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Gene: CRYM (crystallin mu) Pan paniscus

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Symbol:

CRYM

Name:

crystallin mu

RGD ID:

11879978

Description:

ENCODES a protein that exhibits hormone binding (inferred); NADP binding (inferred); protein homodimerization activity (inferred); INVOLVED IN mitochondrial transport (ortholog); response to hormone (ortholog); response to vitamin D (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 40 (ortholog); congestive heart failure (ortholog); Deafness (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ketimine reductase mu-crystallin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CRYM (crystallin mu)	NCBI	Ortholog
Mus musculus (house mouse):	Crym (crystallin, mu)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Crym (crystallin, mu)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Crym (crystallin mu)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CRYM (crystallin mu)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Crym (crystallin mu)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CRYM (crystallin mu)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CRYM (crystallin mu)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Crym (crystallin mu)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	22,429,156 - 22,452,719 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	26,949,691 - 26,969,565 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	17,127,351 - 17,147,210 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	21,290,477 - 21,310,446 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	21,290,477 - 21,310,446 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nonsyndromic deafness 40 (ISO)

congestive heart failure (ISO)

Deafness (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial transport (ISO)

negative regulation of transcription by RNA polymerase II (IEA)

response to hormone (ISO)

response to vitamin D (ISO)

sensory perception of sound (IEA)

thyroid hormone metabolic process (IEA,ISO)

thyroid hormone transport (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

mitochondrion (IEA)

nucleus (IEA)

Molecular Function

hormone binding (IEA)

NADP binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

thiomorpholine-carboxylate dehydrogenase activity (IEA)

thyroid hormone binding (IEA)

transcription corepressor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CRYM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	22,429,156 - 22,452,719 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	26,949,691 - 26,969,565 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	17,127,351 - 17,147,210 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	21,290,477 - 21,310,446 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	21,290,477 - 21,310,446 (-)	Ensembl	panpan1.1		panPan2

CRYM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	21,258,521 - 21,303,062 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	21,238,874 - 21,303,083 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	21,269,842 - 21,314,383 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	21,177,343 - 21,221,918 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	21,177,339 - 21,197,103	NCBI
Celera	16	20,584,147 - 20,628,708 (-)	NCBI		Celera
Cytogenetic Map	16	p12.2	NCBI
HuRef	16	19,805,090 - 19,849,646 (-)	NCBI		HuRef
CHM1_1	16	21,357,178 - 21,401,740 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	21,193,814 - 21,238,355 (-)	NCBI		T2T-CHM13v2.0

Crym
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	119,785,603 - 119,801,212 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	119,785,603 - 119,801,334 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	120,186,380 - 120,201,989 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	120,186,380 - 120,202,111 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	127,329,898 - 127,345,502 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	119,977,533 - 119,993,137 (-)	NCBI		MGSCv36	mm8
Celera	7	120,095,865 - 120,111,506 (-)	NCBI		Celera
Cytogenetic Map	7	F2	NCBI
cM Map	7	64.47	NCBI

Crym
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	183,991,752 - 184,006,923 (-)	NCBI		GRCr8
mRatBN7.2	1	174,560,423 - 174,575,660 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	174,560,416 - 174,575,633 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	182,885,255 - 182,900,529 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	190,071,297 - 190,086,579 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	182,797,872 - 182,813,104 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	189,944,895 - 189,960,069 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	189,944,895 - 189,960,073 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	196,874,283 - 196,889,414 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	172,309,365 - 172,324,553 (-)	NCBI		Celera
Cytogenetic Map	1	q36	NCBI

Crym
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	443,532 - 460,133 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	443,956 - 460,041 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRYM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	24,187,073 - 24,204,304 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	24,187,121 - 24,204,304 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	25,624,820 - 25,642,042 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	24,338,416 - 24,355,639 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	24,338,281 - 24,355,638 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	24,141,814 - 24,159,037 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	24,035,432 - 24,052,651 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	24,420,520 - 24,437,753 (+)	NCBI		UU_Cfam_GSD_1.0

Crym
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	118,344,108 - 118,359,948 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	6,441,597 - 6,458,188 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	6,441,968 - 6,457,814 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRYM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	24,815,010 - 24,835,836 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	24,815,010 - 24,835,837 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	25,531,621 - 25,569,585 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRYM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	19,388,842 - 19,409,230 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	19,388,841 - 19,409,199 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	10,470,811 - 10,491,479 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crym
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	7,321,396 - 7,337,898 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	7,321,396 - 7,337,286 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003812083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034939904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000055346 ⟹ ENSPPAP00000032478

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	21,290,477 - 21,310,446 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000055352 ⟹ ENSPPAP00000032484

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	21,290,737 - 21,310,177 (-)	Ensembl

RefSeq Acc Id:

XM_003812083 ⟹ XP_003812131

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	22,429,156 - 22,452,719 (-)	NCBI
NHGRI_mPanPan1	16	26,949,691 - 26,969,549 (-)	NCBI
Mhudiblu_PPA_v0	16	17,127,368 - 17,147,210 (+)	NCBI
PanPan1.1	16	21,290,477 - 21,310,446 (-)	NCBI

Sequence:

show sequence

CAAACAATATTGACTTCCAGCACGCCACCGCGATGTCCATCTTGGGGAATCCGTTCCTGGAAGG
GACCCATCTCGCCCACCCTTAGGGGTCGAGGTGGGCGAAGCGGGAGGAGAGGGCTGGCGGGGCG
GGGCGGGGTTGCTCCGCCCCCGGAGGCTGGGCTGTGACCAGCAGGCGGCTCCACAGCGCAGCGG
GCGCGCTCATAAAGGGCACAGCCGAGGGTACGTGGATCGCGGTGCGGAGACTGAGGTTAGAAGG
CACAGGTGGCGAGATGAGCCGGGTACCAGCGTTCCTGAGCGCGGCCGAGGTGGAGGAACACCTC
TGCAGCTCCAGCCTCCTCATCCCGCCTCTAGAGACGGCCCTGGCCAACTTCTCCAGCGGTCCCG
AAGGAGGGGTCATGCAGCCCGTGCGCACCGTGGTGCCGGTGACCAAGCACAGGGGCTACCTGGG
GGTCATGCCCGCCTACAGTGCTGCAGAGGATGCGCTGACCACCAAGTTGGTCACCTTCTACGAG
GACCGCGGCATCACCTCGGTCGTCCCTTCCCACCAGGCTACTGTGCTACTCTTTGAGCCCAGCA
ATGGCACCCTGCTGGCGGTCATGGATGGAAATGTCATAACTGCAAAGAGAACAGCTGCAGTTTC
TGCCATTGCCACCAAGTTTCTGAAACCTCCCAGCAGTGAAGTGCTGTGCATCCTTGGGGCTGGG
GTCCAGGCCTACAGCCATTATGAGATCTTCACAGAGCAGTTCTCCTTTAAGGAGGTGAGGATAT
GGAACCGCACCAAAGAAAATGCAGAGAAGTTTGCAGACACAGTGCAAGGAGAGGTACAGGTCTG
TTCTTCGGTCCAGGAGGCTGTGGCAGGTGCAGATGTGATCATCACAGTCACCCTGGCAACAGAG
CCCATTTTGTTTGGTGAATGGGTGAAGCCAGGGGCTCACATCAATGCTGTTGGAGCCAGCAGAC
CTGACTGGAGAGAACTGGATGATGAGCTCATGAAAGAAGCTGTGCTGTACGTGGATTCCCAGGA
GGCTGCCCTGAAGGAGTCTGGAGATGTCCTGCTGTCAGGGGCCGAGATCTTTGCTGAGCTGGGA
GAAGTGATTAAGGGAGTGAAGCCAGCCCACTGTGAGAAGACCACGGTGTTCAAGTCTTTGGGAA
TGGCAGTGGAAGACACAGTTGCAGCCAAACTGATCTATGATTCCTGGTCATCTGGTAAATAAAA
CAAAGGAACTTGATGTTGAGATGGATGCTTGAGGAATGTTGCTGCTGGTTCTCATAATTTCTAG
AGTAAATGAGGGAGTCCAGTCCCCAGTGAACTCTCCTTTTGTGCTTATCATGTTTTACCTTAAA
TGCTGAGATCCTCATTTATGTTTGTAGTTGGAAAGCAAAGCTAGGTAGCCATTTCTTCTGTTCT
ACCAAGTTATAATAGCATTCATTTCCCTTTATATTTCCCTGAAATAAAGCACATTCCAATTGTG
CA

hide sequence

RefSeq Acc Id:

XM_034939904 ⟹ XP_034795795

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	22,429,509 - 22,449,013 (-)	NCBI
NHGRI_mPanPan1	16	26,950,043 - 26,969,565 (-)	NCBI
Mhudiblu_PPA_v0	16	17,127,351 - 17,146,850 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003812131	(Get FASTA)	NCBI Sequence Viewer
	XP_034795795	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000032478
	ENSPPAP00000032478.1
	ENSPPAP00000032484.1

RefSeq Acc Id:	XP_003812131 ⟸ XM_003812083
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9BS23 (UniProtKB/TrEMBL), A0A2R9C156 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSRVPAFLSAAEVEEHLCSSSLLIPPLETALANFSSGPEGGVMQPVRTVVPVTKHRGYLGVMPA YSAAEDALTTKLVTFYEDRGITSVVPSHQATVLLFEPSNGTLLAVMDGNVITAKRTAAVSAIAT KFLKPPSSEVLCILGAGVQAYSHYEIFTEQFSFKEVRIWNRTKENAEKFADTVQGEVQVCSSVQ EAVAGADVIITVTLATEPILFGEWVKPGAHINAVGASRPDWRELDDELMKEAVLYVDSQEAALK ESGDVLLSGAEIFAELGEVIKGVKPAHCEKTTVFKSLGMAVEDTVAAKLIYDSWSSGK hide sequence

RefSeq Acc Id:	XP_034795795 ⟸ XM_034939904
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9C156 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000032478 ⟸ ENSPPAT00000055346

Ensembl Acc Id:

ENSPPAP00000032484 ⟸ ENSPPAT00000055352

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039125	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000055346.1	UniProtKB/TrEMBL
	ENSPPAT00000055352.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1780.10	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	ODC_Mu_crystall	UniProtKB/TrEMBL
	ODC_N	UniProtKB/TrEMBL
KEGG Report	pps:100970861	UniProtKB/TrEMBL
NCBI Gene	CRYM	ENTREZGENE
PANTHER	KETIMINE REDUCTASE MU-CRYSTALLIN	UniProtKB/TrEMBL
	PTHR13812	UniProtKB/TrEMBL
Pfam	OCD_Mu_crystall	UniProtKB/TrEMBL
PIRSF	CryM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A2R9BS23	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9C156	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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