TMEM116 (transmembrane protein 116)

Gene: TMEM116 (transmembrane protein 116) Chlorocebus sabaeus

Analyze

Symbol:

TMEM116

Name:

transmembrane protein 116

RGD ID:

18575375

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (inferred); signal transduction (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	107,192,723 - 107,244,291 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	107,194,412 - 107,228,392 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	137,844,516 - 137,894,670 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

signal transduction (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

TMEM116
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	107,192,723 - 107,244,291 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	107,194,412 - 107,228,392 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	137,844,516 - 137,894,670 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TMEM116
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	111,931,282 - 112,013,219 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	111,931,282 - 112,013,185 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	112,369,086 - 112,451,023 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	110,853,486 - 110,935,318 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	111,994,553 - 112,076,493 (-)	NCBI		Celera
Cytogenetic Map	12	q24.13	NCBI
HuRef	12	109,382,372 - 109,464,309 (-)	NCBI		HuRef
CHM1_1	12	112,336,986 - 112,419,272 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	111,908,187 - 111,990,124 (-)	NCBI		T2T-CHM13v2.0

Tmem116
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	121,590,643 - 121,656,601 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	121,589,956 - 121,662,246 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	121,452,580 - 121,518,188 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	121,451,893 - 121,524,183 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	121,902,718 - 121,945,430 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	121,723,818 - 121,756,038 (+)	NCBI		MGSCv36	mm8
Celera	5	118,542,581 - 118,585,505 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	61.81	NCBI

Tmem116
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	40,681,346 - 40,750,106 (-)	NCBI		GRCr8
mRatBN7.2	12	35,021,912 - 35,089,409 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	35,041,572 - 35,089,430 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	36,214,382 - 36,247,420 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	36,825,591 - 36,858,627 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,878,040 - 35,911,076 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	40,537,261 - 40,618,805 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	40,557,677 - 40,590,361 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	42,403,957 - 42,485,861 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	36,176,676 - 36,209,989 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	36,705,977 - 36,739,335 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

Tmem116
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	8,429,543 - 8,542,216 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	8,388,446 - 8,572,160 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM116
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	120,022,759 - 120,104,480 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	120,019,150 - 120,100,782 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	109,490,385 - 109,610,574 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	112,923,729 - 113,004,037 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	112,923,729 - 113,004,037 (-)	Ensembl	panpan1.1		panPan2

TMEM116
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	9,495,011 - 9,609,819 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	9,495,135 - 9,584,460 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	9,613,631 - 9,727,103 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	9,732,501 - 9,846,235 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	9,680,060 - 9,822,692 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	9,709,923 - 9,823,318 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	9,772,916 - 9,886,729 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	9,819,909 - 9,933,626 (-)	NCBI		UU_Cfam_GSD_1.0

Tmem116
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	154,948,123 - 154,985,166 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	4,494,032 - 4,530,300 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	4,494,340 - 4,531,295 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM116
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	39,695,516 - 39,806,773 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	39,695,739 - 39,812,613 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	42,187,491 - 42,293,211 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tmem116
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	20,190,479 - 20,300,535 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	20,175,061 - 20,383,459 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	13	13	52
Below cutoff	19	4	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008004761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008004762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008004763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008004764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008004765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000000540 ⟹ ENSCSAP00000015520

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	11	107,194,412 - 107,228,392 (-)	Ensembl

RefSeq Acc Id:

XM_008004761 ⟹ XP_008002952

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	11	107,194,087 - 107,244,291 (-)	NCBI
Vero_WHO_p1.0	NW_023666037	137,844,516 - 137,894,670 (+)	NCBI

Sequence:

show sequence

GCTGCCGCGCACGCGTACTCGGCGAAGCTCGCGTAGGGCCTGGGTAAAAGGGCGTGCCACGTTG
GGGGCGGGAAAATGGGCTGCTGCGCGCGCGCACTCGGCGAGTCTCCCGGCGGGTTCGCCCACTT
CCTCTTCCTTCTCCGCGTGAGAAGAGGCGCGAAGCGCGCGTAGGAACGCTACAGCAATTCTTTT
GCTGCCCTTCCTCTCCTTCGAAGATGACAAGGCCTGCCATCCCTTCTTACTAACTTTGGGCCGT
CAGGCAGTTGGTTGGGACCCGCTCCAACCCTAGGTTTTTCCTGCAATACAGTGGATACAATTTG
TCATGGCTACTCTGAGTGTTATAGGTTCAAGTTCACTTATTGCCTATGCTGTATTCCAGAATAT
ACAGAAATCTCCAGAGATAAGACCACTTTTTTATCTGAGCTTCTGTGACCTGCTCCTGGGACTT
TGCTGGCTCACAGAGACACTTCTCTATGGAGCTTCAGTAGCAAATAAGGACATCATCTGCTATA
ACCTACAAGCAGTTGGACAGATATTCTACATTTCCTCATTTCTCTACACCATCAATTACATCTG
GTATTTGTACACAGAACTGAGGATGAAACACACCCAGAGTGGACAGAGCACATCTCCACTGGTG
ATAGATTATACTTGTCGAGTTGGTCAAATGGCCTTTGTTTTCTCAAGCTTGATACCTCTACTAT
TGATGACACCTGTATTCTGTCTGGGCAATACTAGCGAATGTTTCCAAAACTTCAGTCACAGCCA
CAAGTGTATCCTGATGCACTCACCACCATCAGCCGTGGCTGAACTCCCACCTTCTGCCAACACA
TCTGTCTGTAGCACACTTTATTTTTATGGTATCACCATTTTCCTGGGCAGCTTTGTACTCAGCC
TCCTTACCATTATGGTCTTACTTATCCGGGCCCAGACATTGTATAAGAAGTTTGTGAAGTCATC
TGGCTTTCTGGGGAGTGAACAGTGGGCAGTGATTCACATTGTGGACCAGCGGGTACGCTTATAC
CCAATGGCCTTCTTTTGCTGCTGGGGCCCAGCTGTCATTCTGATGATCATAAAGCTGACTAAGC
CACAGGACGCCAAGCTTCACATGGCCCTTTATGTTCTCCAGGCTCTGACAGCAACATCTCAGGG
TCTACTCAACTGTGGAGTATATGGCTGGACACAGCACAAATTCCACCAACTAAAGCAGGAGGCT
CGGCATGATGCAGATACCCAGACACCATTATTATGCTCACAGAAGAGATTCTATAGCAGGGGCT
TAAATTCACTGGAATCCGCCCTTACTTTTCCTACCAGTACTTCCACCATTTTTTGAAACTACAA
TACTGGAACATCCAGGAACTGGAGTTATTCTGCGCTAATGGATTAGAAAGAATGTTGGGAAAGG
ACATCTTAAATCTTTTCTAACTATGCCCTAAACTGTAGAACTCAAAGGAAATATAGTGTCATTG
GTTGGTAGTCATTCTAGGTGAACTGGCAGTATCTCTGCAGTTATTCCCAGATTTACTAGTGATC
CTTAAAGTCTAGAGGTTCAGGGAGAGGAAGACACTTTCCATCTCAGAGATAGATTCATGTTACC
TTGATGGATATTAGATTTGTCTAAGTCTTTTCTAGAAAAAATAAATTCTAGATTATTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008002952	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015520.1

RefSeq Acc Id:	XP_008002952 ⟸ XM_008004761
- UniProtKB:	A0A0D9S3T1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000015520 ⟸ ENSCSAT00000000540

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002525	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000000540.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GCR1-cAMP_receptor	UniProtKB/TrEMBL
NCBI Gene	TMEM116	ENTREZGENE
PANTHER	G PROTEIN-COUPLED RECEPTOR 157-RELATED	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 116	UniProtKB/TrEMBL
PRINTS	GCR1CAMPR	UniProtKB/TrEMBL
UniProt	A0A0D9S3T1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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