PLRG1 (pleiotropic regulator 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: PLRG1 (pleiotropic regulator 1) Canis lupus familiaris
Analyze
Symbol: PLRG1
Name: pleiotropic regulator 1
RGD ID: 12071373
Description: INVOLVED IN positive regulation of G1/S transition of mitotic cell cycle (ortholog); protein localization to nucleus (ortholog); PARTICIPATES IN spliceosome pathway; FOUND IN DNA replication factor A complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,196,998 - 52,213,378 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,198,635 - 52,213,239 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,541,437 - 52,557,901 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,883,804 - 52,900,253 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,883,814 - 52,900,312 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,138,786 - 52,155,267 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,243,408 - 52,259,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,557,769 - 52,574,252 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,196,998 - 52,213,378 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,198,635 - 52,213,239 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,541,437 - 52,557,901 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,883,804 - 52,900,253 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,883,814 - 52,900,312 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,138,786 - 52,155,267 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,243,408 - 52,259,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,557,769 - 52,574,252 (-)NCBIUU_Cfam_GSD_1.0
PLRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,535,005 - 154,550,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,535,005 - 154,550,400 (-)EnsemblGRCh38hg38GRCh38
GRCh374155,456,157 - 155,471,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,677,112 - 155,690,973 (-)NCBINCBI36Build 36hg18NCBI36
Build 344155,815,438 - 155,827,692NCBI
Celera4152,789,011 - 152,802,847 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4151,196,830 - 151,212,267 (-)NCBIHuRef
CHM1_14155,434,061 - 155,449,498 (-)NCBICHM1_1
T2T-CHM13v2.04157,866,774 - 157,882,170 (-)NCBIT2T-CHM13v2.0
Plrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,962,845 - 82,979,598 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,962,829 - 82,979,662 (+)EnsemblGRCm39 Ensembl
GRCm38383,055,538 - 83,072,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,055,522 - 83,072,355 (+)EnsemblGRCm38mm10GRCm38
MGSCv37382,859,460 - 82,876,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,141,465 - 83,158,218 (+)NCBIMGSCv36mm8
Celera383,059,703 - 83,076,420 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.99NCBI
Plrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,706,188 - 170,722,519 (+)NCBIGRCr8
mRatBN7.22168,408,139 - 168,424,470 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,408,124 - 168,424,522 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,598,376 - 175,614,509 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,619,300 - 173,635,434 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,220,722 - 168,236,856 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,040,338 - 182,056,669 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,040,318 - 182,056,673 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,454,958 - 201,471,289 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,780,415 - 174,796,746 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,730,520 - 174,746,852 (+)NCBI
Celera2162,434,780 - 162,451,111 (+)NCBICelera
Cytogenetic Map2q34NCBI
Plrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,763,971 - 8,777,396 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,764,465 - 8,777,396 (-)NCBIChiLan1.0ChiLan1.0
PLRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23152,448,826 - 152,462,909 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14152,802,791 - 152,818,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,900,494 - 146,917,016 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,719,568 - 158,735,103 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4158,719,568 - 158,735,103 (-)Ensemblpanpan1.1panPan2
Plrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,249,134 - 38,263,642 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,282,664 - 1,297,818 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365761,284,758 - 1,297,758 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,614,893 - 74,633,102 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,614,925 - 74,631,072 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,101,263 - 79,118,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,080,254 - 101,096,048 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,079,449 - 101,096,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,735,565 - 80,751,365 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248585,801,884 - 5,818,005 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLRG1
183 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000013353   ⟹   ENSCAFP00000012356
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1552,198,635 - 52,213,239 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000049033   ⟹   ENSCAFP00000037175
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1552,198,635 - 52,211,921 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845017003   ⟹   ENSCAFP00845013243
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1552,883,814 - 52,900,312 (-)Ensembl
RefSeq Acc Id: XM_005629365   ⟹   XP_005629422
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11552,196,998 - 52,213,378 (-)NCBI
Dog10K_Boxer_Tasha1552,541,437 - 52,557,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022403530   ⟹   XP_022259238
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11552,196,998 - 52,213,356 (-)NCBI
Dog10K_Boxer_Tasha1552,541,437 - 52,557,795 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038496677   ⟹   XP_038352605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11552,138,786 - 52,155,267 (-)NCBI
RefSeq Acc Id: XM_038496678   ⟹   XP_038352606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11552,138,786 - 52,155,153 (-)NCBI
RefSeq Acc Id: XM_038559071   ⟹   XP_038414999
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01552,557,769 - 52,574,252 (-)NCBI
RefSeq Acc Id: XM_038559072   ⟹   XP_038415000
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01552,557,769 - 52,574,138 (-)NCBI
RefSeq Acc Id: XM_038623006   ⟹   XP_038478934
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01552,243,408 - 52,259,860 (-)NCBI
RefSeq Acc Id: XM_038623007   ⟹   XP_038478935
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01552,243,408 - 52,259,776 (-)NCBI
RefSeq Acc Id: XM_038688680   ⟹   XP_038544608
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01552,883,804 - 52,900,253 (-)NCBI
RefSeq Acc Id: XM_038688681   ⟹   XP_038544609
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01552,883,804 - 52,900,203 (-)NCBI
RefSeq Acc Id: XP_005629422   ⟸   XM_005629365
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MN88 (UniProtKB/TrEMBL),   A0A8I3N1X7 (UniProtKB/TrEMBL),   A0A8C0JLH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022259238   ⟸   XM_022403530
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JLN0 (UniProtKB/TrEMBL),   A0A8C0SGL3 (UniProtKB/TrEMBL),   A0A8C0JLH8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000037175   ⟸   ENSCAFT00000049033
Ensembl Acc Id: ENSCAFP00000012356   ⟸   ENSCAFT00000013353
RefSeq Acc Id: XP_038352605   ⟸   XM_038496677
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038352606   ⟸   XM_038496678
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038478934   ⟸   XM_038623006
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038478935   ⟸   XM_038623007
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038544608   ⟸   XM_038688680
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MN88 (UniProtKB/TrEMBL),   A0A8I3N1X7 (UniProtKB/TrEMBL),   A0A8C0JLH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038544609   ⟸   XM_038688681
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JLN0 (UniProtKB/TrEMBL),   A0A8C0SGL3 (UniProtKB/TrEMBL),   A0A8C0JLH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414999   ⟸   XM_038559071
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JLH8 (UniProtKB/TrEMBL),   A0A8C0MN88 (UniProtKB/TrEMBL),   A0A8I3N1X7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415000   ⟸   XM_038559072
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JLH8 (UniProtKB/TrEMBL),   A0A8C0JLN0 (UniProtKB/TrEMBL),   A0A8C0SGL3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845013243   ⟸   ENSCAFT00845017003

Promoters
RGD ID:13686003
Promoter ID:EPDNEW_C4071
Type:multiple initiation site
Name:PLRG1_1
Description:pleiotropic regulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11552,213,336 - 52,213,396EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008399 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008732 UniProtKB/TrEMBL
  ENSCAFG00040012581 UniProtKB/TrEMBL
  ENSCAFG00845009646 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013353.3 UniProtKB/TrEMBL
  ENSCAFT00030016395.1 UniProtKB/TrEMBL
  ENSCAFT00040023232.1 UniProtKB/TrEMBL
  ENSCAFT00040023395.1 UniProtKB/TrEMBL
  ENSCAFT00845017003 ENTREZGENE
  ENSCAFT00845017003.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  Prp46/PLRG1-like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:612490 UniProtKB/TrEMBL
NCBI Gene PLRG1 ENTREZGENE
PANTHER PLEIOTROPIC REGULATOR 1 UniProtKB/TrEMBL
  PTHR19923 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A8C0JLH8 ENTREZGENE
  A0A8C0JLN0 ENTREZGENE
  A0A8C0MN88 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SGL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N1X7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44710 ENTREZGENE