TMEM116 (transmembrane protein 116)

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Gene: TMEM116 (transmembrane protein 116) Pan paniscus

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Symbol:

TMEM116

Name:

transmembrane protein 116

RGD ID:

11927795

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); signal transduction (inferred); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	120,022,759 - 120,104,480 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	120,019,150 - 120,100,782 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	109,490,385 - 109,610,574 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	112,923,729 - 113,004,037 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	112,923,729 - 113,004,037 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

signal transduction (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

TMEM116
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	120,022,759 - 120,104,480 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	120,019,150 - 120,100,782 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	109,490,385 - 109,610,574 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	112,923,729 - 113,004,037 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	112,923,729 - 113,004,037 (-)	Ensembl	panpan1.1		panPan2

TMEM116
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	111,931,282 - 112,013,219 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	111,931,282 - 112,013,866 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	112,369,086 - 112,451,023 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	110,853,486 - 110,935,318 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	111,994,553 - 112,076,493 (-)	NCBI		Celera
Cytogenetic Map	12	q24.13	NCBI
HuRef	12	109,382,372 - 109,464,309 (-)	NCBI		HuRef
CHM1_1	12	112,336,986 - 112,419,272 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	111,908,187 - 111,990,124 (-)	NCBI		T2T-CHM13v2.0

Tmem116
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	121,590,643 - 121,656,601 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	121,589,956 - 121,662,246 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	121,452,580 - 121,518,188 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	121,451,893 - 121,524,183 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	121,902,718 - 121,945,430 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	121,723,818 - 121,756,038 (+)	NCBI		MGSCv36	mm8
Celera	5	118,542,581 - 118,585,505 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	61.81	NCBI

Tmem116
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	40,681,346 - 40,750,106 (-)	NCBI		GRCr8
mRatBN7.2	12	35,021,912 - 35,089,409 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	35,041,572 - 35,089,430 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	36,214,382 - 36,247,420 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	36,825,591 - 36,858,627 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,878,040 - 35,911,076 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	40,537,261 - 40,618,805 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	40,557,677 - 40,590,361 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	42,403,957 - 42,485,861 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	36,176,676 - 36,209,989 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	36,705,977 - 36,739,335 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

Tmem116
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	8,429,543 - 8,542,216 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	8,388,446 - 8,572,160 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM116
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	9,495,011 - 9,609,819 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	9,495,135 - 9,584,460 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	9,613,631 - 9,727,103 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	9,732,501 - 9,846,235 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	9,680,060 - 9,822,692 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	9,709,923 - 9,823,318 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	9,772,916 - 9,886,729 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	9,819,909 - 9,933,626 (-)	NCBI		UU_Cfam_GSD_1.0

Tmem116
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	154,948,123 - 154,985,166 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	4,494,032 - 4,530,300 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	4,494,340 - 4,531,295 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM116
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	39,695,516 - 39,806,773 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	39,695,739 - 39,812,613 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	42,187,491 - 42,293,211 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM116
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	107,192,723 - 107,244,291 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	107,194,412 - 107,228,392 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	137,844,516 - 137,894,670 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem116
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	20,190,479 - 20,300,535 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	20,175,061 - 20,383,459 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003832453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034934539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034934540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034934541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034934542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034934543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063593693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000046019 ⟹ ENSPPAP00000023197

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	112,923,729 - 113,004,037 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000046030 ⟹ ENSPPAP00000023208

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	112,924,052 - 112,996,215 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000046032 ⟹ ENSPPAP00000023210

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	112,924,052 - 112,985,001 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000046038 ⟹ ENSPPAP00000023216

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	112,924,052 - 112,929,746 (-)	Ensembl

RefSeq Acc Id:

XM_003832453 ⟹ XP_003832501

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	120,022,759 - 120,104,480 (-)	NCBI
NHGRI_mPanPan1	12	120,019,150 - 120,100,726 (-)	NCBI
Mhudiblu_PPA_v0	12	109,526,904 - 109,610,520 (-)	NCBI
PanPan1.1	12	112,923,729 - 113,004,037 (-)	NCBI

Sequence:

show sequence

GCCACGTTGCGGGCGGGAAAATGGGCTCCTGCGCGCGCGCACTCGCCGAGTCTCCCGGCGGGTC
CGCCCAGTTCCGTTCCTGCTCCGCTTGAGGAGAAGCGCCAAGTGCGCATGGGGACGCTATAGCA
ATTCGTTTGCTGTCCTTCCTCTCCTTCGAAGATGACAAGGCCTACCATCGTTTCTTCCTGCCTT
TGGGCCGTCAGGCAGTTGGTTGGGACCCGCTCCAACCCTCGGTTCTTCCTGCAATACAGTGGAT
ACAATTTGTCATGGCTACTCTGAGTATTATAGGTTCAAGTTCACTTATTGCCTATGCTGTATTC
CAGAATATACAGAAATCTCCAGAGATAAGACCACTTTTTTATCTGAGCTTCTGTGACCTGCTCC
TGGGACTTTGCTGGCTCACGGAGACACTTCTCTATGGAGCTTCAGTAGCAAATAAGGACATCAT
CTGCTATAACCTACAAGCAGTTGGACAGATATTCTACATTTCCTCATTTCTCTACACCGTCAAT
TACATCTGGTATTTGTACACAGCGCTGAGGATGAAACACACCCAGAGTGGACAGAGCACATCTC
CACTGGTGATAGATTATACTTGTCGAGTTGGTCAAATGGCCTTTGTTTTCTCAAGCCTGATACC
TCTGCTATTGATGACACCTGTATTCTGTCTGGGCAATACTAGTGAATGTTTCCAAAACTTCAGT
CAGAGCCACAAGTGTATCTTGATGCACTCACCACCATCAGCCGTGGCTGAACTCCCACCTTCTG
CCAACACATCTGTCTGTAGCACACTTTATTTTTATGGTATCGCCATTTTCCTGGGCAGCTTTGT
ACTCAGCCTCCTTACCATTATGGTCTTACTTATCCGAGCCCAGACATTGTATAAGAAGTTTGTG
AAGTCAACTGGCTTTCTGGGGAGTGAACAGTGGGCAGTGATTCACATTGTGGACCAACGGGTGC
GCTTCTACCCAGTGGCCTTCTTTTGCTGCTGGGGCCCAGCTGTCATTCTAATGATCATAAAGCT
GACTAAGCCACAGGACACCAAGCTTCACATGGCCCTTTATGTTCTCCAGGCTCTAACGGCAACA
TCTCAGGGTCTACTCAACTGTGGAGTATATGGCTGGACGCAGCACAAATTCCACCAACTAAAGC
AGGAGGCTCGGCGTGATGCAGATACCCAGACACCATTATTATGCTCACAGAAGAGATTCTATAG
CAGGGGCTTAAATTCACTGGAATCCACCCTGACTTTTCCTGCCAGTACTTCTACCATTTTTTGA
AACTACAATACTGGAACATCCAGGAACTGGAGTTATTCTACGCTAATGGATTGGAAAGAATGTT
GGGAAAGGACATCTTAAATCTTTTCTAACTATGCCCTAAACTGCAGAACTCAAAGGAAATATAG
TGCCATTGTTAGTAGTCATTCTAGATGAATTGGGAGTATCTCTCCAGTTATTCCCAGATTCACT
AGTGATCCTTAAAGTCTCTATTCAGGGAGAGGAAGACACTTTCCATCTCAGAGATAGACTCGTG
TTACCTTGATGGATATTGGATTTGTCTAAGTCTCTTCTAGAAAAAATAAATTCTAGATTATTAT
TTA

hide sequence

RefSeq Acc Id:

XM_034934541 ⟹ XP_034790432

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	120,022,759 - 120,104,425 (-)	NCBI
NHGRI_mPanPan1	12	120,019,150 - 120,100,730 (-)	NCBI
Mhudiblu_PPA_v0	12	109,526,904 - 109,610,485 (-)	NCBI

RefSeq Acc Id:

XM_063593693 ⟹ XP_063449763

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	120,022,759 - 120,096,515 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003832501	(Get FASTA)	NCBI Sequence Viewer
	XP_034790432	(Get FASTA)	NCBI Sequence Viewer
	XP_063449763	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000023197
	ENSPPAP00000023197.1
	ENSPPAP00000023208.1
	ENSPPAP00000023210.1
	ENSPPAP00000023216.1

RefSeq Acc Id:	XP_003832501 ⟸ XM_003832453
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9B7C8 (UniProtKB/TrEMBL), A0A2R9B0T6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATLSIIGSSSLIAYAVFQNIQKSPEIRPLFYLSFCDLLLGLCWLTETLLYGASVANKDIICYN LQAVGQIFYISSFLYTVNYIWYLYTALRMKHTQSGQSTSPLVIDYTCRVGQMAFVFSSLIPLLL MTPVFCLGNTSECFQNFSQSHKCILMHSPPSAVAELPPSANTSVCSTLYFYGIAIFLGSFVLSL LTIMVLLIRAQTLYKKFVKSTGFLGSEQWAVIHIVDQRVRFYPVAFFCCWGPAVILMIIKLTKP QDTKLHMALYVLQALTATSQGLLNCGVYGWTQHKFHQLKQEARRDADTQTPLLCSQKRFYSRGL NSLESTLTFPASTSTIF hide sequence

RefSeq Acc Id:	XP_034790432 ⟸ XM_034934541
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSPPAP00000023208 ⟸ ENSPPAT00000046030

Ensembl Acc Id:

ENSPPAP00000023210 ⟸ ENSPPAT00000046032

Ensembl Acc Id:

ENSPPAP00000023216 ⟸ ENSPPAT00000046038

Ensembl Acc Id:

ENSPPAP00000023197 ⟸ ENSPPAT00000046019

RefSeq Acc Id:	XP_063449763 ⟸ XM_063593693
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000034779	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000046019.1	UniProtKB/TrEMBL
	ENSPPAT00000046030.1	UniProtKB/TrEMBL
	ENSPPAT00000046032.1	UniProtKB/TrEMBL
	ENSPPAT00000046038.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GCR1-cAMP_receptor	UniProtKB/TrEMBL
KEGG Report	pps:100967317	UniProtKB/TrEMBL
NCBI Gene	TMEM116	ENTREZGENE
PANTHER	G PROTEIN-COUPLED RECEPTOR 157-RELATED	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 116	UniProtKB/TrEMBL
PRINTS	GCR1CAMPR	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A2R9B0T6	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9B121_PANPA	UniProtKB/TrEMBL
	A0A2R9B4V7_PANPA	UniProtKB/TrEMBL
	A0A2R9B7C8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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