NIT2 (nitrilase family member 2) - Rat Genome Database

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Gene: NIT2 (nitrilase family member 2) Pan paniscus
Analyze
Symbol: NIT2
Name: nitrilase family member 2
RGD ID: 11893508
Description: ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (inferred); omega-amidase activity (inferred); INVOLVED IN asparagine metabolic process (inferred); glutamine metabolic process (inferred); oxaloacetate metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN centrosome (inferred); cytosol (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: omega-amidase NIT2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2298,277,630 - 98,298,407 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1398,282,455 - 98,303,191 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0397,427,470 - 97,448,354 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13104,109,805 - 104,130,535 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3104,109,804 - 104,130,535 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (IEA)
cytosol  (IEA)
mitochondrion  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NIT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2298,277,630 - 98,298,407 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1398,282,455 - 98,303,191 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0397,427,470 - 97,448,354 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13104,109,805 - 104,130,535 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3104,109,804 - 104,130,535 (+)Ensemblpanpan1.1panPan2
NIT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383100,334,757 - 100,361,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3100,334,739 - 100,361,635 (+)EnsemblGRCh38hg38GRCh38
GRCh373100,053,601 - 100,080,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363101,536,258 - 101,556,883 (+)NCBINCBI36Build 36hg18NCBI36
Build 343101,536,257 - 101,556,881NCBI
Celera398,444,355 - 98,465,336 (+)NCBICelera
Cytogenetic Map3q12.2NCBI
HuRef397,421,355 - 97,442,271 (+)NCBIHuRef
CHM1_13100,016,590 - 100,037,506 (+)NCBICHM1_1
T2T-CHM13v2.03103,040,105 - 103,066,978 (+)NCBIT2T-CHM13v2.0
Nit2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391656,977,028 - 56,987,695 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1656,977,028 - 56,987,704 (-)EnsemblGRCm39 Ensembl
GRCm381657,156,665 - 57,167,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1657,156,665 - 57,167,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv371657,156,778 - 57,167,445 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361657,078,024 - 57,088,691 (-)NCBIMGSCv36mm8
Celera1657,490,001 - 57,500,718 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1634.22NCBI
Nit2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,832,957 - 56,844,142 (+)NCBIGRCr8
mRatBN7.21143,363,839 - 43,378,713 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,363,985 - 43,375,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1152,139,097 - 52,149,930 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,800,701 - 44,811,534 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,924,795 - 43,935,628 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01145,462,345 - 45,473,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,462,345 - 45,473,104 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,655,096 - 48,665,858 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,287,827 - 44,298,589 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,345,401 - 44,356,395 (+)NCBI
Celera1143,153,636 - 43,164,398 (+)NCBICelera
Cytogenetic Map11q12NCBI
Nit2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554271,856,794 - 1,866,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554271,856,794 - 1,867,545 (+)NCBIChiLan1.0ChiLan1.0
NIT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,944,340 - 6,960,540 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,944,374 - 6,959,074 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha337,099,859 - 7,116,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0337,083,214 - 7,099,449 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,083,156 - 7,099,435 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1336,971,024 - 6,987,109 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,019,085 - 7,035,461 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,348,943 - 7,365,280 (+)NCBIUU_Cfam_GSD_1.0
Nit2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602150,046,553 - 150,065,487 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366302,943,121 - 2,963,367 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366302,944,447 - 2,963,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NIT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13158,630,913 - 158,653,147 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113158,630,997 - 158,653,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213168,425,785 - 168,445,894 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NIT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12280,524,856 - 80,545,615 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2280,524,860 - 80,542,148 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604186,028,430 - 86,048,371 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nit2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478913,754,605 - 13,778,366 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478913,754,573 - 13,778,368 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_063602489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000032433   ⟹   ENSPPAP00000009789
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3104,109,804 - 104,130,535 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032439   ⟹   ENSPPAP00000009795
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3104,113,915 - 104,130,208 (+)Ensembl
RefSeq Acc Id: XM_063602489   ⟹   XP_063458559
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2298,277,630 - 98,298,407 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063458559 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000009789.1
  ENSPPAP00000009795.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000009789   ⟸   ENSPPAT00000032433
RefSeq Acc Id: ENSPPAP00000009795   ⟸   ENSPPAT00000032439
RefSeq Acc Id: XP_063458559   ⟸   XM_063602489
Protein Domains
CN hydrolase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028109 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032433.1 UniProtKB/TrEMBL
  ENSPPAT00000032439.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.110.10 UniProtKB/TrEMBL
InterPro C-N_Hydrolase UniProtKB/TrEMBL
  C-N_Hydrolase_sf UniProtKB/TrEMBL
  Nit1/2_C-N_Hydrolase UniProtKB/TrEMBL
KEGG Report pps:103786670 UniProtKB/TrEMBL
NCBI Gene NIT2 ENTREZGENE
PANTHER NITRILASE-RELATED UniProtKB/TrEMBL
  OMEGA-AMIDASE NIT2 UniProtKB/TrEMBL
Pfam CN_hydrolase UniProtKB/TrEMBL
PROSITE CN_HYDROLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF56317 UniProtKB/TrEMBL
UniProt A0A2R8ZXU2_PANPA UniProtKB/TrEMBL
  A0A2R9A3D8_PANPA UniProtKB/TrEMBL