NLRP12 (NLR family pyrin domain containing 12) - Rat Genome Database

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Gene: NLRP12 (NLR family pyrin domain containing 12) Pan paniscus
Analyze
Symbol: NLRP12
Name: NLR family pyrin domain containing 12
RGD ID: 11831388
Description: ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); dendritic cell migration (ortholog); ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH autoimmune interstitial lung, joint, and kidney disease (ortholog); Chediak-Higashi syndrome (ortholog); Childhood Schizophrenia (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NACHT, LRR and PYD domains-containing protein 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22059,797,427 - 59,836,448 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11961,719,665 - 61,758,320 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01950,735,124 - 50,765,556 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,581,547 - 59,614,665 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1959,582,005 - 59,614,436 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NLRP12Bonoboautoimmune interstitial lung, joint, and kidney disease  ISONLRP12 (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndromeClinVarPMID:25741868 and PMID:28492532
NLRP12BonoboChediak-Higashi syndrome  ISONLRP12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
NLRP12BonoboChediak-Higashi syndrome  ISONLRP12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
NLRP12BonoboChediak-Higashi syndrome  ISONLRP12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
NLRP12BonoboChildhood Schizophrenia  ISONLRP12 (Homo sapiens)8554872ClinVar Annotator: match by term: Childhood-onset schizophreniaClinVarPMID:26508570 and PMID:28492532
NLRP12BonoboCryopyrin-Associated Periodic Syndromes  ISONLRP12 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial cold urticariaClinVarPMID:25741868 and PMID:28492532
NLRP12Bonobofamilial cold autoinflammatory syndrome  ISONLRP12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24033266 more ...
NLRP12Bonobofamilial cold autoinflammatory syndrome 2  ISONLRP12 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
NLRP12Bonobofamilial Mediterranean fever  ISONLRP12 (Homo sapiens)8554872ClinVar Annotator: match by term: Periodic fever syndromeClinVarPMID:25741868 and PMID:28492532
NLRP12Bonobogenetic disease  ISONLRP12 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
NLRP12Bonobomultisystem inflammatory syndrome in children  ISONLRP12 (Homo sapiens)8554872ClinVar Annotator: match by term: Multisystem inflammatory syndrome in childrenClinVarPMID:25741868 and PMID:28492532
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NLRP12Bonoborenal cell carcinoma  ISONLRP12 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:23797736
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NLRP12Bonobofamilial cold autoinflammatory syndrome 2  ISONLRP12 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NLRP12Bonobocellular response to cytokine stimulus involved_inIEAPANTHER:PTN000648002150520179 TreeGrafterGO_REF:0000118
NLRP12Bonobocellular response to cytokine stimulus acts_upstream_of_or_withinISOMGI:48363579068941 PMID:20861349MGIPMID:20861349
NLRP12Bonobodendritic cell migration acts_upstream_of_or_withinISOMGI:48363579068941 PMID:20861349MGIPMID:20861349
NLRP12BonoboERK1 and ERK2 cascade acts_upstream_ofISOMGI:48363579068941 PMID:22503542MGIPMID:22503542
NLRP12Bonobonegative regulation of canonical NF-kappaB signal transduction involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobonegative regulation of canonical NF-kappaB signal transduction involved_inIEAPANTHER:PTN000648002150520179 TreeGrafterGO_REF:0000118
NLRP12Bonobonegative regulation of cytokine production involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobonegative regulation of ERK1 and ERK2 cascade acts_upstream_of_or_withinISOMGI:48363579068941 PMID:22503542MGIPMID:22503542
NLRP12Bonobonegative regulation of inflammatory response involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobonegative regulation of inflammatory response involved_inIEAPANTHER:PTN000648002150520179 TreeGrafterGO_REF:0000118
NLRP12Bonobonegative regulation of interleukin-1 production involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobonegative regulation of interleukin-6 production involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobonegative regulation of non-canonical NF-kappaB signal transduction involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobonegative regulation of signal transduction involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobonegative regulation of Toll signaling pathway involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobopositive regulation of MHC class I biosynthetic process acts_upstream_of_or_withinIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobopositive regulation of MHC class I biosynthetic process involved_inIEAPANTHER:PTN000648002150520179 TreeGrafterGO_REF:0000118
NLRP12Bonobopositive regulation of non-canonical NF-kappaB signal transduction involved_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonoboregulation of canonical NF-kappaB signal transduction acts_upstream_of_or_withinIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonoboregulation of inflammatory response involved_inIEAPANTHER:PTN000648002150520179 TreeGrafterGO_REF:0000118
1 to 20 of 20 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NLRP12Bonobocytoplasm located_inIEAUniProtKB:P59046 and ensembl:ENSP00000319377150520179 EnsemblGO_REF:0000107
NLRP12Bonobocytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
NLRP12Bonobocytoplasm located_inIEAPANTHER:PTN000648002150520179 TreeGrafterGO_REF:0000118
NLRP12Bonobonucleus NOT|located_inISONLRP12 (Homo sapiens)9068941 PMID:12019269MGIPMID:12019269

Molecular Function

  

PMID:22301074   PMID:30032202  



NLRP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22059,797,427 - 59,836,448 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11961,719,665 - 61,758,320 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01950,735,124 - 50,765,556 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,581,547 - 59,614,665 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1959,582,005 - 59,614,436 (-)Ensemblpanpan1.1panPan2
NLRP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,793,584 - 53,824,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,792,139 - 53,824,403 (-)EnsemblGRCh38hg38GRCh38
GRCh371954,296,838 - 54,327,657 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,988,650 - 59,019,404 (-)NCBINCBI36Build 36hg18NCBI36
Build 341958,988,668 - 59,019,405NCBI
Celera1951,337,923 - 51,368,731 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,616,403 - 50,647,262 (-)NCBIHuRef
CHM1_11954,298,613 - 54,329,404 (-)NCBICHM1_1
T2T-CHM13v2.01956,873,043 - 56,904,207 (-)NCBIT2T-CHM13v2.0
Nlrp12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,267,317 - 3,298,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,267,458 - 3,298,370 (-)EnsemblGRCm39 Ensembl
GRCm3873,218,643 - 3,249,771 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,218,784 - 3,249,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv3773,221,511 - 3,249,741 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3673,221,511 - 3,249,741 (-)NCBIMGSCv36mm8
Celera73,172,140 - 3,200,874 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map71.88NCBI
Nlrp12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,848,020 - 74,885,945 (+)NCBIGRCr8
mRatBN7.2165,932,610 - 65,969,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,932,595 - 65,960,934 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,380,449 - 71,408,567 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,803,424 - 79,831,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,136,593 - 73,164,746 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,506,750 - 64,543,908 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,506,735 - 64,534,912 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,493,575 - 63,521,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4164,242,875 - 64,271,212 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1164,320,985 - 64,349,047 (+)NCBI
Celera163,663,350 - 63,691,368 (+)NCBICelera
Cytogenetic Map1q12NCBI
Nlrp12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955604317,987 - 331,051 (+)NCBIChiLan1.0ChiLan1.0
NLRP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,571,756 - 103,605,692 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,437,738 - 103,470,619 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01104,026,723 - 104,061,018 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1104,026,630 - 104,058,744 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11103,658,372 - 103,692,595 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,420,767 - 103,454,359 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01104,139,804 - 104,174,064 (+)NCBIUU_Cfam_GSD_1.0
Nlrp12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,900,786 - 2,931,614 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493699420,854 - 36,757 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493699420,848 - 36,757 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl656,402,665 - 56,425,101 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1656,402,617 - 56,425,038 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2652,741,089 - 52,763,504 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1646,507,241 - 46,533,832 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl646,507,410 - 46,533,615 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607326,577,383 - 26,608,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSPPAT00000034552   ⟹   ENSPPAP00000011890
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1959,582,005 - 59,614,436 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000034554   ⟹   ENSPPAP00000011892
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1959,582,005 - 59,614,436 (-)Ensembl
RefSeq Acc Id: XM_003830143   ⟹   XP_003830191
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22059,797,427 - 59,836,448 (-)NCBI
NHGRI_mPanPan11961,719,665 - 61,758,320 (-)NCBI
Mhudiblu_PPA_v01950,735,267 - 50,765,556 (-)NCBI
PanPan1.11959,581,840 - 59,614,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003830145   ⟹   XP_003830193
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22059,797,427 - 59,836,448 (-)NCBI
NHGRI_mPanPan11961,719,665 - 61,758,320 (-)NCBI
Mhudiblu_PPA_v01950,735,153 - 50,765,556 (-)NCBI
PanPan1.11959,581,547 - 59,614,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955557   ⟹   XP_008953805
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22059,797,427 - 59,836,448 (-)NCBI
NHGRI_mPanPan11961,719,665 - 61,758,320 (-)NCBI
Mhudiblu_PPA_v01950,735,124 - 50,765,556 (-)NCBI
PanPan1.11959,581,547 - 59,614,665 (-)NCBI
Sequence:
Protein RefSeqs XP_003830191 (Get FASTA)   NCBI Sequence Viewer  
  XP_003830193 (Get FASTA)   NCBI Sequence Viewer  
  XP_008953805 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000011890.1
  ENSPPAP00000011892.1
RefSeq Acc Id: XP_003830193   ⟸   XM_003830145
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A8C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008953805   ⟸   XM_008955557
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A8C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003830191   ⟸   XM_003830143
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A8C8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000011890   ⟸   ENSPPAT00000034552
Ensembl Acc Id: ENSPPAP00000011892   ⟸   ENSPPAT00000034554
NACHT   Pyrin



1 to 35 of 35 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000029150 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034552.1 UniProtKB/TrEMBL
  ENSPPAT00000034554.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro DAPIN UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT-assoc UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLRP_HD2 UniProtKB/TrEMBL
  NLRP_innate_immun_reg UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene NLRP12 ENTREZGENE
PANTHER NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
Pfam FISNA UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
PROSITE DAPIN UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
SMART FISNA UniProtKB/TrEMBL
  LRR_RI UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
  SSF47986 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9A3J0_PANPA UniProtKB/TrEMBL
  A0A2R9A8C8 ENTREZGENE, UniProtKB/TrEMBL
1 to 35 of 35 rows