OR8D4 (olfactory receptor family 8 subfamily D member 4) - Rat Genome Database

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Gene: OR8D4 (olfactory receptor family 8 subfamily D member 4) Canis lupus familiaris
Analyze
Symbol: OR8D4
Name: olfactory receptor family 8 subfamily D member 4
RGD ID: 12117488
Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC100688741; LOC106558785; olfactory receptor 8D4; uncharacterized LOC106558785
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1510,572,932 - 10,588,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl510,587,439 - 10,588,374 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha510,643,580 - 10,644,515 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0510,526,888 - 10,537,965 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl510,536,941 - 10,537,876 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1510,642,548 - 10,643,484 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0510,572,619 - 10,573,554 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0510,617,933 - 10,618,868 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
OR8D4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1510,572,932 - 10,588,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl510,587,439 - 10,588,374 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha510,643,580 - 10,644,515 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0510,526,888 - 10,537,965 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl510,536,941 - 10,537,876 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1510,642,548 - 10,643,484 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0510,572,619 - 10,573,554 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0510,617,933 - 10,618,868 (+)NCBIUU_Cfam_GSD_1.0
OR8D4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811123,902,167 - 123,909,229 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11123,902,167 - 123,909,229 (+)EnsemblGRCh38hg38GRCh38
GRCh3711123,772,874 - 123,779,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611123,282,349 - 123,283,293 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411123,282,348 - 123,283,293NCBI
Celera11120,936,319 - 120,937,263 (+)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11119,717,893 - 119,718,837 (+)NCBIHuRef
CHM1_111123,663,308 - 123,664,252 (+)NCBICHM1_1
T2T-CHM13v2.011123,930,777 - 123,937,833 (+)NCBIT2T-CHM13v2.0
Or8d4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,038,220 - 40,039,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl940,037,604 - 40,041,480 (-)EnsemblGRCm39 Ensembl
GRCm38940,126,924 - 40,128,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,126,308 - 40,130,184 (-)EnsemblGRCm38mm10GRCm38
MGSCv37939,934,509 - 39,935,624 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36939,877,595 - 39,878,530 (-)NCBIMGSCv36mm8
Celera937,365,610 - 37,366,725 (-)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.42NCBI
Or8d4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8849,367,154 - 49,368,089 (-)NCBIGRCr8
mRatBN7.2840,469,997 - 40,470,932 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl840,469,997 - 40,470,932 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0843,969,459 - 43,970,400 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl843,969,459 - 43,970,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0861,561,742 - 61,562,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,069,683 - 43,078,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1843,078,448 - 43,086,981 (-)NCBI
Celera840,085,203 - 40,086,144 (-)NCBICelera
Cytogenetic Map8q22NCBI
LOC102028842
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541224,557,873 - 24,558,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541224,557,873 - 24,558,811 (+)NCBIChiLan1.0ChiLan1.0
LOC100972169
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29124,599,166 - 124,606,567 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111125,703,625 - 125,711,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011118,734,966 - 118,736,039 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111122,651,849 - 122,652,922 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11122,651,884 - 122,652,828 (+)Ensemblpanpan1.1panPan2
LOC101955299
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947105,383,048 - 105,384,062 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365428,304,492 - 8,305,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365428,304,457 - 8,305,471 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100524947
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl950,713,124 - 50,714,062 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1950,713,124 - 50,714,241 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2956,002,518 - 56,003,456 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103248710
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,167,659 - 115,221,248 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,220,148 - 115,221,089 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604310,894,508 - 10,896,137 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101697622
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248801,280,736 - 1,281,671 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248801,280,733 - 1,281,695 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OR8D4
194 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 8
Below cutoff 1 2 7 4 3 1 5 4 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018204   ⟹   ENSCAFP00000016857
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl510,587,439 - 10,588,374 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845021671   ⟹   ENSCAFP00845017037
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl510,536,941 - 10,537,876 (+)Ensembl
RefSeq Acc Id: NM_001389109   ⟹   NP_001376038
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha510,643,580 - 10,644,515 (+)NCBI
ROS_Cfam_1.0510,536,941 - 10,537,876 (+)NCBI
UMICH_Zoey_3.1510,642,548 - 10,643,484 (+)NCBI
UNSW_CanFamBas_1.0510,572,619 - 10,573,554 (+)NCBI
UU_Cfam_GSD_1.0510,617,933 - 10,618,868 (+)NCBI
RefSeq Acc Id: XM_038664040   ⟹   XP_038519968
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0510,526,892 - 10,537,965 (+)NCBI
RefSeq Acc Id: XM_038664041   ⟹   XP_038519969
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0510,526,892 - 10,537,965 (+)NCBI
RefSeq Acc Id: XM_038664042   ⟹   XP_038519970
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0510,526,893 - 10,537,965 (+)NCBI
RefSeq Acc Id: XM_038664043   ⟹   XP_038519971
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0510,526,888 - 10,537,965 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000016857   ⟸   ENSCAFT00000018204
RefSeq Acc Id: NP_001376038   ⟸   NM_001389109
- UniProtKB: A0A8C0KAW1 (UniProtKB/TrEMBL),   A0A8I3NBS5 (UniProtKB/TrEMBL),   A0A8P0SGA4 (UniProtKB/TrEMBL),   A0A8C0YUE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519971   ⟸   XM_038664043
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KAW1 (UniProtKB/TrEMBL),   A0A8I3NBS5 (UniProtKB/TrEMBL),   A0A8P0SGA4 (UniProtKB/TrEMBL),   A0A8C0YUE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519969   ⟸   XM_038664041
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KAW1 (UniProtKB/TrEMBL),   A0A8I3NBS5 (UniProtKB/TrEMBL),   A0A8P0SGA4 (UniProtKB/TrEMBL),   A0A8C0YUE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519968   ⟸   XM_038664040
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KAW1 (UniProtKB/TrEMBL),   A0A8I3NBS5 (UniProtKB/TrEMBL),   A0A8P0SGA4 (UniProtKB/TrEMBL),   A0A8C0YUE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519970   ⟸   XM_038664042
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KAW1 (UniProtKB/TrEMBL),   A0A8I3NBS5 (UniProtKB/TrEMBL),   A0A8P0SGA4 (UniProtKB/TrEMBL),   A0A8C0YUE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845017037   ⟸   ENSCAFT00845021671
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011470 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040010289 UniProtKB/TrEMBL
  ENSCAFG00845012192 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018204.4 UniProtKB/TrEMBL
  ENSCAFT00040019023.1 UniProtKB/TrEMBL
  ENSCAFT00845021671 ENTREZGENE
  ENSCAFT00845021671.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
NCBI Gene LOC100688741 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 8D4 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C0KAW1 ENTREZGENE
  A0A8C0YUE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NBS5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SGA4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:98633 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-10 OR8D4  olfactory receptor family 8 subfamily D member 4  LOC100688741  olfactory receptor 8D4  Symbol and/or name change 5135510 APPROVED
2017-11-21 LOC100688741  olfactory receptor 8D4  LOC106558785  uncharacterized LOC106558785  Data merged from RGD:12346606 737654 PROVISIONAL