TBX10 (T-box transcription factor 10) - Rat Genome Database

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Gene: TBX10 (T-box transcription factor 10) Pan paniscus
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Symbol: TBX10
Name: T-box transcription factor 10
RGD ID: 11838692
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell fate specification (inferred); positive regulation of DNA-templated transcription (inferred); regulation of DNA-templated transcription (inferred); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); immunodeficiency 90 (ortholog); intellectual disability (ortholog); FOUND IN chromatin (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-box 10; T-box transcription factor TBX10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,860,615 - 68,866,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,903,427 - 69,910,249 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,991,902 - 62,996,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,303,253 - 66,311,529 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,303,253 - 66,311,529 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TBX10BonoboAicardi-Goutieres Syndrome 3  ISORGD:13424988554872ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 3ClinVarPMID:28492532
TBX10Bonoboimmunodeficiency 90  ISORGD:13424988554872ClinVar Annotator: match by term: Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformationsClinVarPMID:28492532
TBX10Bonobointellectual disability  ISORGD:13424988554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TBX10Bonobocell fate specification involved_inIEAPANTHER:PTN000137853150520179 TreeGrafterGO_REF:0000118
TBX10Bonobopositive regulation of DNA-templated transcription involved_inIEAInterPro:IPR046360150520179 InterProGO_REF:0000002
TBX10Bonoboregulation of DNA-templated transcription involved_inIEAInterPro:IPR001699|InterPro:IPR008967|InterPro:IPR018186|InterPro:IPR036960150520179 InterProGO_REF:0000002
TBX10Bonoboregulation of transcription by RNA polymerase II involved_inIEAPANTHER:PTN000137853150520179 TreeGrafterGO_REF:0000118

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TBX10Bonobochromatin located_inIEAPANTHER:PTN000137853150520179 TreeGrafterGO_REF:0000118
TBX10Bonobonucleus located_inIEAInterPro:IPR018186|InterPro:IPR036960150520179 InterProGO_REF:0000002
TBX10Bonobonucleus located_inIEAPANTHER:PTN000137853150520179 TreeGrafterGO_REF:0000118
TBX10Bonobonucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
TBX10Bonobonucleus located_inIEAUniRule:UR000400702150520179 UniProtGO_REF:0000104
TBX10Bonobonucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TBX10BonoboDNA binding enablesIEAUniRule:UR000400702150520179 UniProtGO_REF:0000104
TBX10BonoboDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
TBX10BonoboDNA-binding transcription factor activity enablesIEAInterPro:IPR001699|InterPro:IPR008967|InterPro:IPR018186|InterPro:IPR036960|InterPro:IPR046360150520179 InterProGO_REF:0000002
TBX10BonoboDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAPANTHER:PTN000137853150520179 TreeGrafterGO_REF:0000118
TBX10BonoboRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAInterPro:IPR001699150520179 InterProGO_REF:0000002
TBX10BonoboRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAPANTHER:PTN000137853150520179 TreeGrafterGO_REF:0000118

PMID:22301074   PMID:30032202  



TBX10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,860,615 - 68,866,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,903,427 - 69,910,249 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,991,902 - 62,996,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,303,253 - 66,311,529 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,303,253 - 66,311,529 (-)Ensemblpanpan1.1panPan2
TBX10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,631,303 - 67,641,754 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,631,303 - 67,639,763 (-)EnsemblGRCh38hg38GRCh38
GRCh371167,398,774 - 67,407,234 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,155,350 - 67,163,607 (-)NCBINCBI36Build 36hg18NCBI36
Build 341167,155,350 - 67,163,607NCBI
Celera1164,733,226 - 64,741,484 (-)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,728,041 - 63,736,303 (-)NCBIHuRef
CHM1_11167,281,822 - 67,290,082 (-)NCBICHM1_1
T2T-CHM13v2.01167,625,990 - 67,636,442 (-)NCBIT2T-CHM13v2.0
Tbx10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,042,752 - 4,049,512 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,042,752 - 4,049,512 (+)EnsemblGRCm39 Ensembl
GRCm38193,992,752 - 3,999,512 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,992,752 - 3,999,512 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,992,752 - 3,999,512 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,992,752 - 3,999,512 (+)NCBIMGSCv36mm8
Celera193,863,807 - 3,870,608 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.71NCBI
Tbx10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,714,992 - 210,722,089 (+)NCBIGRCr8
mRatBN7.21201,285,729 - 201,292,676 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,279,829 - 201,292,601 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01219,237,204 - 219,246,480 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,243,447 - 219,246,262 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,107,855 - 226,117,187 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,573,601 - 206,581,992 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1198,828,339 - 198,837,615 (+)NCBICelera
Cytogenetic Map1q43NCBI
Tbx10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,859,775 - 17,866,226 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,857,038 - 17,866,507 (+)NCBIChiLan1.0ChiLan1.0
TBX10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,870,618 - 49,873,452 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,866,920 - 49,873,190 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,480,274 - 48,482,775 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,792,056 - 50,794,558 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11850,005,510 - 50,008,004 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,580,488 - 49,582,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,373,922 - 50,376,423 (+)NCBIUU_Cfam_GSD_1.0
Tbx10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,709,932 - 5,716,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,152,272 - 2,158,332 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,152,281 - 2,158,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,941,136 - 4,948,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,945,381 - 4,948,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TBX10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,623,195 - 6,640,000 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,623,588 - 6,628,304 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038103,913,637 - 103,918,191 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbx10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,919,516 - 18,924,547 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,918,933 - 18,923,369 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.
RefSeq Transcripts XM_034933171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide DQ977192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JARIFH020000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000036713   ⟹   ENSPPAP00000014038
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1166,303,253 - 66,311,529 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000036721   ⟹   ENSPPAP00000014046
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1166,303,555 - 66,308,748 (-)Ensembl
RefSeq Acc Id: XM_034933171   ⟹   XP_034789062
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2968,860,615 - 68,866,927 (-)NCBI
NHGRI_mPanPan11169,903,427 - 69,910,249 (-)NCBI
Mhudiblu_PPA_v01162,991,902 - 62,996,794 (-)NCBI
Protein RefSeqs XP_034789062 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABM54228 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014038.1
  ENSPPAP00000014046.1
RefSeq Acc Id: XP_034789062   ⟸   XM_034933171
- UniProtKB: A0A2R9AET6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000014046   ⟸   ENSPPAT00000036721
Ensembl Acc Id: ENSPPAP00000014038   ⟸   ENSPPAT00000036713
T-box



1 to 23 of 23 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000030171 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036713.1 UniProtKB/TrEMBL
  ENSPPAT00000036721.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
NCBI Gene TBX10 ENTREZGENE
PANTHER PTHR11267 UniProtKB/TrEMBL
  T-BOX TRANSCRIPTION FACTOR TBX10 UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
PRINTS TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt A0A2R9AAX1_PANPA UniProtKB/TrEMBL
  A0A2R9AET6 ENTREZGENE, UniProtKB/TrEMBL
  A1YG02_PANPA UniProtKB/TrEMBL
  A1YG03_PANPA UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 TBX10  T-box transcription factor 10  TBX10  T-box 10  Symbol and/or name change 5135510 APPROVED