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Gene: ABI3 (ABI family member 3) Pan paniscus

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Symbol:

ABI3

Name:

ABI family member 3

RGD ID:

11965026

Description:

ENCODES a protein that exhibits identical protein binding (inferred); SH3 domain binding (inferred); signaling adaptor activity (inferred); INVOLVED IN modification of postsynaptic actin cytoskeleton (ortholog); peptidyl-tyrosine phosphorylation (ortholog); regulation of cell migration (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); hereditary breast ovarian cancer syndrome (ortholog); trichodontoosseous syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ABI gene family member 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ABI3 (ABI family member 3)	NCBI	Ortholog
Mus musculus (house mouse):	Abi3 (ABI family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Abi3 (ABI family, member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Abi3 (ABI family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ABI3 (ABI family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Abi3 (ABI family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100621521 (ABI gene family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ABI3 (ABI family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Abi3 (ABI family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	15,944,600 - 15,957,229 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	17,910,636 - 17,923,151 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	8,381,551 - 8,394,537 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	8,364,561 - 8,376,930 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	8,364,561 - 8,376,930 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

trichodontoosseous syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to tumor cell (IEA)

modification of postsynaptic actin cytoskeleton (ISO)

negative regulation of lamellipodium assembly (IEA)

negative regulation of protein localization to plasma membrane (IEA)

neuron migration (IEA)

peptidyl-tyrosine phosphorylation (ISO)

positive regulation of cellular senescence (IEA)

regulation of cell migration (IEA,ISO)

Cellular Component

actin-based cell projection (IEA)

cytoplasm (IEA)

glutamatergic synapse (ISO)

lamellipodium (IEA)

postsynapse (ISO)

SCAR complex (IEA)

Molecular Function

identical protein binding (IEA)

protein binding (ISO)

SH3 domain binding (IEA)

signaling adaptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

ABI3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	15,944,600 - 15,957,229 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	17,910,636 - 17,923,151 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	8,381,551 - 8,394,537 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	8,364,561 - 8,376,930 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	8,364,561 - 8,376,930 (-)	Ensembl	panpan1.1		panPan2

ABI3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	49,210,707 - 49,223,225 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	49,210,411 - 49,223,225 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	47,288,069 - 47,300,587 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	44,642,588 - 44,655,586 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	44,642,587 - 44,655,586	NCBI
Celera	17	43,742,068 - 43,755,066 (+)	NCBI		Celera
Cytogenetic Map	17	q21.32	NCBI
HuRef	17	42,653,954 - 42,666,932 (+)	NCBI		HuRef
CHM1_1	17	47,352,844 - 47,365,842 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	50,073,790 - 50,086,309 (+)	NCBI		T2T-CHM13v2.0

Abi3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	95,720,898 - 95,733,302 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	95,720,900 - 95,733,302 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	95,830,072 - 95,842,476 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	95,830,074 - 95,842,476 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	95,691,386 - 95,703,790 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	95,648,481 - 95,658,250 (-)	NCBI		MGSCv36	mm8
Celera	11	105,472,261 - 105,484,667 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	59.01	NCBI

Abi3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	81,266,571 - 81,277,561 (-)	NCBI		GRCr8
mRatBN7.2	10	80,769,819 - 80,780,816 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	80,769,822 - 80,780,816 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	85,718,513 - 85,729,491 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	85,216,547 - 85,227,512 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	80,608,647 - 80,619,712 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	83,644,086 - 83,655,182 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	83,644,086 - 83,655,182 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	83,448,188 - 83,459,284 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	84,542,949 - 84,554,040 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	84,557,318 - 84,568,410 (-)	NCBI
Celera	10	79,537,629 - 79,548,619 (-)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

Abi3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955451	12,241,084 - 12,248,857 (-)	NCBI	ChiLan1.0	ChiLan1.0

ABI3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	25,374,823 - 25,385,016 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	25,374,525 - 25,385,003 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	24,834,241 - 24,844,759 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	26,170,737 - 26,181,212 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	26,171,065 - 26,181,206 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	24,938,804 - 24,949,363 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	25,197,882 - 25,208,480 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	25,326,932 - 25,337,496 (+)	NCBI		UU_Cfam_GSD_1.0

Abi3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	24,770,374 - 24,794,548 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	12,276,239 - 12,290,793 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	12,280,717 - 12,290,602 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100621521
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	12	25,426,116 - 25,441,309 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	25,368,386 - 25,383,802 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABI3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	69,613,308 - 69,625,887 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666077	40,718,582 - 40,731,186 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abi3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	5,448,618 - 5,455,539 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	5,448,375 - 5,455,784 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003810037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034941503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000028455 ⟹ ENSPPAP00000006774

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	8,364,561 - 8,376,930 (-)	Ensembl

RefSeq Acc Id:

XM_003810037 ⟹ XP_003810085

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	15,944,600 - 15,957,229 (-)	NCBI
NHGRI_mPanPan1	17	17,910,636 - 17,923,151 (-)	NCBI
Mhudiblu_PPA_v0	17	8,381,551 - 8,394,537 (-)	NCBI
PanPan1.1	17	8,364,561 - 8,376,930 (-)	NCBI

Sequence:

show sequence

TCCTATCCACCCTCCACTCCCCTGTCCCTTGGTGACTCATCCCTGAGCTTCCCAAGGAAGCCCC
CACCCTCTGCCCTTTCCTCCCGCCTTCCATGAGTGGAAAATCCACCTCCGCCCCCTATAGCAGG
CCAGCCCCCTTCCTCCCCAGTCTCCGACCCCATCCCCCAACCGACCAGTTTCCTCTCCAGGACC
AGGGAGCAATCACAGCTGCCCCGACCTTGGTTTCCTCTGCTGGGTGGGATTGGGGGCTGGGCCC
CCAAATGGGCCCCTGGCTTCCCCCTTCCTCTGGGCAGGGGACAGAGAGACACAGGCTCGGGGAG
CAGGACTGACTTCCTCTTGTCCCGGAATGAGCATGCCTGCCCTTTGCAAGCAGGTTTGGGTCTC
ACGCAGAGGAAACCAAAAGCAATAAGAGGGAGGGAAGGCAGAGCAACCAATCAAGGGCAGGGTG
AGACTCAAAACGAGCGGGCTCCCTGGGGAGCCAGACAGAGGCTGGGGGTGATGGCGGAGCTACA
GCAGCTGCAGGAGTTTGAGATCCCCACGGGCCGGGAGGCTCTGAGGGGCAACCACAGTGCCCTG
CTGCGGGTCGCTGACTACTGCGAGGACAACTATGTGCAGGCCACAGACAAGCGGAAGGCACTGG
AGGAGACCATGGCCTTCACTACCCAGGCACTGGCCAGCGTGGCCTACCAGGTGGGCAACCTGGC
CGGGCACACTCTGCGCATGTTGGACCTGCAGGGGGCCGCCCTGCGGCAGGTGGAAGCCCGTGTA
AGCACGCTGGGCCAGATGGTGAACATGCATATGGAGAAGGTGGCCCGAAGGGAGATTGGCACCT
TAGCCACTGTCCAGCGGCTGCCCCCCGGCCAGAAGGTCATCGCCCCAGAGAACCTACCCCCTCT
CACGCCCTACTGCAGGAGACCCCTCAACTTTGGCTGCCTGGACGACATTGGCCATGGGATCAAG
GACCTCAGCACGCAGCTGTCAAGAACAGGCACCCTGTCTCGAAAGAGCATCAAGGCCCCTGTGA
CACCCGCCTCCGCCACCTTGGGGAGACCACCCCGGATTCCCGAGCCAGTGCACCTGCCGGTGGT
GCCCGATGGCAGACTCTCCGCCGCCTCCTCTGCCTCTTCCCTGGCCTCGGCCGGCAGTGCCGAA
GGTGTCGGTGGGGCCCCCACGCCCAAGGGGCAGGCAGCACCTCCAGCCCCACCTCTCCCCAGCT
CCTTGGACCCACCTCCTCCACCAGCAGCCGTCGAGGTGTTCCAGCGGCCTCCCACGCTGGAGGA
GTTGTCCCCACCCCCACCGGACGAAGAGCTGCCCTTGCCACTGGACCTGCCTCCTCCTCCACCC
CTGGATGGAGATGAATTGGGGCTGCCTCCACCCCCACCAGGATTTGGGCCTGATGAGCCCAGCT
GGGTGCCTGCCTCATACTTGGAGAAAGTGGTGACACTGTACCCATACACCAGCCAGAAGGACAA
TGAGCTCTCCTTCTCTGAGGGCACTGTCATCTGTGTCACTCGCCGCTACTCCGATGGCTGGTGC
GAGGGCGTCAGCTCAGAGGGGACTGGATTCTTCCCTGGGAACTATGTGGAGCCCAGCTGCTGAC
AGCCCAGGGCTCTCTGGGCAGCTGATGTCTGCACTGAGTGGGTTTCATGAGCCCCAAGCCAAAA
CCAGCTCCAGTCACAGCTGGACTGGGTCTGCCCACCTCTTGGGCTGTGAGCTGTGTTCTGTCCC
TCCTCCCATTGGAGGGAGAAGGGGTCCTGGGGAGAGAGAATTTATCCAGAGGCCTGCTGCAGAT
GGGGAAGAGCTGGAAACCAAGAAGTTTGTCAACAGAGGACCCCTACTCCATGCAGGACAGGGTC
TCCTGCTGCAAGTCCCAACTTTGAATAAAACAGATGATGTCCTGTGACTGCCCCACAGAGATAA
GGGGCCAGGAGGGATTGAAAGGCATCCCAGTTCTAAGGCTGCTGCTAATTACAGCCCCCAACCT
CCAACCCACCAGCTGACCCAGAAGCAGCATCTTCCCATTTCCTCAGTACCCACAAAGTGCAGCC
CACATTGGACCCCAGACACCCCTCTGCAGCCATTGACTGCAACTTGTTCTTTTGCCCATTG

hide sequence

RefSeq Acc Id:

XM_034941503 ⟹ XP_034797394

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	15,944,600 - 15,957,229 (-)	NCBI
NHGRI_mPanPan1	17	17,910,636 - 17,923,151 (-)	NCBI
Mhudiblu_PPA_v0	17	8,381,551 - 8,394,080 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003810085	(Get FASTA)	NCBI Sequence Viewer
	XP_034797394	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000006774.1

RefSeq Acc Id:	XP_003810085 ⟸ XM_003810037
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R8ZV64 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALASVAYQ VGNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPPGQKVIAPE NLPPLTPYCRRPLNFGCLDDIGHGIKDLSTQLSRTGTLSRKSIKAPVTPASATLGRPPRIPEPV HLPVVPDGRLSAASSASSLASAGSAEGVGGAPTPKGQAAPPAPPLPSSLDPPPPPAAVEVFQRP PTLEELSPPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPDEPSWVPASYLEKVVTLYPYT SQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVEPSC hide sequence

RefSeq Acc Id:	XP_034797394 ⟸ XM_034941503
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSPPAP00000006774 ⟸ ENSPPAT00000028455

Protein Domains

SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000025669	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000028455.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.140.1620	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	ABI	UniProtKB/TrEMBL
	ABI3	UniProtKB/TrEMBL
	Abl-interactor_HHR_dom	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
KEGG Report	pps:100993537	UniProtKB/TrEMBL
NCBI Gene	ABI3	ENTREZGENE
PANTHER	PTHR10460	UniProtKB/TrEMBL
	PTHR10460:SF7	UniProtKB/TrEMBL
Pfam	Abi_HHR	UniProtKB/TrEMBL
	SH3_9	UniProtKB/TrEMBL
PRINTS	SH3DOMAIN	UniProtKB/TrEMBL
PROSITE	SH3	UniProtKB/TrEMBL
SMART	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50044	UniProtKB/TrEMBL
UniProt	A0A2R8ZV64	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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