TMEM127 (transmembrane protein 127) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: TMEM127 (transmembrane protein 127) Canis lupus familiaris
Analyze
Symbol: TMEM127
Name: transmembrane protein 127
RGD ID: 12151364
Description: ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN endosome organization (ortholog); regulation of TOR signaling (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); early endosome (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,512,753 - 34,527,208 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,512,792 - 34,523,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,282,678 - 34,295,473 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,283,964 - 35,296,760 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,283,938 - 35,296,757 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,413,107 - 34,426,110 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,481,752 - 34,494,521 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,688,570 - 34,701,364 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
early endosome  (IEA)
membrane  (IBA,IEA)
plasma membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TMEM127
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,512,753 - 34,527,208 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,512,792 - 34,523,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,282,678 - 34,295,473 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,283,964 - 35,296,760 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,283,938 - 35,296,757 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,413,107 - 34,426,110 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,481,752 - 34,494,521 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,688,570 - 34,701,364 (+)NCBIUU_Cfam_GSD_1.0
TMEM127
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,248,514 - 96,265,997 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,248,500 - 96,266,047 (-)EnsemblGRCh38hg38GRCh38
GRCh37296,914,252 - 96,931,735 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,280,039 - 96,295,459 (-)NCBINCBI36Build 36hg18NCBI36
Celera291,357,500 - 91,372,939 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef290,877,443 - 90,893,248 (-)NCBIHuRef
CHM1_1296,920,300 - 96,936,106 (-)NCBICHM1_1
T2T-CHM13v2.0296,755,122 - 96,772,605 (-)NCBIT2T-CHM13v2.0
Tmem127
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,089,868 - 127,103,028 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,089,828 - 127,103,027 (+)EnsemblGRCm39 Ensembl
GRCm382127,247,904 - 127,261,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,247,908 - 127,261,107 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,073,711 - 127,086,500 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,939,416 - 126,952,205 (+)NCBIMGSCv36mm8
Celera2128,487,347 - 128,500,147 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.87NCBI
Tmem127
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,919,416 - 134,932,210 (+)NCBIGRCr8
mRatBN7.23114,466,095 - 114,478,894 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,466,171 - 114,477,519 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,357,660 - 118,370,450 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,953,204 - 126,965,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,613,584 - 124,626,374 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,677,575 - 119,690,371 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,677,575 - 119,690,366 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,202,774 - 126,215,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,746,454 - 114,759,251 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,652,049 - 114,664,824 (+)NCBI
Celera3113,306,634 - 113,319,570 (+)NCBICelera
Cytogenetic Map3q36NCBI
Tmem127
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,808,455 - 3,822,497 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,809,835 - 3,822,442 (-)NCBIChiLan1.0ChiLan1.0
TMEM127
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21232,042,817 - 32,057,217 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A32,045,577 - 32,059,977 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A103,049,655 - 103,065,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A97,174,322 - 97,189,177 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A97,174,322 - 97,189,171 (-)Ensemblpanpan1.1panPan2
Tmem127
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,091,414 - 83,106,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744344,356 - 359,044 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936744344,356 - 359,086 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM127
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl346,966,892 - 46,978,810 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1346,966,858 - 47,017,659 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,108,738 - 49,121,833 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM127
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114671,259 - 685,217 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14673,375 - 685,228 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041168,096,788 - 168,111,829 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem127
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,333,472 - 2,344,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,333,472 - 2,344,652 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMEM127
131 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000010919   ⟹   ENSCAFP00000010119
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1734,512,792 - 34,523,692 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845010920   ⟹   ENSCAFP00845008521
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1735,283,938 - 35,296,757 (+)Ensembl
RefSeq Acc Id: XM_038498817   ⟹   XP_038354745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11734,413,107 - 34,426,110 (+)NCBI
RefSeq Acc Id: XM_038561378   ⟹   XP_038417306
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01734,688,570 - 34,701,364 (+)NCBI
RefSeq Acc Id: XM_038625432   ⟹   XP_038481360
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01734,481,752 - 34,494,521 (+)NCBI
RefSeq Acc Id: XM_038691359   ⟹   XP_038547287
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01735,283,964 - 35,296,760 (+)NCBI
RefSeq Acc Id: XM_859311   ⟹   XP_864404
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11734,512,753 - 34,527,208 (+)NCBI
Dog10K_Boxer_Tasha1734,282,678 - 34,295,473 (+)NCBI
Sequence:
RefSeq Acc Id: XP_864404   ⟸   XM_859311
- UniProtKB: A0A8C0TY12 (UniProtKB/TrEMBL),   A0A8C0L2D7 (UniProtKB/TrEMBL),   A0A8I3N230 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000010119   ⟸   ENSCAFT00000010919
RefSeq Acc Id: XP_038354745   ⟸   XM_038498817
RefSeq Acc Id: XP_038481360   ⟸   XM_038625432
RefSeq Acc Id: XP_038547287   ⟸   XM_038691359
- UniProtKB: A0A8C0TY12 (UniProtKB/TrEMBL),   A0A8C0L2D7 (UniProtKB/TrEMBL),   A0A8I3N230 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038417306   ⟸   XM_038561378
- UniProtKB: A0A8C0L2D7 (UniProtKB/TrEMBL),   A0A8C0TY12 (UniProtKB/TrEMBL),   A0A8I3N230 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845008521   ⟸   ENSCAFT00845010920
Protein Domains
Transmembrane protein 127 transmembrane region


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006783 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012599 UniProtKB/TrEMBL
  ENSCAFG00040025736 UniProtKB/TrEMBL
  ENSCAFG00845006154 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010919.4 UniProtKB/TrEMBL
  ENSCAFT00030023361.1 UniProtKB/TrEMBL
  ENSCAFT00040048051.1 UniProtKB/TrEMBL
  ENSCAFT00845010920 ENTREZGENE
  ENSCAFT00845010920.1 UniProtKB/TrEMBL
InterPro TMEM127 UniProtKB/TrEMBL
  TMEM127_TM UniProtKB/TrEMBL
KEGG Report cfa:609057 UniProtKB/TrEMBL
NCBI Gene TMEM127 ENTREZGENE
PANTHER PTHR28358 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 127 UniProtKB/TrEMBL
Pfam TMEM127 UniProtKB/TrEMBL
UniProt A0A8C0L2D7 ENTREZGENE
  A0A8C0TY12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N230 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47461 ENTREZGENE