CBLC (Cbl proto-oncogene C) - Rat Genome Database

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Gene: CBLC (Cbl proto-oncogene C) Pan paniscus
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Symbol: CBLC
Name: Cbl proto-oncogene C
RGD ID: 11702749
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN negative regulation of epidermal growth factor receptor signaling pathway (ortholog); negative regulation of MAPK cascade (ortholog); negative regulation of neuron apoptotic process (ortholog); FOUND IN membrane raft (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Cbl proto-oncogene, E3 ubiquitin protein ligase C; E3 ubiquitin-protein ligase CBL-C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22050,933,383 - 50,960,455 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,808,296 - 52,832,395 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,726,272 - 41,748,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,331,257 - 50,353,865 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CBLC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22050,933,383 - 50,960,455 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,808,296 - 52,832,395 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,726,272 - 41,748,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,331,257 - 50,353,865 (+)NCBIpanpan1.1PanPan1.1panPan2
CBLC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,777,869 - 44,800,652 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,777,869 - 44,800,652 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,281,126 - 45,303,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361949,972,988 - 49,995,731 (+)NCBINCBI36Build 36hg18NCBI36
Build 341949,972,987 - 49,995,731NCBI
Celera1942,085,488 - 42,107,328 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,713,154 - 41,735,790 (+)NCBIHuRef
CHM1_11945,283,856 - 45,306,632 (+)NCBICHM1_1
T2T-CHM13v2.01947,602,623 - 47,625,402 (+)NCBIT2T-CHM13v2.0
Cblc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,513,643 - 19,530,734 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,512,806 - 19,530,734 (-)EnsemblGRCm39 Ensembl
GRCm38719,779,718 - 19,796,809 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,778,881 - 19,796,809 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,365,067 - 20,382,158 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,938,242 - 18,955,331 (-)NCBIMGSCv36mm8
Celera717,187,514 - 17,204,632 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Cblc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,567,930 - 88,584,709 (-)NCBIGRCr8
mRatBN7.2179,439,975 - 79,456,755 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,439,977 - 79,456,755 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,834,432 - 84,851,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,385,937 - 93,402,717 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,589,544 - 86,606,331 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,699,321 - 80,716,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,699,323 - 80,716,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,964,679 - 81,981,515 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,091,412 - 79,108,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,170,940 - 79,186,278 (-)NCBI
Celera173,898,303 - 73,914,949 (-)NCBICelera
Cytogenetic Map1q21NCBI
Cblc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,921,912 - 1,935,096 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,921,896 - 1,941,247 (+)NCBIChiLan1.0ChiLan1.0
CBLC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,590,548 - 110,606,775 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,590,804 - 110,606,781 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,071,648 - 110,088,645 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,153,520 - 111,169,844 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,153,776 - 111,169,908 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,794,862 - 110,811,626 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,430,583 - 110,447,333 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,299,843 - 111,316,680 (-)NCBIUU_Cfam_GSD_1.0
Cblc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,089,393 - 17,106,072 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,436,732 - 1,450,485 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBLC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,276,544 - 51,292,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,274,717 - 51,292,546 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,174,865 - 47,192,017 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBLC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,257,418 - 38,285,534 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,257,672 - 38,280,051 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607317,821,913 - 17,852,623 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cblc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,676,021 - 1,691,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,676,296 - 1,690,479 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_034945482   ⟹   XP_034801373
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22050,933,383 - 50,960,455 (+)NCBI
NHGRI_mPanPan11952,808,296 - 52,832,395 (+)NCBI
Mhudiblu_PPA_v01941,726,272 - 41,748,829 (+)NCBI
RefSeq Acc Id: XM_034945483   ⟹   XP_034801374
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22050,933,383 - 50,960,455 (+)NCBI
NHGRI_mPanPan11952,808,296 - 52,832,395 (+)NCBI
Mhudiblu_PPA_v01941,726,272 - 41,748,829 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034801373 (Get FASTA)   NCBI Sequence Viewer  
  XP_034801374 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000037262.1
RefSeq Acc Id: XP_034801373   ⟸   XM_034945482
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CGE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034801374   ⟸   XM_034945483
- Peptide Label: isoform X2
Protein Domains
Cbl-PTB   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041388 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000060162.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.930.20 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro Adaptor_Cbl UniProtKB/TrEMBL
  Adaptor_Cbl_N_dom_sf UniProtKB/TrEMBL
  Adaptor_Cbl_N_hlx UniProtKB/TrEMBL
  Adaptor_Cbl_SH2-like UniProtKB/TrEMBL
  Cbl_PTB UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
NCBI Gene CBLC ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE CBL-C UniProtKB/TrEMBL
  PTHR23007 UniProtKB/TrEMBL
Pfam Cbl_N UniProtKB/TrEMBL
  Cbl_N3 UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PROSITE CBL_PTB UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF47668 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9CGE0 ENTREZGENE, UniProtKB/TrEMBL