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Gene: HPDL (4-hydroxyphenylpyruvate dioxygenase like) Pan paniscus

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Symbol:

HPDL

Name:

4-hydroxyphenylpyruvate dioxygenase like

RGD ID:

11986865

Description:

ENCODES a protein that exhibits 4-hydroxymandelate synthase activity (inferred); 4-hydroxyphenylpyruvate dioxygenase activity (inferred); dioxygenase activity (inferred); INVOLVED IN aromatic amino acid metabolic process (inferred); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

4-hydroxyphenylpyruvate dioxygenase-like protein-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	181,480,018 - 181,481,687 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	180,621,287 - 180,623,136 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	44,629,560 - 44,631,394 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	45,988,044 - 45,989,883 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	45,988,494 - 45,989,609 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

familial adenomatous polyposis 2 (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 83 (ISO)

neurodegenerative disease (ISO)

Neurodevelopmental Disorder with Progressive Spasticity and Brain White Matter Abnormalities (ISO)

paraplegia (ISO)

spastic ataxia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aromatic amino acid metabolic process (IEA)

Cellular Component

mitochondrion (IEA)

Molecular Function

4-hydroxymandelate synthase activity (IEA)

4-hydroxyphenylpyruvate dioxygenase activity (IEA)

dioxygenase activity (IEA)

metal ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HPDL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	181,480,018 - 181,481,687 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	180,621,287 - 180,623,136 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	44,629,560 - 44,631,394 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	45,988,044 - 45,989,883 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	45,988,494 - 45,989,609 (+)	Ensembl	panpan1.1		panPan2

HPDL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	45,326,895 - 45,328,710 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	45,326,895 - 45,328,710 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	45,792,567 - 45,794,382 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	45,565,132 - 45,566,934 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	44,075,922 - 44,077,724 (+)	NCBI		Celera
Cytogenetic Map	1	p34.1	NCBI
HuRef	1	43,904,200 - 43,906,002 (+)	NCBI		HuRef
CHM1_1	1	45,909,348 - 45,911,150 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	45,198,451 - 45,200,266 (+)	NCBI		T2T-CHM13v2.0

Hpdl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	116,677,104 - 116,678,705 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	116,677,101 - 116,678,904 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	116,819,907 - 116,821,508 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	116,819,904 - 116,821,707 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	116,492,512 - 116,494,113 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	116,317,839 - 116,319,440 (-)	NCBI		MGSCv36	mm8
Celera	4	115,559,324 - 115,560,925 (-)	NCBI		Celera
Cytogenetic Map	4	D1	NCBI
cM Map	4	53.35	NCBI

Hpdl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	135,523,258 - 135,524,864 (-)	NCBI		GRCr8
mRatBN7.2	5	130,286,627 - 130,288,233 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	130,286,631 - 130,288,233 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	132,917,327 - 132,918,933 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	134,671,930 - 134,673,536 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	134,694,331 - 134,695,937 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	135,675,826 - 135,677,432 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	135,675,832 - 135,677,432 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	139,471,945 - 139,473,551 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	137,116,378 - 137,117,984 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	137,121,605 - 137,123,210 (-)	NCBI
Celera	5	128,813,296 - 128,814,902 (-)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

Hpdl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955464	12,936,996 - 12,940,050 (-)	NCBI	ChiLan1.0	ChiLan1.0

HPDL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	15,019,273 - 15,028,932 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	15,027,472 - 15,028,671 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	15,140,618 - 15,150,283 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	15,174,596 - 15,184,265 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	15,182,797 - 15,183,996 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	14,971,693 - 14,981,350 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	15,039,578 - 15,049,242 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	15,111,689 - 15,121,352 (-)	NCBI		UU_Cfam_GSD_1.0

Hpdl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	60,657,068 - 60,658,485 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	26,481,883 - 26,482,998 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	26,481,300 - 26,483,143 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HPDL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	166,012,601 - 166,014,323 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	166,012,590 - 166,015,051 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	153,420,659 - 153,423,107 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HPDL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	87,463,202 - 87,465,467 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	87,463,636 - 87,464,748 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	29,496,866 - 29,498,911 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hpdl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624906	1,236,450 - 1,237,565 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624906	1,235,307 - 1,238,381 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003812780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000027636 ⟹ ENSPPAP00000006406

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	45,988,494 - 45,989,609 (+)	Ensembl

RefSeq Acc Id:

XM_003812780 ⟹ XP_003812828

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	181,480,018 - 181,481,687 (-)	NCBI
NHGRI_mPanPan1	1	180,621,287 - 180,623,136 (-)	NCBI
Mhudiblu_PPA_v0	1	44,629,560 - 44,631,394 (+)	NCBI
PanPan1.1	1	45,988,044 - 45,989,883 (+)	NCBI

Sequence:

show sequence

AGTTCCTGGGCTGGGGAAGGGAGGCTCAGTGCCCAAGGAGGTGACCAGGCGTGAGGCCCGGGGA
AAGAGCAGCTCGGCGACCCCGCAGTATCCTAGGCGACAGGGTGTGGGGGAGGGGGTGGGGAGTC
AAAGGCGGAGTCACGGGCTCCGCCCTCTTTCTCCTGCTTGGCGCGAGCACAGGCACCGCGTGGT
TCTCACAACCAGCAGCTCGGCTCACTGAGACCCGGTGGTCCAGACGCTGCTCCTGGCTGGGGTG
GCGCTGCAGGGAGAACCGCGAGCTCTCAGGGGTCGGCGGGTGACTTCTTTCCGGAAGAAAGCGA
GGAACGCGCTCTGCGGGGTGAGCCGGACTCCCCAACTCCGGACGATCAGCCCAGGACTGAGAGC
CCCGAAGTCCCCAACCACAAGTAAGCGGCCCCAGAAGGACAAGTCTAGGTCGCCGTCCAGAGCG
CCATGGCCGCGCCCGCCCTTCGTTTGTGCCACATCGCCTTCCACGTGCCCGCCGGGCAGCCCCT
AGCCCGGGACCTGCAGCGCCTCTTCGGCTTCCAGCCCCTGGCTTCGCGGGAGGTGGACGGCTGG
CGGCAGCTAGCCCTGCGCAGCGGCGACGCGGTCTTTTTGGTGAACGAGGGCGCAGGGTCTGGAG
AGCCGCTGTACGGCCTGGATCCGCGTCACGCCGTGCCCAGCGCCACAAACCTGTGCTTCGACGT
GGCGGACGCCGGCGCTGCAACCCGGGAGCTGGCAGCGCTGGGCTGCAGCGTGCCTGTCCCTCCC
GTTCGCGTGCGGGACGCGCAGGGTGCCGCCACTTACGCCGTGGTCAGCTCGCCTGCCGGCATCC
TCAGCCTGACCTTGCTGGAGCGCGCCGGCTACCGCGGACCCTTCCTACCCGGCTTCAGGCCCGT
GTCCTCTGCGCCTGGCCCCGGGTGGGTCAGCCGCGTGGACCACCTGACCTTGGCCTGCACCCCC
GGCAGCTCCCCCACACTTTTGCGCTGGTTCCACGACTGCCTGGGCTTTTGCCACTTGCCGCTGA
GCCCAGGTGAGGATCCCGAGCTGGGCCTCGAAATGACAGCAGGGTTTGGGCTTGGGGGACTGAG
GCTTACAGCCCTGCAGGCCCAGCCGGGCAGCATTGTCCCCACTCTCGTTCTGGCTGAGTCCCTT
CCGGGGGCGACGACACGACAGGACCAGGTGGAGCAGTTCCTGGCCCGGCACAAGGGGCCAGGCC
TGCAGCACGTGGGGCTGTATACGCCTAACATTGTGGAGGCCACTGAGGGGGTGGCAACTGCTGG
AGGCCAGTTCCTGGCTCCCCCTGGGGCATACTACCAGCAGCCAGGAAAGGAGAGGCAGATCCGA
GCTGCAGGGCACGAGCCTCATCTGCTTGCTCGACAGGGGATCCTGCTAGATGGTGATAAAGGCA
AGTTTCTGCTTCAGGTCTTCACCAAGTCCCTTTTTACTGAGGACACTTTCTTCCTGGAGCTGAT
TCAGAGGCAGGGGGCCACTGGCTTTGGTCAGGGCAACATCAGAGCTCTGTGGCAGTCCGTACAG
GAGCAATCTGCCAGGAGCCAGGAAGCCTAAGGATGCCCAGGGCTGGGTGCAGCCAGCTGTCCTG
CAGCTCTGGGGAGACCAGCACAGAACTGAGGAACATCTGCAGGAGGCCCAACTAGTGAAAGGCT
TTGCCTCCGGGGGGCAGGTGTGACTTCCATTTCATCAGTGCCTGCCAGAAGCCGTGTCTCTCAT
TGGGCTCCAAAGAGGTGGGATTTTTTAAAACTAAAACATTTCTTATATACAGTCTATAATAAAT
ATGTAAGATACAAAGAACAATAAAAGAATTACACACTAGGAAACAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003812828	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000006406
	ENSPPAP00000006406.1

RefSeq Acc Id:

XP_003812828 ⟸ XM_003812780

- UniProtKB:

A0A2R8ZR72 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAPALRLCHIAFHVPAGQPLARDLQRLFGFQPLASREVDGWRQLALRSGDAVFLVNEGAGSGE
PLYGLDPRHAVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAVVSSPAGIL
SLTLLERAGYRGPFLPGFRPVSSAPGPGWVSRVDHLTLACTPGSSPTLLRWFHDCLGFCHLPLS
PGEDPELGLEMTAGFGLGGLRLTALQAQPGSIVPTLVLAESLPGATTRQDQVEQFLARHKGPGL
QHVGLYTPNIVEATEGVATAGGQFLAPPGAYYQQPGKERQIRAAGHEPHLLARQGILLDGDKGK
FLLQVFTKSLFTEDTFFLELIQRQGATGFGQGNIRALWQSVQEQSARSQEA

hide sequence

Ensembl Acc Id:

ENSPPAP00000006406 ⟸ ENSPPAT00000027636

Protein Domains

VOC

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000025021	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000027636.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.180.10	UniProtKB/TrEMBL
InterPro	4OHPhenylPyrv_dOase	UniProtKB/TrEMBL
	4OHPhenylPyrv_dOase_C	UniProtKB/TrEMBL
	4OHPhenylPyrv_dOase_N	UniProtKB/TrEMBL
	Glyas_Bleomycin-R_OHBP_Dase	UniProtKB/TrEMBL
	VOC	UniProtKB/TrEMBL
KEGG Report	pps:100994349	UniProtKB/TrEMBL
NCBI Gene	HPDL	ENTREZGENE
PANTHER	4-HYDROXYPHENYLPYRUVATE DIOXYGENASE-LIKE PROTEIN	UniProtKB/TrEMBL
	PTHR11959	UniProtKB/TrEMBL
PIRSF	HPP_dOase	UniProtKB/TrEMBL
PROSITE	VOC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54593	UniProtKB/TrEMBL
UniProt	A0A2R8ZR72	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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