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Gene: MPND (MPN domain containing) Pan paniscus

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Symbol:

MPND

Name:

MPN domain containing

RGD ID:

12019151

Description:

ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); metal-dependent deubiquitinase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH amenorrhea (ortholog); COVID-19 (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MPND (MPN domain containing)	NCBI	Ortholog
Mus musculus (house mouse):	Mpnd (MPN domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mpnd (MPN domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mpnd (MPN domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MPND (MPN domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mpnd (MPN domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MPND (MPN domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MPND (MPN domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mpnd (MPN domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	8,727,140 - 8,757,998 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	7,956,543 - 7,987,160 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	3,362,867 - 3,382,984 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	4,312,351 - 4,329,465 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,313,178 - 4,329,382 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MPND	Bonobo	COVID-19		ISO	RGD:1605915	9068941	mRNA:increased expression:peripheral blood mononuclear cell (human)	RGD	PMID:32228226\|REF_RGD_ID:28912744

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MPND	Bonobo	amenorrhea		ISO	RGD:1605915	8554872	ClinVar Annotator: match by term: Primary amenorrhea	ClinVar	PMID:21681106

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MPND	Bonobo	proteolysis	involved_in	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MPND	Bonobo	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
MPND	Bonobo	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
MPND	Bonobo	metal-dependent deubiquitinase activity	enables	IEA	ARBA:ARBA00043561	150520179		UniProt	GO_REF:0000117
MPND	Bonobo	metallopeptidase activity	enables	IEA	InterPro:IPR000555	150520179		InterPro	GO_REF:0000002
MPND	Bonobo	metallopeptidase activity	enables	IEA	UniProtKB-KW:KW-0482	150520179		UniProt	GO_REF:0000043
MPND	Bonobo	peptidase activity	enables	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
MPND	Bonobo	peptidase activity	enables	IEA	InterPro:IPR000555	150520179		InterPro	GO_REF:0000002
MPND	Bonobo	protein binding	enables	ISO	UniProtKB:G5E9A7\|UniProtKB:O43464\|UniProtKB:O60260-5\|UniProtKB:O60333-2\|UniProtKB:O76024\|UniProtKB:P00441\|UniProtKB:P04792\|UniProtKB:P05067\|UniProtKB:P28358\|UniProtKB:P29474\|UniProtKB:P35240-4\|UniProtKB:P37840\|UniProtKB:P42858\|UniProtKB:P54253\|UniProtKB:P60891\|UniProtKB:Q13148\|UniProtKB:Q14203-5\|UniProtKB:Q7Z699\|UniProtKB:Q8WXH2\|UniProtKB:Q9Y3C5	9068941	PMID:32814053	IntAct	PMID:32814053

PMID:22301074	PMID:30032202

MPND
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	8,727,140 - 8,757,998 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	7,956,543 - 7,987,160 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	3,362,867 - 3,382,984 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	4,312,351 - 4,329,465 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,313,178 - 4,329,382 (+)	Ensembl	panpan1.1		panPan2

MPND
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	4,343,562 - 4,360,078 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	4,343,527 - 4,360,086 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	4,343,559 - 4,360,075 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	4,294,570 - 4,311,075 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	4,281,776 - 4,298,329 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	4,105,998 - 4,122,602 (+)	NCBI		HuRef
CHM1_1	19	4,343,227 - 4,359,729 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	4,327,019 - 4,343,527 (+)	NCBI		T2T-CHM13v2.0

Mpnd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	56,316,201 - 56,323,790 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	56,312,711 - 56,323,790 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	56,009,201 - 56,016,790 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	56,005,711 - 56,016,790 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	56,148,624 - 56,156,213 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	55,602,619 - 55,609,955 (+)	NCBI		MGSCv36	mm8
Celera	17	59,427,863 - 59,435,452 (+)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.11	NCBI

Mpnd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	926,714 - 933,620 (+)	NCBI		GRCr8
mRatBN7.2	9	839,473 - 846,446 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	840,143 - 846,439 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	1,287,342 - 1,293,596 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	6,633,888 - 6,640,137 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	5,592,377 - 5,598,632 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	11,055,370 - 11,061,611 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	11,055,371 - 11,061,611 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	10,040,659 - 10,047,589 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,660,577 - 7,666,824 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

Mpnd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	4,531,895 - 4,538,030 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	4,531,895 - 4,538,030 (-)	NCBI	ChiLan1.0	ChiLan1.0

MPND
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	55,311,890 - 55,320,226 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	55,304,529 - 55,320,196 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,032,429 - 55,048,360 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	55,963,333 - 55,979,259 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	55,970,987 - 55,979,247 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,031,495 - 55,039,433 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,504,806 - 55,520,722 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,703,487 - 55,719,409 (-)	NCBI		UU_Cfam_GSD_1.0

Mpnd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,330,707 - 215,338,277 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	2,496,506 - 2,503,959 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	2,491,059 - 2,504,076 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MPND
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,445,662 - 74,455,881 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,445,660 - 74,455,928 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	74,938,611 - 74,948,868 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MPND
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	4,072,007 - 4,090,524 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	4,112,744 - 4,132,173 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mpnd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	5,328,783 - 5,337,946 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	5,330,536 - 5,337,973 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_034945477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034945478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034945479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000040937 ⟹ ENSPPAP00000018208

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	4,313,178 - 4,329,382 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000040941 ⟹ ENSPPAP00000018212

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	4,313,178 - 4,329,382 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000040946 ⟹ ENSPPAP00000018217

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	4,313,178 - 4,329,382 (+)	Ensembl

RefSeq Acc Id:

XM_034945477 ⟹ XP_034801368

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	8,727,140 - 8,757,998 (+)	NCBI
NHGRI_mPanPan1	19	7,956,543 - 7,987,160 (+)	NCBI
Mhudiblu_PPA_v0	19	3,362,867 - 3,382,984 (+)	NCBI

RefSeq Acc Id:

XM_034945478 ⟹ XP_034801369

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	8,737,765 - 8,757,998 (+)	NCBI
NHGRI_mPanPan1	19	7,967,262 - 7,987,160 (+)	NCBI
Mhudiblu_PPA_v0	19	3,362,867 - 3,382,984 (+)	NCBI

RefSeq Acc Id:

XM_034945479 ⟹ XP_034801370

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	8,741,407 - 8,757,998 (+)	NCBI
NHGRI_mPanPan1	19	7,970,825 - 7,987,160 (+)	NCBI
Mhudiblu_PPA_v0	19	3,366,433 - 3,382,984 (+)	NCBI


Protein RefSeqs	XP_034801368	(Get FASTA)	NCBI Sequence Viewer
	XP_034801369	(Get FASTA)	NCBI Sequence Viewer
	XP_034801370	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000018208.1
	ENSPPAP00000018212.1
	ENSPPAP00000018217.1

RefSeq Acc Id:	XP_034801368 ⟸ XM_034945477
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9AM26 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034801369 ⟸ XM_034945478
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9AM26 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034801370 ⟸ XM_034945479
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9AM26 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000018208 ⟸ ENSPPAT00000040937

Ensembl Acc Id:

ENSPPAP00000018212 ⟸ ENSPPAT00000040941

Protein Domains

MPN

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000032201	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000040937.1	UniProtKB/TrEMBL
	ENSPPAT00000040941.1	UniProtKB/TrEMBL
	ENSPPAT00000040946.1	UniProtKB/TrEMBL
Gene3D-CATH	Cytidine Deaminase, domain 2	UniProtKB/TrEMBL
InterPro	JAB_dom_prok	UniProtKB/TrEMBL
	JAMM/MPN+_dom	UniProtKB/TrEMBL
	JAMM_MPN+_peptidase_M67A	UniProtKB/TrEMBL
	MPN	UniProtKB/TrEMBL
	RAMA	UniProtKB/TrEMBL
NCBI Gene	MPND	ENTREZGENE
PANTHER	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED	UniProtKB/TrEMBL
Pfam	JAB	UniProtKB/TrEMBL
	Prok-JAB	UniProtKB/TrEMBL
	RAMA	UniProtKB/TrEMBL
PROSITE	MPN	UniProtKB/TrEMBL
Superfamily-SCOP	JAB1/MPN domain	UniProtKB/TrEMBL
UniProt	A0A2R9ALI5_PANPA	UniProtKB/TrEMBL
	A0A2R9ALJ0_PANPA	UniProtKB/TrEMBL
	A0A2R9AM26	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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