MARCHF4 (membrane associated ring-CH-type finger 4) - Rat Genome Database

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Gene: MARCHF4 (membrane associated ring-CH-type finger 4) Pan paniscus
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Symbol: MARCHF4
Name: membrane associated ring-CH-type finger 4
RGD ID: 12034510
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (inferred); zinc ion binding (inferred); INVOLVED IN protein ubiquitination (inferred); ASSOCIATED WITH frontotemporal dementia (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN endomembrane system (inferred); Golgi stack (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase MARCHF4; MARCH4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213118,884,516 - 118,998,758 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B118,899,480 - 119,013,727 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B103,517,175 - 103,632,197 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B222,121,032 - 222,235,291 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B222,121,032 - 222,235,548 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MARCHF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213118,884,516 - 118,998,758 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B118,899,480 - 119,013,727 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B103,517,175 - 103,632,197 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B222,121,032 - 222,235,291 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B222,121,032 - 222,235,548 (-)Ensemblpanpan1.1panPan2
MARCHF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,257,865 - 216,372,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2216,257,865 - 216,372,483 (-)EnsemblGRCh38hg38GRCh38
GRCh372217,122,588 - 217,237,206 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362216,830,834 - 216,944,995 (-)NCBINCBI36Build 36hg18NCBI36
Build 342216,948,094 - 217,062,256NCBI
Celera2210,889,243 - 211,003,395 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2208,976,394 - 209,090,552 (-)NCBIHuRef
CHM1_12217,128,106 - 217,242,266 (-)NCBICHM1_1
T2T-CHM13v2.02216,740,406 - 216,854,601 (-)NCBIT2T-CHM13v2.0
Marchf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,466,271 - 72,576,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,466,271 - 72,576,089 (-)EnsemblGRCm39 Ensembl
GRCm38172,427,112 - 72,537,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,427,112 - 72,536,930 (-)EnsemblGRCm38mm10GRCm38
MGSCv37172,473,686 - 72,583,138 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36172,360,322 - 72,470,499 (-)NCBIMGSCv36mm8
Celera172,999,270 - 73,104,429 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.54NCBI
Marchf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8981,527,703 - 81,647,448 (-)NCBIGRCr8
mRatBN7.2974,078,437 - 74,196,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,078,434 - 74,198,199 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0979,781,752 - 79,898,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl979,782,845 - 79,898,912 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,554,293 - 79,670,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4971,617,505 - 71,735,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera971,473,921 - 71,591,034 (-)NCBICelera
Cytogenetic Map9q33NCBI
Marchf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,820,344 - 16,933,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545316,820,344 - 16,933,106 (+)NCBIChiLan1.0ChiLan1.0
MARCHF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13723,218,664 - 23,330,115 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,220,458 - 23,330,077 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3724,047,570 - 24,161,054 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03723,245,433 - 23,359,713 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,245,431 - 23,357,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,130,632 - 23,244,121 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03723,083,496 - 23,196,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03723,101,072 - 23,215,243 (-)NCBIUU_Cfam_GSD_1.0
Marchf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,599,517 - 171,701,771 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936586925,192 - 1,029,578 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936586923,254 - 1,026,340 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARCHF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,480,239 - 118,587,549 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115118,480,243 - 118,587,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215131,361,322 - 131,466,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MARCHF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110102,099,296 - 102,213,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10102,099,150 - 102,211,499 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604097,188,351 - 97,300,419 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marchf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248238,748,490 - 8,864,330 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248238,748,487 - 8,864,304 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003818586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000048114   ⟹   ENSPPAP00000025287
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B222,121,032 - 222,235,548 (-)Ensembl
RefSeq Acc Id: XM_003818586   ⟹   XP_003818634
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213118,884,516 - 118,998,758 (-)NCBI
NHGRI_mPanPan12B118,899,480 - 119,013,727 (-)NCBI
Mhudiblu_PPA_v02B103,517,175 - 103,632,197 (-)NCBI
PanPan1.12B222,121,032 - 222,235,291 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003818634 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000025287
  ENSPPAP00000025287.1
RefSeq Acc Id: XP_003818634   ⟸   XM_003818586
- UniProtKB: A0A2R9B6S4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000025287   ⟸   ENSPPAT00000048114
Protein Domains
RING-CH-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035784 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048114.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro MARCHF4/9/11 UniProtKB/TrEMBL
  MARCHF4_RING_CH-C4HC3 UniProtKB/TrEMBL
  Znf_RING-CH UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report pps:100971233 UniProtKB/TrEMBL
NCBI Gene MARCH4 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MARCHF4 UniProtKB/TrEMBL
  PTHR46053 UniProtKB/TrEMBL
Pfam RINGv UniProtKB/TrEMBL
PROSITE ZF_RING_CH UniProtKB/TrEMBL
SMART RINGv UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A2R9B6S4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-16 MARCHF4  membrane associated ring-CH-type finger 4  MARCH4  membrane associated ring-CH-type finger 4  Symbol and/or name change 5135510 APPROVED