProtKB/TrEMBL), A0A8I3PDU0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038318414 ⟸ XM_038462486
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0MSI4 (UniProtKB/TrEMBL), A0A8P0TAM0 (UniProtKB/TrEMBL), A0A8C0T7H5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038438890 ⟸ XM_038582962
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0K0R5 (UniProtKB/TrEMBL), A0A8C0MZ30 (UniProtKB/TrEMBL), A0A8P0NDB6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038438889 ⟸ XM_038582961
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0MSI4 (UniProtKB/TrEMBL), A0A8C0T7H5 (UniProtKB/TrEMBL), A0A8P0TAM0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845026685 ⟸ ENSCAFT00845034086

Ensembl Acc Id:

ENSCAFP00845026413 ⟸ ENSCAFT00845033745

Ensembl Acc Id:

ENSCAFP00845026178 ⟸ ENSCAFT00845033440

Ensembl Acc Id:

ENSCAFP00845026301 ⟸ ENSCAFT00845033595

Ensembl Acc Id:

ENSCAFP00845026506 ⟸ ENSCAFT00845033875

Ensembl Acc Id:

ENSCAFP00845026614 ⟸ ENSCAFT00845034010

Ensembl Acc Id:

ENSCAFP00845026744 ⟸ ENSCAFT00845034162

Protein Domains

Homogentisate 1,2-dioxygenase C-terminal Homogentisate 1,2-dioxygenase N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000011254	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030009901	UniProtKB/TrEMBL
	ENSCAFG00040019711	UniProtKB/TrEMBL
	ENSCAFG00845018928	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000017915.5	UniProtKB/TrEMBL
	ENSCAFT00000075383.2	UniProtKB/TrEMBL
	ENSCAFT00000080556.2	UniProtKB/TrEMBL
	ENSCAFT00030018332.1	UniProtKB/TrEMBL
	ENSCAFT00030018419.1	UniProtKB/TrEMBL
	ENSCAFT00030018534.1	UniProtKB/TrEMBL
	ENSCAFT00040036436.1	UniProtKB/TrEMBL
	ENSCAFT00040036530.1	UniProtKB/TrEMBL
	ENSCAFT00040036656.1	UniProtKB/TrEMBL
	ENSCAFT00040036728.1	UniProtKB/TrEMBL
	ENSCAFT00845033440.1	UniProtKB/TrEMBL
	ENSCAFT00845033595	ENTREZGENE
	ENSCAFT00845033595.1	UniProtKB/TrEMBL
	ENSCAFT00845033745	ENTREZGENE
	ENSCAFT00845033745.1	UniProtKB/TrEMBL
	ENSCAFT00845033875.1	UniProtKB/TrEMBL
	ENSCAFT00845034162.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	HgmA_C	UniProtKB/TrEMBL
	HgmA_N	UniProtKB/TrEMBL
	Homogentis_dOase	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RmlC-like_jellyroll	UniProtKB/TrEMBL
	RmlC_Cupin_sf	UniProtKB/TrEMBL
NCBI Gene	HGD	ENTREZGENE
PANTHER	DRAB5-RELATED	UniProtKB/TrEMBL
	HOMOGENTISATE 1,2-DIOXYGENASE	UniProtKB/TrEMBL
	PTHR11056	UniProtKB/TrEMBL
Pfam	HgmA	UniProtKB/TrEMBL
	HgmA_N	UniProtKB/TrEMBL
	Roc	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
	RAB	UniProtKB/TrEMBL
SMART	RAB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51182	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8C0K0R5	ENTREZGENE
	A0A8C0MS29_CANLF	UniProtKB/TrEMBL
	A0A8C0MSI4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0MZ30	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0T7H5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NX38_CANLF	UniProtKB/TrEMBL
	A0A8I3P3K4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P673_CANLF	UniProtKB/TrEMBL
	A0A8I3P921	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PDU0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NDB6	ENTREZGENE
	A0A8P0TAM0	ENTREZGENE
UniProt Secondary	A0A8P0NDB6	UniProtKB/TrEMBL
	A0A8P0P8N4	UniProtKB/TrEMBL
	A0A8P0TAM0	UniProtKB/TrEMBL
VGNC ID	VGNC:41673	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB