PKDCC (protein kinase domain containing, cytoplasmic)

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Gene: PKDCC (protein kinase domain containing, cytoplasmic) Pan paniscus

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Symbol:

PKDCC

Name:

protein kinase domain containing, cytoplasmic

RGD ID:

12018450

Description:

ENCODES a protein that exhibits non-membrane spanning protein tyrosine kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); embryonic digestive tract development (ortholog); limb morphogenesis (ortholog); ASSOCIATED WITH genetic disease (ortholog); Lynch syndrome (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extracellular region (ortholog); Golgi apparatus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

extracellular tyrosine-protein kinase PKDCC; protein kinase domain containing, cytoplasmic homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	84,351,451 - 84,361,978 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	84,355,424 - 84,365,933 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	42,146,153 - 42,156,652 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	42,999,423 - 43,009,337 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Lynch syndrome (ISO)

Neurodevelopmental Disorders (ISO)

RHIZOMELIC LIMB SHORTENING WITH DYSMORPHIC FEATURES (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone mineralization (ISO)

embryonic digestive tract development (ISO)

limb morphogenesis (ISO)

lung alveolus development (ISO)

multicellular organism growth (ISO)

negative regulation of Golgi to plasma membrane protein transport (ISO)

peptidyl-tyrosine phosphorylation (ISO)

positive regulation of bone mineralization (ISO)

positive regulation of chondrocyte differentiation (ISO)

roof of mouth development (ISO)

skeletal system development (ISO)

Cellular Component

extracellular region (ISO)

Golgi apparatus (ISO)

Molecular Function

non-membrane spanning protein tyrosine kinase activity (ISO)

protein kinase activity (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PKDCC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	84,351,451 - 84,361,978 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	84,355,424 - 84,365,933 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	42,146,153 - 42,156,652 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	42,999,423 - 43,009,337 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

PKDCC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	42,048,021 - 42,058,517 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	42,048,021 - 42,058,517 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	42,275,161 - 42,285,657 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	42,129,257 - 42,139,144 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	42,114,692 - 42,125,199 (+)	NCBI		Celera
Cytogenetic Map	2	p21	NCBI
HuRef	2	41,976,661 - 42,020,247 (+)	NCBI		HuRef
CHM1_1	2	42,204,788 - 42,215,229 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	42,053,518 - 42,064,014 (+)	NCBI		T2T-CHM13v2.0

Pkdcc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	83,522,708 - 83,532,496 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	83,522,721 - 83,532,499 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	83,215,283 - 83,225,069 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	83,215,292 - 83,225,070 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	83,614,623 - 83,624,409 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	83,123,628 - 83,133,392 (+)	NCBI		MGSCv36	mm8
Celera	17	87,561,813 - 87,571,116 (+)	NCBI		Celera
Cytogenetic Map	17	E4	NCBI
cM Map	17	52.25	NCBI

Pkdcc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	17,208,171 - 17,217,488 (-)	NCBI		GRCr8
mRatBN7.2	6	11,455,686 - 11,465,002 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	11,455,686 - 11,465,556 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	11,749,731 - 11,759,048 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	12,059,079 - 12,068,396 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	11,572,700 - 11,582,029 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	6,427,657 - 6,436,974 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	6,427,657 - 6,436,974 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	6,384,829 - 6,394,146 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	6,554,313 - 6,563,630 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	6,553,108 - 6,563,623 (+)	NCBI
Celera	6	11,160,388 - 11,169,705 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

Pkdcc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	9,462,530 - 9,471,446 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	9,462,530 - 9,471,446 (+)	NCBI	ChiLan1.0	ChiLan1.0

PKDCC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	33,659,352 - 33,669,237 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	33,659,272 - 33,668,892 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	33,430,046 - 33,439,952 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	34,426,469 - 34,436,390 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	34,426,498 - 34,436,370 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	33,552,650 - 33,562,557 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	33,614,371 - 33,624,301 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	33,831,677 - 33,841,621 (+)	NCBI		UU_Cfam_GSD_1.0

Pkdcc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	38,121,581 - 38,130,884 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	9,550,224 - 9,559,499 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	9,550,201 - 9,559,493 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PKDCC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	98,258,463 - 98,268,553 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	98,258,456 - 98,268,539 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	104,399,317 - 104,410,926 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PKDCC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	65,203,757 - 65,214,386 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	65,204,620 - 65,214,190 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	46,688,090 - 46,698,587 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pkdcc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	23,759,398 - 23,771,639 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	23,759,382 - 23,768,743 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003809133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063594615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003809133 ⟹ XP_003809181

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	12	84,351,451 - 84,361,974 (-)	NCBI
NHGRI_mPanPan1	2A	84,355,424 - 84,365,933 (-)	NCBI
Mhudiblu_PPA_v0	2A	42,146,153 - 42,156,652 (+)	NCBI
PanPan1.1	2A	42,999,423 - 43,009,337 (+)	NCBI

Sequence:

show sequence

GGCGCGCAGTACATGGGCTCAGGCTACACCAAGGCCGTGTACCGGGTCCGCCTGCCCGGCGGCG
CCGCGGTGGCGCTCAAGGCGGTGGACTTTAGCGGCCACGATCTGGGCAGCTGCGTGCGCGAGTT
CGGGGTACGGAGGGGCTGCTATCGGCTGGCGGCCCACAAGCTGCTTAAGGAGATGGTGCTGCTG
GAGCGGCTGCGGCACCCCAACGTGCTGCAGCTCTATGGCTACTGCTACCAGGACAGCGAGGACA
TCCCAGACACCCTGACCACCATCACGGAGCTGGGCGCCCCTGTAGAAATGATCCAGCTGCTGCA
AACTTCCTGGGAGGATCGATTCCGAATCTGCCTGAGCCTGGGCCGCCTCCTCCACCACCTGGCC
CACTCCCCACTGGGCTCCGTCACTCTGCTGGACTTCCGCCCTCGGCAGTTTGTGCTGGTGGATG
GGGAGCTCAAAGTGACGGACCTGGATGACGCACGTGTGGAGGAGACGCCGTGTGCAGGCAGCAC
CGACTGCATACTCGAGTTTCCGGCCAGGAACTTCACCCTGCCCTGCTCAGCCCAGGGCTGGTGC
GAGGGCATGAACGAGAAGCGGAACCTCTATAATGCCTACAGGTTTTTCTTCACATACCTCCTGC
CTCACAGTGCCCCGCCTTCATTGCGTCCTCTGCTGGACAGCATCGTCAACGCCACAGGAGAGCT
CACCTGGGGGGTGGACGAGACCCTGGCCCAGCTGGAGAAGGTGCTGCACCTGTACCGGAGCGGG
CAGTATCTGCAGAACTCCACGGCAAGCAGCAGTACCGAGTACCAGTGTATCCCAGACAGCACCA
TCCCCCAGGAAGACTACCGCTGCTGGCCATCCTACCACCACGGGAGCTGCCTCCTTTCAGTGTT
CAACCTGGCTGAGGCCGTGGATGTCTGTGAGAGCCATGCCCAGTGTCGGGCCTTTGTGGTCACC
AACCAGACCACCTGGACAGGTCGGCAGCTGGTCTTTTTCAAGACTGGATGGAGCCAAGTGGTCC
CTGATCCCAACAAGACCACATATGTGAAGGCCTCTGGCTGACCTATCTGAGGGCTCTGCTGACC
AGCTGACTATCCTCAGCAGCTGGGCTTGCCTGTGGAGGGAGTGACTTGCATTGGCAGCACTGCA
TGTCACCTGGGAACCCCTGCAGACAAAGCTAACATCCCAGACAGACAGATGTGACCAGGACAAA
CGTGCAATAATGCCAAATGTTAAAATGTGAGTTTACCAGCCTAGCTATGGGACTGCTGGCTCCT
AGTCCAGGAATCATGGGGGTATGACTGCCTCTCCAACCCTCTGGGCTGTAAGCAAGCTCAGGCT
AGTCTCCCCACTGGGGGCTGTGCCCCTCCCTGGGACGGTTCCGTGGGCAGCCCCATCACTGTGT
TCAATAGTGTGAGAATGTAGCTAAAGCCCCTGCTGCTGCTGCTGCACATGCCACAGCAGGCGGG
GGGGCTGCGTGGGGACAATCCATCGTGGAGTGTTCTCTCAGCTTAGGTCTGGACAGGAGACTTG
GCGGGGGATGCTCCAGGATGTGGGTGATTCTGTACCTGGGGAGGCTATCTCTGACCTCCCGACA
GGGGACACTCCCAGGCCAGCCCAGGGGTCAGGGGCAGAGGTGCACACCTCAGCATGAGCCAAGA
CTGGGGTCAGGGAGCAGGTGTGGTTTGAGCCAGGACCTGGGGCGGGGGTGGGGCCGGGGCCTTT
CTGCCTCATTTGCTTTCAATGAAAGCCGCAAAGCAGCCAAAACCAGGCTTTCCCCCTTCCTCGA
GTTTGAATATCCAGAATCTTTTGTACTTCTTGTTGGTTAAATTGTTTATTTTTGTAAAAAATAA
AATAAAATTAGTTAATAAAATGATGTTTCACAGCAAACTCTTCCCTAA

hide sequence

RefSeq Acc Id:

XM_063594615 ⟹ XP_063450685

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	12	84,351,451 - 84,361,978 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003809181	(Get FASTA)	NCBI Sequence Viewer
	XP_063450685	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_003809181 ⟸ XM_003809133

- Peptide Label:

isoform X1

- Sequence:

show sequence

MGSGYTKAVYRVRLPGGAAVALKAVDFSGHDLGSCVREFGVRRGCYRLAAHKLLKEMVLLERLR
HPNVLQLYGYCYQDSEDIPDTLTTITELGAPVEMIQLLQTSWEDRFRICLSLGRLLHHLAHSPL
GSVTLLDFRPRQFVLVDGELKVTDLDDARVEETPCAGSTDCILEFPARNFTLPCSAQGWCEGMN
EKRNLYNAYRFFFTYLLPHSAPPSLRPLLDSIVNATGELTWGVDETLAQLEKVLHLYRSGQYLQ
NSTASSSTEYQCIPDSTIPQEDYRCWPSYHHGSCLLSVFNLAEAVDVCESHAQCRAFVVTNQTT
WTGRQLVFFKTGWSQVVPDPNKTTYVKASG

hide sequence

RefSeq Acc Id:	XP_063450685 ⟸ XM_063594615
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	PKDCC	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM