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Gene: MED10 (mediator complex subunit 10) Pan paniscus

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Symbol:

MED10

Name:

mediator complex subunit 10

RGD ID:

11841742

Description:

ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); protein ubiquitination (ortholog); somatic stem cell population maintenance (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; FOUND IN ubiquitin ligase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mediator of RNA polymerase II transcription subunit 10

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	6,622,054 - 6,628,725 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	4,775,661 - 4,782,318 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	6,695,045 - 6,701,703 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	6,370,806 - 6,377,467 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	6,370,806 - 6,377,467 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of transcription by RNA polymerase II (ISO)

protein ubiquitination (ISO)

regulation of transcription by RNA polymerase II (IEA)

somatic stem cell population maintenance (ISO)

Cellular Component

core mediator complex (IEA)

mediator complex (IEA)

nucleoplasm (IEA)

nucleus (IEA)

ubiquitin ligase complex (ISO)

Molecular Function

protein binding (ISO)

transcription coregulator activity (IEA)

ubiquitin protein ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MED10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	6,622,054 - 6,628,725 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	4,775,661 - 4,782,318 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	6,695,045 - 6,701,703 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	6,370,806 - 6,377,467 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	6,370,806 - 6,377,467 (-)	Ensembl	panpan1.1		panPan2

MED10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	6,371,874 - 6,378,547 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	6,371,874 - 6,378,571 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	6,371,987 - 6,378,660 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	6,425,039 - 6,431,639 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	6,397,998 - 6,404,598 (-)	NCBI		Celera
Cytogenetic Map	5	p15.31	NCBI
HuRef	5	6,345,867 - 6,352,467 (-)	NCBI		HuRef
CHM1_1	5	6,372,106 - 6,378,706 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	6,300,635 - 6,307,308 (-)	NCBI		T2T-CHM13v2.0

Med10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	69,950,467 - 69,964,221 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	69,950,514 - 69,964,223 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	69,802,348 - 69,816,102 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	69,802,395 - 69,816,104 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	69,948,760 - 69,954,972 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	70,277,254 - 70,283,466 (+)	NCBI		MGSCv36	mm8
Celera	13	72,154,588 - 72,160,710 (+)	NCBI		Celera
Cytogenetic Map	13	C1	NCBI
cM Map	13	35.55	NCBI

Med10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	35,298,494 - 35,310,163 (-)	NCBI		GRCr8
mRatBN7.2	1	33,470,064 - 33,481,698 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	33,470,066 - 33,475,767 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	33,305,432 - 33,311,100 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	39,304,037 - 39,309,705 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	33,498,226 - 33,503,886 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	36,107,249 - 36,118,887 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	36,107,232 - 36,112,993 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	37,504,217 - 37,515,856 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	3,621,205 - 3,626,895 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	3,621,203 - 3,626,864 (-)	NCBI
Celera	1	32,079,798 - 32,085,458 (-)	NCBI		Celera
Cytogenetic Map	1	p11	NCBI

Med10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955504	4,184,606 - 4,193,002 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955504	4,186,814 - 4,192,760 (-)	NCBI	ChiLan1.0	ChiLan1.0

MED10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	7,327,370 - 7,334,833 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	11,837,968 - 11,844,881 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	7,238,300 - 7,245,253 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	7,238,323 - 7,244,961 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	7,285,003 - 7,291,940 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	7,265,116 - 7,272,029 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	7,478,463 - 7,485,376 (+)	NCBI		UU_Cfam_GSD_1.0

Med10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	240,362,348 - 240,392,207 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936634	953,567 - 983,426 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MED10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	75,517,023 - 75,524,758 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	75,516,992 - 75,524,761 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	81,876,181 - 81,883,992 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MED10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	6,058,380 - 6,064,916 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	6,057,955 - 6,064,901 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666064	22,694,261 - 22,700,794 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Med10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	4,136,776 - 4,141,949 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624751	4,136,615 - 4,141,959 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003807967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000038459 ⟹ ENSPPAP00000015768

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	6,370,806 - 6,377,467 (-)	Ensembl

RefSeq Acc Id:

XM_003807967 ⟹ XP_003808015

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	4	6,622,054 - 6,628,725 (-)	NCBI
NHGRI_mPanPan1	5	4,775,661 - 4,782,318 (-)	NCBI
Mhudiblu_PPA_v0	5	6,695,045 - 6,701,703 (-)	NCBI
PanPan1.1	5	6,370,806 - 6,377,467 (-)	NCBI

Sequence:

show sequence

CAGAGGAAACGGAAGTCGTATCTGTCCGGACGGAAGCAGGAAGCGGGAGCGTAGGGCCACGCCT
GCGGCGCTGCTGGTTGAGGCTGTGTGGGTGGGGGACGGGCCGAGGCGATGGCGGAGAAGTTTGA
CCACCTAGAGGAGCACCTGGAGAAGTTCGTGGAGAACATTCGGCAGCTCGGCATCATCGTCAGT
GACTTCCAGCCCAGCAGCCAGGCCGGGCTCAACCAAAAGCTGAATTTTATTGTTACTGGCTTAC
AGGATATTGACAAGTGCAGACAGCAGCTTCATGATATTACTGTACCGTTAGAAGTTTTTGAATA
TATAGATCAAGGTCGAAACCCCCAGCTCTACACCAAAGAGTGCCTGGAGAGGGCTCTAGCTAAA
AATGAGCAAGTTAAAGGCAAGATCGACACCATGAAGAAATTTAAAAGCCTGTTGATTCAAGAAC
TTTCTAAAGTATTTCCGGAAGACATGGCTAAGTATCGAAGCATCCGGGGGGAGGATCACCCGCC
TTCTTAACCAGCTCACCCTCCCTGTGTGAAGATCCCCCGGGACTGCGATGCGGCGTGAGGCTGG
GACTGCGAGTGCTGATGCCACCTTCCTGCTGAGGTGGGACTGGGCCCTGGACACACCCCTCAGC
CCCTCTGTCCTCGTTGTTTGGCCTCATGGGACCGAGGGGCTGGAGGAGAGGCGGAGCTGTGCCC
CAGCTGTTCCAGCAGCTTGTCTGGCGTCAACTGGCTTTCAGAGTGCTGACCCCTCGTCACTGTG
GGGATCATTCTCTCTGAGGGCAGATGAGGCGCAGGAAAATAGGCTTGGAAATGTTAAATATGAT
GGGTAAATTAAAAGTTTTACAACATTCTACCTAATATTTTTCTTTTAACGTACTCTTTCTGTTC
TATTGTATTATGGTGTCCGAAAGCTAAATAACGACTAGGAAAAATTTTTTTAAAAAGAGAAAAA
TCAGTTTAATGTGGGAAGTACTTAAGTGGTATTATATTTTACATTTTCAAGTATAGTGCATAAA
GAATGTTTTAAATGTAACTGTTTTCATGGATTTCAATTAGACATGCCTATAATAAACTAAGTAT
GTGGCTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003808015	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000015768.1

RefSeq Acc Id:	XP_003808015 ⟸ XM_003807967
- UniProtKB:	A0A2R9ALB0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVP LEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIR GEDHPPS hide sequence

Ensembl Acc Id:

ENSPPAP00000015768 ⟸ ENSPPAT00000038459

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000031009	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000038459.1	UniProtKB/TrEMBL
InterPro	Mediator_Med10	UniProtKB/TrEMBL
KEGG Report	pps:100979752	UniProtKB/TrEMBL
NCBI Gene	MED10	ENTREZGENE
PANTHER	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10	UniProtKB/TrEMBL
	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10	UniProtKB/TrEMBL
Pfam	Med10	UniProtKB/TrEMBL
UniProt	A0A2R9ALB0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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