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Gene: DUSP14 (dual specificity phosphatase 14) Pan paniscus

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Symbol:

DUSP14

Name:

dual specificity phosphatase 14

RGD ID:

11860468

Description:

ENCODES a protein that exhibits hydrolase activity (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); phosphoprotein phosphatase activity (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); chromosome 17q12 deletion syndrome (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

dual specificity protein phosphatase 14

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	27,239,045 - 27,271,607 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	29,122,439 - 29,146,229 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	19,562,013 - 19,585,798 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	19,861,604 - 19,883,739 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	19,862,235 - 19,862,831 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP14	Bonobo	autism spectrum disorder		ISO	DUSP14 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism spectrum disorder	ClinVar	PMID:21844811 more ...
DUSP14	Bonobo	autistic disorder		ISO	DUSP14 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106 and PMID:30208311
DUSP14	Bonobo	chromosome 17q12 deletion syndrome		ISO	DUSP14 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Chromosome 17q12 deletion syndrome	ClinVar	PMID:17924346 more ...
DUSP14	Bonobo	hyperphosphatasia with impaired intellectual development syndrome 5		ISO	DUSP14 (Homo sapiens)	8554872	ClinVar Annotator: match by term: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 11	ClinVar	PMID:12148114 more ...
DUSP14	Bonobo	Neurodevelopmental Disorders		ISO	DUSP14 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
DUSP14	Bonobo	schizophrenia		ISO	DUSP14 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Schizophrenia	ClinVar	PMID:21681106 and PMID:30208311

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP14	Bonobo	cytoplasm	located_in	IEA	PANTHER:PTN000017548	150520179		TreeGrafter	GO_REF:0000118

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP14	Bonobo	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
DUSP14	Bonobo	MAP kinase tyrosine/serine/threonine phosphatase activity	enables	IEA	InterPro:IPR020420	150520179		InterPro	GO_REF:0000002
DUSP14	Bonobo	phosphoprotein phosphatase activity	enables	IEA	UniProtKB-KW:KW-0904	150520179		UniProt	GO_REF:0000043
DUSP14	Bonobo	phosphoprotein phosphatase activity	enables	IEA	ARBA:ARBA00027651	150520179		UniProt	GO_REF:0000117
DUSP14	Bonobo	protein binding	enables	ISO	UniProtKB:Q8NA61	9068941	PMID:25416956	IntAct	PMID:25416956
DUSP14	Bonobo	protein serine/threonine phosphatase activity	enables	IEA	EC:3.1.3.16	150520179		UniProt	GO_REF:0000003
DUSP14	Bonobo	protein tyrosine phosphatase activity	enables	IEA	EC:3.1.3.48	150520179		UniProt	GO_REF:0000003

PMID:22301074	PMID:30032202

DUSP14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	27,239,045 - 27,271,607 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	29,122,439 - 29,146,229 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	19,562,013 - 19,585,798 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	19,861,604 - 19,883,739 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	19,862,235 - 19,862,831 (-)	Ensembl	panpan1.1		panPan2

DUSP14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	37,488,566 - 37,513,498 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	37,489,891 - 37,513,501 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	35,849,997 - 35,873,600 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	32,924,064 - 32,947,701 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	32,924,119 - 32,947,707	NCBI
Celera	17	32,672,947 - 32,696,576 (+)	NCBI		Celera
Cytogenetic Map	17	q12	NCBI
HuRef	17	31,787,319 - 31,810,865 (+)	NCBI		HuRef
CHM1_1	17	35,881,408 - 35,905,049 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	38,472,550 - 38,500,180 (+)	NCBI		T2T-CHM13v2.0

Dusp14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	83,938,859 - 83,960,016 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	83,938,867 - 83,960,087 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	84,048,033 - 84,069,256 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	84,048,041 - 84,069,261 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	83,861,547 - 83,881,859 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	83,864,240 - 83,884,552 (-)	NCBI		MGSCv36	mm8
Celera	11	93,653,573 - 93,673,883 (-)	NCBI		Celera
Cytogenetic Map	11	C	NCBI
cM Map	11	51.29	NCBI

Dusp14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	69,433,949 - 69,463,863 (-)	NCBI		GRCr8
mRatBN7.2	10	68,936,483 - 68,966,347 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	68,935,330 - 68,965,329 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	73,556,462 - 73,576,372 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	73,061,473 - 73,081,387 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	68,525,896 - 68,545,810 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	71,363,688 - 71,383,602 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	71,363,688 - 71,383,602 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	71,277,385 - 71,297,310 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	72,336,519 - 72,337,115 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	72,350,302 - 72,376,112 (-)	NCBI
Celera	10	67,865,947 - 67,885,861 (-)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

Dusp14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	515,889 - 535,017 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	515,889 - 537,762 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUSP14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	37,253,305 - 37,277,320 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	37,276,084 - 37,276,680 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	36,477,898 - 36,501,889 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	38,064,200 - 38,088,178 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	38,065,748 - 38,088,170 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	36,845,114 - 36,869,076 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	37,132,736 - 37,156,673 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	37,219,444 - 37,243,416 (+)	NCBI		UU_Cfam_GSD_1.0

Dusp14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	36,214,535 - 36,234,146 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	840,907 - 860,439 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	840,907 - 860,457 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUSP14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	38,941,124 - 38,975,000 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	38,941,052 - 38,978,568 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	40,562,469 - 40,616,456 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DUSP14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	30,269,127 - 30,291,771 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	30,269,779 - 30,270,375 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	992,377 - 1,015,740 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dusp14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624871	4,481,493 - 4,503,723 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624871	4,481,426 - 4,503,723 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_008971222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034942029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034942030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000017306 ⟹ ENSPPAP00000003763

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	19,862,235 - 19,862,831 (-)	Ensembl

RefSeq Acc Id:

XM_008971222 ⟹ XP_008969470

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	27,239,045 - 27,262,206 (-)	NCBI
NHGRI_mPanPan1	17	29,122,439 - 29,145,610 (-)	NCBI
Mhudiblu_PPA_v0	17	19,562,013 - 19,583,939 (-)	NCBI
PanPan1.1	17	19,861,604 - 19,883,739 (-)	NCBI

Sequence:

show sequence

CTTCTGACGCTTGGGGGAGGAGAGGTAGTTGCTTGGTATTTTTGGCTTTCCCCCATAAAACTGGAGACAGTTTCCTTCATTCCAAGACGTTTTAATGTCACTGTTGAACGTGTGTGTCCTGAGTTCTC
ATCTGAAAGCTTTCATATCGGTTGACTGCAGACTTGATTTGTATCCACTGTCACCAGCACTGCTCACTTAGGACTTTCTGGATCCGGACCCAGGCAGCGCACACTGGACTCTTGAGGAAGAAGGAGAC
TCTAATTTTGGATTCCTTGGTGGAGGAAAATAAAACACTCTGGTCTTGCCCCCAACAATGCAAGTGTGACTGCTGGCGTCTTCATGAGCTCCAGAGGTCACAGCACGCTACCAAGGACTCTCATGGCC
CCTCGGATGATTTCCGAGGGAGACATAGGAGGCATTGCTCAAATCACCTCCTCTCTATTCCTGGGCAGAGGCAGTGTGGCCTCCAATCGGCACCTCCTCCAGGCTCGTGGCATCACCTGCATTGTTAA
TGCTACCATTGAGATCCCTAATTTCAACTGGCCCCAATTTGAGTATGTTAAAGTGCCTCTGGCTGACATGCCGCATGCCCCCATTGGACTGTACTTTGACACCGTGGCTGACAAGATCCACAGTGTGA
GCAGGAAGCACGGGGCCACCTTGGTGCACTGTGCTGCAGGGGTGAGCCGCTCAGCCACGCTGTGTATCGCGTACCTGATGAAATTCCACAACGTGTGCCTGCTGGAGGCGTACAACTGGGTGAAAGCC
CGGCGACCTGTCATCAGGCCCAACGTAGGCTTCTGGAGGCAACTGATAGACTACGAGCGCCAGCTCTTTGGGAAGTCGACAGTTAAAATGGTACAGACACCTTATGGCATAGTTCCCGACGTCTATGA
GAAGGAGTCCCGACACCTGATGCCTTACTGGGGGATTTAGTGCCACTGAAGCCTGCGTCAGCAGCCCGAGCGGGGCCGGCATCTGCTCCCCGCCGTCTGCTCCCTCTTCACTCTCTTCTCAAATGGCT
GACTTCTGGTTCTCCCTCAAGTGTTTTTTACACTGGGTGTTCAAATTTATTTTAAGAGATAGGGAGGGAGGGGACATAAAGGGAATGCATACATTGCTAGTCACATTTTTAAAATTAACATTTTGGAA
TAGTGTTTATGGAAATCTTTAGCTTTTAATCATTTTTACCAATTTGAACAGTTTAATAAACTGGTTCTGCTCTCTTCTGAATCTCATGCCTTTGGCACCTTGGTAGGTGCAGGAGGAGCTCAGTGCAA
AAATCACTTTGGGGCCTCATTAACCCTTTAGAGACAAGCTTTGCCCCAGGCTGCGGACCAGACAGATGCTTGGGGAAGGTTGATACCAGCTTCAGTCTCTACTGGATTAGCCCTACTCTTTCCTTTCC
CCTCCATTATTTAGTGACTCTGTAAGTAAGTTAAATACACCCTTATTATTTAGCTGTTAAGTAACTATAATGAAATCTGCTGCAAAAACTCTCTTGGAATCCATGTGCCCAGGATTATATTAGCATTA
TTTTTAATAAATCTATATGCTTAACATATTA

hide sequence

RefSeq Acc Id:

XM_034942029 ⟹ XP_034797920

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	27,239,045 - 27,262,650 (-)	NCBI
NHGRI_mPanPan1	17	29,122,439 - 29,146,051 (-)	NCBI
Mhudiblu_PPA_v0	17	19,562,013 - 19,585,608 (-)	NCBI

RefSeq Acc Id:

XM_034942030 ⟹ XP_034797921

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	27,239,045 - 27,271,607 (-)	NCBI
NHGRI_mPanPan1	17	29,122,439 - 29,146,229 (-)	NCBI
Mhudiblu_PPA_v0	17	19,562,013 - 19,585,798 (-)	NCBI


Protein RefSeqs	XP_008969470	(Get FASTA)	NCBI Sequence Viewer
	XP_034797920	(Get FASTA)	NCBI Sequence Viewer
	XP_034797921	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000003763.1

RefSeq Acc Id:	XP_008969470 ⟸ XM_008971222
- UniProtKB:	A0A2R8ZFH2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMK FHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGIVPDVYEKESRHLMPYWGI hide sequence

RefSeq Acc Id:	XP_034797921 ⟸ XM_034942030
- UniProtKB:	A0A2R8ZFH2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034797920 ⟸ XM_034942029
- UniProtKB:	A0A2R8ZFH2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000003763 ⟸ ENSPPAT00000017306

Protein Domains

Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000015794	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000017306.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.190.10	UniProtKB/TrEMBL
InterPro	Atypical_DUSP_subfamB	UniProtKB/TrEMBL
	Dual-sp_phosphatase_cat-dom	UniProtKB/TrEMBL
	Dual_spec_Phospatases	UniProtKB/TrEMBL
	Prot-tyrosine_phosphatase-like	UniProtKB/TrEMBL
	Tyr_Pase_AS	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_dom	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL_dom	UniProtKB/TrEMBL
KEGG Report	pps:100984563	UniProtKB/TrEMBL
NCBI Gene	DUSP14	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE 14	UniProtKB/TrEMBL
	IP21249P	UniProtKB/TrEMBL
Pfam	DSPc	UniProtKB/TrEMBL
PRINTS	ADSPHPHTASE	UniProtKB/TrEMBL
	ADSPHPHTASEB	UniProtKB/TrEMBL
PROSITE	TYR_PHOSPHATASE_1	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_2	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL	UniProtKB/TrEMBL
SMART	DSPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52799	UniProtKB/TrEMBL
UniProt	A0A2R8ZFH2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar